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Showing 1–24 of 140 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Epidural Anesthesia Clear all
Completed Phase 4 Interventional Results available

Loss of Resistance, w/wo Stimulation, For Epidural Placement

NCT03087604
View directory record Official record
Conditions
Anesthesia
Interventions
Thoracic epidural block, Electrical Nerve stimulation, Solution For Thoracic epidural block
Procedure · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia

NCT05487196
View directory record Official record
Conditions
Pregnancy Related
Interventions
Clonidine, Dexmedetomidine, Fentanyl, Ropivacaine
Drug
Lead sponsor
Grace Lim, MD, MS
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 26, 2025 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Neuraxial Versus Systemic Analgesia for Latent Phase Labor Effect on Rate of Operative Delivery

NCT00380978
View directory record Official record
Conditions
Labor Pain, Pregnancy
Interventions
combined spinal epidural analgesia, late analgesia (systemic)
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
1,026 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2008
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 13, 2014 · Synced Sep 7, 2026, 4:35 PM EDT
Withdrawn Phase 3 Interventional Accepts healthy volunteers

Parturient Controlled Epidural Analgesia (PCEA) With or Without a Basal Infusion for Early Labor

NCT00871442
View directory record Official record
Conditions
Labor Pain
Interventions
No Basal Infusion, Basal infusion, PCEA solution (bupivacaine and fentanyl)
Other · Drug
Lead sponsor
Neil Roy Connelly, MD
Other
Eligibility
18 Years to 45 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 17, 2015 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Thoracic Epidural Analgesia vs Surgical Site Infiltration With Liposomal Bupivacaine Following Open Gynecologic Surgery

NCT04117074
View directory record Official record
Conditions
Surgery, Analgesia
Interventions
Liposomal bupivacaine, Thoracic epidural analgesia (bupivacaine)
Drug · Other
Lead sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Other
Eligibility
18 Years and older · Female only
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Lower Limb Compression Prevents Hypotension After Epidural in Labor

NCT04750486
View directory record Official record
Conditions
Labor Pain, Maternal Hypotension
Interventions
Sequential compression devices
Device
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 13, 2023 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Phase 3 Interventional Results available

Postoperative Thoracic Epidural Analgesia Versus Intravenous Patient-Controlled Analgesia For Liver and/or Pancreas

NCT01438476
View directory record Official record
Conditions
Liver Cancer, Pancreatic Cancer
Interventions
Intravenous Patient-Controlled Analgesia (IVPCA), Thoracic Epidural Analgesia (TEA), Questionnaires, Pain Assessment
Procedure · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Sep 7, 2026, 4:35 PM EDT
Withdrawn Phase 1Phase 2 Interventional Accepts healthy volunteers

"Loss of Resistance" Versus CompuFlo® for Epidural Placement

NCT00178750
View directory record Official record
Conditions
Pain, Epidural Analgesia
Interventions
18G Tuohy epidural needle, CompuFlo® computerized syringe pump
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 65 Years · Female only
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 4, 2020 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Phase 3 Interventional Results available

Use of Epidurals Intraoperatively for Patients Undergoing Pancreas Resection

NCT03434678
View directory record Official record
Conditions
Pancreatic Cancer
Interventions
Propofol+ Rocuronium+ Fentanyl 2 mcg/kg+ Inhalational Agent, Bupivacaine 0.125% + Fentanyl 5 mcg/ml, Propofol+ Rocuronium+ Fentanyl + Inhalational, Open Pancreaticoduodenectomy
Drug · Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
3
States / cities
Basking Ridge, New Jersey • Commack, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Sep 7, 2026, 4:35 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Compare Epidural vs. Lumbar Plexus Analgesia After Hip Arthroplasty

NCT02493621
View directory record Official record
Conditions
Arthropathy of Hip
Interventions
Not listed
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 21, 2019 · Synced Sep 7, 2026, 4:35 PM EDT
Not yet recruiting Not applicable Interventional

The Use of Electrical Stimulation for Determination of Epidural Catheter Placement

NCT06055686
View directory record Official record
Conditions
Obstetric Pain, Anesthesia, Local
Interventions
Electrical Epidural Stimulation Test
Diagnostic Test
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Sep 7, 2026, 4:35 PM EDT
Withdrawn No phase listed Observational

Intrapartum Epidural Fentanyl and Breast-feeding in the Immediate Postpartum Period: a Prospective Cohort Study

