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ClinicalTrials.gov public records Last synced Oct 2, 2026, 2:29 PM EDT

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Showing 1–24 of 220 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Eclampsia; Complicating Pregnancy Clear all
Active, not recruiting No phase listed Observational

MIRACLE of LIFE Study

NCT06074601
View directory record Official record
Conditions
Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane, Preeclampsia, HELLP, Gestational Hypertension, Gestational Diabetes Mellitus in Pregnancy, Small for Gestational Age at Delivery, Intrauterine Growth Restriction
Interventions
Mirvie Predictive Test for Adverse Pregnancy Outcomes
Diagnostic Test
Lead sponsor
Mirvie
Industry
Eligibility
18 Years and older · Female only
Enrollment
10,000 participants
Timeline
2021 – 2025
U.S. locations
10
States / cities
San Diego, California • Orlando, Florida • New Orleans, Louisiana + 7 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2024 · Synced Oct 2, 2026, 2:29 PM EDT
Completed Not applicable Interventional

Mild Preeclampsia Near Term: Deliver or Deliberate?

NCT00789919
View directory record Official record
Conditions
Preeclampsia
Interventions
Delivery of infant
Procedure
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Feb 10, 2017 · Synced Oct 2, 2026, 2:29 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Progesterone Preeclampsia

NCT07448597
View directory record Official record
Conditions
Preeclampsia, Hypertensive Disorder of Pregnancy
Interventions
Progesterone supplementation
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older · Female only
Enrollment
642 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Oct 2, 2026, 2:29 PM EDT
Completed Phase 1 Interventional Results available

Phase I Study of Nicotinamide for Early Onset Preeclampsia

NCT02213094
View directory record Official record
Conditions
Pregnancy Induced Hypertension, Superimposed Preeclampsia, Hypertension
Interventions
Nicotinamide 500 mg, Nicotinamide 1000 mg
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 2, 2018 · Synced Oct 2, 2026, 2:29 PM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Preeclampsia: A Marker for Future Cardiovascular Risk in Women

NCT01519297
View directory record Official record
Conditions
Preeclampsia, Pregnancy Induced Hypertension
Interventions
Irbesartan
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 50 Years · Female only
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2019 · Synced Oct 2, 2026, 2:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia

NCT00719654
View directory record Official record
Conditions
Preeclampsia
Interventions
Not listed
Lead sponsor
Medical University of South Carolina
Other
Eligibility
Female only
Enrollment
316 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2018 · Synced Oct 2, 2026, 2:29 PM EDT
Recruiting Phase 2 Interventional

Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

NCT07041281
View directory record Official record
Conditions
Preeclampsia, Gestational Hypertension
Interventions
spironolactone 25 mg orally once daily, Placebo tablet to match spironolactone
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
3
States / cities
Boston, Massachusetts • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 3, 2026 · Synced Oct 2, 2026, 2:29 PM EDT
Completed No phase listed Observational

Comparison of Catheterized and Clean Catch Urine Specimens for Protein/Creatinine Ratio in Preeclampsia Evaluation

NCT00654771
View directory record Official record
Conditions
Preeclampsia, Proteinuria, Hypertension, Pregnancy
Interventions
urine collection
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
14 Years to 50 Years · Female only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 16, 2012 · Synced Oct 2, 2026, 2:29 PM EDT
Completed Phase 2 Interventional Results available

Study of Nicotinamide in Early Onset Preeclampsia

NCT03419364
View directory record Official record
Conditions
Pre-Eclampsia, Pregnancy Related
Interventions
nicotinamide
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 8, 2022 · Synced Oct 2, 2026, 2:29 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

162 mg of Aspirin for Prevention of Preeclampsia

NCT05221164
View directory record Official record
Conditions
Preeclampsia
Interventions
Aspirin 162 mg
Drug
Lead sponsor
Methodist Medical Center of Illinois
Other
Eligibility
Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 2, 2022 · Synced Oct 2, 2026, 2:29 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Gene Expression In Pregnancies Complicated by Preeclampsia

NCT00919360
View directory record Official record
Conditions
Preeclampsia
Interventions
collection of maternal blood specimen prior to delivery, collection of placental cord blood after delivery, collection of placental tissue, collection of strip of decidua from uterine lining from cesarean section deliveries
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older · Female only
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2015
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2015 · Synced Oct 2, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

Remote BP Monitoring in the PP Period

NCT03728790
View directory record Official record
Conditions
Hypertensive Disorder of Pregnancy
Interventions
Remote Patient Monitoring
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
213 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 1, 2025 · Synced Oct 2, 2026, 2:29 PM EDT
Recruiting Phase 2 Interventional

Aspirin for Postpartum Patients With Preeclampsia

NCT05924971
View directory record Official record
Conditions
Preeclampsia Postpartum
Interventions
Aspirin 81Mg Ec Tab
Drug
Lead sponsor
MemorialCare Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Long Beach, California
Source: ClinicalTrials.gov public record
Updated Jun 6, 2025 · Synced Oct 2, 2026, 2:29 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

