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ClinicalTrials.gov public records Last synced Sep 10, 2026, 4:46 AM EDT

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Showing 1–24 of 51 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Early Lung Cancer Detection Clear all
Recruiting No phase listed Observational

Avera Cancer Sequencing and Analytics Protocol (ASAP)

NCT05142033
View directory record Official record
Conditions
Cancer, Cancer Diagnosis, Early Detection of Cancer, Breast Cancer, Lung Cancer, Colon Cancer, GI Cancer, Gynecologic Cancer, Ovarian Cancer, Endometrial Cancer, CNS Cancer, Hematologic Cancer
Interventions
Not listed
Lead sponsor
Avera McKennan Hospital & University Health Center
Other
Eligibility
18 Years and older
Enrollment
25,000 participants
Timeline
2021 – 2026
U.S. locations
6
States / cities
Marshall, Minnesota • Aberdeen, South Dakota • Mitchell, South Dakota + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 10, 2026, 4:46 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)

NCT04200534
View directory record Official record
Conditions
Smoking, Lung Cancer
Interventions
Best Practice, Nicotine Patch, Quality-of-Life Assessment, Questionnaire Administration, Tobacco Cessation Counseling
Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
55 Years to 77 Years
Enrollment
358 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
3
States / cities
Galveston, Texas • Houston, Texas • Tyler, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Sep 10, 2026, 4:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Digital Outreach Intervention for Lung Cancer Screening

NCT04083859
View directory record Official record
Conditions
Lung Cancer
Interventions
mPATH-Lung, Lung health video
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
50 Years to 77 Years
Enrollment
26,998 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 24, 2025 · Synced Sep 10, 2026, 4:46 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Early Detection of Lung Cancer Via Bi-plane Correlation Chest Imaging

NCT00673283
View directory record Official record
Conditions
Lung Cancer, Metastatic Cancer in the Lungs
Interventions
bi-plane chest radiography
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 31, 2014 · Synced Sep 10, 2026, 4:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Early Detection of Lung Cancer in a High-Risk Population Defined by PFT, Biomarkers, and CT Scanning

NCT00596310
View directory record Official record
Conditions
Lung Cancer
Interventions
CT
Other
Lead sponsor
Susanne Arnold
Other
Eligibility
55 Years to 75 Years
Enrollment
531 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2020
U.S. locations
4
States / cities
Hazard, Kentucky • Morehead, Kentucky • Prestonsburg, Kentucky + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Sep 10, 2026, 4:46 AM EDT
Completed Not applicable Interventional

Improving Implementation of Lung Cancer Screening in Diverse Populations II

NCT05265897
View directory record Official record
Conditions
Early Detection of Cancer, Lung Cancer
Interventions
CAQ
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
230 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Sep 10, 2026, 4:46 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sputum Labeling Utilizing Synthetic Meso-Tetra (4-Carboxyphenyl) Porphine (TCPP) for Detection of Lung Cancer

NCT02388074
View directory record Official record
Conditions
Lung Cancer
Interventions
CyPath®
Device
Lead sponsor
bioAffinity Technologies Inc.
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 13, 2015 · Synced Sep 10, 2026, 4:46 AM EDT
Completed No phase listed Observational

Non-Invasive Biomarkers For Early Detection Of Lung Cancers

NCT01580332
View directory record Official record
Conditions
Lung Cancer
Interventions
Not listed
Lead sponsor
Douglas W. Johnson MD, FACR
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 22, 2014 · Synced Sep 10, 2026, 4:46 AM EDT
Completed No phase listed Observational

Biomarkers to Detect Mesothelioma Early in Patients Exposed to Asbestos or Vermiculite

NCT00897247
View directory record Official record
Conditions
Malignant Mesothelioma, Pulmonary Complications
Interventions
microarray analysis, protein expression analysis, proteomic profiling, laboratory biomarker analysis
Genetic · Other
Lead sponsor
Barbara Ann Karmanos Cancer Institute
Other
Eligibility
25 Years to 80 Years
Enrollment
494 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 4, 2014 · Synced Sep 10, 2026, 4:46 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Tailored Patient Navigation to Improve the Uptake of Lung Cancer Screening in Tribal Communities in Western Washington State, SACRED LUNGS Trial

NCT07176000
View directory record Official record
Conditions
Lung Carcinoma
Interventions
Patient Navigation, Educational Intervention, Best Practice, Interview, Survey Administration, Electronic Health Record Review
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
237 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
2
States / cities
Auburn, Washington • Shelton, Washington
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 10, 2026, 4:46 AM EDT
Completed Not applicable Interventional

Early Detection of Second Lung Cancer in Patients With Stage I Non-small Cell Lung Cancer

NCT00002667
View directory record Official record
Conditions
Lung Cancer
Interventions
cytology specimen collection procedure, immunoenzyme technique, study of high risk factors
Other · Procedure
Lead sponsor
Eastern Cooperative Oncology Group
Network
Eligibility
18 Years to 120 Years
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2004
U.S. locations
5
States / cities
Tampa, Florida • Des Moines, Iowa • Hackensack, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Sep 10, 2026, 4:46 AM EDT
Terminated No phase listed Observational

Utility of CAML as Diagnostic for Early Stage Lung Cancer

NCT03992183
View directory record Official record
Conditions
Pulmonary Nodule, Multiple, Pulmonary Nodule, Solitary
Interventions
Not listed
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Sep 10, 2026, 4:46 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Tribally Engaged Approaches to Lung Screening (TEALS)

