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ClinicalTrials.gov public records Last synced Oct 19, 2026, 10:14 AM EDT

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Showing 1–24 of 24 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Epigenetic Aging Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Exercise-Induced Epigenetic Modifications in Obese Aging Women

NCT01977885
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
High Protein Diet, Exercise
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
50 Years to 64 Years · Female only
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 25, 2015 · Synced Oct 19, 2026, 10:14 AM EDT
Not yet recruiting Phase 2 Interventional

Effects of Switch to Doravirine/Islatravir vs. Continued Antiretroviral Therapy on Biomarkers of Aging Among Virologically Suppressed People With HIV

NCT07871552
View directory record Official record
Conditions
Epigenetic Aging
Interventions
Switch from an ART regimen containing lamivudine (3TC) or emtricitabine (FTC) + tenofovir alafenamide (TAF) or tenofovir disoproxil fumarate (TDF) to DOR/ISL, Switch from an nucleoside reverse transcriptase inhibitor (NRTI)-sparing ART regimen containing greater than or equal to 2 drugs to DOR/ISL, Continue SoC ART
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
35 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Aurora, Colorado • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 10:14 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Ketamine and Epigenetic Aging

NCT05294835
View directory record Official record
Conditions
Depression, Post Traumatic Stress Disorder
Interventions
Ketamine
Drug
Lead sponsor
TruDiagnostic
Industry
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 8, 2022 · Synced Oct 19, 2026, 10:14 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Epigenetics in the Aging Process

NCT00242255
View directory record Official record
Conditions
Aging
Interventions
Not listed
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
14 Years to 90 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2021
U.S. locations
4
States / cities
Washington D.C., District of Columbia • Bethesda, Maryland • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 9, 2021 · Synced Oct 19, 2026, 10:14 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Safety and Effectivness of Quercetin & Dasatinib on Epigenetic Aging

NCT04946383
View directory record Official record
Conditions
Aging
Interventions
Dasatinib plus Quercetin
Drug
Lead sponsor
TruDiagnostic
Industry
Eligibility
40 Years and older
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Oct 19, 2026, 10:14 AM EDT
Recruiting Phase 1 Interventional

Evaluating ER-100 for Safety in People With Glaucoma or Non-Arteritic Anterior Ischemic Optic Neuropathy (Optic Nerve Conditions)

NCT07290244
View directory record Official record
Conditions
Open Angle Glaucoma (OAG), NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
Interventions
ER-100 epigenetic therapy
Genetic
Lead sponsor
Life Biosciences Inc.
Industry
Eligibility
40 Years to 85 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
4
States / cities
Glendale, California • Boston, Massachusetts • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 19, 2026, 10:14 AM EDT
Completed Not applicable Interventional Results available

Functional Interval Training for Veterans Exercising Through Telehealth.

NCT04103593
View directory record Official record
Conditions
HIV Infection
Interventions
exercise training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
3
States / cities
Decatur, Georgia • Baltimore, Maryland • Salem, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 19, 2026, 10:14 AM EDT
Not listed Phase 1Phase 2 Interventional Accepts healthy volunteers

Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects

NCT03353597
View directory record Official record
Conditions
Aging
Interventions
Plasma Transfusion
Biological
Lead sponsor
Chandra Duggirala
Industry
Eligibility
40 Years and older
Enrollment
2,120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
San Mateo, California
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Oct 19, 2026, 10:14 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

NCT02339012
View directory record Official record
Conditions
Healthy Volunteers, Non-Healthy/Non-Frail, Frail
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
20 Years to 120 Years
Enrollment
900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2099
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 10:14 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial

NCT04375657
View directory record Official record
Conditions
Epigenetic Aging, Immunosenescence
Interventions
TRIIM Treatment, Active Control
Combination Product
Lead sponsor
Intervene Immune, Inc.
Industry
Eligibility
40 Years to 80 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated May 7, 2025 · Synced Oct 19, 2026, 10:14 AM EDT
Suspended No phase listed Observational Accepts healthy volunteers

Biomarker Study to Evaluate Correlations Between Epigenetic Aging and NAD+ Levels in Healthy Volunteers

NCT04220658
View directory record Official record
Conditions
Epigenetics
Interventions
Biomarker study
Other
Lead sponsor
Elysium Health
Industry
Eligibility
25 Years to 80 Years
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Oct 19, 2026, 10:14 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

The Effects Of Therapeutic Plasma Exchange (TPE) On Age Related Biomarkers And Epigenetics

NCT06534450
View directory record Official record
Conditions
Aging
Interventions
Sham, Therapeutic Plasma Exchange, IVIG
Device · Drug
Lead sponsor
Dobri Kiprov
Industry
Eligibility
50 Years to 95 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Mill Valley, California
Source: ClinicalTrials.gov public record
Updated Aug 2, 2024 · Synced Oct 19, 2026, 10:14 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

