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ClinicalTrials.gov public records Last synced Oct 10, 2026, 10:20 AM EDT

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Showing 145–168 of 218 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Esophagus, Barrett Clear all
Completed No phase listed Observational

Epidemiology of Barrett's Esophagus: A Population Based Study

NCT01286155
View directory record Official record
Conditions
Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD), Olmsted County Resident
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 95 Years
Enrollment
534 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2013 · Synced Oct 10, 2026, 10:20 AM EDT
Completed Not applicable Interventional Results available

Micro-Layer Ablation of Barrett's Metaplasia- A Two-Phase, Multi-Center Trial - Extension of Follow-up to 5 Years

NCT00489268
View directory record Official record
Conditions
Barrett Esophagus
Interventions
HALO Ablation System
Device
Lead sponsor
Covidien, GI Solutions
Industry
Eligibility
18 Years to 75 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
9
States / cities
Scottsdale, Arizona • Orange, California • Boston, Massachusetts + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Oct 10, 2026, 10:20 AM EDT
Completed Not applicable Interventional

Confocal Endomicroscopy for Improved Diagnosis of Barrett's Esophagus and Early Esophageal Cancer(CEBE Study)

NCT01124214
View directory record Official record
Conditions
Barrett's Esophagus, Esophageal Intraepithelial Neoplasia
Interventions
endomicroscopy
Procedure
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
3
States / cities
Boston, Massachusetts • New York, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Oct 10, 2026, 10:20 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

The Study of Barrett's Esophagus: What Are the Factors of Progression

NCT00586404
View directory record Official record
Conditions
Barrett's Esophagus, Esophageal Neoplasms
Interventions
Not listed
Lead sponsor
Midwest Biomedical Research
Other
Eligibility
18 Years to 80 Years
Enrollment
1,250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2017
U.S. locations
4
States / cities
Tucson, Arizona • Bethesda, Maryland • Kansas City, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 10, 2026, 10:20 AM EDT
Completed Early Phase 1 Interventional

Photoacoustic Endoscopy of Barrett's Esophagus

NCT02606292
View directory record Official record
Conditions
Barrett Esophagus
Interventions
Photoacoustic endoscopy, Endoscopic ultrasound (standard of care), Endoscopic surgery (standard of care)
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Oct 10, 2026, 10:20 AM EDT
Completed No phase listed Observational

Preliminary Longitudinal Validation of Biomarkers Predictive of Barrett's Esophagus

NCT00844077
View directory record Official record
Conditions
Barrett's Esophagus
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 80 Years
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
5
States / cities
Boston, Massachusetts • Ann Arbor, Michigan • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2011 · Synced Oct 10, 2026, 10:20 AM EDT
Active, not recruiting Not applicable Interventional

Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE)

NCT03554356
View directory record Official record
Conditions
Barrett Esophagus, Intestinal Metaplasia, Esophageal Dysplasia
Interventions
CryoBalloon Focal Ablation System
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
11
States / cities
Birmingham, Alabama • Washington D.C., District of Columbia • Baltimore, Maryland + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 10, 2026, 10:20 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Evaluation of MicroRNA Expression in Blood and Cytology for Detecting Barrett's Esophagus and Associated Neoplasia

NCT02464930
View directory record Official record
Conditions
Barrett's Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
Interventions
Not listed
Lead sponsor
Midwest Biomedical Research
Other
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 8, 2015 · Synced Oct 10, 2026, 10:20 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

NCT03961945
View directory record Official record
Conditions
Barrett Esophagus, Esophageal Adenocarcinoma
Interventions
Sponge Capsule
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
1,550 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2030
U.S. locations
9
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Austin, Minnesota + 6 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 10, 2026, 10:20 AM EDT
Terminated Not applicable Interventional

Pilot Study of Oral 852A for Elimination of High-Grade Dysplasia in Barrett's Esophagus

NCT00386594
View directory record Official record
Conditions
Barrett Esophagus
Interventions
852A
Drug
Lead sponsor
Rogers, B.H. Gerald, M.D.
Individual
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
2
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 10, 2026, 10:20 AM EDT
Completed No phase listed Observational

A Liquid Biopsy for High-risk Pre-cancer Screening of Esophageal Adenocarcinoma

NCT06381583
View directory record Official record
Conditions
Esophagus Cancer, Esophageal Cancer Stage, Esophageal Cancer, Esophageal Neoplasms, Esophagus Adenocarcinoma, Esophagus, Barrett, Barrett Esophagus, Barrett Adenocarcinoma, Barrett Epithelium, Barretts Esophagus With Dysplasia, Barrett's Esophagus Without Dysplasia, Barretts Esophagus With High Grade Dysplasia, Barretts Esophagus With Low Grade Dysplasia, Barrett Esophagus, Long-Segment, Barrett's Esophagus With Dysplasia, Unspecified, Barrett's Esophagus With Esophagitis, Gastroesophageal Reflux, Reflux Disease, Esophageal Adenocarcinoma, Esophageal Dysplasia, Esophageal Neoplasms Malignant
Interventions
EMERALD (Esophageal MicroRNAs for BaRRett's esophagus, Adenocarcinoma, and Dysplasia)
Diagnostic Test
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
658 participants
Timeline
2023 – 2024
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated May 10, 2024 · Synced Oct 10, 2026, 10:20 AM EDT
Completed No phase listed Observational

