- Conditions
- Neurocognitive Disorders, Anesthesia, Post-operative Delirium, Post-operative Cognitive Dysfunction
- Interventions
- Sevoflurane, Propofol
- Drug
- Lead sponsor
- Oregon Health and Science University
- Other
- Eligibility
- 70 Years to 110 Years
- Enrollment
- 260 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2023 – 2027
- U.S. locations
- 1
- States / cities
- Portland, Oregon
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Showing 25–48
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- Conditions
- Procedural Sedation, Emergence Delirium
- Interventions
- Positive Imagery Therapy
- Behavioral
- Lead sponsor
- Mercy Health Ohio
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 180 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2021 – 2023
- U.S. locations
- 1
- States / cities
- Youngstown, Ohio
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Obstructive Sleep Apnea
- Interventions
- Goal directed therapy (GDT)
- Other
- Lead sponsor
- University of California, Los Angeles
- Other
- Eligibility
- 45 Years to 75 Years
- Enrollment
- 7 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2022
- U.S. locations
- 1
- States / cities
- Los Angeles, California
- Conditions
- Post-operative Delirium
- Interventions
- L-tryptophan supplementation, placebo
- Drug
- Lead sponsor
- University of Colorado, Denver
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 301 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2012
- U.S. locations
- 1
- States / cities
- Denver, Colorado
- Conditions
- Postoperative Delirium, Postoperative Pain, Opioid Use, Hospital Length of Stay
- Interventions
- Gabapentin
- Drug
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 750 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2006 – 2014
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Alzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
- Interventions
- Total intravenous anesthesia with propofol, General anesthesia with isoflurane
- Drug
- Lead sponsor
- Duke University
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 191 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2013 – 2019
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries, Anesthesia
- Interventions
- Not listed
- Lead sponsor
- University of Texas Southwestern Medical Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 300 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Effect of Drug, Complication of Treatment
- Interventions
- Dexmedetomidine
- Other
- Lead sponsor
- Nemours Children's Clinic
- Other
- Eligibility
- 6 Months to 5 Years
- Enrollment
- 276 participants
- Timeline
- 2022 – 2023
- U.S. locations
- 1
- States / cities
- Wilmington, Delaware
- Conditions
- Emergence Delirium, Anesthesia Emergence Delirium
- Interventions
- Monochromatic blue light
- Device
- Lead sponsor
- Baylor College of Medicine
- Other
- Eligibility
- 2 Years to 6 Years
- Enrollment
- 104 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2017 – 2020
- U.S. locations
- 1
- States / cities
- Houston, Texas
- Conditions
- Perioperative Care, EEG Power Spectra, Delirium - Postoperative
- Interventions
- Standard of Care EEG-Guided Emergence, Extended EEG Emergence Trajectory
- Procedure
- Lead sponsor
- Harrison Shong-Wen Chow
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 300 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- Redwood City, California
- Conditions
- Delirium, Postoperative Delirium, Cognitive Impairment
- Interventions
- Not listed
- Lead sponsor
- Stanford University
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 250 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2024
- U.S. locations
- 1
- States / cities
- Palo Alto, California
- Conditions
- Surgery, Delirium - Postoperative, Delirium
- Interventions
- Virtual Reality Software, Virtual Reality movies, Nurse led control arm
- Other
- Lead sponsor
- The Methodist Hospital Research Institute
- Other
- Eligibility
- Up to 65 Years
- Enrollment
- 90 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2029
- U.S. locations
- 2
- States / cities
- Houston, Texas
- Conditions
- Delirium on Emergence
- Interventions
- Propofol, Sevoflurane, Isoflurane
- Drug
- Lead sponsor
- State University of New York at Buffalo
- Other
- Eligibility
- 2 Years to 12 Years
- Enrollment
- 6 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014
- U.S. locations
- 1
- States / cities
- Buffalo, New York
- Conditions
- Delayed Emergence From Anesthesia, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Interventions
- Functional magnetic resonance imaging
- Procedure
- Lead sponsor
- Icahn School of Medicine at Mount Sinai
- Other
- Eligibility
- 40 Years to 80 Years
- Enrollment
- 104 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2020
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Insomnia, Postoperative Delirium, Delayed Neurocognitive Recovery, Postoperative Neurocognitive Disorder
- Interventions
- digital Cognitive Behavioral Therapy for Insomnia (dCBT-I), Sleep Health Education
- Behavioral
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 65 Years and older
- Enrollment
- 50 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Surgery, Stress, Pain, Children, Post-Traumatic Stress Disorder
- Interventions
- Healing Touch, Healing Touch Sham Treatment
- Procedure
- Lead sponsor
- Children's Hospital Medical Center, Cincinnati
- Other
- Eligibility
- 3 Years to 4 Years
- Enrollment
- 240 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2013 – 2017
- U.S. locations
- 1
- States / cities
- Cincinnati, Ohio
- Conditions
- Postoperative Delirium
- Interventions
- Not listed
- Lead sponsor
- Washington University School of Medicine
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 234 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2024
- U.S. locations
- 1
- States / cities
- St Louis, Missouri
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
- Interventions
- Dextrose Water, Caffeine citrate
- Drug
- Lead sponsor
- University of Michigan
- Other
- Eligibility
- 70 Years and older
- Enrollment
- 250 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 1
- States / cities
- Ann Arbor, Michigan
- Conditions
- Delirium, Cognitive Impairment, Delirium, Postoperative
- Interventions
- Not listed
- Lead sponsor
- Stanford University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 199 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2024
- U.S. locations
- 1
- States / cities
- Palo Alto, California
- Conditions
- Delirium, Psychomotor Agitation
- Interventions
- Acupuncture
- Other
- Lead sponsor
- Oregon Health and Science University
- Other
- Eligibility
- 1 Year to 6 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2016
- U.S. locations
- 1
- States / cities
- Portland, Oregon
- Conditions
- Emergence Agitation
- Interventions
- Depth of anesthesia
- Other
- Lead sponsor
- Duke University
- Other
- Eligibility
- 2 Years to 8 Years
- Enrollment
- 40 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2010
- U.S. locations
- 1
- States / cities
- Durham, North Carolina
- Conditions
- Delirium
- Interventions
- Mini-Mental State Examination, Self-Administered Gerocognitive Examination, Geriatric Depression Scale, Charlson Comorbidity Index, Short Form 36 Health Survey, Confusion Assessment Method, Memorial Delirium Assessment Scale, Postoperative Quality of Recovery Scale
- Other
- Lead sponsor
- Ohio State University
- Other
- Eligibility
- 60 Years and older
- Enrollment
- 322 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2015 – 2019
- U.S. locations
- 1
- States / cities
- Columbus, Ohio
- Conditions
- Post Operative Delirium, Cognitive Impairment, Vagus Nerve Stimulation, Depression
- Interventions
- Transcutaneous vagal nerve stimulation, Sham (No Treatment)
- Device
- Lead sponsor
- Northwestern University
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 40 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2029
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Obstructive Sleep Apnea
- Interventions
- dexmedetomidine, fentanyl
- Drug
- Lead sponsor
- University of Medicine and Dentistry of New Jersey
- Other
- Eligibility
- 2 Years to 10 Years
- Enrollment
- 122 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2008
- U.S. locations
- 1
- States / cities
- Newark, New Jersey