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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Erectile Dysfunction, CTCAE Clear all
Completed No phase listed Observational Accepts healthy volunteers

Predicting Peripheral Arterial Disease in Men With Erectile Dysfunction

NCT00743613
View directory record Official record
Conditions
Erectile Dysfunction, Peripheral Arterial Disease
Interventions
Sexual Health Inventory for Men (SHIM), Ankle-Brachial Index (ABI)
Behavioral · Procedure
Lead sponsor
Bruton Avenue Family Practice
Other
Eligibility
50 Years and older · Male only
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
5
States / cities
Fitchburg, Massachusetts • Hampton, Virginia • Newport News, Virginia + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2008 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Udenafil on Spermatogenesis

NCT01230541
View directory record Official record
Conditions
Spermatogenesis, Erectile Dysfunction
Interventions
Placebo, Udenafil
Drug
Lead sponsor
Warner Chilcott
Industry
Eligibility
25 Years to 64 Years · Male only
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
23
States / cities
Huntsville, Alabama • Anaheim, California • San Diego, California + 19 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2011 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 3 Interventional Results available

Tadalafil Taken Daily Compared to Placebo on Improvement of Getting and Maintaining an Erection and Sexual Quality of Life

NCT00422734
View directory record Official record
Conditions
Impotence
Interventions
tadalafil, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older · Male only
Enrollment
342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
10
States / cities
Huntsville, Alabama • Little Rock, Arkansas • Newport Beach, California + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2009 · Synced Sep 23, 2026, 4:17 AM EDT
Recruiting Not applicable Interventional

Double-S: a Wearable Device for Erectile Dysfunction

NCT05451563
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Double-S
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Male only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 21, 2025 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 3 Interventional

To Determine Effect and Safety of Tadalafil Taken by Men of Different Races and With Different Diseases When Needed for Erections

NCT00547417
View directory record Official record
Conditions
Impotence
Interventions
tadalafil
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older · Male only
Enrollment
1,933 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 21, 2007 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 4 Interventional

Investigate the Responsiveness of the Erectile Quality Scale to Vardenafil Flexible Dose vs Placebo in Males With Erectile Dysfunction (ED)

NCT00665340
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Placebo, Levitra (Vardenafil, BAY38-9456)
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years to 64 Years · Male only
Enrollment
219 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
12
States / cities
Phoenix, Arizona • Beverly Hills, California • Laguna Hills, California + 9 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2013 · Synced Sep 23, 2026, 4:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of Bicycle Seat Effects on Male Perineal Blood Flow

NCT01804725
View directory record Official record
Conditions
Effect of Bike Seats on Male Perineal Blood Flow
Interventions
Not listed
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 64 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 24, 2017 · Synced Sep 23, 2026, 4:17 AM EDT
Withdrawn Phase 3 Interventional

BioDFence® G3 For Full Nerve-Sparing Robotic-Assisted Radical Prostatectomy

NCT05363644
View directory record Official record
Conditions
Prostate Cancer, Prostatectomy, Erectile Dysfunction Following Radical Prostatectomy, Incontinence, Urinary
Interventions
BioDFence G3
Biological
Lead sponsor
AdventHealth
Other
Eligibility
40 Years to 70 Years · Male only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Celebration, Florida
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 23, 2026, 4:17 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Yohimbine and Naltrexone on Sexual Function

NCT00042536
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Naltrexone HCL/ Yohimbine HCL
Drug
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of an External Erectile Device in Transgender Man Following Phalloplasty

NCT03823014
View directory record Official record
Conditions
Transsexualism, Surgery, Sex Behavior, Erectile Dysfunction
Interventions
Elator
Device
Lead sponsor
Boston Children's Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Sep 23, 2026, 4:17 AM EDT
Not listed Not applicable Interventional

Safety and Efficacy of Bi-Polar Radiofrequency for the Treatment of Erectile Dysfunction

NCT06299332
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Device treatment
Device
Lead sponsor
InMode MD Ltd.
Industry
Eligibility
40 Years to 80 Years · Male only
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 6, 2024 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Not applicable Interventional

Vacuum Erection Device in Improving Recovery of Erectile Function in Patients With Prostate Cancer Undergoing Surgery

NCT01660152
View directory record Official record
Conditions
Male Erectile Disorder, Prostate Cancer, Sexual Dysfunction
Interventions
Sexual Health Inventory for Men (SHIM) questionnaire administration, management of therapy complications, Daily vacuum therapy
Other · Procedure
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
Up to 70 Years · Male only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 12, 2017 · Synced Sep 23, 2026, 4:17 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Natesto Testosterone Nasal Gel for Hypogonadal Men

NCT05484167
View directory record Official record
Conditions
Erectile Dysfunction, Sexual Dysfunction
Interventions
Natesto Nasal Product, Placebo
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 64 Years · Male only
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 4 Interventional

