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ClinicalTrials.gov public records Last synced Oct 19, 2026, 4:25 PM EDT

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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Epigenetic Changes Clear all
Terminated Phase 1Phase 2 Interventional Results available

Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostat

NCT00925132
View directory record Official record
Conditions
Metastatic Melanoma
Interventions
Temozolomide, Decitabine, Panobinostat
Drug
Lead sponsor
University of Iowa
Other
Eligibility
18 Years and older
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2016
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 19, 2026, 4:25 PM EDT
Completed No phase listed Observational

Opioid Physiology Project

NCT03462797
View directory record Official record
Conditions
Tolerance, Withdrawal, Addiction, Epigenetic Changes
Interventions
Not listed
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
87 participants
Timeline
2017 – 2018
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 11, 2018 · Synced Oct 19, 2026, 4:25 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Epigenetic and Metabolomic Changes in Childhood Cancer Survivors

NCT03866707
View directory record Official record
Conditions
Childhood Cancer
Interventions
One-time blood draw, Evaluation of CpG methylation, Metabolomic analysis
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
1 Year to 18 Years
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Oct 19, 2026, 4:25 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Perinatal Autism Genetics and Epigenetics Study

NCT07738003
View directory record Official record
Conditions
Autism Disorders and Maternal Stress, Development Delay, Prenatal Stress, Social Behavior
Interventions
Change in child's DNA methylation, Perinatal stress, Early social experience, Polygenic risk scores for social communication and repetitive behavior
Genetic · Behavioral
Lead sponsor
University of Iowa
Other
Eligibility
0 Years to 50 Years
Enrollment
7,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 19, 2026, 4:25 PM EDT
Terminated Phase 1 Interventional

Treatment of a Resistant Disease Using Decitabine Combined With Vemurafenib Plus Cobimetinib

NCT01876641
View directory record Official record
Conditions
Metastatic Melanoma, Melanoma, BRAF-mutated Metastatic Melanoma, V600EBRAF-mutated Metastatic Melanoma
Interventions
Vemurafenib + Cobimetinib, Decitabine
Drug
Lead sponsor
Mohammed M Milhem
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Oct 19, 2026, 4:25 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

DNA Methylation and Vascular Function

NCT03527420
View directory record Official record
Conditions
Obesity, Vascular Dysfunction
Interventions
Exercise training
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 50 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Oct 19, 2026, 4:25 PM EDT
Completed Phase 2 Interventional Results available

Superenhancer Inhibitor Minnelide in Advanced Refractory Adenosquamous Carcinoma of the Pancreas (ASCP)

NCT04896073
View directory record Official record
Conditions
Adenosquamous Carcinoma of the Pancreas
Interventions
Minnelide, ECG, CT/MRI, Tumor Biopsy
Drug · Diagnostic Test · Procedure
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 19, 2026, 4:25 PM EDT
Completed No phase listed Observational

Proteomic-Based Profiling of Lymphomas: Chromatin Proteomics; Composition and Modification of Histone and Non-Histone Chromosomal Proteins

NCT01563874
View directory record Official record
Conditions
Lymphoma, Lymphoid Hyperplasia
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 4:25 PM EDT
Recruiting No phase listed Observational

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining

NCT00242723
View directory record Official record
Conditions
Thoracic Cancers, Malignant Pleural Mesotheliomas NOS, Lung Cancer NOS, Esophageal Cancers NOS, Cancers of Non Thoracic Origin With Metastases to the Lungs or Pleura, Thoracic Malignancies
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
2 Years to 120 Years
Enrollment
1,559 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 19, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certain Genes in the Skin Using Non-invasive Measurements

NCT06658847
View directory record Official record
Conditions
Retinoid, Skin Aging, Epigenomics
Interventions
Night Cream Usage, No Night Cream Usage
Other
Lead sponsor
Johnson & Johnson Consumer Inc. (J&JCI)
Industry
Eligibility
40 Years to 65 Years · Female only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2025 · Synced Oct 19, 2026, 4:25 PM EDT
Recruiting Phase 1 Interventional

