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ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:25 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 124 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Epilepsy, Drug Resistant Clear all

Conditions: Drug Resistant Epilepsy
Interventions: Cannabidiol; Drug
Lead sponsor: John; Other
Eligibility: 5 Years to 19 Years
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Sturge-Weber Syndrome
Interventions: Cannabidiol; Drug
Lead sponsor: Anne Comi, MD; Other
Eligibility: 1 Month to 45 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Seizures
Interventions: Cannabidiol Oral Solution; Drug
Lead sponsor: INSYS Therapeutics Inc; Industry
Eligibility: 1 Year to 18 Years
Enrollment: 52 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 11
States / cities: San Francisco, California • Miami, Florida • Pensacola, Florida + 8 more

Conditions: Epilepsy, Refractory Epilepsy, Music
Interventions: Experimental Intervention (Music A), Active Comparator Intervention (Music B), Active Comparator Intervention (Music C); Other
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Worcester, Massachusetts • Lebanon, New Hampshire

Conditions: Epilepsy
Interventions: Carvedilol-CR; Drug
Lead sponsor: Columbia University; Other
Eligibility: 10 Years to 75 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Focal Epilepsy, Drug-resistant Focal Epilepsy
Interventions: NeuroPace RNS System; Device
Lead sponsor: NeuroPace; Industry
Eligibility: 13 Years to 19 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Waltham, Massachusetts

Conditions: Epilepsy, Seizure, Catamenial Epilepsy, Medically Resistant Epilepsy, Medically Resistant Seizures
Interventions: betaquik®; Dietary Supplement
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Baltimore, Maryland • Madison, Wisconsin

Conditions: Drug-Resistant Epilepsy, Focal-Onset Seizures
Interventions: Padsevonil; Drug
Lead sponsor: UCB Biopharma SRL; Industry
Eligibility: 18 Years and older
Enrollment: 406 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 25
States / cities: Chandler, Arizona • La Jolla, California • San Francisco, California + 21 more

Conditions: Seizures, Epilepsies, Partial, Epilepsy, Complex Partial, Epilepsy, Generalized, Epilepsy
Interventions: Placebo, Vanquix Auto-Injector (Diazepam Injection); Drug
Lead sponsor: Pfizer; Industry
Eligibility: 2 Years and older
Enrollment: 234 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2014
U.S. locations: 86
States / cities: Northport, Alabama • Little Rock, Arkansas • Irvine, California + 44 more

Conditions: Epilepsy, Seizure Disorders
Interventions: Trigeminal Nerve Stimulation; Device
Lead sponsor: Olive View-UCLA Education & Research Institute; Other
Eligibility: 18 Years to 70 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 2
States / cities: Los Angeles, California • Sylmar, California

Conditions: Refractory Epilepsy
Interventions: Cathodal Transcranial Direct Current Stimulation (tDCS).; Device
Lead sponsor: Neuroelectrics Corporation; Industry
Eligibility: 9 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: No Condition, Study Mental State in Healthy Populations and Drug-resistant Epilepsy Patients With Existing iEEG
Interventions: Virtual human social interaction, Cold pressor test; Behavioral
Lead sponsor: University of Southern California; Other
Eligibility: 18 Years and older
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2028
U.S. locations: 2
States / cities: Downey, California • Los Angeles, California

Conditions: Epilepsy, Partial Seizure, Neurostimulator; Complications, Drug Resistant Epilepsy, Focal Epilepsy
Interventions: RNS System; Device
Lead sponsor: NeuroPace; Industry
Eligibility: 12 Years to 17 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 2
States / cities: Grand Rapids, Michigan • Hawthorne, New York

Conditions: Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
Interventions: Not listed
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 8 Years to 99 Years
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2011
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Epilepsy, Epilepsy Intractable
Interventions: Green Light Exposure; Device
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 6 Months to 30 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Epilepsy
Interventions: Cannabidiol (Epidiolex); Drug
Lead sponsor: Augusta University; Other
Eligibility: 1 Year to 18 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2020
U.S. locations: 1
States / cities: Augusta, Georgia

Conditions: Epilepsies, Myoclonic, Drug Resistant Epilepsy
Interventions: Lorcaserin; Drug
Lead sponsor: Eisai Inc.; Industry
Eligibility: 2 Years and older
U.S. locations: 18
States / cities: Birmingham, Alabama • Los Angeles, California • Aurora, Colorado + 14 more

Conditions: Epilepsy
Interventions: ataluren, Placebo; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 2 Years to 12 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Seizures
Interventions: Retigabine, Placebo; Drug
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 539 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 2
States / cities: Bethesda, Maryland • Dallas, Texas

Conditions: Epilepsy Intractable
Interventions: Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Behavioral
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Epilepsy, Unspecified, Refractory (Medically)
Interventions: Medical Cannabis; Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 1 Month to 20 Years
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders, Epilepsy Comorbidities, Epilepsy Intractable, Epilepsy Surgery, Epilepsy, Temporal Lobe, Memory Deficits, Memory Disorder, Spatial, Memory Dysfunction, Spatial Perception
Interventions: Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I); Behavioral · Device · Diagnostic Test
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years to 55 Years
Enrollment: 620 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2030
U.S. locations: 2
States / cities: Sacramento, California • Atlanta, Georgia

Conditions: Epilepsy, Epilepsy Intractable, Epilepsy, Temporal Lobe
Interventions: 3T Magnetic Resonance Imaging, Intracranial electroencephalography recordings, 7T Magnetic Resonance Imaging; Diagnostic Test
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years and older
Enrollment: 290 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Refractory Epilepsy
Interventions: Electrical Stimulation; Other
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Search by objective public record fields.

Cannabidiol for Drug Resistant Pediatric Epilepsy (Expanded Access Use)

Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome

Cannabidiol Oral Solution as an Adjunctive Treatment for Treatment-resistant Seizure Disorder

Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application

P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.

RNS System for Drug-Resistant Focal Epilepsy in Adolescents: A Real-World Study

Medium Chain Triglycerides as an Adjunct to the Modified Atkins Diet for Women With Catamenial Epilepsy

Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy

Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures.

External Trigeminal Nerve Stimulation for Epilepsy

Safety and Therapeutic Measures of Tdcs in Patients With Refractory Focal Epilepsy

Novel Multimodal Neural, Physiological, and Behavioral Sensing and Machine Learning for Mental States

RNS System RESPONSE Study

Surgery as a Treatment for Medically Intractable Epilepsy

Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy

Epidiolex and Drug Resistant Epilepsy in Children

Extended Access Program With Lorcaserin For The Treatment of Dravet Syndrome and Other Refractory Epilepsies

Ataluren for Nonsense Mutation in CDKL5 and Dravet Syndrome

Retigabine Efficacy and Safety Trial for Partial Onset Refractory Seizures in Epilepsy

Neural Computations of Goal-directed Decision-making

The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy

Spatial Scene Recognition Memory in Epilepsy Surgery

Localizing Epileptic Networks Using MRI and iEEG

Modulation of Emotion Perception in Humans Via Amygdala Stimulation