NCT04948060
View directory record Official record
Conditions
Lung Cancer
Interventions
Enhanced lung cancer screening services
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
50 Years to 80 Years
Enrollment
275 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Sep 10, 2026, 4:46 AM EDT
Not listed No phase listed Observational

LungLB in Subjects Presenting With Indeterminate Pulmonary Nodules

NCT05171491
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
Not listed
Lead sponsor
LungLife AI
Industry
Eligibility
40 Years and older
Enrollment
425 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
12
States / cities
Los Angeles, California • Bay Pines, Florida • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 12, 2024 · Synced Sep 10, 2026, 4:46 AM EDT
Recruiting Not applicable Interventional

Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT

NCT06910956
View directory record Official record
Conditions
Lung Cancer, Health Screening, Early Cancer Detection, Deep Learning
Interventions
CXR-LC
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
50 Years to 77 Years
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Sep 10, 2026, 4:46 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

DECAMP-1: Diagnosis and Surveillance of Indeterminate Pulmonary Nodules

NCT01785342
View directory record Official record
Conditions
Lung Cancer
Interventions
Biosample and Imaging Collection
Other
Lead sponsor
Boston University
Other
Eligibility
45 Years and older
Enrollment
489 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2022
U.S. locations
15
States / cities
Los Angeles, California • San Diego, California • Denver, Colorado + 9 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2022 · Synced Sep 10, 2026, 4:46 AM EDT
Completed No phase listed Observational

Fluorescence Bronchoscopy and Molecular Characterization of Abnormal Bronchial Lesions: Novel Approaches for Early Detection of Lung Cancer in High Risk Patients

NCT00512642
View directory record Official record
Conditions
Cancer
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
35 Years to 150 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2019
U.S. locations
1
States / cities
Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 20, 2019 · Synced Sep 10, 2026, 4:46 AM EDT
Terminated Not applicable Interventional

Surgical Versus Non-surgical Staging of Lung Cancer

NCT01117714
View directory record Official record
Conditions
Lung Cancer
Interventions
Integrated Staging for Early Detection of Metastases in Lung Cancer
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
3
States / cities
Jacksonville, Florida • Rochester, Minnesota • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 15, 2018 · Synced Sep 10, 2026, 4:46 AM EDT
Completed Phase 2 Interventional Results available

18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules

NCT03824535
View directory record Official record
Conditions
Cigarette Smoker, Current Smoker, Former Smoker, Multiple Pulmonary Nodules, Pulmonary Nodule
Interventions
Computed Tomography, Fludeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392, Positron Emission Tomography (PET/CT)
Diagnostic Test · Drug
Lead sponsor
Andrei Iagaru
Other
Eligibility
45 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Sep 10, 2026, 4:46 AM EDT
Recruiting Not applicable Interventional

Integrating Telehealth to Advance Lung Cancer Screening

NCT06638554
View directory record Official record
Conditions
Early Detection of Cancer, Telemedicine, Decision Making
Interventions
Active Choice, Telehealth Only, Low Touch Strategy, High Touch Strategy
Behavioral
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
50 Years to 80 Years
Enrollment
6,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 10, 2026, 4:46 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Liquid Biopsy for Early Non-small Lung Cancer Detection

NCT05462795
View directory record Official record
Conditions
Non Small-cell Lung Cancer
Interventions
Liquid biopsy for aberrant DNA methylation analysis - Indeterminate pulmonary nodule, Liquid biopsy for aberrant DNA methylation analysis - Known lung cancer for surgical resection, Liquid biopsy for aberrant DNA methylation analysis - Healthy volunteer, Liquid biopsy for aberrant DNA methylation analysis - Benign lung disease
Diagnostic Test
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
171 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Sep 10, 2026, 4:46 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sputum Labeling Utilizing Synthetic Meso-Tetra (4-Carboxyphenyl) Porphyrin (TCPP) for Detection of Lung Cancer

NCT03837600
View directory record Official record
Conditions
Lung Cancer
Interventions
Not listed
Lead sponsor
bioAffinity Technologies Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
197 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
5
States / cities
Waterbury, Connecticut • Neptune City, New Jersey • Summit, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Sep 10, 2026, 4:46 AM EDT
Recruiting Not applicable Interventional

Evaluate the Clinical Performance of the Flow Cytometry - FlowPath Lung Test as a Sensitive and Specific Non-invasive Diagnostic of Sputum Samples to Identify/Detect the Presence of Lung Cancer in High-risk Individuals Who Have Existing Lung Nodules, 6 to <30 mm in Diameter, Determined by LDCT.

NCT07168993
View directory record Official record
Conditions
Lung Cancer (Diagnosis)
Interventions
Standard medical treatment
Other
Lead sponsor
bioAffinity Technologies Inc.
Industry
Eligibility
50 Years to 80 Years
Enrollment
2,063 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
11
States / cities
Palo Alto, California • Grand Junction, Colorado • Bay Pines, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 10, 2026, 4:46 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Breath Test for Early Detection of Lung Cancer

NCT00639067
View directory record Official record
Conditions
Lung Neoplasms
Interventions
Breath Collection Apparatus
Device
Lead sponsor
Menssana Research, Inc.
Industry
Eligibility
18 Years and older
Enrollment
215 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2013
U.S. locations
4
States / cities
Newark, Delaware • Orlando, Florida • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated May 15, 2014 · Synced Sep 10, 2026, 4:46 AM EDT