NCT01488149
View directory record Official record
Conditions
Maternal Anaesthesia and Analgesia Affecting Fetus or Newborn, Breast Feeding, Fentanyl, Bupivacaine, Nalbuphine
Interventions
Not listed
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 17, 2022 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Not applicable Interventional

The Effect of a Culturally Sensitive Educational Intervention on Acceptance of Neuraxial Anesthesia

NCT02672397
View directory record Official record
Conditions
Labor Pain
Interventions
Additional Epidural Education
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 3, 2020 · Synced Sep 7, 2026, 4:35 PM EDT
Active, not recruiting Phase 3 Interventional

Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection

NCT02523443
View directory record Official record
Conditions
Liver Cancer, Pain Management
Interventions
IV PCA, PCEA
Other
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
3
States / cities
Basking Ridge, New Jersey • Commack, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Sep 7, 2026, 4:35 PM EDT
Not yet recruiting Phase 4 Interventional

A Prospective Cohort Study to Evaluate the Safety, Efficacy, and Usability of the EpiZact Device

NCT06729255
View directory record Official record
Conditions
Postdural Puncture Headache, Epidural Analgesia, Obstetric
Interventions
EpiZact-assisted epidural placement
Device
Lead sponsor
Oregon Health and Science University
Other
Eligibility
15 Years to 50 Years · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Phase 3 Interventional Results available

Epidural Anesthesia Within an Enhanced Recovery Pathway in Reducing Pain in Patients Undergoing Gynecologic Surgery

NCT02423876
View directory record Official record
Conditions
Intraoperative Complication, Malignant Female Reproductive System Neoplasm, Pain
Interventions
Epidural analgesia, Intraoperative Complication Management and Prevention, Pain Therapy
Drug · Other · Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older · Female only
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Phase 4 Interventional

TAPB vs. Caudal for Lower Abdominal Surgery in Children: A Double-Blinded Randomized Controlled Trial

NCT02160821
View directory record Official record
Conditions
Anesthesia, Recovery Period
Interventions
Caudal Epidural, Transversus Abdominis Plane Block
Procedure
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
1 Year to 9 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 10, 2014 · Synced Sep 7, 2026, 4:35 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

A Comparison Trial Between PCA and Epidural Analgesia for Pectus Excavatum Repair

NCT02056301
View directory record Official record
Conditions
Pectus Excavatum
Interventions
Hydromorphone, Morphine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
8 Years to 18 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 10, 2020 · Synced Sep 7, 2026, 4:35 PM EDT
Terminated Phase 2 Interventional Results available

Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy

NCT05017246
View directory record Official record
Conditions
Cancer Debulking, Enlarged Uterus, Fibroid Uterus, Adnexal Mass
Interventions
Bupivacaine, Morphine, Lidocaine
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older · Female only
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Sep 7, 2026, 4:35 PM EDT
Completed No phase listed Observational

Chloroprocaine for Continuous Epidural Analgesia in Neonates and Infants

NCT02207855
View directory record Official record
Conditions
Anesthesia
Interventions
Chloroprocaine
Drug
Lead sponsor
Joseph D. Tobias
Other
Eligibility
Up to 2 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 28, 2016 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Not applicable Interventional Results available

Compare Preperitoneal Analgesia to Epidural Analgesia for Pain Control After Colon and Rectal Surgery

NCT01552226
View directory record Official record
Conditions
Colon Cancer, Rectal Cancer, Colonic Diverticulosis
Interventions
Continuous Preperitoneal Analgesia, Continuous Epidural Analgesia
Device
Lead sponsor
Trinity Health Michigan
Other
Eligibility
18 Years and older
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 14, 2025 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SKIN WHEAL - Subcutaneous or Intradermal Lidocaine in Epidural for Laboring Pain.

NCT06236126
View directory record Official record
Conditions
Analgesia, Obstetrical
Interventions
1% Lidocaine Injection
Procedure
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 7, 2026, 4:35 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Analgesic Techniques on Duration of Labor for Induction Patients

NCT01982851
View directory record Official record
Conditions
Effects of; Anesthesia, in Labor and Delivery, Pregnancy, Prolonged First Stage of Labor
Interventions
Epidural de novo, CSE
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
134 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 10, 2014 · Synced Sep 7, 2026, 4:35 PM EDT
Completed Not applicable Interventional

Paravertebral Catheters for Pancreatic Surgery

NCT02363777
View directory record Official record
Conditions
Acute Pain
Interventions
Epidural, Paravertebral catheters
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Sep 7, 2026, 4:35 PM EDT