ASPIRIN: Neurodevelopmental Follow-up Trial

NCT04888377
View directory record Official record
Conditions
Neurodevelopmental Abnormality
Interventions
Aspirin, Placebo
Drug
Lead sponsor
NICHD Global Network for Women's and Children's Health
Network
Eligibility
33 Months to 39 Months
Enrollment
666 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
8
States / cities
Birmingham, Alabama • Denver, Colorado • Newark, Delaware + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2024 · Synced Oct 2, 2026, 2:29 PM EDT
Not listed No phase listed Observational

Select Nutrient and Gene Variant Analysis in a Targeted Diet and Lifestyle Intervention Reduces Preterm Birth

NCT05436119
View directory record Official record
Conditions
Premature Birth, Pre-Eclampsia, Small for Gestational Age Infant
Interventions
GrowBaby
Dietary Supplement
Lead sponsor
GrowBaby Life Project
Other
Eligibility
Female only
Enrollment
200 participants
Timeline
2022 – 2023
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Oct 2, 2026, 2:29 PM EDT
Completed No phase listed Observational

Continuous Non-invasive Hemodynamic Monitoring in Early-onset Severe Preeclampsia: a Comparison of Echocardiography, Bioreactance, and Finger Cuff Measurements

NCT05299229
View directory record Official record
Conditions
Pre-Eclampsia
Interventions
Echocardiogrpahy and non-invasive monitoring
Diagnostic Test
Lead sponsor
Yale University
Other
Eligibility
18 Years and older · Female only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 12, 2022 · Synced Oct 2, 2026, 2:29 PM EDT
Not yet recruiting Phase 4 Interventional

Biomarkers in Management of Post Partum Preeclampsia

NCT07478055
View directory record Official record
Conditions
Preeclampsia Severe, Preeclampsia Postpartum
Interventions
Magnesium Sulfate
Drug
Lead sponsor
Alexander Harrison
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 2, 2026, 2:29 PM EDT
Completed Not applicable Interventional Results available

Neonatal Sleep Intervention to Improve Postpartum Hypertension

NCT04864249
View directory record Official record
Conditions
Pre-Eclampsia, Gestational Hypertension, Sleep
Interventions
SNOO, Safe sleep education in the postpartum period
Device · Other
Lead sponsor
Alisse Hauspurg
Other
Eligibility
18 Years and older · Female only
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 8, 2023 · Synced Oct 2, 2026, 2:29 PM EDT
Recruiting Phase 1Phase 2 Interventional

Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)

NCT06826859
View directory record Official record
Conditions
Preterm Birth, Preeclampsia
Interventions
Daily aspirin (ASA), Split dose aspirin (ASA)
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
16 Years to 55 Years · Female only
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Oct 2, 2026, 2:29 PM EDT
Completed No phase listed Observational

Racial Differences: Nitric Oxide(NO) and Endothelin-1(ET-1) in Preeclampsia (PreE)

NCT00653809
View directory record Official record
Conditions
Preeclampsia
Interventions
Not listed
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Apr 6, 2012 · Synced Oct 2, 2026, 2:29 PM EDT
Withdrawn Phase 2Phase 3 Interventional

Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial

NCT00293735
View directory record Official record
Conditions
Preeclampsia, Pregnancy Induced Hypertension, Gestational Hypertension, Chronic Hypertension, Superimposed Preeclampsia
Interventions
labetalol (seizure prevention), MgSO4 (seizure prevention)
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
15 Years to 60 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 13, 2017 · Synced Oct 2, 2026, 2:29 PM EDT
Completed Phase 2 Interventional Results available

Efficacy Study of Digibind for Treatment of Severe Preeclampsia

NCT00158743
View directory record Official record
Conditions
Pre-eclampsia
Interventions
Anti-digoxin antibody (FAB fragment), sodium chloride
Drug · Other
Lead sponsor
BTG International Inc.
Other
Eligibility
Female only
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
8
States / cities
Mobile, Alabama • Phoenix, Arizona • Orlando, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Aug 8, 2014 · Synced Oct 2, 2026, 2:29 PM EDT
Not yet recruiting Phase 3 Interventional Accepts healthy volunteers

Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial

NCT07746271
View directory record Official record
Conditions
Hypertension in Pregnancy, Obstetrical Complications
Interventions
Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
Drug · Other
Lead sponsor
The George Washington University Biostatistics Center
Other
Eligibility
14 Years to 56 Years · Female only
Enrollment
4,120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
14
States / cities
Birmingham, Alabama • San Francisco, California • Chicago, Illinois + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 2, 2026, 2:29 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise in Pregnancy for Reduction of Blood Pressure in Obese Patients

NCT01261884
View directory record Official record
Conditions
Hypertension, Pregnancy, Preeclampsia, Exercise
Interventions
Exercise support, Exercise intervention
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 16, 2015 · Synced Oct 2, 2026, 2:29 PM EDT