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ClinicalTrials.gov public records Last synced Jul 22, 2026, 10:39 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Elastic Skin Clear all
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Two Point Discrimination

NCT03686748
View directory record Official record
Conditions
Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS), Amplified Musculoskeletal Pain Syndrome (AMPS), Low Back Pain, Fibromyalgia, Chronic Widespread Pain
Interventions
Two-point discrimination training, One-point discrimination training
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2027
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 5, 2025 · Synced Jul 22, 2026, 10:39 AM EDT
Completed No phase listed Observational

Skin/Soft Tissue Elasticity in Head and Neck Cancer Survivors With Lymphedema and Fibrosis

NCT02676752
View directory record Official record
Conditions
Lymphedema
Interventions
Medical Examination, Questionnaire Administration, Shear Wave Elastography
Procedure · Other
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
22 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 8, 2022 · Synced Jul 22, 2026, 10:39 AM EDT
Completed No phase listed Observational

WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)

NCT02692846
View directory record Official record
Conditions
Williams Syndrome, Cardiovascular Disease, Multisystem Developmental Disorder, Elastin Gene Deletion, Hypertension
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
1 Year to 70 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Jul 22, 2026, 10:39 AM EDT
Completed No phase listed Observational

Classification of Breast Masses Based on Visco-elastic Properties Using SAVE Method

NCT04841252
View directory record Official record
Conditions
Breast Cancer
Interventions
FDA approved GE LOGIQ E9 (LE9) ultrasound, Alpinion clinical ultrasound machine
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Female only
Enrollment
266 participants
Timeline
2012 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Jul 22, 2026, 10:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes

NCT02213484
View directory record Official record
Conditions
Marfan Syndrome, Loeys-Dietz Syndrome, Thoracic Aortic Aneurysm and Dissection Syndromes, Ehlers-Danlos Type IV Syndrome, Turner Syndrome
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
30 Days to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 14, 2017 · Synced Jul 22, 2026, 10:39 AM EDT
Recruiting Not applicable Interventional

Heart Coherence Training on Vascular Ehlers-Danlos Syndrome Patients

NCT05994664
View directory record Official record
Conditions
Vascular Ehlers-Danlos Syndrome
Interventions
Heartmath Intervention, Control Group
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
12 Years to 45 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 30, 2024 · Synced Jul 22, 2026, 10:39 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles

NCT06571721
View directory record Official record
Conditions
Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin, Sebum Deficiency
Interventions
Topical Product: Almond Oil, Topical Product: Almond oil augmented with 0.5% Vitamin E, Topical Product: 0.025% Tretinoin oil augmented with castor oil
Other
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Jul 22, 2026, 10:39 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

A Clinical Trial to Examine the Efficacy of a Supplement to Support Healthy Hair and Skin

NCT06579742
View directory record Official record
Conditions
Hair Thinning, Hair Loss
Interventions
Live Conscious Beyond Collagen, Placebo
Dietary Supplement
Lead sponsor
Scale Media Inc
Industry
Eligibility
40 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Aug 29, 2024 · Synced Jul 22, 2026, 10:39 AM EDT
Recruiting Not applicable Interventional

Breast Elasticity Imaging During Neoadjuvant Chemotherapy

NCT04824027
View directory record Official record
Conditions
Breast Cancer
Interventions
Harmonic motion imaging
Procedure
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Jul 22, 2026, 10:39 AM EDT
Not yet recruiting No phase listed Observational Accepts healthy volunteers

Presentation of Young Adults With and Without Joint Hypermobility

NCT07657507
View directory record Official record
Conditions
Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome (POTS)
Interventions
Not listed
Lead sponsor
Clarkson University
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2036
U.S. locations
1
States / cities
Potsdam, New York
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Jul 22, 2026, 10:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Studies of Heritable Disorders of Connective Tissue

NCT00270686
View directory record Official record
Conditions
Ehlers-Danlos Syndrome, Stickler Syndrome, Marfan Syndrome
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
2 Years and older
Enrollment
929 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Jul 22, 2026, 10:39 AM EDT
Completed No phase listed Observational

Gene First Approach to Connective Tissue Disease

NCT04664478
View directory record Official record
Conditions
Abnormal Elastogenesis, Vascular Diseases, Connective Tissue Diseases
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
2 Years to 100 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 3, 2025 · Synced Jul 22, 2026, 10:39 AM EDT
Active, not recruiting No phase listed Observational

