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Showing 1–24 of 112 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Elderly, Frail Clear all
Completed Phase 1Phase 2 Interventional

Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer

NCT00496236
View directory record Official record
Conditions
Head and Neck Cancer, Head and Neck Neoplasms
Interventions
TNFerade biologic
Drug
Lead sponsor
GenVec
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 22, 2012 · Synced Sep 19, 2026, 4:53 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Frailty and Dysphagia in Older Adults

NCT04975815
View directory record Official record
Conditions
Dysphagia, Frailty
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
65 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Sep 19, 2026, 4:53 AM EDT
Terminated Phase 1 Interventional

Randomized Study Of Exercise And Vitamin D In Frail Elderly Subjects

NCT00249704
View directory record Official record
Conditions
Elderly, Frail
Interventions
Vitamin D + Sham Exercise, Vitamin D Placebo + Exercise, Vitamin D Placebo + Sham Exercise, Vitamin D + Exercise
Drug · Procedure
Lead sponsor
Pfizer
Industry
Eligibility
75 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
4
States / cities
Farmington, Connecticut • Hyattsville, Maryland • Roslindale, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 7, 2009 · Synced Sep 19, 2026, 4:53 AM EDT
Recruiting Phase 2 Interventional

Pembrolizumab in Combination With Chemotherapy for the Treatment of Frail Hodgkin Lymphoma Patients Ineligible for Standard Treatment

NCT07275216
View directory record Official record
Conditions
Classic Hodgkin Lymphoma
Interventions
Biospecimen Collection, Brentuximab Vedotin, Computed Tomography, Dacarbazine, Echocardiography Test, Gemcitabine, Pembrolizumab, Physical Performance Testing, Positron Emission Tomography, Pulmonary Function Test
Procedure · Drug · Biological + 1 more
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Ghrelin in Healthy and Frail Older Women

NCT00520884
View directory record Official record
Conditions
Frailty
Interventions
Ghrelin Infusion - Healthy, Ghrelin Infusion - Frail, Placebo Infusion -Healthy, Placebo Infusion - Frail
Drug · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
70 Years and older · Female only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 12, 2019 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Making Health Care Safer for Older Adults Receiving Skilled Home Health Care Services After Hospital Discharge

NCT05182060
View directory record Official record
Conditions
Transitional Care, Frail Elderly, Home Health Care
Interventions
Transition Intervention
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
761 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 22, 2023 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 3 Interventional

Project ABLE:Advancing Better Living for Elders

NCT00249925
View directory record Official record
Conditions
Frail Elderly
Interventions
Home-Based Intervention, Multi-component home-based intervention
Behavioral
Lead sponsor
Thomas Jefferson University
Other
Eligibility
70 Years and older
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 25, 2016 · Synced Sep 19, 2026, 4:53 AM EDT
Recruiting Not applicable Interventional

Comparison of Smartphone and Community-Based Delivery of the Otago Exercise Program for Fall Risk in Older Adults

NCT07433153
View directory record Official record
Conditions
Frail Elderly, Fall
Interventions
Smartphone-Based Intervention, Group-Based Intervention
Behavioral
Lead sponsor
Binghamton University
Other
Eligibility
55 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Binghamton, New York
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 19, 2026, 4:53 AM EDT
Terminated Phase 2 Interventional

Effects Of An Oral Growth Hormone Secretagogue In Older Functionally Limited Adults

NCT00527046
View directory record Official record
Conditions
Aging, Frail Older Adults
Interventions
CP-424,391
Drug
Lead sponsor
Pfizer
Industry
Eligibility
65 Years to 84 Years
Enrollment
396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2001
U.S. locations
12
States / cities
Palo Alto, California • San Diego, California • Hamden, Connecticut + 9 more
Source: ClinicalTrials.gov public record
Updated Feb 1, 2012 · Synced Sep 19, 2026, 4:53 AM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

High-Dose Influenza Vaccine in Nursing Homes

NCT01815268
View directory record Official record
Conditions
Influenza
Interventions
HD Vaccine, SD Vaccine, Free Vaccine, Usual Care
Biological
Lead sponsor
Insight Therapeutics, LLC
Other
Eligibility
65 Years and older
Enrollment
823 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
3
States / cities
Cleveland, Ohio • Providence, Rhode Island • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 15, 2018 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 2 Interventional Results available

Ghrelin Repeated Dose Study

NCT01833078
View directory record Official record
Conditions
Frailty in Aging
Interventions
ghrelin
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
70 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Vitamin D in Vulnerable Adults (VIVA-VA)

NCT01170273
View directory record Official record
Conditions
Frail Elderly, Vitamin d Deficiency
Interventions
vitamin D, placebo
Dietary Supplement
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 95 Years · Male only
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 20, 2016 · Synced Sep 19, 2026, 4:53 AM EDT
Completed No phase listed Observational

