Search | Clinical Trials Finder

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Nov 15, 2026, 12:34 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 721–744 of 803 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Extremity Injuries Lower Clear all

Conditions: ACL Injury, ACL Tears, ACL Surgery
Interventions: Tranexamic Acid (TXA), Placebo; Drug
Lead sponsor: Campbell Clinic; Other
Eligibility: 14 Years to 22 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 6
States / cities: Evanston, Illinois • Chesterfield, Missouri • Durham, North Carolina + 3 more

Conditions: Ankle Sprain
Interventions: diclofenac sodium, Matching placebo patch; Drug
Lead sponsor: Cerimon Pharmaceuticals; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Hip Fractures, Tibial Fractures, Ankle Fractures, Humeral Fracture, Proximal, Distal Radius Fracture
Interventions: All treatments will remain the standard (routine) care procedures based on individual clinician's judgment and the patient characteristics.; Other
Lead sponsor: AO Innovation Translation Center; Other
Eligibility: 18 Years and older
Enrollment: 1,500 participants
Timeline: 2021 – 2026
U.S. locations: 4
States / cities: Los Angeles, California • Miami, Florida • Boston, Massachusetts + 1 more

Conditions: Tibial Fractures
Interventions: Exogen 4000+, Sham; Device
Lead sponsor: Bioventus LLC; Industry
Eligibility: 18 Years and older
Enrollment: 501 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 13
States / cities: San Francisco, California • Tampa, Florida • Indianapolis, Indiana + 9 more

Conditions: Sedentary Lifestyle, Knee Osteoarthritis, Knee Injuries, Knee Pain Chronic
Interventions: NEAT!2, NEAT!2+Calls, Delayed NEAT!2; Behavioral
Lead sponsor: University of South Carolina; Other
Eligibility: 40 Years and older
Enrollment: 11 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: ACL, ACL Injury
Interventions: Split-belt Training, Tied-Belt Training; Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 14 Years to 45 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Spinal Cord Injury (SCI), Gait, Reduced Physical Activity, Lower Limb Functions, Walking Impairment, Mobility Impairment, Functional Mobility
Interventions: CLV, Sham; Device
Lead sponsor: The University of Texas at Dallas; Other
Eligibility: 18 Years to 64 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 4
States / cities: Boston, Massachusetts • Dallas, Texas • Richardson, Texas

Conditions: Hip Fracture, Frailty, Sarcopenia
Interventions: Testosterone, Placebo gel, Supervised exercise training, Home exercise program, Health Education Modules; Drug · Behavioral
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 65 Years and older · Female only
Enrollment: 129 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 8
States / cities: Aurora, Colorado • Farmington, Connecticut • Baltimore, Maryland + 5 more

Conditions: ACL - Anterior Cruciate Ligament Rupture, ACL Injury, Healthy
Interventions: Anterior cruciate ligament reconstruction; Procedure
Lead sponsor: University of Michigan; Other
Eligibility: 18 Years to 30 Years
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 2
States / cities: Ann Arbor, Michigan

Conditions: Surgical Site Infection, Unplanned Fracture-Related Reoperation, Open Appendicular Fracture, Closed Lower Extremity Fracture, Pelvic Fracture
Interventions: DuraPrep, ChloraPrep; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 18 Years and older
Enrollment: 8,485 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2024
U.S. locations: 24
States / cities: Irvine, California • Los Angeles, California • San Jose, California + 20 more

Conditions: Surgical Wound, Wound Heal, Amputation
Interventions: PrevenaTM Device, Standard Dry Dressing; Device · Other
Lead sponsor: Georgetown University; Other
Eligibility: 18 Years and older
Enrollment: 112 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Tibial Plateau Fracture
Interventions: bupivacaine; Drug
Lead sponsor: University of Utah; Other
Eligibility: 18 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Hip Fractures
Interventions: VK5211, Placebo; Drug
Lead sponsor: Viking Therapeutics, Inc.; Industry
Eligibility: 65 Years and older
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 7
States / cities: Yorba Linda, California • Boynton Beach, Florida • Doral, Florida + 4 more

