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Showing 1–24 of 432 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Energy Metabolism Clear all
Completed No phase listed Observational Accepts healthy volunteers

Effect of Isocaloric Ultra Processed Versus Unprocessed Diets on Insulin Sensitivity

NCT03189121
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 50 Years · Male only
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 9, 2019 · Synced Jul 21, 2026, 10:50 AM EDT
No Longer Available No phase listed Expanded access

Compassionate Use of Triheptanoin (C7) for Inherited Disorders of Energy Metabolism

NCT01461304
View directory record Official record
Conditions
Very Long-chain acylCoA Dehydrogenase (VLCAD) Deficiency, Carnitine Palmitoyltransferase Deficiencies (CPT1, CPT2), Mitochondrial Trifunctional Protein Deficiency, Long-chain Hydroxyacyl-CoA Dehydrogenase Deficiency, Glycogen Storage Disorders, Pyruvate Carboxylase Deficiency Disease, ACYL-CoA DEHYDROGENASE FAMILY, MEMBER 9, DEFICIENCY of, Barth Syndrome
Interventions
triheptanoin
Drug
Lead sponsor
Jerry Vockley, MD, PhD
Other
Eligibility
1 Month and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 9, 2021 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise Dose Response for Improving Insulin Sensitivity

NCT01452035
View directory record Official record
Conditions
Obesity
Interventions
Exercise
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Acute Intake of Meals Containing Higher vs. Lower Energy From Protein on DIT

NCT06494449
View directory record Official record
Conditions
Healthy, Overweight and Obesity
Interventions
Higher protein, Lower protein
Other
Lead sponsor
Midwest Center for Metabolic and Cardiovascular Research
Other
Eligibility
18 Years to 55 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Addison, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Food Rheology and Feeding in Lean and Obese Humans

NCT00260130
View directory record Official record
Conditions
Obesity, Overweight, Diabetes
Interventions
food in fluid form, food in solid form
Other
Lead sponsor
Purdue University
Other
Eligibility
18 Years to 40 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2009
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated May 29, 2013 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The DEB Pilot Study

NCT03190993
View directory record Official record
Conditions
Nutritional Physiological Phenomena, Obesity
Interventions
Sugar Sweetened Solid Treatment, Sugar Sweetened Beverage Treatment
Other
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
21 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Jul 21, 2026, 10:50 AM EDT
Active, not recruiting Not applicable Interventional

Functional Snack Foods With Safflower Oil and Soy in Postmenopausal Women Having Metabolic Syndrome

NCT02199054
View directory record Official record
Conditions
Metabolic Syndrome, Overweight
Interventions
wheat-safflower oil pretzels, soy-safflower oil pretzels, control wheat pretzels
Other
Lead sponsor
Ohio State University
Other
Eligibility
45 Years to 70 Years · Female only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 19, 2026 · Synced Jul 21, 2026, 10:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A New Approach to Measuring Energy Expenditure in Humans

NCT01938794
View directory record Official record
Conditions
Human Energy Expenditure
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 99 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Oct 8, 2019 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Intergenerational Community Based Participatory Research (CBPR) Intervention to Reduce Appalachian Health Disparities

NCT01373307
View directory record Official record
Conditions
Overweight, Obesity
Interventions
LHA-delivered energy balance classes/activities
Behavioral
Lead sponsor
Nancy Schoenberg
Other
Eligibility
8 Years and older
Enrollment
1,250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Whitesburg, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 12, 2015 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Effects of Exercise on Dietary Intake

NCT00943436
View directory record Official record
Conditions
Active Lifestyle Males, Inactive Lifestyle Males
Interventions
Exercise Session, Rest Session
Other
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years to 30 Years · Male only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 28, 2018 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional

The TREND Study: Tapered Reduction in Energy Intake as a Novel Approach to Dieting

NCT02837211
View directory record Official record
Conditions
Obesity
Interventions
Tapered Low Calorie Diet, Traditional Low-Calorie Diet
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 45 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2018 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Breakfast and Muscle Health in Children