The Impact of a Human Breast Milk Supplement on Epigenetic and Cellular Markers

NCT05297097
View directory record Official record
Conditions
Aging
Interventions
Trulacta breastmilk supplement
Dietary Supplement
Lead sponsor
TruDiagnostic
Industry
Eligibility
18 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Sep 8, 2022 · Synced Oct 19, 2026, 10:14 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Clinical Trial Evaluating the Impact of a Dietary Supplement Containing Humic and Fulvic Acid on Epigenetic Markers of Biological Age, Detoxification, Inflammation, and Oxidative Stress

NCT07579845
View directory record Official record
Conditions
Detoxification, Inflammation, Biological Aging
Interventions
Humic and Fulvic Acid Dietary Supplement
Dietary Supplement
Lead sponsor
OvationLab
Network
Eligibility
40 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 29, 2026 · Synced Oct 19, 2026, 10:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certain Genes in the Skin Using Non-invasive Measurements

NCT06658847
View directory record Official record
Conditions
Retinoid, Skin Aging, Epigenomics
Interventions
Night Cream Usage, No Night Cream Usage
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
40 Years to 65 Years · Female only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 19, 2026, 10:14 AM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

A Dosing Study of Hyperbaric Oxygen Therapy (HBOT) on Epigenetic Aging

NCT05297019
View directory record Official record
Conditions
Aging
Interventions
Hyperbaric Oxygen Therapy
Procedure
Lead sponsor
TruDiagnostic
Industry
Eligibility
40 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Florham Park, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Oct 19, 2026, 10:14 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effects of Tildrakizumab on Epigenetic Age

NCT05110313
View directory record Official record
Conditions
Psoriasis, Aging, Epigenetic Disorder, Inflammation; Skin
Interventions
TILDRAKIZUMAB
Biological
Lead sponsor
Carlos Wambier
Other
Eligibility
35 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 18, 2024 · Synced Oct 19, 2026, 10:14 AM EDT
Recruiting Not applicable Interventional

Halt Aging in Survivors of Blood Cancers

NCT07292272
View directory record Official record
Conditions
Hematological Malignancy, Leukemia, Lymphoid Leukemia, Multiple Myeloma, Myeloid Leukemia, Monocytic Leukemia, Non-hodgkin Lymphoma, Other Hematologic Condition
Interventions
Behavioral Coaching Intervention, Virtual Exercise Platform
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
50 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2033
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Oct 19, 2026, 10:14 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Safety & Efficacy of Extended Longevity Protocol

NCT05296993
View directory record Official record
Conditions
Aging
Interventions
Extracts found in the Extended Longevity supplements
Dietary Supplement
Lead sponsor
TruDiagnostic
Industry
Eligibility
55 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Carlsbad, California
Source: ClinicalTrials.gov public record
Updated May 11, 2022 · Synced Oct 19, 2026, 10:14 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

AC-11 Supplement and Biological Aging

NCT05310123
View directory record Official record
Conditions
Aging
Interventions
AC-11
Dietary Supplement
Lead sponsor
TruDiagnostic
Industry
Eligibility
55 Years and older
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Sugar Land, Texas
Source: ClinicalTrials.gov public record
Updated Apr 11, 2022 · Synced Oct 19, 2026, 10:14 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock

NCT04608448
View directory record Official record
Conditions
Aging, Epigenetics, Inflammatory Mediators
Interventions
Rapamycin Topical Ointment, Placebo
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
65 Years to 95 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2023 · Synced Oct 19, 2026, 10:14 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Greens-Based Crossover Trial to Improve Epigenetic Aging in Adults

NCT06537232
View directory record Official record
Conditions
Aging
Interventions
Greens-based Supplement
Dietary Supplement
Lead sponsor
Auburn University
Other
Eligibility
50 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Oct 19, 2026, 10:14 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Impact of an Evidence-Based Parenting Service on Maternal Sensitivity and Infant Cellular Aging in a Population of Under-Resourced Families

NCT06740266
View directory record Official record
Conditions
Parent Child Relationship, Child Social-Emotional Development, Telomere Length, Epigenetic Aging
Interventions
Promoting First Relationships in Primary Care (PFR-PC)
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 19, 2026, 10:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age

NCT05234203
View directory record Official record
Conditions
Immunity Disorders, Aging, Inflammation
Interventions
HTB Rejuvenate
Dietary Supplement
Lead sponsor
Big Bold Health, PBC
Industry
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Bainbridge Island, Washington
Source: ClinicalTrials.gov public record
Updated Dec 6, 2022 · Synced Oct 19, 2026, 10:14 AM EDT