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Showing 1–24 of 257 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Electronic Cigarette Use Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Electronic Cigarette Flavors on Abuse Liability in Smokers (P3-Taste)

NCT05971823
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

E-Visit for COPD and Smoking Cessation

NCT04155073
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, Cigarette Smoking, Telemedicine
Interventions
smoking cessation, early COPD detection, electronic visit, Treatment As Usual
Behavioral · Other
Lead sponsor
Medical University of South Carolina
Other
Eligibility
40 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]

NCT05030194
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Cigarette Smoking, Smokeless Tobacco Cessation
Interventions
Electronic Cigarette, Oral Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder

NCT04092101
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cigarettes with varying nicotine content, E-Cigarettes
Other
Lead sponsor
University of Vermont
Other
Eligibility
21 Years to 70 Years
Enrollment
326 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Mar 29, 2025 · Synced Sep 8, 2026, 10:51 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

An Evaluation of the Tobacco Prevention Toolkit Healthy Futures: Alternative-to-Suspension Vaping Intervention

NCT06483412
View directory record Official record
Conditions
Tobacco Use Cessation, Addiction
Interventions
Healthy Futures: Alternative-to-Suspension Curriculum
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
14 Years to 18 Years
Enrollment
2,540 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Phase 2 Interventional Results available

CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes

NCT06087328
View directory record Official record
Conditions
Smoking Cessation, Electronic Cigarette Use, Cigarette Smoking
Interventions
Regular Nicotine patch and lozenge dose, Augmented Nicotine patch and lozenge dose
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Text Message Quit Vaping Intervention for Young Adults

NCT04251273
View directory record Official record
Conditions
Tobacco Cessation
Interventions
This is Quitting, Assessment only Control
Other
Lead sponsor
Truth Initiative
Other
Eligibility
18 Years to 24 Years
Enrollment
2,588 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Phase 2 Interventional Results available

A Study of Cytisinicline for Vaping Cessation in Adult Smokers

NCT05431387
View directory record Official record
Conditions
Vaping, E-Cig Use
Interventions
cytisinicline, Placebo, Behavioral support
Drug · Behavioral
Lead sponsor
Achieve Life Sciences
Industry
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
5
States / cities
Lexington, Kentucky • Boston, Massachusetts • Rochester, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns

NCT03844672
View directory record Official record
Conditions
Smoking, Tobacco Use
Interventions
Low Power, High Power, Low Concentration, High Concentration
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Predictors and Consequences of Combustible Cigarette Smokers' Switch to Standardized Research E-Cigarettes

NCT03277495
View directory record Official record
Conditions
Tobacco Use
Interventions
Brief behavioral counseling
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
21 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Results available

E-cigarettes to Promote Smoking Reduction Among Individuals With Schizophrenia

NCT02918630
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Nicotine Patch, E-cigarette
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 4, 2018 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Switching to a Vaping Device: Evaluating Risk Reduction Among Quitline Treatment Failures

NCT03502200
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
JUUL, Treatment As Usual
Device · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 99 Years
Enrollment
350 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional

Influencer Marketing and Adolescent E-cigarette Use

NCT07420842
View directory record Official record
Conditions
Vaping
Interventions
Youth Perceptions of Influencer Age and Fitness Contexts in E-Cigarette Marketing
Other
Lead sponsor
University of Southern California
Other
Eligibility
14 Years to 17 Years
Enrollment
700 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Sep 8, 2026, 10:51 PM EDT
Active, not recruiting Not applicable Interventional

Respiratory Effects of E-Cigarettes in Obese Youth

NCT05869318
View directory record Official record
Conditions
E-Cig Use
Interventions
ECIG own, ECIG Vuse
Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 25 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Sep 8, 2026, 10:51 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Impact of E-cigarette Use on the Body

NCT04972513
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Biospecimen Collection, Nitric Oxide Breath Test, Oscillometry, Spirometry, Survey Administration, Endothelial function
Procedure · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
15 Years to 25 Years
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 8, 2026, 10:51 PM EDT
Recruiting Not applicable Interventional

Harm Reduction for Smokers With Mental Illness

NCT06543407
View directory record Official record
Conditions
Tobacco Dependence
Interventions
SWITCH IT, E-cig Provision Only
Behavioral · Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
2
States / cities
Louisville, Kentucky • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 8, 2026, 10:51 PM EDT
Terminated No phase listed Observational

Adolescent Vaping Characterization and Parent Views on Adolescent Vaping Protocol

NCT05669716
View directory record Official record
Conditions
Healthy Volunteers, Vaping Teens
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
13 Years to 120 Years
Enrollment
726 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Understanding the Impact of Cartridge-Based Electronic Cigarettes and Generated Aerosols on Cardiopulmonary Health

NCT05199480
View directory record Official record
Conditions
E-Cig Use
Interventions
Tobacco flavored liquid type 1, Tobacco flavored liquid type 2
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?

NCT02825459
View directory record Official record
Conditions
Substance Withdrawal Syndrome
Interventions
Abstinence from e-cigarettes
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
2
States / cities
Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Nov 19, 2018 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Examination of Low Wattage and High Wattage E-Cigarettes

NCT03113136
View directory record Official record
Conditions
Smoking, Cigarette, Smoking, Tobacco, Nicotine Dependence, Exposure to Toxic Agent
Interventions
Low wattage E cigarette device, High wattage E cigarette device, Usual brand cigarette
Behavioral
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
18 Years to 99 Years
Enrollment
372 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 16, 2026 · Synced Sep 8, 2026, 10:51 PM EDT
Enrolling by invitation No phase listed Observational

Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids

NCT06619964
View directory record Official record
Conditions
Nicotine Addiction
Interventions
Not listed
Lead sponsor
Rochester Institute of Technology
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Development of UP2UTobacco for High School Youth

NCT05396911
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Use, Electronic Cigarette Use
Interventions
UP2UTobacco
Behavioral
Lead sponsor
University of Virginia
Other
Eligibility
14 Years to 15 Years
Enrollment
597 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-cigarettes, Nicotine Inhaler, and Blood Vessel Function

NCT03072628
View directory record Official record
Conditions
Nicotine Dependence
Interventions
e-cig with nicotine, e-cig without nicotine, nicotine inhaler, sham control
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 45 Years
Enrollment
148 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2023 · Synced Sep 8, 2026, 10:51 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessing Electronic Cigarette Nicotine Flux

NCT04378907
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Cigarette Smoker/ECIG users: 0 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 6 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 15 mg/ml nicotine concentration, Cigarette Smokers/ECIG users: 30 mg/ml nicotine concentration
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Sep 8, 2026, 10:51 PM EDT