NCT03602144
View directory record Official record
Conditions
Body Weight Changes, Body Composition, Muscle Mass, Energy Expenditure, Nutrition
Interventions
Carbohydrate, Protein
Other
Lead sponsor
University of Arkansas, Fayetteville
Other
Eligibility
7 Years to 14 Years
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Fayetteville, Arkansas
Source: ClinicalTrials.gov public record
Updated Feb 3, 2021 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study of the Effects of Temperature on Metabolism in Human Muscle

NCT00001753
View directory record Official record
Conditions
Healthy
Interventions
Magnetic resonance imaging
Procedure
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Not listed
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 21, 2026, 10:50 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

NCT04055428
View directory record Official record
Conditions
Diabetes Mellitus, Cardiovascular Diseases, Insulin Sensitivity/Resistance, Metabolic Disease, Natriuretic Peptides, Metabolism, Energy Expenditure
Interventions
Sacubitril, Valsartan 97-103 mg Oral Tablet, Valsartan 160 mg, Intravenous Glucose Tolerance Test, Standardized Meals, Exercise capacity VO2 maximum determination
Drug · Other · Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jul 21, 2026, 10:50 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Study of Energy Expenditure in Infants With Ventricular Septal Defects

NCT00006272
View directory record Official record
Conditions
Heart Septal Defects, Ventricular
Interventions
Not listed
Lead sponsor
National Center for Research Resources (NCRR)
NIH
Eligibility
3 Months to 4 Months
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 1994
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance

NCT00830999
View directory record Official record
Conditions
Cardiovascular Diseases
Interventions
Positive energy balance, Energy balance with exercise, Negative energy balance, Negative energy balance with exercise, Energy balance
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
21 Years to 50 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2012
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 20, 2013 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Manual Wheelchair Propulsion Workload on Speed, Energy Expenditure, and Propulsion Mechanics

NCT04987177
View directory record Official record
Conditions
Healthy Participants
Interventions
Workload of Manual Wheelchair Propulsion
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Homewood, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 23, 2022 · Synced Jul 21, 2026, 10:50 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Bone Mineral Density in Women With Major Depression

NCT00001413
View directory record Official record
Conditions
Healthy, Involutional Depression, Osteoporosis
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years and older
Enrollment
585 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1994 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 21, 2026, 10:50 AM EDT
Withdrawn Not applicable Interventional

Deep Brain Stimulation Effects in Patients With Chronic Refractory Obesity

NCT04453020
View directory record Official record
Conditions
Obesity
Interventions
DBS of the LHA
Device
Lead sponsor
donald whiting
Other
Eligibility
22 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 26, 2025 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Acute Effect of and Energy Drink vs. Water Consumption on MAP, HR, and Energy Metabolism

NCT06330649
View directory record Official record
Conditions
Cardiovascular Diseases, Hypertension, Diet
Interventions
Energy Drink, Water Control
Dietary Supplement · Other
Lead sponsor
The University of Texas at Arlington
Other
Eligibility
18 Years to 30 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of PrimaVie and Exercise Training on Human Skeletal Muscle (PrimaVie)

NCT02026414
View directory record Official record
Conditions
Obesity
Interventions
PrimaVie, Exercise
Dietary Supplement · Other
Lead sponsor
Sanni Raju
Industry
Eligibility
21 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 30, 2022 · Synced Jul 21, 2026, 10:50 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Factors Affecting Caloric Regulation in Human Feeding

NCT00108784
View directory record Official record
Conditions
Obesity
Interventions
Reduced-energy-density diet
Behavioral
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
20 Years to 60 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2004
U.S. locations
1
States / cities
State College, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 12, 2010 · Synced Jul 21, 2026, 10:50 AM EDT
Active, not recruiting Phase 1 Interventional

A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With Obesity

NCT06745284
View directory record Official record
Conditions
Obesity
Interventions
Survodutide, Semaglutide
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years to 65 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
2
States / cities
Orlando, Florida • Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jul 21, 2026, 10:50 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Leptin in Human Energy and Neuroendocrine Homeostasis

NCT00265980
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Subcutaneous Placebo, Leptin
Drug
Lead sponsor
Columbia University
Other
Eligibility
19 Years to 45 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 17, 2019 · Synced Jul 21, 2026, 10:50 AM EDT