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These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 12, 2026, 1:36 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 289–312 of 976 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Endothelial Clear all

Conditions: Healthy
Interventions: Besifloxacin Ophthalmic Suspension 0.6%; Drug
Lead sponsor: Bausch & Lomb Incorporated; Industry
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Endothelial Dysfunction
Interventions: Aliskiren, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Overweight, Obesity, Aging, Menopause
Interventions: 70 mL red beetroot juice, 70 mL red beetroot juice without nitrate, 70 mL placebo drink plus potassium nitrate, 70 mL placebo drink; Dietary Supplement
Lead sponsor: Colorado State University; Other
Eligibility: 40 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Fort Collins, Colorado

Conditions: Type II Diabetes Mellitus
Interventions: Linagliptin, Placebo, Microcirculation testing, Macrocirculation testing, MRI Scans; Drug · Other
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 30 Years to 70 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Sepsis, Septic Shock
Interventions: Starling Stroke Volume (Starling SV)- Passive Leg Raise, Microscan Sublingual Microscopy, Venous Excess Ultrasound Scoring (VExUS), Urine Collection; Diagnostic Test · Other
Lead sponsor: Denver Health and Hospital Authority; Other
Eligibility: 18 Years to 99 Years
Enrollment: 68 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Kidney Diseases, Endothelial Dysfunction
Interventions: Cell isolation; Diagnostic Test
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years to 85 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Type 2 Diabetes Mellitus
Interventions: rosiglitazone, glyburide; Drug
Lead sponsor: St. Paul Heart Clinic; Other
Eligibility: 25 Years to 75 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Saint Paul, Minnesota

Conditions: Healthy
Interventions: Active drink, Placebo drink; Dietary Supplement
Lead sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology; Industry
Eligibility: 18 Years to 45 Years
Enrollment: 7 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Diastolic Heart Failure
Interventions: Eplerenone; Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 11 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2007
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Coronary Disease, Myocardial Ischemia
Interventions: Nitric Oxide and INOpulse Delivery System; Drug
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI); NIH
Eligibility: Not listed
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2003
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Complications of Corneal Transplant
Interventions: Corneal donor storage in Optisol GS media solution, Life 4°C solution for cornea storage; Other
Lead sponsor: University Hospitals Cleveland Medical Center; Other
Eligibility: 30 Years to 85 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 4
States / cities: Indianapolis, Indiana • Grand Rapids, Michigan • Cleveland, Ohio + 1 more

Conditions: Diabetes Mellitus, Type 2, Endothelial Dysfunction
Interventions: Dapagliflozin, Placebo; Drug · Other
Lead sponsor: Boston University; Other
Eligibility: 30 Years to 75 Years
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Blood Pressure, Endothelial Dysfunction, Hypertension
Interventions: Inspiratory muscle strength training, Brisk walking; Other
Lead sponsor: University of Colorado, Boulder; Other
Eligibility: 50 Years and older
Enrollment: 102 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Boulder, Colorado

Conditions: Chronic Kidney Disease, Cardiovascular Disease
Interventions: Lanthanum carbonate, placebo, Ascorbic Acid, Nitroglycerin, Flow-mediated dilation measurement, Aortic pulse-wave velocity, Endothelial cell collection; Drug · Procedure
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 40 Years to 79 Years
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2019
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Cardioprotection
Interventions: Chocolate; Other
Lead sponsor: Griffin Hospital; Other
Eligibility: 30 Years to 75 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2006
U.S. locations: 1
States / cities: Derby, Connecticut

Conditions: 1. Endothelial Dysfunction (EndoPAT Score <=2)
Interventions: Chardonnay Seed Flour (CSF), Placebo; Dietary Supplement
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 168 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Gestational Diabetes, Vascular Endothelial Function
Interventions: Acetylcholine, insulin aspart; Drug
Lead sponsor: Anna Stanhewicz, PhD; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 28 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Scleroderma
Interventions: atorvastatin, Placebo; Drug
Lead sponsor: Robyn T. Domsic, MD, MPH; Other
Eligibility: 18 Years to 70 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Fuchs Dystrophy, Corneal Edema
Interventions: Corneal transplantation; Procedure
Lead sponsor: Mayo Clinic; Other
Eligibility: 21 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Diabetes
Interventions: Walnut Ad libitum diet, Walnut Calorie controlled; Dietary Supplement
Lead sponsor: Griffin Hospital; Other
Eligibility: 25 Years to 75 Years
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Derby, Connecticut

Conditions: Fuchs' Endothelial Corneal Dystrophy
Interventions: K-321 Solution, Placebo Solution; Drug
Lead sponsor: Kowa Research Institute, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 19
States / cities: Los Angeles, California • Palo Alto, California • Sacramento, California + 14 more

Conditions: Atherosclerosis, Cardiovascular Disease, Vascular Diseases
Interventions: Not listed
Lead sponsor: National Institute on Aging (NIA); NIH
Eligibility: 30 Years and older
Enrollment: 495 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2017
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Healthy Volunteers
Interventions: Bendavia, Sterile saline (0.9%), Cigarette smoking; Drug · Other
Lead sponsor: Mighty Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years · Male only
Enrollment: 6 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Non-small Cell Lung Cancer
Interventions: Pumitamig, Docetaxel; Drug
Lead sponsor: BioNTech SE; Industry
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 5
States / cities: Birmingham, Alabama • Tampa, Florida • Elizabethtown, Kentucky + 2 more

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Corneal Endothelial Cell Density Changes In Healthy Subjects, When Administered ISV-403 for 5 Days

The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis

Effects of Red Beetroot Juice on High-Fat Meal-Induced Endothelial Dysfunction and Cardiometabolic Disturbances

The Effect of Linagliptin on Mitochondrial and Endothelial Function

Micro and Macro Circulation in Sepsis

Isolation of Cells From Biopsy Tissue to Aid in Kidney Repair

Vascular Effects of Rosiglitazone Versus Glyburide in Type 2 Diabetic Patients

Acute Strawberry Intake on Endothelial Function

Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure

Nitric Oxide Inhalation Therapy to Relieve Chest Pain in Patients With Coronary Artery Disease

Life 4°C Versus Optisol in Corneal Storage Media

Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 Diabetes

Novel Time-efficient Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure

Phosphate Lowering in CKD Trial

Cocoa and Endothelial Function in Adults With Elevated BMI

Effects of Chardonnay Seed Flour on Vascular Health

Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes

Atorvastatin for Microvascular Endothelial Function and Raynaud in Early Diffuse Scleroderma

A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema

Walnut Ingestion in Adults at Risk for Diabetes: Effects on Body Composition, Diet Quality, and Cardiac Risk Measures

Study to Investigate the Safety and Efficacy of K-321 in Patients With Fuchs Endothelial Corneal Dystrophy (FECD) Following Descemetorhexis

Vascular Aging: The Link That Bridges Age to Atherosclerosis (The VALIDATE Study)

The Impact of Intravenous Bendavia™ on Endothelial Reactivity Dysfunction in Cigarette Smoking

Safety and Preliminary Efficacy of Pumitamig (BNT327), an Investigational Therapy for Patients With Non-small Cell Lung Cancer in Combination With Chemotherapy as First-line or Second-line Treatment