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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Extremely Premature Infant Clear all
Recruiting Not applicable Interventional

Humidity in Incubators for Tiny Infants

NCT06399861
View directory record Official record
Conditions
Extremely Premature Infant
Interventions
Incubator ambient relative humidity (RH) of 70%, Incubator ambient relative humidity (RH) of 90%
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
0 Days to 1 Day
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
6
States / cities
Columbus, Ohio • Houston, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Jun 26, 2026, 10:28 AM EDT
Completed Phase 1Phase 2 Interventional

Delivery Room CPAP in Extremely Low Birth Weight Infants

NCT01223274
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Bronchopulmonary Dysplasia, Continuous Positive Airway Pressure
Interventions
CPAP/PEEP, Standard management practices
Device
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 10 Minutes
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
6
States / cities
Birmingham, Alabama • San Diego, California • Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Jun 26, 2026, 10:28 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia

NCT03576885
View directory record Official record
Conditions
Pulmonary Hypertension, Bronchopulmonary Dysplasia
Interventions
inhaled nitric oxide, Placebo
Drug
Lead sponsor
AdventHealth
Other
Eligibility
23 Weeks to 29 Weeks
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Jun 26, 2026, 10:28 AM EDT
Completed Phase 3 Interventional Results available

Surfactant Positive Airway Pressure and Pulse Oximetry Trial

NCT00233324
View directory record Official record
Conditions
Infant, Newborn, Diseases, Other Preterm Infants, Infant, Small for Gestational Age, Premature Birth, Bronchopulmonary Dysplasia, Retinopathy of Prematurity
Interventions
Surfactant, Continuous Positive Airway Pressure (CPAP), Supplemental oxygen with target saturation of 85 to 89%, Supplemental oxygen with target saturation of 91 to 95%
Drug · Device
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
24 Weeks to 27 Weeks
Enrollment
1,316 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2016
U.S. locations
22
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 18 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2019 · Synced Jun 26, 2026, 10:28 AM EDT
Not listed No phase listed Observational

Vibroacoustic Study of Lung Development in Newborn Infants

NCT05827250
View directory record Official record
Conditions
Prematurity, Premature Birth, Premature Lungs, Prematurity; Extreme
Interventions
imPulse Tor
Device
Lead sponsor
Level 42 AI, Inc.
Industry
Eligibility
0 Years to 2 Years
Enrollment
200 participants
Timeline
2023 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Jun 26, 2026, 10:28 AM EDT
Completed Not applicable Interventional

LISA in the Delivery Room for Extremely Preterm Infants

NCT04715373
View directory record Official record
Conditions
Extreme Prematurity, Respiratory Distress Syndrome
Interventions
LISA
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
5 Minutes to 20 Minutes
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Jun 26, 2026, 10:28 AM EDT
Not listed Phase 2 Interventional

Brain Oxygenation-II

NCT05171881
View directory record Official record
Conditions
Cerebral Hypoxia
Interventions
Intervention for cerebral hypoxia
Other
Lead sponsor
Valerie Chock, M.D., M.S. Epi
Other
Eligibility
Up to 6 Hours
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
5
States / cities
Loma Linda, California • Palo Alto, California • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2024 · Synced Jun 26, 2026, 10:28 AM EDT
Active, not recruiting Not applicable Interventional

Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants

NCT04413097
View directory record Official record
Conditions
IVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, Hyperoxia, Respiratory Insufficiency
Interventions
Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
Procedure
Lead sponsor
Sharp HealthCare
Other
Eligibility
22 Weeks to 28 Weeks
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
3
States / cities
Davis, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 11, 2025 · Synced Jun 26, 2026, 10:28 AM EDT
Not yet recruiting Phase 2 Interventional

Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?

NCT07447739
View directory record Official record
Conditions
Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD)
Interventions
Betamethasone
Drug
Lead sponsor
Khang Nguyen
Other
Eligibility
Up to 28 Weeks
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jun 26, 2026, 10:28 AM EDT
Completed Not applicable Interventional

Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants

NCT03695900
View directory record Official record
Conditions
Apnea of Prematurity, Desaturation of Blood, Central Apnea, Periodic Breathing, Obstructive Apnea of Newborn
Interventions
Targeting SpO2 at 93-95%, Targeting SpO2 at 90-92%
Other
Lead sponsor
University of Miami
Other
Eligibility
Up to 18 Weeks
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Jun 26, 2026, 10:28 AM EDT
Completed Not applicable Interventional

Randomized Control Trial: Synchronized Non-invasive Positive Pressure Ventilation Versus Non Synchronized Non Invasive Positive Pressure Ventilation in Extremely Low Birth Weight Infants

NCT03613987
View directory record Official record
Conditions
BPD - Bronchopulmonary Dysplasia
Interventions
NAVA technology to synchronize NIPPV
Device
Lead sponsor
New York Medical College
Other
Eligibility
24 Weeks to 30 Weeks
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Mar 26, 2023 · Synced Jun 26, 2026, 10:28 AM EDT
Recruiting Phase 3 Interventional

Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT

NCT05011149
View directory record Official record
Conditions
Patent Ductus Arteriosus After Premature Birth
Interventions
Ibuprofen
Drug
Lead sponsor
IWK Health Centre
Other
Eligibility
Up to 72 Hours
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
Orange, California • San Diego, California • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 20, 2024 · Synced Jun 26, 2026, 10:28 AM EDT
Active, not recruiting Phase 3 Interventional Results available

The Budesonide in Babies (BiB) Trial

NCT04545866
View directory record Official record
Conditions
Bronchopulmonary Dysplasia (BPD), Respiratory Distress Syndrome, Prematurity; Extreme, Neonatal
Interventions
budesonide (Pulmicort nebulizing suspension)., surfactant (poractant alfa;Curosurf)
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 48 Hours
Enrollment
642 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
19
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 15 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jun 26, 2026, 10:28 AM EDT
Not listed Not applicable Interventional

Effects of Mother's Voice and Heartbeat Sounds on Preterm Newborns

NCT01913288
View directory record Official record
Conditions
Preterm Birth
Interventions
Biological Maternal Sounds
Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
24 Weeks to 34 Weeks
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 31, 2013 · Synced Jun 26, 2026, 10:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Therapist Education and Massage for Parent Infant-Outcomes

NCT04121897
View directory record Official record
Conditions
Parent-Child Relations, Parents, Extreme Prematurity
Interventions
Therapist Education and Massage for Parents of Extremely Preterm Infants
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
Not listed
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2023 · Synced Jun 26, 2026, 10:28 AM EDT
Terminated Phase 3 Interventional

Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure

NCT00016523
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Respiratory Distress Syndrome (RDS), Sepsis, Pneumonia, Hypertension, Pulmonary
Interventions
Inhaled nitric oxide, Placebo
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 120 Hours
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2006
U.S. locations
17
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2017 · Synced Jun 26, 2026, 10:28 AM EDT
Recruiting Not applicable Interventional

Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates

NCT06849596
View directory record Official record
Conditions
Neonatal Resuscitation, Apnea Neonatal
Interventions
Ventilator derived positive pressure ventilation - V-PPV, T-piece resuscitator (TPR)
Device
Lead sponsor
Michelle Baczynski
Other
Eligibility
25 Weeks to 29 Weeks
Enrollment
780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jun 26, 2026, 10:28 AM EDT
Completed Phase 3 Interventional

Iron Supplementation and Neurodevelopmental Outcome in ELGANs

NCT04691843
View directory record Official record
Conditions
Iron-deficiency
Interventions
Iron Sulfate
Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
7 Days to 4 Weeks
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 11, 2024 · Synced Jun 26, 2026, 10:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Inflammatory Cytokines Associated With Perinatal Brain Injury

NCT01035697
View directory record Official record
Conditions
Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Cerebral Palsy
Interventions
Not listed
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
Up to 72 Hours
Enrollment
1,067 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2004
U.S. locations
18
States / cities
Birmingham, Alabama • Palo Alto, California • San Diego, California + 14 more
Source: ClinicalTrials.gov public record
Updated Mar 21, 2019 · Synced Jun 26, 2026, 10:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

MMR and Varicella Vaccine in Premature Infants

NCT00156559
View directory record Official record
Conditions
Chickenpox, Rubella, Rubeola, Mumps
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
12 Months to 16 Months
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Sep 16, 2015 · Synced Jun 26, 2026, 10:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Targeted Protein Fortification in Extremely Low Birth Weight Preterm Infants

NCT02943746
View directory record Official record
Conditions
Premature Infants
Interventions
Standard Protein Diet, High Protein Diet
Dietary Supplement
Lead sponsor
Baylor College of Medicine
Other
Eligibility
14 Days and older
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Jun 26, 2026, 10:28 AM EDT
Recruiting Not applicable Interventional

Flow and Grow - The Ideal Time to Wean CPAP Off In Extremely Low Birth Weight Infants

NCT06123143
View directory record Official record
Conditions
Neonatal Respiratory Failure
Interventions
Standardized/structured CPAP weaning protocol
Other
Lead sponsor
University of California, San Diego
Other
Eligibility
Up to 30 Weeks
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
5
States / cities
Escondido, California • La Jolla, California • Murrieta, California + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Jun 26, 2026, 10:28 AM EDT
Active, not recruiting Not applicable Interventional Results available

Early Protein Supplementation in Extremely Preterm Infants Fed Human Milk

NCT04325308
View directory record Official record
Conditions
Prematurity; Extreme, Feeding Disorder Neonatal, Breast Milk Expression, Growth Failure, Microbial Colonization
Interventions
Protein-enriched human milk diet, Usual human milk diet
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
1 Day to 4 Days
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Jun 26, 2026, 10:28 AM EDT
Not yet recruiting Phase 2Phase 3 Interventional Accepts healthy volunteers

Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants

NCT04614714
View directory record Official record
Conditions
Preterm Birth, Inadequate Milk Production
Interventions
Nicotinamide Riboside (NR), Placebo
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Jun 26, 2026, 10:28 AM EDT