Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
Search Results

Search by objective public record fields.

Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.

Clear filters
ClinicalTrials.gov public records Last synced Jul 22, 2026, 2:27 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 47 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Endodontic Disease Clear all
Not yet recruiting No phase listed Observational Accepts healthy volunteers

Evaluation of Three Pulp Vitality Tests

NCT02636504
View directory record Official record
Conditions
Dental Pulp Diseases, Dental Pulp Vitality Testing
Interventions
Laser Doppler Flowmetry
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Results available

Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material

NCT02698163
View directory record Official record
Conditions
Dental Pulp Diseases, Dental Pulp Necrosis, Nerve Root Pain Nec
Interventions
Nanodiamond reinforced Gutta Percha, Gutta Percha
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 20, 2022 · Synced Jul 22, 2026, 2:27 PM EDT
Not yet recruiting Phase 4 Interventional

Endodontic Microsurgery

NCT06776289
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Platelet rich fibrin
Biological
Lead sponsor
Mark Schachman
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Terminated Not applicable Interventional

Clinical Study Evaluating Solventum™ Vitrebond™ Pulp Protect Liner/Base for Direct Capping of Pulpal Exposure

NCT07231237
View directory record Official record
Conditions
Dental Caries, Pulp Exposure, Dental, Tooth Decay, Dental Decay
Interventions
Vitrebond™ Pulp Protect Liner/Base
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
7 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament

NCT03700788
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Chlorhexidine, Calcium Hydroxide
Drug
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2023 · Synced Jul 22, 2026, 2:27 PM EDT
Withdrawn Phase 2Phase 3 Interventional

Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy

NCT03376984
View directory record Official record
Conditions
Dental Pulp Diseases, Dental Pulp Necrosis, Nerve Root Pain Nec
Interventions
ND and AMOX modified Gutta Percha, Gutta Percha
Combination Product · Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots

NCT01976065
View directory record Official record
Conditions
Pulp Necrosis, Regeneration
Interventions
Triple Antibiotic Paste, Standard Treatment
Drug · Other
Lead sponsor
Kenneth Hargreaves
Other
Eligibility
6 Years to 20 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
4
States / cities
Loma Linda, California • Baltimore, Maryland • Chapel Hill, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 6, 2023 · Synced Jul 22, 2026, 2:27 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)

NCT06545084
View directory record Official record
Conditions
Apical Periodontitis
Interventions
Leukocyte and Platelet Rich Fibrin
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 26, 2025 · Synced Jul 22, 2026, 2:27 PM EDT
Withdrawn Not applicable Interventional

Endodontic Regenerative Procedure for Immature Non-vital Teeth

NCT03425123
View directory record Official record
Conditions
Tooth, Nonvital
Interventions
Regenerative Endodontic Procedure (REP)
Other
Lead sponsor
Boston University
Other
Eligibility
7 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pulp Capping With Two Different Agents

NCT00812877
View directory record Official record
Conditions
Dental Pulp Exposure
Interventions
Mineral Trioxide Aggregate, Calcium Hydroxide
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
7 Years and older
Enrollment
376 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 24, 2015 · Synced Jul 22, 2026, 2:27 PM EDT
Recruiting Not applicable Interventional

Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals

NCT06569329
View directory record Official record
Conditions
Dental Pulp Necroses
Interventions
GentleWave System Root Canal Therapy, EdgePro Laser Root Canal Therapy, The ProUltra Piezo Ultrasonic with EndoUltra Tips Root Canal Therapy
Device
Lead sponsor
Abhishek Parolia
Other
Eligibility
18 Years to 95 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 16, 2025 · Synced Jul 22, 2026, 2:27 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection

NCT05959629
View directory record Official record
Conditions
Endodontic Disease, Root Canal Infection
Interventions
Waterlase Express™, BIOLASE®, Sodium Hypochlorite
Device · Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Apical Size and Root Canal Treatment Success Trial (AS-RCT Trial)

NCT03053037
View directory record Official record
Conditions
Root Canal Therapy
Interventions
final apical size instrumentation
Procedure
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 85 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
2
States / cities
San Antonio, Texas • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 23, 2022 · Synced Jul 22, 2026, 2:27 PM EDT
Recruiting Not applicable Interventional

Bacterial Load Reduction by GentleWave and EdgePro Irrigation Systems in Mandibular Necrotic Molars

NCT06554366
View directory record Official record
Conditions
Pulp Necroses
Interventions
GentleWave, EdgePro laser irrigation, Irrisafe passive ultrasonic irrigation
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 4, 2025 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Tissue Characterization in Teeth Treated With a Regeneration Protocol

NCT00881907
View directory record Official record
Conditions
Pulp Necrosis
Interventions
Triple Antibiotic Paste
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
10 Years to 60 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 4, 2016 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional Results available

Alternative EndoCrowns Designs for Chairside CAD/CAM

NCT04604314
View directory record Official record
Conditions
Endodontically Treated Teeth
Interventions
CEREC Tessera
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 110 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 12, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment

NCT05338671
View directory record Official record
Conditions
Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
Interventions
Local anesthetic
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Jul 22, 2026, 2:27 PM EDT
Not yet recruiting No phase listed Observational Accepts healthy volunteers

Apple Watch Evaluation of Endodontics Occupational Stress

NCT07498348
View directory record Official record
Conditions
Occupational Stress
Interventions
Not listed
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
Not listed
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Accuracy of Electronic Apex Locators ProMark, RootZX II and NRG Rider on Working Length of Multi-rooted Teeth

NCT02521909
View directory record Official record
Conditions
Dental Pulp Diseases
Interventions
ProMark (Tooth Extraction for Assessment of Different Apex Locators), Root ZX II (Tooth Extraction for Assessment of Different Apex Locators), NRG Rider (Tooth Extraction for Assessment of Different Apex Locators)
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 21, 2017 · Synced Jul 22, 2026, 2:27 PM EDT
Recruiting Phase 2 Interventional

Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment

NCT06655454
View directory record Official record
Conditions
Pain Assessment, Quality of Life (QOL), Analgesic Use
Interventions
Supplemental Postoperative Bupivacaine, Placebo Injection
Drug
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 22, 2026, 2:27 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth

NCT00595595
View directory record Official record
Conditions
Dental Pulp Regeneration, Dental Pulp Diseases
Interventions
Not listed
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
16 Years to 65 Years
Enrollment
1,080 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 16, 2012 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

A Clinical Trial Comparing FS With ZOE and Non-eugenol Based Materials in Primary Teeth Pulpotomies

NCT05557812
View directory record Official record
Conditions
Pulpitis
Interventions
non-eugenol based ZOE base material with Ferric Sulfate in primary molar pulpotomies, eugenol based zinc oxide and Ferric Sulfate
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
3 Years to 7 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Not applicable Interventional

A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation

NCT01827098
View directory record Official record
Conditions
Dental Pulp Necrosis, Disorder of Tooth Development
Interventions
Endodontic Regeneration
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
6 Years to 25 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 10, 2023 · Synced Jul 22, 2026, 2:27 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment

NCT06110494
View directory record Official record
Conditions
Apical Periodontitis, Pulp Disease, Dental
Interventions
Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl, supplementary irrigation
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Jul 22, 2026, 2:27 PM EDT