Risk Factors for Barrett's Esophagus in Patients With BE, Gastroesophageal Reflux, or Gastrointestinal Bleeding

NCT00445653
View directory record Official record
Conditions
Precancerous Condition
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 90 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2013
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 10, 2026, 10:20 AM EDT
Completed No phase listed Observational

Ramanspectroscopy in Barrett's Esophagus

NCT00588575
View directory record Official record
Conditions
Barrett's Esophagus
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 11, 2019 · Synced Oct 10, 2026, 10:20 AM EDT
Completed Not applicable Interventional Results available

Detection Of Neoplastic Tissue in Barrett's Esophagus With In vivO Probe-based Confocal Endomicroscopy

NCT00795184
View directory record Official record
Conditions
Barrett Syndrome, Barrett's Syndrome, Barrett's Esophagus, Barrett Esophagus, Adenocarcinoma
Interventions
Imaging procedures (NBI), HDWLE, pCLE
Device
Lead sponsor
Mauna Kea Technologies
Industry
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
3
States / cities
Jacksonville, Florida • Kansas City, Missouri • New York, New York
Source: ClinicalTrials.gov public record
Updated May 3, 2016 · Synced Oct 10, 2026, 10:20 AM EDT
Completed Early Phase 1 Interventional

Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus

NCT01465113
View directory record Official record
Conditions
Short Segment Barrett's Esophagus, Long Segment Barrett's Esophagus
Interventions
Omeprazole, Vitamin D3, upper endoscopy, Metformin
Drug · Procedure
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
3
States / cities
Beachwood, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 10, 2016 · Synced Oct 10, 2026, 10:20 AM EDT
Terminated Not applicable Interventional Results available

Polar Wand Carbon Dioxide Cryotherapy for Barrett's Esophagus

NCT01477177
View directory record Official record
Conditions
Barrett's Esophagus
Interventions
Polar Wand carbon dioxide cryotherapy
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 98 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 15, 2019 · Synced Oct 10, 2026, 10:20 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

EsophaCap for the Detection of Early Esophageal Carcinoma

NCT04214119
View directory record Official record
Conditions
Barrett Esophagus, Esophageal Cancer, Gastric Cancer
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
2,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2028
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Oct 10, 2026, 10:20 AM EDT
Suspended No phase listed Observational

Narrow Band Imaging Project on Barrett's Esophagus

NCT01580631
View directory record Official record
Conditions
Barrett's Esophagus, Gastroesophageal Reflux Disease
Interventions
Not listed
Lead sponsor
Midwest Biomedical Research
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2025
U.S. locations
2
States / cities
Chicago, Illinois • Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 16, 2023 · Synced Oct 10, 2026, 10:20 AM EDT
Completed No phase listed Observational

Novel Method of Surveillance in Barrett's Esophagus

NCT00955019
View directory record Official record
Conditions
Barrett Esophagus
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 16, 2009 · Synced Oct 10, 2026, 10:20 AM EDT
Completed Phase 1 Interventional

GCC Agonist Signal in the Small Intestine

NCT05107219
View directory record Official record
Conditions
Barrett Esophagus, Gastroesophageal Reflux Disease, Malignant Digestive System Neoplasm
Interventions
Biopsy, Biospecimen Collection, Esophagogastroduodenoscopy, Linaclotide, Plecanatide
Procedure · Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
4
States / cities
Scottsdale, Arizona • Philadelphia, Pennsylvania • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 10, 2026, 10:20 AM EDT
Completed Early Phase 1 Interventional

Endoscopic Multispectral Imaging for the Early Detection of Barrett's Neoplasia

NCT01384864
View directory record Official record
Conditions
Barrett's Esophagus, Intraepithelial Neoplasia
Interventions
proflavine
Drug
Lead sponsor
Anandasabapathy, Sharmila, M.D.
Individual
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 11, 2016 · Synced Oct 10, 2026, 10:20 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

NCT06687603
View directory record Official record
Conditions
Barrett Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
Interventions
EsoCheck, EsoGuard
Device · Diagnostic Test
Lead sponsor
Case Comprehensive Cancer Center
Other
Eligibility
50 Years and older
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
5
States / cities
Aurora, Colorado • Baltimore, Maryland • Chapel Hill, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 10, 2026, 10:20 AM EDT
Terminated Not applicable Interventional

A Dose-Optimization Study for the Initial Treatment of Dysplastic Barrett's Esophagus With trūFreeze™ Spray Cryotherapy

NCT01845454
View directory record Official record
Conditions
Barrett's Esophagus
Interventions
trūFreeze™ Spray Cryotherapy
Device
Lead sponsor
CSA Medical, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
6
States / cities
Jacksonville, Florida • Baltimore, Maryland • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2016 · Synced Oct 10, 2026, 10:20 AM EDT
Not listed Not applicable Interventional

Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection

NCT03427346
View directory record Official record
Conditions
Barrett Esophagus, Barrett Adenocarcinoma, Esophagus Neoplasm
Interventions
Endoscopic mucosal resection, Endoscopic submucosal dissection
Procedure
Lead sponsor
Universitätsklinikum Hamburg-Eppendorf
Other
Eligibility
18 Years to 99 Years
Enrollment
407 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Oct 10, 2026, 10:20 AM EDT