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ClinicalTrials.gov public records Last synced Oct 23, 2026, 9:22 AM EDT

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Showing 337–360 of 871 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Extremity Lower Wounds Clear all
Completed Not applicable Interventional Results available

A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Distal Femur Fractures

NCT00429663
View directory record Official record
Conditions
Femoral Fractures
Interventions
reamed, interlocking intramedullary nail, locking periarticular plate
Device
Lead sponsor
Boston Medical Center
Other
Eligibility
Not listed
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
22
States / cities
Sacramento, California • Tampa, Florida • Indianapolis, Indiana + 18 more
Source: ClinicalTrials.gov public record
Updated May 11, 2017 · Synced Oct 23, 2026, 9:22 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Examining the Long-Term Risks of Oophorectomy

NCT00655447
View directory record Official record
Conditions
Coronary Heart Disease, Stroke, Breast Cancer, Ovarian Cancer, Cancer, Hip Fracture, Death
Interventions
Not listed
Lead sponsor
Parker, William H., M.D.
Other
Eligibility
30 Years to 55 Years · Female only
Enrollment
32,175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1980 – 2004
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2008 · Synced Oct 23, 2026, 9:22 AM EDT
Completed Not applicable Interventional Results available

Post-Operative Delirium in Elderly Surgical Patients

NCT00590707
View directory record Official record
Conditions
Hip Fractures, Delirium
Interventions
Deeper sedation, Moderate sedation
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 11, 2018 · Synced Oct 23, 2026, 9:22 AM EDT
Completed Not applicable Interventional Results available

Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries

NCT00582998
View directory record Official record
Conditions
Fracture of Calcaneus, Pilon or Tibial Plateau
Interventions
Standard Wound Dressing, Vacuum Assisted Closure Device
Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 25, 2019 · Synced Oct 23, 2026, 9:22 AM EDT
Completed No phase listed Observational

Retrospective Study Evaluating Outcomes for Integra® Skin Sheet Products in Lower Extremity Complex Wounds

NCT01947387
View directory record Official record
Conditions
Complex Lower Extremity Soft Tissue Reconstruction
Interventions
Not listed
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
18 Years and older
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
4
States / cities
Washington D.C., District of Columbia • Chicago, Illinois • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 2, 2016 · Synced Oct 23, 2026, 9:22 AM EDT
Recruiting No phase listed Observational

Pelvic and Acetabular Fracture: A Prospective Observational Study

NCT04615104
View directory record Official record
Conditions
Pelvic Fracture, Acetabular Fracture, Pubic Rami Fracture
Interventions
Operative, Nonoperative
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2029
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 23, 2026, 9:22 AM EDT
Not listed Phase 3 Interventional

Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction

NCT04764916
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Pain, Postoperative, Opioid Use
Interventions
Liposomal bupivacaine, Bupivacaine Hydrochloride
Drug
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 21, 2021 · Synced Oct 23, 2026, 9:22 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study

NCT04754087
View directory record Official record
Conditions
Total Hip Arthroplasty, Degenerative Joint Disease of Hip, Avascular Necrosis of Hip, Rheumatoid Arthritis of Hip, Osteoarthritis, Hip, Osteoarthritis of Hip, Fractures, Hip, Fracture of Hip
Interventions
Vivacit-E and Longevity (HXLPE) Liners
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2033
U.S. locations
6
States / cities
Denver, Colorado • South Bend, Indiana • Durham, North Carolina + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 23, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional

Lateral Ankle Treatment

NCT07751068
View directory record Official record
Conditions
Avulsion Fracture
Interventions
Prolonged Immobilization (Casting), Standard of Care (SOC)
Procedure
Lead sponsor
Texas Scottish Rite Hospital for Children
Other
Eligibility
5 Years to 12 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2034
U.S. locations
1
States / cities
Frisco, Texas
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 23, 2026, 9:22 AM EDT
Terminated Phase 2 Interventional Results available

Effects of Liposomal Bupivacaine for Acute Pain in Hip and Femur Fractures

NCT02679560
View directory record Official record
Conditions
Femoral Fractures
Interventions
Liposomal Bupivacaine, Ropivacaine HCL
Drug
Lead sponsor
Ian Elliott Brown
Other
Eligibility
18 Years to 70 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Feb 21, 2021 · Synced Oct 23, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional

Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets

NCT06341868
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
KneeStim
Device
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
17 Years to 27 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Jan 2, 2026 · Synced Oct 23, 2026, 9:22 AM EDT
Active, not recruiting Not applicable Interventional

Maximizing Patient Goal Attainment

NCT05652270
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Injuries, Knee Pain Chronic, Knee Injuries and Disorders
Interventions
Goal Attainment, Goal Development, Goal Tracking
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 23, 2026, 9:22 AM EDT
Completed Not applicable Interventional

Trial of a Distal Targeting System for Cephalomedullary Nails as Part of Surgical Repair of Hip and Femoral Shaft Fractures

NCT03943329
View directory record Official record
Conditions
Hip Fractures, Femoral Shaft Fractures
Interventions
Standard of Care, Distal targeting device technique of distal screw placement
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 14, 2022 · Synced Oct 23, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction Training in Patients With Lower Extremity Fractures

NCT06496035
View directory record Official record
Conditions
Tibial Fractures, Lower Extremity Fracture
Interventions
Blood Flow Restriction with low load exercise, Therapeutic Exercise
Device · Other
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 100 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 23, 2026, 9:22 AM EDT
Terminated Not applicable Interventional

A Geriatric Home Visit Program to Reduce Post-Hip Fracture Complications

NCT02058329
View directory record Official record
Conditions
Fracture, Infection, Depression, Gait Instability, Debility
Interventions
Home Visit
Other
Lead sponsor
Northwell Health
Other
Eligibility
65 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Staten Island, New York
Source: ClinicalTrials.gov public record
Updated Feb 10, 2014 · Synced Oct 23, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional

Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction

NCT06529692
View directory record Official record
Conditions
ACL, Anterior Cruciate Ligament, ACL Injury
Interventions
Placebo Split-Belt Training, Split-Belt Training
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 45 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 23, 2026, 9:22 AM EDT
Not yet recruiting Not applicable Interventional

DePuy Synthes Variable Angle LCP Patella Plating System Study

NCT05824676
View directory record Official record
Conditions
Trauma, Patella Fracture, Knee Cap, Knee Cap Injury, Knee Discomfort, Knee Deformity
Interventions
Variable Angle LCP Patella Plating System, Traditional Fixation
Device
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 74 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 21, 2023 · Synced Oct 23, 2026, 9:22 AM EDT
Completed Not applicable Interventional Results available

Blood Flow Restriction Following ACL Reconstruction

NCT03758755
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction Therapy, ACL Reconstruction rehabilitation
Device · Other
Lead sponsor
Inova Health Care Services
Other
Eligibility
13 Years to 50 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Oct 23, 2026, 9:22 AM EDT
Completed Phase 3 Interventional

Improving Pain and Function in Hip Fracture

NCT00749489
View directory record Official record
Conditions
Pain, Hip Fractures
Interventions
Femoral Nerve Block
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
60 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
3
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2014 · Synced Oct 23, 2026, 9:22 AM EDT
Completed Not applicable Interventional

Manual Therapy and Exercise Versus Home Exercises in the Management of Patients Status Post Ankle Sprain

NCT00797368
View directory record Official record
Conditions
Ankle Sprain
Interventions
Manual Therapy and Exercise, Home exercises
Other
Lead sponsor
Franklin Pierce University
Other
Eligibility
16 Years to 60 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
3
States / cities
Denver, Colorado • Concord, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 9, 2013 · Synced Oct 23, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional

Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury

NCT07739992
View directory record Official record
Conditions
Spinal Cord Injuries (SCI)
Interventions
Sham AIH, Acute Intermittent Hypoxia (AIH) 15, Acute Intermittent Hypoxia (AIH) 23
Other
Lead sponsor
Milap Sandhu
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 31, 2026 · Synced Oct 23, 2026, 9:22 AM EDT
Completed Not applicable Interventional Results available

Role of Vacuum Assisted Closure (VAC) Device in Postoperative Management of Pelvic and Acetabular Fractures

NCT00635479
View directory record Official record
Conditions
Pelvic Fractures, Acetabular Fractures, Hip Fractures
Interventions
VAC device, Gauze dressing
Device · Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 11, 2017 · Synced Oct 23, 2026, 9:22 AM EDT
Recruiting Not applicable Interventional

Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

NCT06942754
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
post-surgical functional bracing
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
14 Years to 39 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 23, 2026, 9:22 AM EDT
Completed Not applicable Interventional

The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD

NCT04937179
View directory record Official record
Conditions
Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions
Ischemic Conditioning Low - Sham Comparator, Ischemic Conditioning High - Active Comparator
Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Oct 23, 2026, 9:22 AM EDT