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ClinicalTrials.gov public records Last synced Oct 8, 2026, 6:59 AM EDT

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Showing 49–72 of 296 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Endothelial Physiopathology Clear all
Withdrawn Phase 2 Interventional

Effects of Prolonged Delivery of Nitric Oxide Gas on Plasma Reduction-Oxidation Reactions in Cardiac Surgical Patients

NCT04022161
View directory record Official record
Conditions
Cardiovascular Diseases, Oxidative Stress, Endothelial Dysfunction
Interventions
Nitrogen Gas for Inhalation, Blood withdrawal, Nitric Oxide
Drug · Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Proton Pump Inhibitors on Endothelial Function

NCT02022280
View directory record Official record
Conditions
Endothelial Dysfunction
Interventions
Lansoprazole, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 23, 2022 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Not applicable Interventional

The Effect of Dietary Nitrates on Physical Performance and Vascular Function in Chronic Kidney Disease

NCT04103736
View directory record Official record
Conditions
Kidney Disease, Chronic, Endothelial Dysfunction
Interventions
Beet It Sport Shot, Nitrate-depleted placebo
Dietary Supplement
Lead sponsor
University of Delaware
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 2 Interventional Results available

Nitrite, Isoquercetin and Endothelial Dysfunction (NICE) Trial

NCT02552888
View directory record Official record
Conditions
Chronic Kidney Disease
Interventions
Immediate release sodium nitrite, Isoquercetin, placebos
Drug · Dietary Supplement · Other
Lead sponsor
Tulane University
Other
Eligibility
21 Years to 74 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Oct 8, 2026, 6:59 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Phenylketonuria, Oxidative Stress, and BH4

NCT01395394
View directory record Official record
Conditions
Phenylketonuria
Interventions
Kuvan, Meal Challenge
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
10 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 28, 2014 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Impact of Smoking Cessation and γ-Tocopherol to Restore Vascular Endothelial Function

NCT01314443
View directory record Official record
Conditions
Endothelial Dysfunction
Interventions
Nicotine Replacement Therapy (NRT), Gamma-Tocopherol, Placebo, Smoking cessation
Other · Dietary Supplement · Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years to 60 Years
Enrollment
67 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 21, 2015 · Synced Oct 8, 2026, 6:59 AM EDT
Terminated Not applicable Interventional Results available

Effect of a Fibrate and a Statin on Endothelial Dysfunction

NCT00491400
View directory record Official record
Conditions
Diabetes Mellitus, Metabolic Syndrome
Interventions
Fenofibrate, Atorvastatin
Drug
Lead sponsor
Boston University
Other
Eligibility
30 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 24, 2012 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Aged Garlic Extract (AGE) on Improving Coronary Atherosclerosis in People With Type 2 Diabetes Mellitus

NCT03931434
View directory record Official record
Conditions
Coronary Arteriosclerosis, Endothelial Dysfunction, Type 2 Diabetes Mellitus
Interventions
Aged Garlic Extract (AGE), Placebo
Dietary Supplement
Lead sponsor
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Other
Eligibility
30 Years to 75 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2019 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 2 Interventional

Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes.

NCT01839344
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
Quercetin, Acarbose, placebo
Dietary Supplement · Drug
Lead sponsor
Bastyr University
Other
Eligibility
18 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Mar 18, 2015 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 4 Interventional Results available

The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes

NCT01181986
View directory record Official record
Conditions
Type 2 Diabetes Mellitus
Interventions
Exenatide SC, Exenatide IV, Placebo SC, Exendin-9, Placebo IV
Drug
Lead sponsor
Carl T. Hayden VA Medical Center
Federal
Eligibility
35 Years to 70 Years
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 20, 2014 · Synced Oct 8, 2026, 6:59 AM EDT
Recruiting No phase listed Observational

A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).