Pathogenetic Basis of Aortopathy and Aortic Valve Disease

NCT03440697
View directory record Official record
Conditions
Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease, Thoracic Aortic Dissection, Thoracic Aortic Rupture, Ascending Aortic Disease, Descending Aortic Disease, Ascending Aortic Aneurysm, Descending Aortic Aneurysm, Marfan Syndrome, Loeys-Dietz Syndrome, Vascular Ehlers-Danlos Syndrome, Shprintzen-Goldberg Syndrome, Turner Syndrome, PHACE Syndrome, Autosomal Recessive Cutis Laxa, Congenital Contractural Arachnodactyly, Arterial Tortuosity Syndrome, Bicuspid Aortic Valve-Associated Aortopathy, Bicuspid Aortic Valve, Familial Thoracic Aortic Aneurysm and Aortic Dissection
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2030
U.S. locations
2
States / cities
Atlanta, Georgia • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 22, 2026, 10:39 AM EDT
Not yet recruiting Phase 3 Interventional

The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients

NCT05279937
View directory record Official record
Conditions
Ehlers-Danlos Syndrome, Low Back Pain, Sacroiliac Instability
Interventions
Dextrose 50% Intravenous Solution, Lidocaine 1% Injectable Solution
Drug
Lead sponsor
Tulane University
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jul 22, 2026, 10:39 AM EDT
Recruiting Not applicable Interventional

DermaSensor Postmarket Surveillance Study

NCT06666790
View directory record Official record
Conditions
Melanoma, Skin
Interventions
Scan with elastic scattering spectroscopy device to assess risk of malignancy
Device
Lead sponsor
DermaSensor, Inc.
Industry
Eligibility
40 Years and older
Enrollment
396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
2
States / cities
New Smyrna Beach, Florida • Morehead City, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Jul 22, 2026, 10:39 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of Almond on Facial Skin Collagen and Wrinkles

NCT06074276
View directory record Official record
Conditions
Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin
Interventions
Food: whole almonds, Food: non-nut snack
Other
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
35 Years to 70 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 17, 2024 · Synced Jul 22, 2026, 10:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Trial Evaluating the Efficacy of a Skin Cream in Improving Facial Appearance and Skin Elasticity

NCT04769193
View directory record Official record
Conditions
Atrophy, Hemifacial, Elastosis, Photoaging
Interventions
Adipeau face cream
Other
Lead sponsor
Adipeau Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jul 22, 2026, 10:39 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Oral Supplementation of Astaxanthin on Skin Photoaging, Hydration and Elasticity

NCT05882084
View directory record Official record
Conditions
Photoaging
Interventions
Astaxanthin 6 mg daily, Placebo
Dietary Supplement
Lead sponsor
Integrative Skin Science and Research
Industry
Eligibility
30 Years to 55 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jul 24, 2023 · Synced Jul 22, 2026, 10:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Standing Cognition and Co-morbidities of POTS Evaluation

NCT03602482
View directory record Official record
Conditions
Postural Tachycardia Syndrome, Ehlers-Danlos Syndrome
Interventions
Standing, Supine
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
13 Years to 60 Years
Enrollment
139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 13, 2021 · Synced Jul 22, 2026, 10:39 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Oxytocin for Hypermobile Ehlers-Danlos Syndrome

NCT05405257
View directory record Official record
Conditions
Hypermobile Ehlers-Danlos Syndrome, Pain Assessment
Interventions
Oxytocin, Placebo
Drug · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Jul 22, 2026, 10:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Nonlinear Elasticity Mapping of Breast Masses

NCT04863443
View directory record Official record
Conditions
Breast Cancer
Interventions
Ultrasound
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2025
U.S. locations
2
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Jul 22, 2026, 10:39 AM EDT
Enrolling by invitation Not applicable Interventional

Group Coaching Study for Life Goals

NCT07083713
View directory record Official record
Conditions
Students, Spinal Cord Injury, Ehlers Danlos Syndrome, Care Givers
Interventions
Group Coaching
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jul 22, 2026, 10:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of a Dietary Supplement on Parameters of Skin Aging in Men and Women

NCT06083402
View directory record Official record
Conditions
Skin Aging
Interventions
HyaCera™, Placebo
Dietary Supplement
Lead sponsor
Natals, Inc. dba Ritual
Industry
Eligibility
25 Years to 70 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Raritan, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 15, 2023 · Synced Jul 22, 2026, 10:39 AM EDT
Suspended Phase 3 Interventional

Investigate Efficacy, Safety, and Pharmacokinetics of Enzastaurin for the Prevention of Arterial Events in Patients With Vascular Ehlers-Danlos Syndrome.

NCT05463679
View directory record Official record
Conditions
Vascular Ehlers-Danlos Syndrome
Interventions
Enzastaurin, Placebo
Drug
Lead sponsor
Aytu BioPharma, Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Englewood, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Jul 22, 2026, 10:39 AM EDT