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ClinicalTrials.gov public records Last synced Nov 15, 2026, 5:34 AM EST

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Showing 1–10 of 10 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Enamel Lesions Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant

NCT03306433
View directory record Official record
Conditions
Dental Caries
Interventions
UDMA-K18 smooth surface sealant
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
12 Years to 89 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 7, 2021 · Synced Nov 15, 2026, 5:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

3D Scanning as an Advanced Tool for Identifying Tooth Lesions in Children

NCT06829550
View directory record Official record
Conditions
Dental Caries in Children, Tooth Erosion, Fluorosis, Dental, Dental Caries
Interventions
indirect- 3D digital scanning
Diagnostic Test
Lead sponsor
Indiana University
Other
Eligibility
3 Years to 12 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Nov 15, 2026, 5:34 AM EST
Completed Phase 1 Interventional Accepts healthy volunteers

Development and Validation of a Multi-Mineral Fluoride Mouthrinse

NCT00642252
View directory record Official record
Conditions
Dental Caries
Interventions
Fluoride
Drug
Lead sponsor
Indiana Nanotech, LLC
Other
Eligibility
13 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Nov 15, 2026, 5:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste

NCT07419685
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Toothpaste, Active Comparator, Test Toothpaste
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Nov 15, 2026, 5:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation

NCT04155658
View directory record Official record
Conditions
Enamel Caries
Interventions
Experimental Toothpaste containing 1450ppm SMFP, Toothpaste containing 1450ppm SMFP, Toothpaste with no fluoride
Other
Lead sponsor
Unilever R&D
Industry
Eligibility
18 Years to 85 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 18, 2020 · Synced Nov 15, 2026, 5:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste

NCT07419763
View directory record Official record
Conditions
Dental Caries
Interventions
Negative Control Toothpaste, Active Comparator, Test toothpaste
Drug
Lead sponsor
Church & Dwight Company, Inc.
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Noblesville, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Nov 15, 2026, 5:34 AM EST
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions

NCT01641237
View directory record Official record
Conditions
Enamel Erosion
Interventions
sodium fluoride, no added fluoride in a silica base
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 24, 2014 · Synced Nov 15, 2026, 5:34 AM EST
Not yet recruiting Phase 4 Interventional

Enamel Lesion Detection With New DX Tool

NCT07819370
View directory record Official record
Conditions
Enamel Lesions, Caries
Interventions
BlueCheck, Prevident 5000ppm Booster Plus Toothpaste
Device · Drug
Lead sponsor
Colgate Palmolive
Industry
Eligibility
13 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Lithonia, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Nov 15, 2026, 5:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Evaluation of a Universal Adhesive in Noncarious Cervical Lesions

NCT02172664
View directory record Official record
Conditions
Cervical Lesions
Interventions
Self etch enamel etching, selective etch protocol, Adhese Universal
Procedure · Device
Lead sponsor
Indiana University
Other
Eligibility
20 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 28, 2019 · Synced Nov 15, 2026, 5:34 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients

NCT04560478
View directory record Official record
Conditions
White Spot Lesion
Interventions
Pro Seal Sealant, MI Varnish
Device
Lead sponsor
Texas A&M University
Other
Eligibility
12 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2020 · Synced Nov 15, 2026, 5:34 AM EST