Conditions: Hip Fractures
Interventions: Not listed
Lead sponsor: AO Innovation Translation Center; Other
Eligibility: 70 Years and older
Enrollment: 282 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: St Louis, Missouri • New York, New York

Conditions: Orthopedic Disorders, Tibial Fractures
Interventions: Not listed
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Injuries, Injury Arm, Injury;Sports, Injury, Knee, Injury Wrist, Injury, Ankle, Injury Foot, Injury, Hand, Injury Finger, Injury Leg
Interventions: RelieveVRx; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Injury Leg
Interventions: Not listed
Lead sponsor: University of Miami; Other
Eligibility: 18 Years to 55 Years
Enrollment: 1,891 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Fort Bragg, North Carolina

Conditions: Wound Healing, Lower Extremity Amputation, Above Knee Amputation, Below Knee Amputation
Interventions: Lower Extremity Amputation, SPY Elite Imaging System, Indocyaine Green; Procedure · Device · Drug
Lead sponsor: Corewell Health West; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Grand Rapids, Michigan

Conditions: Ankle Sprain
Interventions: Esflurbiprofen Hydrogel Patch; Drug
Lead sponsor: Teikoku Seiyaku Co., Ltd.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Knee Injuries, Knee Osteoarthritis, Patellofemoral Syndrome
Interventions: Limber Digital Application, Physical therapy Therapy; Device · Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 75 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Fracture of Tibia, Wound Heal, Infected Wound, Wound Complication, Wound Dehiscence
Interventions: Incisional Negative Pressure Wound Therapy (NPWT); Device
Lead sponsor: Major Extremity Trauma Research Consortium; Other
Eligibility: 18 Years and older
Enrollment: 352 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 6
States / cities: Baltimore, Maryland • Lebanon, New Hampshire • Nashville, Tennessee + 2 more

Conditions: Lower Extremity Wound Infected, Venous Stasis Ulcers
Interventions: VAC VeraFlo with Dakins Instillation, VAC Ulta Therapy; Device
Lead sponsor: St. Luke's-Roosevelt Hospital Center; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: New York, New York

Conditions: Hip Fracture
Interventions: Navigated, Conventional; Procedure
Lead sponsor: AO Clinical Investigation and Publishing Documentation; Other
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Charlottesville, Virginia

Conditions: Tibial Fracture
Interventions: Intramedullary tibial Nail, Intermedullary nail; Device
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years and older
Enrollment: 372 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: Chicago, Illinois

Search by objective public record fields.

Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction

Diclofenac Patch for Treatment of Mild to Moderate Ankle Sprain

Go Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS®

Trial to Evaluate UltraSound in the Treatment of Tibial Fractures

NEAT!2 Sedentary Behavior Reduction for Individuals With Past or Present Knee Symptoms, Injuries, or Surgeries

Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction

Closed-Loop Vagus Nerve Stimulation (CLV) for Recovery of Gait After Spinal Cord Injury (SCI)

Starting a Testosterone and Exercise Program After Hip Injury

Longitudinal Assessment of Cartilage Injury and Remodeling After Anterior Cruciate Ligament Rupture and Reconstruction:

Pre-operative Alcohol Skin Solutions in Fractured Extremities

Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations

Continuous Femoral Nerve Block With a Tibial Plateau Fracture

Acute Hip Fracture Study in Patients 65 Years or Greater

Geriatric Fracture Centers - Evaluation of a Geriatric Co-management Program

Reliability of Sensor Spacing for NIRS in Traumatic Tibia Fractures

Virtual Reality for Pain in Acute Orthopedic Injuries

Sensors Prediction Study

Pilot Study to Assess the Use of Spy Elite for Assessment of Amputation Healing

Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain

Digital Home-Exercise Therapy Application For Patients With Non-Surgical Knee Injuries

Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures

V.A.C. VeraFlo™ Instillation Therapy vs V.A.C. Ulta™ Therapy on Biofilm in Chronically Infected Wounds

Accuracy of Navigation in Placement of Sacroiliac Screw

Tibial IMN Vs. Tibial Micromotion IMN