Improving The Safety And Nutritional Adequacy Of The Home Food Supply Of Elderly Recipients Of Home Delivered Meals

NCT02719626
View directory record Official record
Conditions
Food Safety, Nutritive Value, Homebound Persons, Frail Elderly
Interventions
Not listed
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
60 Years and older
Enrollment
740 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
7
States / cities
Little Rock, Arkansas • Los Angeles, California • Cedar Rapids, Iowa + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2016 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

A Community Health Worker Program to Support Rural Older Adults

NCT03843333
View directory record Official record
Conditions
Frail Elderly, Cognitive Impairment, Mobility Limitation, Depressive Symptoms
Interventions
Tai Ji Quan: Moving for Better Balance, Behavioral Activation, Resource Navigation, Enhanced Usual Care
Behavioral · Other
Lead sponsor
University of Vermont
Other
Eligibility
65 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Augusta, Maine • Lyme, New Hampshire • Montpelier, Vermont
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Measuring Eating, Activity and Strength: Understanding the Response -Using Protein

NCT01715753
View directory record Official record
Conditions
Weight Loss
Interventions
Protein supplementation, Diet counseling and group education lessons
Dietary Supplement · Behavioral
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

The Effect of Intradialytic Exercise on the Physical Function of People Undergoing Hemodialysis

NCT03944824
View directory record Official record
Conditions
End Stage Renal Failure on Dialysis, Frail Elderly Syndrome
Interventions
Exercise Plan using resistance bands, Modified Fried Frailty Scale
Other · Diagnostic Test
Lead sponsor
Satellite Healthcare
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Milpitas, California
Source: ClinicalTrials.gov public record
Updated Sep 22, 2019 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional Results available

Pilot Testing a Home-Based Rehabilitation Intervention Designed to Improve Outcomes of Frail Veterans Following Cardiothoracic Surgery

NCT03299101
View directory record Official record
Conditions
Coronary Artery Bypass Graft, Non-cardiac Thoracic Surgery, Frailty
Interventions
Prehabilitation
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 12, 2021 · Synced Sep 19, 2026, 4:53 AM EDT
Recruiting Not applicable Interventional

Prehabilitation for Kidney Transplant Candidates

NCT06886256
View directory record Official record
Conditions
Kidney Transplantation, Frailty, Chronic Kidney Insufficiency
Interventions
Polar H10 Heart Rate Monitor, Empatica EmbracePlus, Apple Watch Ultra 2
Device
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
55 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 17, 2025 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Phase 2 Interventional Results available

Ghrelin Plus Strength Training in Frail Elderly Study

NCT01898611
View directory record Official record
Conditions
Frailty Syndrome
Interventions
Ghrelin, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
70 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 10, 2019 · Synced Sep 19, 2026, 4:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Targeting Aging With a Ketone Ester for Function in Frailty

NCT06645847
View directory record Official record
Conditions
Frail Elderly, Aging, Immune Function, Muscle Function
Interventions
Ketone ester, Placebo Comparator: Non-ketone placebo
Other
Lead sponsor
Buck Institute for Research on Aging
Other
Eligibility
65 Years and older
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
3
States / cities
Novato, California • Farmington, Connecticut • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Reconfiguring the Patient Room to Increase Patient Stability

NCT04003779
View directory record Official record
Conditions
Elderly, Frail, Accidental Falls, Hospitals
Interventions
Room configuration
Other
Lead sponsor
University of Utah
Other
Eligibility
60 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 27, 2025 · Synced Sep 19, 2026, 4:53 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Geriatric Anorexia Study 2.0

NCT05211973
View directory record Official record
Conditions
Healthy, Frailty
Interventions
Wrist Actigraphy Device, Smart Body Weight Scale, Chair Scale, Handheld Body Fat Percentage Device, Bioelectric Impedance Analysis Scale
Device
Lead sponsor
Boston University
Other
Eligibility
65 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Improving Function, Participation and Function After Acute Hospitalization in Older Adults

NCT01872637
View directory record Official record
Conditions
Frail Older Adults
Interventions
Progressive Multi-Component Intervention, Usual Care
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
2
States / cities
Aurora, Colorado • Glenside, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Sep 19, 2026, 4:53 AM EDT
Completed Not applicable Interventional

Relationships Between Exercise and Emotion Regulation on Physical Activity in Frail Older Adults

NCT03514160
View directory record Official record
Conditions
Mobility Limitation, Sedentary Lifestyle, Older Adults
Interventions
Group exercise
Behavioral
Lead sponsor
Northeastern University
Other
Eligibility
60 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Sep 19, 2026, 4:53 AM EDT