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ClinicalTrials.gov public records Last synced Jun 10, 2026, 3:29 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Excision Margin Clear all
Not listed Not applicable Interventional

Intraoperative Use of ClearEdge Device in Breast Conserving Surgery

NCT05456373
View directory record Official record
Conditions
Breast Cancer
Interventions
ClearEdge device
Device
Lead sponsor
LS BioPath
Industry
Eligibility
18 Years and older · Female only
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Jun 10, 2026, 3:29 AM EDT
Completed No phase listed Observational

Observational Study to Evaluate Neurodevelopmental Status in Pediatric Patients With Hunter Syndrome (MPS II)

NCT01822184
View directory record Official record
Conditions
Mucopolysaccharidosis (MPS), Hunter Syndrome
Interventions
Not listed
Lead sponsor
Shire
Industry
Eligibility
2 Years to 18 Years · Male only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
3
States / cities
Oakland, California • Chicago, Illinois • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Jun 10, 2026, 3:29 AM EDT
Suspended Not applicable Interventional Accepts healthy volunteers

Real-time Diagnosis and Visualization of Tumor Margins in Excised Breast Specimens Using Zenith FLIM Diagnostics

NCT04683120
View directory record Official record
Conditions
Oncology, Breast Cancer, Cancer Diagnosis, Margins of Excision, Margins, Tumor-Free
Interventions
Zenith FLIM Diagnostics
Diagnostic Test
Lead sponsor
Laser LabCorp
Industry
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Jun 10, 2026, 3:29 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Lipids of the Human Tear Film and Their Effect on Tear Stability

NCT00803452
View directory record Official record
Conditions
Blepharitis
Interventions
doxycycline, azithromycin
Drug
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 80 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 21, 2017 · Synced Jun 10, 2026, 3:29 AM EDT
Recruiting Not applicable Interventional

Investigation of Standard Excision Surgical Margins Using Two Photon Fluorescence Microscopy

NCT06473103
View directory record Official record
Conditions
Basal Cell Carcinoma
Interventions
Two photon fluorescence microscopy imaging
Device
Lead sponsor
University of Rochester
Other
Eligibility
Not listed
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Victor, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Jun 10, 2026, 3:29 AM EDT
Recruiting No phase listed Observational

Microendoscopic EI Sensing for Real-time Intraoperative Surgical Margin Assessment

NCT06039085
View directory record Official record
Conditions
Prostate Cancer
Interventions
custom device to demonstrate a significant difference in electrical impedance signatures
Device
Lead sponsor
Ryan J. Halter
Other
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jun 10, 2026, 3:29 AM EDT
Completed No phase listed Observational

Lumpectomy Specimen Margin Evaluation With Tomography and Structured Light Imaging

NCT04257799
View directory record Official record
Conditions
Breast Cancer Female
Interventions
Structured Light Imaging (SLI) System
Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jun 21, 2022 · Synced Jun 10, 2026, 3:29 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy Study of Bimatoprost to Treat Hypotrichosis of the Eyelashes After Application to the Eyelid Margin

NCT00907426
View directory record Official record
Conditions
Hypotrichosis
Interventions
Bimatoprost 0.03% solution, Vehicle solution
Drug
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
368 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2012 · Synced Jun 10, 2026, 3:29 AM EDT
Recruiting No phase listed Observational

Evaluating Adenoma Recurrence After Endoscopic Mucosal Resection With Margin Marking or Post Treatment With Snare Tip Soft Coagulation

NCT06476145
View directory record Official record
Conditions
Adenoma Colon Polyp
Interventions
Not listed
Lead sponsor
AdventHealth
Other
Eligibility
18 Years and older
Enrollment
342 participants
Timeline
2023 – 2027
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Jun 10, 2026, 3:29 AM EDT
Terminated Phase 3 Interventional Results available

Fluorescence Imaging of Carcinoma During Breast Conserving Surgery

NCT04815083
View directory record Official record
Conditions
Breast Neoplasm Female, Breast Cancer
Interventions
Aminolevulinic Acid Hydrochloride, Eagle V1.2 Imaging System, Placebo
Drug · Device
Lead sponsor
SBI ALApharma Canada, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
7
States / cities
Stamford, Connecticut • Clearwater, Florida • Miami, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Jun 10, 2026, 3:29 AM EDT
Not listed Not applicable Interventional

Glioma Supra Marginal Incision Trial

NCT04737577
View directory record Official record
Conditions
High Grade Glioma
Interventions
Supramarginal resection, Conventional (i.e. GTR) resection
Procedure
Lead sponsor
Sunnybrook Health Sciences Centre
Other
Eligibility
18 Years to 85 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
University Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 17, 2023 · Synced Jun 10, 2026, 3:29 AM EDT
Active, not recruiting Phase 3 Interventional

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

NCT03233711
View directory record Official record
Conditions
Anal Basaloid Carcinoma, Anal Canal Cloacogenic Carcinoma, Anal Margin Squamous Cell Carcinoma, Stage IIB Anal Cancer AJCC v8, Stage III Anal Cancer AJCC v8
Interventions
Biopsy Procedure, Biospecimen Collection, Colonoscopy, Computed Tomography, Digital Rectal Examination, High Resolution Anoscopy, Magnetic Resonance Imaging, Nivolumab, Patient Observation, Proctoscopy, Sigmoidoscopy, X-Ray Imaging
Procedure · Biological · Other
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
18 Years and older
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
889
States / cities
Birmingham, Alabama • Anchorage, Alaska • Fairbanks, Alaska + 569 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 10, 2026, 3:29 AM EDT
Recruiting Phase 2 Interventional