NCT05090345
View directory record Official record
Conditions
Hematopoietic Cell Transplantation
Interventions
Biorepository Trial
Other
Lead sponsor
Duke University
Other
Eligibility
0 Years to 26 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
3
States / cities
Rochester, Minnesota • Durham, North Carolina • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 8, 2026, 6:59 AM EDT
Active, not recruiting Not applicable Interventional

Understanding and Addressing Disparities in Cancer Therapy Induced Inflammation and Associated Endothelial Dysfunction

NCT05223322
View directory record Official record
Conditions
Breast Cancer
Interventions
Taking Charge during Treatment (TCT) Intervention
Behavioral
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 100 Years · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
2
States / cities
Chicago, Illinois • Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

The Role of Angiotensin Type I Receptor in the Regulation of Human Peripheral Vascular Function

NCT00001628
View directory record Official record
Conditions
Atherosclerosis, Heart Failure, Congestive, Hypertension, Myocardial Infarction
Interventions
Angiotensin II type 1 receptor antagonists
Drug
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Not listed
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1997 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 2 Interventional

The Study of CU06-1004 in Patients With Diabetic Macular Edema (DME)

NCT05573100
View directory record Official record
Conditions
Diabetic Macular Edema
Interventions
CU06-1004
Drug
Lead sponsor
Curacle Co., Ltd.
Industry
Eligibility
18 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
10
States / cities
Deerfield Beach, Florida • Baltimore, Maryland • Hagerstown, Maryland + 7 more
Source: ClinicalTrials.gov public record
Updated May 3, 2024 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 2 Interventional Results available

CAndesartan vs LIsinopril Effects on the BRain

NCT01984164
View directory record Official record
Conditions
Hypertension, Mild Cognitive Impairment
Interventions
Candesartan, Lisinopril
Drug
Lead sponsor
Emory University
Other
Eligibility
55 Years and older
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 21, 2021 · Synced Oct 8, 2026, 6:59 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

NightWare and Cardiovascular Health in Veterans With PTSD

NCT06419959
View directory record Official record
Conditions
Post-traumatic Stress Disorder (PTSD), Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness, Nightmare, Endothelial Dysfunction, Veteran
Interventions
NightWare
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
22 Years to 88 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial

NCT03318783
View directory record Official record
Conditions
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral, Endothelial Dysfunction
Interventions
GSK2256294, Placebo
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 22, 2021 · Synced Oct 8, 2026, 6:59 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Effects of Hesperidin on Insulin Sensitivity

NCT01773486
View directory record Official record
Conditions
Obesity, Insulin Resistance
Interventions
Hesperidin, Placebo
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
21 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2022 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of an Inhaled Glucocorticosteroid (ICS) on Endothelial Dysfunction in Cigarette Smokers

NCT01216735
View directory record Official record
Conditions
Tobacco Abuse Smoke
Interventions
Fluticasone, Placebo
Drug
Lead sponsor
University of Miami
Other
Eligibility
30 Years to 65 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 29, 2016 · Synced Oct 8, 2026, 6:59 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM

NCT06547619
View directory record Official record
Conditions
Gestational Diabetes, Endothelial Dysfunction, Physical Inactivity
Interventions
Insulin aspart
Drug
Lead sponsor
Anna Stanhewicz, PhD
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Wild Blueberries and Cardiovascular Health in Middle-aged/Older Men and Postmenopausal Women

NCT04530916
View directory record Official record
Conditions
Hypertension, Aging, Endothelial Dysfunction, Men
Interventions
Blueberry Powder, Placebo Powder
Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
45 Years to 70 Years · Male only
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Oct 8, 2026, 6:59 AM EDT
Completed No phase listed Observational

Endothelial Function in Mechanical Circulatory Support

NCT04539093
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction, Endothelial Dysfunction, LVAD
Interventions
Exposure of interest - Use of left ventricular assist device (LVAD)
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Oct 8, 2026, 6:59 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Cardiovascular Effects of Electronic Hookah Vaping

NCT03690427
View directory record Official record
Conditions
Endothelial Dysfunction, Inflammation, Oxidative Stress
Interventions
Traditional hookah smoking, Electronic hookah vaping
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 39 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 16, 2023 · Synced Oct 8, 2026, 6:59 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Flavonoids in the Treatment of Endothelial Dysfunction in Children With Diabetes

NCT01307917
View directory record Official record
Conditions
Diabetic Nephropathy, Endothelial Dysfunction
Interventions
flavonoids
Dietary Supplement
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
12 Years to 21 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Amarillo, Texas
Source: ClinicalTrials.gov public record
Updated Dec 17, 2012 · Synced Oct 8, 2026, 6:59 AM EDT