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ClinicalTrials.gov public records Last synced Nov 15, 2026, 4:13 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 97–120 of 373 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: E Cig Use Clear all

Conditions: Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions: JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS, JUUL 3% Mint ENDS, JUUL 5% Menthol ENDS, JUUL 3% Menthol ENDS, JUUL 5% Mango ENDS, JUUL 3% Mango ENDS, US Cigarette, Non-menthol - Marlboro Gold King Size, US Cigarette, Menthol - Newport King Size; Other
Lead sponsor: Juul Labs, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 135 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 3
States / cities: Secaucus, New Jersey • Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Coronary Artery Disease, Myocardial Perfusion
Interventions: Cigarettes, E-cigarettes (nicotine free e-liquid), E-cigarettes (low nicotine e-liquid), E-cigarettes (high nicotine e-liquid); Other
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 49 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Products, Cigarettes, Electronic Cigarettes
Interventions: communication; Other
Lead sponsor: UNC Lineberger Comprehensive Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 99 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Smoking Cigarette, Smoking Behaviors, Vaping, Vaping Behaviors
Interventions: Not listed
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 21 Years to 65 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use
Interventions: Anti-vaping and anti-smoking digital advertising; Behavioral
Lead sponsor: George Washington University; Other
Eligibility: 18 Years to 24 Years
Enrollment: 2,800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Cigarette Smoking
Interventions: NIDA Standard Research E-cigarette (SREC); Device
Lead sponsor: University of Southern California; Other
Eligibility: 22 Years to 55 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Cervical Dysplasia
Interventions: Nicotine Replacement Therapy, Electronic Cigarettes; Other · Device
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 31 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping
Interventions: E-cigarette; Other
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 461 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Airway Morbidity, Smoking Cessation, Nicotine Adverse Reaction, Smoking, Tobacco, Smoking, Cigarette
Interventions: Electronic cigarette use, Control regular cigarette smokers; Device · Other
Lead sponsor: Miami VA Healthcare System; Federal
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Nicotine Addiction, Cigarette Smoking
Interventions: Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds; Drug
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Electronic Cigarettes
Interventions: ECIG Lab Session 15 watts, 10 mg nicotine, ECIG Lab Session 15 watts, 15 mg nicotine, ECIG Lab Session 15 watts, 30 mg nicotine, ECIG Lab Session 30 watts, 10 mg nicotine, ECIG Lab Session 30 watts, 15 mg nicotine, ECIG Lab Session 30 watts, 30 mg nicotine; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Cigarette Smoking, Nicotine Vaping
Interventions: Promotion factors, Mitigation strategies; Behavioral
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Electronic Cigarette Use
Interventions: RELX ENDS Tobacco Flavor, RELX ENDS Menthol Flavor, Subject Usual Brand ENDS; Other
Lead sponsor: Cheerain HK Limited; Industry
Eligibility: 22 Years to 59 Years
Enrollment: 29 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 2
States / cities: Cypress, California • Overland Park, Kansas

Conditions: E-cigarette Use
Interventions: ECIG lab session 1, ECIG lab session 2, ECIG lab session 3, ECIG lab session 4, ECIG lab session 5, ECIG lab session 6, ECIG lab session 7, ECIG lab session 8; Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 25 Years
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2023
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
Interventions: CSD1902-11, CSD1902-12, CSD1902-13, CSD1902-14, CSD1902-21, CSD1902-22, CSD1902-23, CSD1902-24; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 146 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: High Point, North Carolina

Conditions: Nicotine Dependence
Interventions: ECIG Session; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Vaping, Nicotine Dependence
Interventions: Varenicline, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 25 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking, Cigarette
Interventions: Standardized Research E-cigarette (SREC); Drug
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking-Related Carcinoma, E-Cig Use
Interventions: Effectiveness of different recruitment approaches, Choice of study completion locations, Cannabis Engagement Assessment, E-cigarette dependence Scale, Nicotine dependence Scale, Co use practices QUestionnaire; Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years to 25 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Nicotine Dependence, Other Tobacco Product, Bladder Cancer, Lung Cancer, Cancer of Head and Neck
Interventions: HALO; Device
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Smoking, Tobacco Use
Interventions: Electronic Cigarette; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 638 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Electronic Cigarette Use
Interventions: Standardized research e-cigarette (SREC); Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 41 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Electronic Cigarette Use, Endothelial Dysfunction, Inflammation
Interventions: Placebo, Salsalate 750 MG Oral Tablet [DISALCID]; Drug
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 24 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 2
States / cities: Iowa City, Iowa

Conditions: Smoking
Interventions: NNC Spectrum Cigarette, VLNC Spectrum Cigarette, Moderate nicotine level e-liquid, Low nicotine level e-liquid, Tobacco Flavors, Tobacco and non-tobacco e-liquid flavors; Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 156 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 2
States / cities: Winston-Salem, North Carolina • Philadelphia, Pennsylvania

Search by objective public record fields.

Evaluating Selected Constituents in the Exhaled Breath Samples

E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion

Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes

Vape Use Among Younger & Older Smokers

Digital Media for Cancer Control (to Prevent Vaping and Smoking Behavior)

Are Smokers Switching to Vaping at Lower Risk for Cancer? (Electronic Cigarettes and Cancer Risk)

Smoking Cessation in Women With Gynecological Conditions

Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 2

Adverse Airway Effects From Tobacco and E-Cigarettes

Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

Effects of Electronic Cigarette Settings and Liquid Concentrations in Cigarette Smokers and Electronic Cigarette Users

Promotion and Mitigation Factors Leading to Illegal Tobacco Purchases

Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by ENDS Consumers

Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth

CSD190203: A Study to Determine Subject Puffing Patterns of an Electronic Nicotine Delivery System in an Ambulatory Setting

The Influence of Electronic (ECIG) Heater Resistance on ECIG Acute Effects

Varenicline For Nicotine Vaping Cessation In Non Smoker Vaper Adolescents

Biomarkers of Exposure and Effect in Standardized Research E-cigarette (SREC) Users

Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)

Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers

Clinical Outcomes of a Nationwide, Naturalistic E-Cig Trial (CONNECT)

Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC

Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use

Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors