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Showing 1–24 of 385 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Extremity Injury Clear all
Not listed Not applicable Interventional

TeleRehab to Restore Upper Limb Function in People With Chronic TBI

NCT06184932
View directory record Official record
Conditions
Traumatic Brain Injury, Upper Extremity Dysfunction, Disability Physical
Interventions
HAHE, Exergame
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
45 Years to 75 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Jul 21, 2026, 4:40 PM EDT
Completed No phase listed Observational

Pre-hospital Tourniquet in Extremity Injury

NCT04216225
View directory record Official record
Conditions
Extremity Injury
Interventions
pre-hospital tourniquet placement
Other
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years and older
Enrollment
55 participants
Timeline
2018 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Jul 21, 2026, 4:40 PM EDT
Recruiting Phase 1Phase 2 Interventional

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.

NCT04752774
View directory record Official record
Conditions
Spasticity
Interventions
IPN10200, Placebo, Dysport
Biological · Drug
Lead sponsor
Ipsen
Industry
Eligibility
18 Years to 70 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2029
U.S. locations
5
States / cities
Downey, California • Overland Park, Kansas • Farmington Hills, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 21, 2026, 4:40 PM EDT
Completed No phase listed Observational

Insole Sensor to Determine Optimal Limb Loading in the Rehabilitation of Ankle Fractures

NCT02334618
View directory record Official record
Conditions
Ankle Fracture
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 90 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Jul 21, 2026, 4:40 PM EDT
Terminated Not applicable Interventional

Effect of NIRS-assisted Assessment on Chronic Lower Extremity and Other Chronic Non-healing Ulcers

NCT06702852
View directory record Official record
Conditions
Ulcers
Interventions
NIRS imaging in addition to SOC
Device
Lead sponsor
Kent Imaging Inc
Industry
Eligibility
18 Years and older
Enrollment
221 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
4
States / cities
New Braunfels, Texas • San Antonio, Texas • San Marcos, Texas
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Jul 21, 2026, 4:40 PM EDT
Completed Not applicable Interventional

Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Range of Motion, and Functional Outcome Scores in Individuals With Chronic Ankle Instability

NCT00601471
View directory record Official record
Conditions
Ankle Sprain, Ankle Injuries, Sprain
Interventions
proximal tibiofibular manipulation, distal tibiofibular manipulation, no intervention
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
61 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Jul 21, 2026, 4:40 PM EDT
Completed Not applicable Interventional Results available

Effect of Vibration Exercise on Upper Limb Strength, Function, and Pain

NCT02998021
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Vibrating Dumbbell, Standard Dumbbell
Device
Lead sponsor
Alicia Koontz
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 22, 2019 · Synced Jul 21, 2026, 4:40 PM EDT
Terminated No phase listed Observational

Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System

NCT06400732
View directory record Official record
Conditions
Fractures, Bone, Fractures, Closed, Fractures, Open, Fracture of Femur, Fracture Nonunion, Fracture of Tibia, Limb Deformity, Limb Fracture, Limb Defect, Limb Asymmetry
Interventions
Fitbone Transport and Lengthening System
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
9
States / cities
Los Angeles, California • Orange, California • Atlanta, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jul 21, 2026, 4:40 PM EDT
Terminated Not applicable Interventional

Diagnosing Extremity Fractures and/or Dislocations Using Ultrasound Presenting to the Emergency Department

NCT00356837
View directory record Official record
Conditions
Fractures, Dislocations
Interventions
Ultrasound
Procedure
Lead sponsor
United States Army Institute of Surgical Research
Federal
Eligibility
18 Years and older
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 12, 2010 · Synced Jul 21, 2026, 4:40 PM EDT
Terminated Not applicable Interventional Results available

Standard Versus PICO Dressings in Lower-Extremity Bypass Patients

NCT02492854
View directory record Official record
Conditions
Of Bypass Graft of the Extremities, Peripheral Arterial Disease, Vascular Diseases, Cardiovascular Diseases
Interventions
PICO Single-Use Negative Pressure Dressings, Sterile Gauze Dressings
Device · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
35 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 3, 2021 · Synced Jul 21, 2026, 4:40 PM EDT
Completed Not applicable Interventional

The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD

NCT04937179
View directory record Official record
Conditions
Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions
Ischemic Conditioning Low - Sham Comparator, Ischemic Conditioning High - Active Comparator
Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Jul 21, 2026, 4:40 PM EDT
Active, not recruiting Not applicable Interventional

Arm and Leg Cycling for Accelerated Recovery From SCI

NCT05619146
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Motor-assisted arms and legs cycling
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 75 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 24, 2025 · Synced Jul 21, 2026, 4:40 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Treatment for Phantom Limb Pain

NCT03338842
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Phantom Limb Pain
Interventions
Distractor and Lower limb VR
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 15, 2020 · Synced Jul 21, 2026, 4:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

An Osteopathic Assessment of Lower Extremity Somatic Dysfunction in Runners

NCT05132894
View directory record Official record
Conditions
Somatic Dysfunction of Sacral Region, Somatic Dysfunction of Both Sacroiliac Joints, Somatic Dysfunction of Bilateral Lower Extremities
Interventions
Osteopathic Assessment
Other
Lead sponsor
The Touro College and University System
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Jul 21, 2026, 4:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Do Common Physical Tests Predict Injury or Performance

NCT01804894
View directory record Official record
Conditions
Lower Extremity Musculoskeletal Injury
Interventions
Not listed
Lead sponsor
High Point University
Other
Eligibility
18 Years to 23 Years
Enrollment
359 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2015 · Synced Jul 21, 2026, 4:40 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Comparison of Cosmetic Outcomes of Lacerations Repaired Using Absorbable Versus Non-absorbable Sutures

NCT00933829
View directory record Official record
Conditions
Lacerations, Wounds, Injuries
Interventions
Absorbable Suture Arm, Non-absorbable suture (Prolene), suture
Procedure · Device
Lead sponsor
Temple University
Other
Eligibility
1 Year to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2020 · Synced Jul 21, 2026, 4:40 PM EDT
Not listed No phase listed Observational

Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests

NCT00258869
View directory record Official record
Conditions
Sepsis, Septicemia, Sepsis Syndrome, Shock, Septic, Community Acquired Pneumonia
Interventions
Not listed
Lead sponsor
National Center for Genome Resources
Other
Eligibility
6 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
3
States / cities
Detroit, Michigan • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 8, 2010 · Synced Jul 21, 2026, 4:40 PM EDT
Completed No phase listed Observational

Predictive Models for Spine and Lower Extremity Injury After Discharge From Rehab

NCT02776930
View directory record Official record
Conditions
Musculoskeletal Injury, Spinal Injuries, Leg Injuries
Interventions
Not listed
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 45 Years
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Fort Bragg, North Carolina • Fort Bliss, Texas • San Antonio, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Jul 21, 2026, 4:40 PM EDT
Not yet recruiting Phase 1 Interventional

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

NCT07004764
View directory record Official record
Conditions
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions
Nitroglycerin Ointment 2%
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jul 21, 2026, 4:40 PM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Longitudinal Study of Weight Change Following Lower Limb Amputation

NCT00932399
View directory record Official record
Conditions
Amputation Wound, Traumatic Amputation of Toe, Dysvascular Amputation of Lower Limb
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
27 Years to 89 Years · Male only
Enrollment
4,549 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2016
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 7, 2016 · Synced Jul 21, 2026, 4:40 PM EDT
Enrolling by invitation Early Phase 1 Interventional

Evaluation of In-Vitro Cryo Therapeutic Protocols on Human Cell Samples (TWH-CRYO-001)

NCT07321028
View directory record Official record
Conditions
Cellular Injury and Post-Cryogenic Recovery, Cryogenic Cellular Stress, Cold-Induced Cellular Injury, Thermal Injury Response, Post-Thaw Viability Impairment, Osmotic Stress Injury, Biomechanical Injury Modeling (In-Vitro), Blunt Force Injuries to the Extremities (Cellular Injury Model), Tissue Damage and Recovery Pathways, Hypothermic Tissue Stress, Cellular Regeneration and Repair
Interventions
Standard Laboratory Cryopreservation Procedure, Enhanced Laboratory Cryopreservation Procedure, Normothermic Cell Culture Control
Other
Lead sponsor
Truway Health, Inc.
Industry
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2066
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 5, 2026 · Synced Jul 21, 2026, 4:40 PM EDT
Completed No phase listed Observational

Women's-Specific Footwear With Prosthetic Feet

NCT03673371
View directory record Official record
Conditions
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury)
Interventions
Questionnaire
Other
Lead sponsor
Minneapolis Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 21, 2023 · Synced Jul 21, 2026, 4:40 PM EDT
Recruiting Phase 4 Interventional

A Prospective, Randomized, Assessor-Blinded, Multicenter Study Comparing Avance Nerve Graft and Autograft for Functional Recovery Following Mixed and Motor Peripheral Nerve Reconstruction

NCT07657182
View directory record Official record
Conditions
Peripheral Nerve Injury, Peripheral Nerve Discontinuity, Mixed Peripheral Nerve Injury, Motor Peripheral Nerve Injury, Upper Extremity Nerve Injury
Interventions
Avance Nerve Graft, Sural nerve autograft
Biological · Procedure
Lead sponsor
Axogen Corporation
Industry
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Jul 21, 2026, 4:40 PM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

Rebuilding Inter-limb Transfer in Cervical SCI

NCT06440538
View directory record Official record
Conditions
Cervical Spinal Cord Injury
Interventions
PCMS + Contralateral Motor Training, PCMS + Rest, Sham PCMS + Contralateral Motor Training
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 75 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Jul 21, 2026, 4:40 PM EDT