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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:10 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 193–216 of 373 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: E Cig Use Clear all

Conditions: Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions: Acute (24-hour) abstinence, Ad libitum smoking/vaping; Behavioral
Lead sponsor: State University of New York at Buffalo; Other
Eligibility: 21 Years to 50 Years
Enrollment: 370 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Abuse Tobacco, Exposure
Interventions: Behavioral Intervention, Biospecimen Collection, Survey Administration; Behavioral · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 29 Years
Enrollment: 158 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Dependence, Electronic Cigarette Use
Interventions: Electronic Cigarette, Nicotine Lozenge; Drug
Lead sponsor: Butler Hospital; Other
Eligibility: 21 Years to 65 Years
Enrollment: 183 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Vaping, Underage
Interventions: IKE System; Other
Lead sponsor: IKE Tech; Industry
Eligibility: 18 Years and older
Enrollment: 102 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025
U.S. locations: 4
States / cities: Los Angeles, California • Chicago, Illinois • New York, New York + 1 more

Conditions: Smoking, E-Cig Use, Oncology
Interventions: Harm Reduction (E-cigarette switching), Standard of Care; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 208 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Electronic Cigarettes
Interventions: e-Cigarette; Other
Lead sponsor: University of Southern California; Other
Eligibility: 21 Years and older
Enrollment: 37 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Tobacco Use Disorder, Smoking
Interventions: e-cigarettes; Device
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years to 35 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Tobacco Use Disorder
Interventions: E-cigarette product; Device
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Pulmonary Disease, Chronic Obstructive, Tobacco Smoking
Interventions: Brief advice, Single Training, Training to Competency; Behavioral
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Pulmonary Disease, Chronic Obstructive, E-cigarettes
Interventions: E-cigarette, Sham, Hyperpolarized 3-Helium, Gadolinium; Device · Other · Drug
Lead sponsor: Columbia University; Other
Eligibility: 21 Years to 35 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: New York, New York

Conditions: Implementation Science, Engagement, Patient, E Cigarette Use, Peer Support, Vaping Teens, Vaping Cessation, Parent Support
Interventions: Parents Helping Parents program; Behavioral
Lead sponsor: University of Nebraska; Other
Eligibility: 15 Years to 18 Years
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Electronic Cigarettes
Interventions: Own Brand Cigarette, ECIG 15 mg nicotine, sweetened, ECIG 15 mg nicotine, unsweet, ECIG 0 mg nicotine, sweetened, ECIG 0 mg nicotine, unsweet; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Nicotine Addiction
Interventions: Nicotine patch and gum, Minnesota Nicotine Withdrawal Scale (MNWS), ASSIST (the Alcohol, Smoking and Substance Involvement Screening), Counseling, NIDA Standardized Research E-cigarettes (SREC); Other · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: New York, New York

Conditions: Vaping, Smoking Cessation
Interventions: Virtual Reality Program, VR Program; Behavioral
Lead sponsor: Boston University; Other
Eligibility: 13 Years to 19 Years
Enrollment: 119 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Electronic Cigarette Use
Interventions: Electronic Cigarette containing nicotine, Electronic Cigarette without nicotine; Device
Lead sponsor: Michigan Technological University; Other
Eligibility: 21 Years to 40 Years
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Houghton, Michigan

Conditions: Vascular Health
Interventions: Electronic cigarette, traditional cigarette, (sham cigarette) - no actual exposure to cigarettes; Behavioral
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years to 50 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Cigarette Smoking
Interventions: E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling, Ecological Momentary Intervention (EMI) Text Messaging; Other · Behavioral
Lead sponsor: NYU Langone Health; Other
Eligibility: 21 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Smoking
Interventions: Own Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Electronic Cigarette #3, Leading U.S. Nicotine Gum; Other
Lead sponsor: R.J. Reynolds Vapor Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Lincoln, Nebraska

Conditions: Smoking, Tobacco Use
Interventions: Salt Base Nicotine, Free Base Nicotine; Other
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 21 Years and older
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema, Asthma-COPD Overlap Syndrome
Interventions: E-Cigarette, Financial Incentives; Other · Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 40 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 159 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2013
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Vaping, Vaping Cessation
Interventions: Behavioral: Quitting Program (TIQ); Device
Lead sponsor: St. Jude Children's Research Hospital; Other
Eligibility: 13 Years to 24 Years
Enrollment: 539 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Memphis, Tennessee

Conditions: Nicotine Administration & Dosage, E-cigarettes, Vaping, E-Liquid, Tobacco Smoking
Interventions: JUUL, Tobacco; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 21 Years to 70 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2022
U.S. locations: 2
States / cities: San Francisco, California

Conditions: Cigarette Smoking, Nicotine Vaping
Interventions: All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Heated tobacco products at 1/2 market price., Nicotine pouch products at 1/2 market price.; Other
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Eligibility: 21 Years and older
Enrollment: 440 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Roanoke, Virginia

Search by objective public record fields.

Vaping and Smoking Withdrawal Project

Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study

Methadone-Maintained Smokers Switching to E-Cigarettes

Human Factors Validation and Usability Testing of the IKE Age-Gating System

Clinical Alternatives for Reducing Harm Using E-cigarettes

Effects of e-Cigarettes on Nicotine Withdrawal

Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy

Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes

COPD E-cigarette Topography Training

Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study

Parents Helping Parents for Youth Vaping Cessation

The Effect of Electronic Cigarette Liquid Characteristics in Smokers.

Electronic Cigarettes as a Harm Reduction Strategy Among People Living With HIV/AIDS

Vaping Prevention and Vaping in Youth (Vapechat)

Vaporized Nicotine and Autonomic Control

Investigation of the Effects of Electronic Cigarettes on Vascular Health

E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness

Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Electronic Cigarettes vs Combustible Cigarettes and Nicotine Gum

Salt-Based E-cigarette

Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes

Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity

Implementing an Adolescent and Young Adult (AYA) mHealth Vaping Cessation Program Into Oncology Clinics

Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes

Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study