Venetoclax to Augment Epigenetic Modification and Chemotherapy

NCT05317403
View directory record Official record
Conditions
Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory
Interventions
Venetoclax, Azacitadine, Vorinostat, Cytarabine, Fludarabine, Filgrastim
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
1 Year to 25 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 12, 2026 · Synced Oct 19, 2026, 4:25 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Epigenetics, DNA Methylation Patterns and Periodontal Disease

NCT01399034
View directory record Official record
Conditions
Periodontal Disease
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2011 · Synced Oct 19, 2026, 4:25 PM EDT
Completed Not applicable Interventional

Valued EpiGenetic Glycemic ImprovEments Through Weight Loss

NCT02869659
View directory record Official record
Conditions
Obesity, Pre-diabetes
Interventions
Weight Loss Group, Delayed Weight Loss
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
40 Years to 65 Years
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 31, 2020 · Synced Oct 19, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation

NCT03319173
View directory record Official record
Conditions
Mild Cognitive Impairment, Metabolic Syndrome
Interventions
Dietary intervention
Behavioral
Lead sponsor
Bristlecone Health, Inc.
Industry
Eligibility
35 Years to 80 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Maple Grove, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Oct 19, 2026, 4:25 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Periodontal Inflammation and Epigenetics in Obese Individuals

NCT07610902
View directory record Official record
Conditions
Obesity, Periodontitis
Interventions
Non-surgical periodontal therapy will be administered
Procedure
Lead sponsor
Louisiana State University Health Sciences Center in New Orleans
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 19, 2026, 4:25 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Diet-Induced Changes in GEnetic Material

NCT06252922
View directory record Official record
Conditions
Diet, Healthy, Body Weight, Metabolic Disturbance
Interventions
Not listed
Lead sponsor
Pennington Biomedical Research Center
Other
Eligibility
20 Years to 35 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baton Rouge, Louisiana
Source: ClinicalTrials.gov public record
Updated May 31, 2025 · Synced Oct 19, 2026, 4:25 PM EDT
Active, not recruiting Phase 1 Interventional

Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation

NCT03843528
View directory record Official record
Conditions
Acute Myeloid Leukemia, Myelodysplastic Syndromes, Mixed Phenotype Acute Leukemia, Juvenile Myelomonocytic Leukemia
Interventions
Vorinostat, Azacitidine Injection
Drug
Lead sponsor
Johns Hopkins All Children's Hospital
Other
Eligibility
1 Year to 21 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Oct 19, 2026, 4:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Natural Product System and Lifestyle Modification

NCT06931977
View directory record Official record
Conditions
Healthy
Interventions
Supplement system + copaiba softgels, Supplement system + placebo softgels
Dietary Supplement
Lead sponsor
dōTERRA International
Industry
Eligibility
30 Years to 55 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Pleasant Grove, Utah
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 19, 2026, 4:25 PM EDT
Not listed No phase listed Observational

Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis

NCT03145922
View directory record Official record
Conditions
Sarcoidosis, Sarcoidosis, Pulmonary
Interventions
Observational Study
Other
Lead sponsor
National Jewish Health
Other
Eligibility
18 Years to 85 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 6, 2020 · Synced Oct 19, 2026, 4:25 PM EDT
Terminated Phase 2 Interventional Results available

Reversing Therapy Resistance With Epigenetic-Immune Modification

NCT02395627
View directory record Official record
Conditions
Breast Neoplasms
Interventions
Tamoxifen, Vorinostat, Pembrolizumab
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 19, 2026, 4:25 PM EDT
Terminated No phase listed Observational

Biomarkers, Neurodevelopment and Preterm Infants

NCT02557191
View directory record Official record
Conditions
Preterm, Neurodevelopmental Disorder, Epigenetic Changes
Interventions
Observational study
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
1 Day to 2 Days
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Oct 19, 2026, 4:25 PM EDT
Withdrawn Not applicable Interventional

Antiorbital Calcium in Chronic Conditions

NCT05302713
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Ionic Calcium, Calcium Carbonate
Dietary Supplement
Lead sponsor
National University of Natural Medicine
Other
Eligibility
55 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 7, 2024 · Synced Oct 19, 2026, 4:25 PM EDT