Mild To Moderate Erectile Dysfunction Study

NCT00137072
View directory record Official record
Conditions
Impotence
Interventions
Viagra (Sildenafil Citrate) 100 mg
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years to 70 Years · Male only
Enrollment
355 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
33
States / cities
Birmingham, Alabama • Homewood, Alabama • Hoover, Alabama + 30 more
Source: ClinicalTrials.gov public record
Updated Jan 31, 2021 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 2 Interventional

Phase 2a Topical Sildenafil Proof-of-Concept Study in Men With Mild to Moderate ED

NCT02390960
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Sildenafil Cream, Placebo Cream, Penile Plethysmography (RigiScan)
Drug · Device
Lead sponsor
Strategic Science & Technologies, LLC
Industry
Eligibility
18 Years to 70 Years · Male only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
3
States / cities
San Diego, California • New Orleans, Louisiana • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 11, 2017 · Synced Sep 23, 2026, 4:17 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

The Objective of This Phase 1 Study is to Evaluate the Food Effect of 100 mg Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fed Versus 100 mg of Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fasted Conditions in Healthy Adult Male Subjects

NCT06872866
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
ASP-001.1, ASP-001.1
Drug · Device
Lead sponsor
Aspargo Labs, Inc
Industry
Eligibility
20 Years to 70 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 3 Interventional Results available

Clinical Investigation Using MED3000 Gel or Tadalafil Tablets in the Treatment of Erectile Dysfunction

NCT04984993
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
MED3000 (Male), Tadalafil 5mg (Male), MED3000 (Female), Tadalafil 5mg (Female)
Device · Drug
Lead sponsor
Futura Medical Developments Ltd.
Industry
Eligibility
22 Years to 70 Years · Male only
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 20, 2023 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 2 Interventional Results available

Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer

NCT03830164
View directory record Official record
Conditions
Male Erectile Disorder, Prostate Adenocarcinoma, Erectile Dysfunction, CTCAE, Impotence
Interventions
Atorvastatin, Pentoxifylline, Vitamin E Compound
Drug · Dietary Supplement
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Male only
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 16, 2023 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 3 Interventional

A New Sildenafil Oral Film in Patients With Erectile Dysfunction

NCT05490680
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
Sildenafil Oral Film 25 mg, 50 mg, 75 mg or 100 mg, Placebo
Drug
Lead sponsor
IBSA Institut Biochimique SA
Industry
Eligibility
18 Years and older · Male only
Enrollment
488 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
18
States / cities
Foley, Alabama • Huntsville, Alabama • Little Rock, Arkansas + 14 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 3 Interventional Results available

A Study in the Treatment of Erectile Dysfunction and Benign Prostate Hyperplasia

NCT00855582
View directory record Official record
Conditions
Erectile Dysfunction, Benign Prostatic Hyperplasia
Interventions
Tadalafil, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
45 Years and older · Male only
Enrollment
606 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
17
States / cities
Anchorage, Alaska • Phoenix, Arizona • La Mesa, California + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2011 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 2 Interventional

Efficacy Study of RX-10100 to Treat Erectile Dysfunction (ED)

NCT00693056
View directory record Official record
Conditions
Erectile Dysfunction (ED)
Interventions
Placebo, RX-10100 5mg, RX-10100 10mg, RX-10100 15mg
Drug
Lead sponsor
Rexahn Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 65 Years · Male only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
3
States / cities
Greenbelt, Maryland • Woodlane, New Jersey • Greer, South Carolina
Source: ClinicalTrials.gov public record
Updated May 4, 2009 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 2 Interventional

Efficacy and Safety Evaluating Fispemifene in the Treatment of Hypogonadal Men With Erectile Dysfunction Unresponsive to PDE5 Inhibitors

NCT00415571
View directory record Official record
Conditions
Hypogonadism, Erectile Dysfunction
Interventions
Fispemifene (once daily for 8 weeks)
Drug
Lead sponsor
QuatRx Pharmaceuticals Company
Industry
Eligibility
20 Years and older · Male only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
14
States / cities
Birmingham, Alabama • Tucson, Arizona • Hot Springs, Arkansas + 11 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2010 · Synced Sep 23, 2026, 4:17 AM EDT
Recruiting Not applicable Interventional

EndoPAT Device for Endothelial Dysfunction in ED

NCT06720597
View directory record Official record
Conditions
Erectile Dysfunction, Hypogonadism, Male, Endothelial Dysfunction
Interventions
Daily low-dose PDE5 inhibitor therapy, Testosterone therapy as per clinical guidelines.
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Male only
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Newport Beach, California
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Sep 23, 2026, 4:17 AM EDT
Completed Phase 4 Interventional

Study Of Men With Mild To Moderate Erectile Dysfunction To Evaluate The Efficacy Of Viagra 8 Hours Post-Dose

NCT00143260
View directory record Official record
Conditions
Impotence
Interventions
Viagra (Sildenafil Citrate) 100 mg
Drug
Lead sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Industry
Eligibility
18 Years to 70 Years · Male only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
25
States / cities
Birmingham, Alabama • Homewood, Alabama • Hoover, Alabama + 22 more
Source: ClinicalTrials.gov public record
Updated Jan 31, 2021 · Synced Sep 23, 2026, 4:17 AM EDT