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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:03 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 169–192 of 373 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: E Cig Use Clear all

Conditions: Tobacco Use
Interventions: Not listed
Lead sponsor: University of Oklahoma; Other
Eligibility: 18 Years to 99 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Oklahoma City, Oklahoma

Conditions: E-cigarette Use, Vaping, Nicotine Dependence
Interventions: Varenicline 1mg BID, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 326 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 2
States / cities: New Haven, Connecticut • Charleston, South Carolina

Conditions: Smoking
Interventions: blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (2.4% nicotine, glycerin/PG vehicle), blu™ Magnificent Menthol rechargeable (2.4% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin vehicle), blu™ Classic Tobacco rechargeable (1.6% nicotine, glycerin/PG vehicle), Marlboro Cigarette; Other
Lead sponsor: Lorillard Tobacco Company; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Smoking Prevention and Control
Interventions: Non-Menthol Cigarettes, Tobacco Flavored E-cigarettes, Menthol Cigarettes, Menthol Flavored E-cigarettes; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Tobacco Use Disorder
Interventions: menthol flavored e-cigarette, tobacco flavored e-cigarette; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 64 Years
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Electronic Cigarette Use
Interventions: Menthol-flavored e-cigarette, Tobacco-flavored e-cigarette; Other
Lead sponsor: Florida International University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Nicotine Dependence
Interventions: Nicotine patch, ENDS, Placebo patch, Placebo ENDS; Drug · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2022
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Nicotine Dependence, E-cigarette Use
Interventions: Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml); Other
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 44 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Cigarette Smoking
Interventions: Research ENDS S-TA-U001, Nicorette Inhalator; Drug
Lead sponsor: NJOY, Inc.; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 34 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Burbank, California

Conditions: Vaping
Interventions: Youth Perceptions of Influencer Age and Fitness Contexts in E-Cigarette Marketing; Other
Lead sponsor: University of Southern California; Other
Eligibility: 14 Years to 17 Years
Enrollment: 700 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Vaping
Interventions: Not listed
Lead sponsor: Yale University; Other
Eligibility: 12 Years to 15 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: New Haven, Connecticut • Boston, Massachusetts

Conditions: Perceptions of Tobacco Products
Interventions: Each intervention will be a picture of a social media post. The posts will vary (in a 3X2 factorial design) the type of flavor described and whether concealability is described.; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 14 Years to 17 Years
Enrollment: 4,500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: E-Cig Use
Interventions: Viewing e-cigarette ads; Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years to 26 Years
Enrollment: 62 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Tobacco Smoking
Interventions: Nicotine Patch, E-cigarette; Drug
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 65 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Cannabis Use, Tobacco Use, Electronic Cigarette Use
Interventions: THC High Dose, THC Low Dose, THC 0mg, E-Cigarette Full Nicotine, E-Cigarette Placebo Nicotine; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Tobacco Dependence
Interventions: Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes, Zero Nicotine e-cigarette; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 70 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Vaping
Interventions: Expert, one-sided, Expert, two-sided, Peer, one-sided, Peer, two-sided; Other
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 18 Years to 24 Years
Enrollment: 848 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Cough
Interventions: electronic cigarette exposure; Device
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014
U.S. locations: 1
States / cities: The Bronx, New York

Conditions: Evaluate the Association of Vaping With Seizures
Interventions: Vaping; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 21 Years and older
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Cardiovascular Risk Factor, Nicotine Dependence
Interventions: Low Nicotine E-Liquid, Medium or High Nicotine E-Liquid; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Electronic Cigarette Related Lung Damage
Interventions: Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test, Chest CT; Drug · Diagnostic Test
Lead sponsor: Y. Michael Shim, MD; Other
Eligibility: 18 Years to 35 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2032
U.S. locations: 2
States / cities: Durham, North Carolina • Charlottesville, Virginia

Conditions: Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
Interventions: very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette; Other
Lead sponsor: Duke University; Other
Eligibility: 21 Years and older
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Nicotine Dependence
Interventions: Dual nicotine patch and electronic cigarette; Other
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 45 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2027
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Smoking
Interventions: Own Brand Menthol Cigarette, Electronic Menthol Cigarette #1, Electronic Menthol Cigarette #2, Electronic Menthol Cigarette #3, Leading U.S. Nicotine Gum; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 71 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: Lincoln, Nebraska

Search by objective public record fields.

Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability

A Trial of Varenicline for E-cigarette Cessation

Characterization of Nicotine Exposure and Urge-to-Smoke Following Use of Electronic and Conventional Cigarettes

Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes

Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes

Effect of Menthol on ENDS Users' Addiction and Exposure

Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment

Sex Differences in E-Cigarette Perception

Nicotine Pharmacokinetics From Research Electronic Nicotine Delivery System S-TA-U001 in Smokers and E-Cigarette Users

Influencer Marketing and Adolescent E-cigarette Use

A Virtual Reality Vaping Prevention Intervention for Adolescents

Social Media Influences on Engagement and Susceptibility to Non-combustible Tobacco Product Use Among Youth and Young Adults (AYA)

Responses to E-Cigarette Advertising

E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia

Effect of Cannabis on E-Cigarette Use Behavior

Low Nicotine Cigarettes Plus Electronic Cigarettes

Responses to E-cigarette Message Source and Presentation

Effect of Electronic Cigarette Use on Cough Reflex Sensitivity

Vaping-Related Seizures - A Prospective Study

Vaping High vs. Low Nicotine E-Liquid

Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology

Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2

Electronic Cigarettes and Reactivity to Smoking Cues

Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum