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ClinicalTrials.gov public records Last synced Oct 22, 2026, 11:54 PM EDT

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Showing 1–24 of 370 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: E-Cig Use Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors

NCT03185546
View directory record Official record
Conditions
Smoking
Interventions
NNC Spectrum Cigarette, VLNC Spectrum Cigarette, Moderate nicotine level e-liquid, Low nicotine level e-liquid, Tobacco Flavors, Tobacco and non-tobacco e-liquid flavors
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Winston-Salem, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 14, 2021 · Synced Oct 22, 2026, 11:54 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Guiding Good Choices for Health

NCT04040153
View directory record Official record
Conditions
Adolescent Substance Use
Interventions
Guiding Good Choices
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
11 Years to 12 Years
Enrollment
3,636 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
3
States / cities
Oakland, California • Aurora, Colorado • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Oct 22, 2026, 11:54 PM EDT
Recruiting Phase 4 Interventional

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

NCT07145866
View directory record Official record
Conditions
Nicotine Dependence, Transcranial Magnetic Stimulation, Vaping, Smoking Cessation, Smoking (Tobacco) Addiction
Interventions
Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham, Nicotine Cessation Counseling, D-cycloserine
Drug · Device · Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 22, 2026, 11:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Human Factors Validation and Usability Testing of the IKE Age-Gating System

NCT06952569
View directory record Official record
Conditions
Vaping, Underage
Interventions
IKE System
Other
Lead sponsor
IKE Tech
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
4
States / cities
Los Angeles, California • Chicago, Illinois • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]

NCT05030194
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Cigarette Smoking, Smokeless Tobacco Cessation
Interventions
Electronic Cigarette, Oral Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 26, 2023 · Synced Oct 22, 2026, 11:54 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of Pharmacokinetic Parameters Between Adopters of Electronic Cigarettes and a Historical Sample of Combustible Cigarette Smokers

NCT02730676
View directory record Official record
Conditions
Smoking
Interventions
Electronic Cigarette #1, Electronic Cigarette #2
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Electronic Cigarettes as a Harm Reduction Strategy in Individuals With Substance Use Disorder

NCT04063267
View directory record Official record
Conditions
Cigarette Smoking, Addiction, E Cig Use
Interventions
E cigarettes, Nicotine Replacement Therapy
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Vaporized Nicotine and Autonomic Control

NCT04613609
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Electronic Cigarette containing nicotine, Electronic Cigarette without nicotine
Device
Lead sponsor
Michigan Technological University
Other
Eligibility
21 Years to 40 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houghton, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating the Comparative Pharmacokinetics of Nicotine After Administration Via JUUL or Tobacco Cigarettes

NCT04053868
View directory record Official record
Conditions
Nicotine Administration & Dosage, E-cigarettes, Vaping, E-Liquid, Tobacco Smoking
Interventions
JUUL, Tobacco
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 16, 2025 · Synced Oct 22, 2026, 11:54 PM EDT
Completed No phase listed Observational

Electronic Cigarette Use During Pregnancy

NCT03480373
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Not listed
Lead sponsor
UConn Health
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
182 participants
Timeline
2018 – 2023
U.S. locations
6
States / cities
Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

NCT03625986
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Oct 22, 2026, 11:54 PM EDT
Active, not recruiting Not applicable Interventional

Developing an E-Cigarette Cessation Intervention for Hispanic/Latina(o) Youth in Florida: The BReATHE Study

NCT07192601
View directory record Official record
Conditions
Vaping Teens, Vaping Behaviors, Vaping Cessation, Tobacco Use Disorder
Interventions
E-cigarette Cessation Manual
Behavioral
Lead sponsor
Florida International University
Other
Eligibility
14 Years to 18 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Electronic Cigarette Use on the Lungs

NCT02596685
View directory record Official record
Conditions
Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker, E-cig User
Interventions
Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis, Questionnaire Administration
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 45 Years
Enrollment
142 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Oct 22, 2026, 11:54 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effects of Nicotine Salt Aerosol on Cigarette Smokers

NCT03974152
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Subox Mini C with Avail 18 mg nicotine salt (protonated), Subox Mini C with Avail 18 mg nicotine (unprotonated), Own brand cigarette
Other
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
21 Years to 55 Years
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

E-cigarette Nicotine Study

NCT04709471
View directory record Official record
Conditions
Nicotine Dependence, Electronic Cigarette Use, Cigarette Smoking
Interventions
Nicotine, Juul e-cigarette, Reduction
Drug · Device · Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
21 Years and older
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use

NCT07010601
View directory record Official record
Conditions
Alcohol Use, E-cigarette Use, Cigarette Use
Interventions
Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks
Behavioral
Lead sponsor
Mark J Rzeszutek, PhD
Other
Eligibility
21 Years and older
Enrollment
737 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 22, 2026, 11:54 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

NCT05962229
View directory record Official record
Conditions
Nicotine Dependence, Nicotine Vaping
Interventions
(S)-Nicotine, (R)- nicotine, Racemic nicotine
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Middle School Cluster Randomized Controlled Trial (RCT) to Evaluate E-Cigarette Prevention Program: CATCH My Breath

NCT04843501
View directory record Official record
Conditions
E-cigarette Use
Interventions
CATCH My Breath (CMB) program for E-cigarette prevention among adolescents, Texas Education Agency (TEA) required tobacco prevention program
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
10 Years to 15 Years
Enrollment
2,059 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age

NCT04092387
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Varying the nicotine content of cigarettes, E-Cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
21 Years to 44 Years · Female only
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Oct 22, 2026, 11:54 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Attentional Bias Modification Training for E-cigarette Users

NCT05112562
View directory record Official record
Conditions
E-cigarette Use, Tobacco Use Cessation
Interventions
Computerized attentional bias modification training, Placebo attention control training
Behavioral
Lead sponsor
University of Wisconsin, Milwaukee
Other
Eligibility
18 Years to 29 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 4, 2022 · Synced Oct 22, 2026, 11:54 PM EDT
Recruiting Not applicable Interventional

Behavioral Intervention for Youth to Promote Vaping Cessation

NCT06765291
View directory record Official record
Conditions
Vaping, Vaping Teens, Nicotine Dependence
Interventions
QuitVaping, This is Quitting (TIQ)
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
14 Years to 19 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 22, 2026, 11:54 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Impact of E-cigarette Use on the Body

NCT04972513
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Biospecimen Collection, Nitric Oxide Breath Test, Oscillometry, Spirometry, Survey Administration, Endothelial function
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
15 Years to 25 Years
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Oct 22, 2026, 11:54 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Biomarkers of Exposure and Effect in Standardized Research E-cigarette (SREC) Users

NCT04003805
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
Standardized Research E-cigarette (SREC)
Drug
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 22, 2026, 11:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Social Media Support Groups for Adolescent Vaping Cessation

NCT07540780
View directory record Official record
Conditions
Vaping, Vaping Cessation, Nicotine Dependence
Interventions
Social Media Intervention
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
13 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 17, 2026 · Synced Oct 22, 2026, 11:54 PM EDT