Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:14 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 673–696 of 803 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Extremity Injuries Lower Clear all

Conditions: Tibial Fractures
Interventions: T2 Alpha Tibia Nailing System; Device
Lead sponsor: Stryker Trauma and Extremities; Industry
Eligibility: 18 Years to 99 Years
Enrollment: 103 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 4
States / cities: Sartell, Minnesota • New York, New York • Cincinnati, Ohio + 1 more

Conditions: Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Knee
Interventions: Revo-M, Taleo, Proflex XC; Device
Lead sponsor: Otto Bock Healthcare Products GmbH; Industry
Eligibility: 18 Years and older
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 4
States / cities: Mesa, Arizona • Linthicum, Maryland • Dayton, Ohio + 1 more

Conditions: Tibial Fractures, Fractures, Open
Interventions: Reselution V Tibial Intramedullary Fixation System, Reselution VT Tibial Intramedullary Fixation System; Device
Lead sponsor: Reselute, Inc.; Industry
Eligibility: 22 Years to 80 Years
Enrollment: 317 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Femur Fracture, Femur Fracture Intertrochanteric, Garden Grade I Subcapital Fracture of Femoral Neck, Garden Grade II Subcapital Fracture of Femoral Neck, Garden Grade III Subcapital Fracture of Femoral Neck, Garden Grade IV Subcapital Fracture of Femoral Neck
Interventions: THP Hip Fracture Plating System with telescoping lag screws; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 3
States / cities: Indianapolis, Indiana • Ann Arbor, Michigan • Falls Church, Virginia

Conditions: Tibial Fractures, Leg Injuries
Interventions: Monochromatic Near-Infrared Light Energy (MIRE); Device
Lead sponsor: Samueli Institute for Information Biology; Other
Eligibility: 18 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: El Paso, Texas

Conditions: Ankle Sprains, Telerehabilitation, Analgesic, Opioid, Analgesics, Non-narcotic, Anti-Inflammatory Agents, Non-Steroidal, Implementation Science, Acute Pain, Quality of Life
Interventions: Telehealth Protocol, Usual Care; Other
Lead sponsor: Kyle Kosik; Other
Eligibility: 15 Years to 35 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Fracture;Pelvis, Sacral Fracture, Sacroiliac; Fusion, Fragility Fracture, Insufficiency Fractures, Osteoporosis
Interventions: Surgical Intervention, Non-Surgical Management; Device · Other
Lead sponsor: SI-BONE, Inc.; Industry
Eligibility: 60 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 7
States / cities: Chicago, Illinois • Lincoln, Nebraska • Livingston, New Jersey + 4 more

Conditions: Lower Extremity or Diabetic Foot Ulcers, Bacterial Infection
Interventions: Larval Debridement Therapy, Bedside Sharp Debridement; Device · Procedure
Lead sponsor: North Florida Foundation for Research and Education; Other
Eligibility: 21 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Gainesville, Florida

Conditions: Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions: Nitroglycerin Ointment 2%; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions: Ossur Power Knee, Reboocon Intuy Knee; Device
Lead sponsor: Liberating Technologies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Austin, Texas

Conditions: ACL Tear, Opioid Misuse, Pain, Anxiety
Interventions: Exparel; Drug
Lead sponsor: Children's Hospital of Orange County; Other
Eligibility: 7 Years to 17 Years
Enrollment: 96 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Orange, California

Conditions: ACL Injury
Interventions: Telerehabilitation Therapy, In-person Rehabilitation Therapy; Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 40 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: New York, New York

Conditions: Musculoskeletal Injury
Interventions: Passive Dynamic Brace; Behavioral
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 370 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2028
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Pain, Postoperative, Ankle Fractures
Interventions: Ropivacaine, Epinephrine, Morphine, 0.9% sodium chloride solution; Drug
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 100 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Diabetic Foot Ulcer
Interventions: DermACELL, GraftJacket, Conventional Care Dressings; Other
Lead sponsor: LifeNet Health; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 202 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2016
U.S. locations: 12
States / cities: Montgomery, Alabama • Tucson, Arizona • Carlsbad, California + 8 more

Conditions: Anterior Cruciate Ligament Injury
Interventions: Anatomic Double-Bundle ACL Reconstruction, Anatomic Single-Bundle ACL Reconstruction; Procedure
Lead sponsor: University of Pittsburgh; Other
Eligibility: 14 Years to 50 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Ankle Fractures
Interventions: Telerehabilitation, Standard rehabilitation; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: Ankle Fractures
Interventions: GameReady, RICE; Device · Other
Lead sponsor: AdventHealth; Other
Eligibility: Not listed
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Orlando, Florida

Conditions: Hip Fractures
Interventions: Exparel, Sodium Chloride; Drug
Lead sponsor: University of Massachusetts, Worcester; Other
Eligibility: 55 Years and older
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 2
States / cities: Lexington, Kentucky • Worcester, Massachusetts

Conditions: Tibial Fracture
Interventions: Intramedullary nail implant; Procedure
Lead sponsor: University of Minnesota; Other
Eligibility: 16 Years and older
Enrollment: 1,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2006
U.S. locations: 16
States / cities: San Francisco, California • Jacksonville, Florida • Evansville, Indiana + 13 more

Conditions: ACL, ACL Injury
Interventions: 3D printed knee extender device, Standard Prehabilitation Education; Device · Other
Lead sponsor: Sanford Health; Other
Eligibility: 14 Years to 60 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 2
States / cities: Fargo, North Dakota • Sioux Falls, South Dakota

Conditions: Anterior Cruciate Ligament Tear
Interventions: Regenexx SD, Exercise Therapy; Procedure · Other
Lead sponsor: Regenexx, LLC; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2022
U.S. locations: 1
States / cities: Broomfield, Colorado

Conditions: Knee Injuries, Shoulder Injuries, Pain, Postoperative
Interventions: Endonovo SofPulse; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Redwood City, California

Conditions: Rupture of Anterior Cruciate Ligament
Interventions: Not listed
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 12 Years to 65 Years
Enrollment: 1,234 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2030
U.S. locations: 47
States / cities: La Jolla, California • Los Angeles, California • San Francisco, California + 39 more

Search by objective public record fields.

A Post-Market Clinical Evaluation of the Treatment of Tibia Fractures With the T2 Alpha Tibia Nailing System

Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot

Local Antibiotic Delivery From an Intramedullary Nail After Surgical Treatment of Tibial Fractures at High Risk of Infection

THP Hip Fracture Plating System Study

Light Therapy in the Treatment of Leg Pain

Telehealth Delivered Physical Rehabilitation for an Ankle Sprain

Sacral Fracture Fusion/Fixation for Rapid Rehabilitation

Larval Debridement Therapy Versus Sharp Debridement to Remove Biofilm

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees

Exparel vs. ACB With Bupivacaine for ACL Reconstruction

TeleRehabilitation Following ACL Reconstruction

Use of an Integrated Orthotic and Rehabilitation Initiative for Treatment of Lower Extremity Musculoskeletal Disorders

Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures

DermACELL in Subjects With Chronic Wounds of the Lower Extremities

Single- vs. Double-Bundle ACL Reconstruction

Telerehabilitation Following Ankle Fractures

Preliminary Review of Cold and Active Compression Therapy for Traumatic Calcaneus or Ankle Fractures

Randomized Controlled Trial for Exparel Hip Fracture

SPRINT - Randomized Trial of Tibial Fracture Fixation

Playmaker 3D Printed Knee Extender

Regenexx™ SD Versus Exercise Therapy for ACL Tears

Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery

Multicenter ACL Revision Study (MARS)