Fluorescent Intra-operative Tumor Margin Examination

NCT04719156
View directory record Official record
Conditions
Sarcoma
Interventions
Indocyanine green solution administered at 2.0mg/kg., Stryker SPY-PHI Imaging Device
Drug · Device
Lead sponsor
Kurt Weiss
Other
Eligibility
18 Years to 100 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 19, 2026 · Synced Jun 10, 2026, 3:29 AM EDT
Not yet recruiting Phase 2 Interventional

Defining the Ablative Dose for Y-90 TARE

NCT07586046
View directory record Official record
Conditions
HCC - Hepatocellular Carcinoma
Interventions
Yttrium-90 Radiation Segmentectomy (Y90 RS) using glass microspheres
Other
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jun 10, 2026, 3:29 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

DAILIES TOTAL1 Versus ACUVUE TruEye - Effects on the Biology of the Ocular Surface and Lid Margin

NCT02347631
View directory record Official record
Conditions
Soft Contact Lenses, Myopia
Interventions
Soft Contact Lens - Daily Disposable Alcon Dailies Total 1 and ACUVUE TruEye, Soft Contact Lens - Acuvue TruEye and Alcon DAILIES TOTAL 1.
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 38 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Jun 10, 2026, 3:29 AM EDT
Terminated Phase 2 Interventional Results available

FOLFIRINOX in Patients With Inoperable Pancreatic Cancer

NCT01359007
View directory record Official record
Conditions
Adenocarcinoma of Pancreas
Interventions
Irinotecan, Oxaliplatin, Leucovorin, 5-FU
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 8, 2018 · Synced Jun 10, 2026, 3:29 AM EDT
Recruiting Not applicable Interventional

Feasibility of Timesaving When Using Histolog Confocal Laser Endomicroscopy for Margin Assessment in Prostatectomy Specimen

NCT07141121
View directory record Official record
Conditions
Prostate Cancer
Interventions
Histolog Scan
Device
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older · Male only
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 6, 2025 · Synced Jun 10, 2026, 3:29 AM EDT
Completed Not applicable Interventional Results available

SBRT for Close or Positive Margins After Resection of Pancreatic Adenocarcinoma

NCT01357525
View directory record Official record
Conditions
Adenocarcinoma of the Pancreas
Interventions
Stereotactic Body Radiation Therapy (SBRT)
Radiation
Lead sponsor
David A. Clump, MD, PhD
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 23, 2021 · Synced Jun 10, 2026, 3:29 AM EDT
Completed Not applicable Interventional Results available

MarginProbe, a Device for Intraoperative Assessment of Margin Status in Breast Conservation Surgery

NCT00749931
View directory record Official record
Conditions
Breast Cancer
Interventions
MarginProbe, Lumpectomy
Device · Procedure
Lead sponsor
Dune Medical Devices
Industry
Eligibility
18 Years to 90 Years · Female only
Enrollment
664 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
18
States / cities
Costa Mesa, California • Los Angeles, California • Newport Beach, California + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2014 · Synced Jun 10, 2026, 3:29 AM EDT
Completed Not applicable Interventional

Evaluating and Comparing Two Surgical Methods for Treatment of Early Stage Breast Cancer

NCT01271738
View directory record Official record
Conditions
Breast Neoplasms, Breast Cancer, Breast Tumors, Cancer of Breast, Cancer of the Breast, Human Mammary Carcinoma, Neoplasms, Breast
Interventions
Remove tumor only, Removal of tumor and tissue
Procedure
Lead sponsor
Emory University
Other
Eligibility
18 Years and older · Female only
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 16, 2015 · Synced Jun 10, 2026, 3:29 AM EDT
Suspended No phase listed Observational

Computed Optical Margin Assessment for Breast Cancer Surgery, Phase I (Part B)

NCT02313116
View directory record Official record
Conditions
Breast Cancer
Interventions
Interferometric Synthetic Aperture Microscopy
Device
Lead sponsor
Diagnostic Photonics, Inc.
Industry
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Jun 10, 2026, 3:29 AM EDT
Completed Not applicable Interventional

Lid Margin And Conjunctival Microbial Flora Following Punctum Occlusion

NCT00735865
View directory record Official record
Conditions
Dry Eye Syndrome
Interventions
Punctal plugs, punctal cautery, Punctal Plug, Punctal thermocauterization, Silicone plug or thermodynamic hydrophobic acrylic plug, Previous subjects with Punctal occlusion
Procedure · Other
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
2
States / cities
Burlington, Massachusetts • Peabody, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 24, 2009 · Synced Jun 10, 2026, 3:29 AM EDT
Completed Phase 2 Interventional Results available

Safety and Efficacy of Bevacizumab Plus RAD001 Versus Interferon Alfa-2a and Bevacizumab for the First-line Treatment in Adult Patients With Kidney Cancer

NCT00719264
View directory record Official record
Conditions
Carcinoma, Adenocarcinoma, Renal Cell, Nephroid Carcinoma, Hypernephroid
Interventions
RAD001(everolimus), interferon alfa-2a, bevacizumab
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
9
States / cities
Fayetteville, Arkansas • Duarte, California • Los Angeles, California + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 19, 2017 · Synced Jun 10, 2026, 3:29 AM EDT
Completed No phase listed Observational

The AIM Study: Assessing the Impact of Margin Reduction

NCT00754000
View directory record Official record
Conditions
Prostate Cancer
Interventions
Observation
Other
Lead sponsor
Varian, a Siemens Healthineers Company
Industry
Eligibility
18 Years and older · Male only
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
4
States / cities
Scottsdale, Arizona • Santa Monica, California • Cape Coral, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2012 · Synced Jun 10, 2026, 3:29 AM EDT