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ClinicalTrials.gov public records Last synced Oct 21, 2026, 8:24 AM EDT

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Showing 49–72 of 871 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Extremity Lower Wounds Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Bio ACL Reconstruction Amnion Collagen Matrix Wrap and Stem Cells

NCT03294759
View directory record Official record
Conditions
ACL - Anterior Cruciate Ligament Rupture
Interventions
Bio ACL, Control
Other
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
18 Years to 45 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Feb 21, 2024 · Synced Oct 21, 2026, 8:24 AM EDT
Recruiting Phase 3 Interventional

Tissue Repair Gel in Venous Leg Ulcers in AU/US

NCT06707103
View directory record Official record
Conditions
Venous Leg Ulcer, Venous Ulcer, Venous Stasis Ulcer, Venous Stasis, Wound Heal, Wound, Venous Insufficiency of Leg, Non-healing Wound
Interventions
TR987 0.1% gel + Standard of Care, Standard of care
Drug · Other
Lead sponsor
TR Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
4
States / cities
Jacksonville, Florida • Clinton Twp, Michigan • Lake Success, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2025 · Synced Oct 21, 2026, 8:24 AM EDT
Recruiting Not applicable Interventional

Accuro XV Ultrasound Imaging System for BoneEnhance and Fracture Detection Algorithms

NCT07853768
View directory record Official record
Conditions
Fracture Arm, Fracture Leg, Wrist Injury, Ankle Injury
Interventions
Accuro XV Ultrasound Imaging System
Device
Lead sponsor
Rivanna Medical, Inc.
Industry
Eligibility
5 Years and older
Enrollment
25,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
10
States / cities
San Francisco, California • Denver, Colorado • New Haven, Connecticut + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 21, 2026, 8:24 AM EDT
Completed No phase listed Observational

Opioid Laws and Pediatric Use

NCT04543227
View directory record Official record
Conditions
Burns, Knee Injuries, Opioid Use, Pain
Interventions
Opioid Use 90-Days Post Treatment
Behavioral
Lead sponsor
Nationwide Children's Hospital
Other
Eligibility
0 Years to 18 Years
Enrollment
980 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Oct 21, 2026, 8:24 AM EDT
Enrolling by invitation Not applicable Interventional

The Safety of Reusing Walking Boot Components for Patients Recovering From Acute Foot and Ankle Injuries

NCT07287969
View directory record Official record
Conditions
Foot Injuries, Ankle Injuries
Interventions
New durable medical equipment (DME) walking boot, Re-used durable medical equipment (DME) walking boot
Device
Lead sponsor
University of Utah
Other
Eligibility
1 Year to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 21, 2026, 8:24 AM EDT
Withdrawn Phase 4 Interventional

Supracondylar Distal Femur Fractures and Abaloparatide

NCT04626141
View directory record Official record
Conditions
Femoral Fractures
Interventions
Abaloparatide, Placebo
Drug
Lead sponsor
Daniel Horwitz
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Danville, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2024 · Synced Oct 21, 2026, 8:24 AM EDT
Completed Phase 2Phase 3 Interventional

Restoring Tissue and Evaluating Novel Treatments for Efficacy in Wounds

NCT05607979
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Lavior Diabetic Wound Gel, Smith & Nephew Solosite Gel Hydrogel Wound Dressing
Drug
Lead sponsor
Lavior Pharma Inc.
Industry
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Oct 21, 2026, 8:24 AM EDT
Completed Not applicable Interventional Results available

Comparative Effectiveness Between Microprocessor Knees and Non-Microprocessor Knees

NCT02240186
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury)
Interventions
Microprocessor Knee (MPK), Non-Microprocessor Knee (NMPK)
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
55 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 12, 2018 · Synced Oct 21, 2026, 8:24 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

PUSH Plus Protein Pilot for Hip Fracture Patients

NCT03410823
View directory record Official record
Conditions
Hip Fracture
Interventions
PUSH, Protein, Nutrition
Behavioral · Dietary Supplement
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
2
States / cities
Baltimore, Maryland • Towson, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 26, 2024 · Synced Oct 21, 2026, 8:24 AM EDT
Recruiting Phase 3 Interventional

Tissue Repair Gel in Venous Leg Ulcers (US)

NCT06707090
View directory record Official record
Conditions
Venous Leg Ulcer, Venous Ulcer, Venous Stasis Ulcer, Venous Stasis, Wound Heal, Wounds, Venous Insufficiency of Leg, Non-healing Wound
Interventions
TR987 0.1% gel + Standard of Care, Standard of care
Drug · Other
Lead sponsor
TR Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
33
States / cities
Tucson, Arizona • Castro Valley, California • Fresno, California + 27 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 21, 2026, 8:24 AM EDT
Completed Not applicable Interventional Results available

Electromyostimulation and Strength Walking for Knee Injuries

NCT02065518
View directory record Official record
Conditions
Knee Injury
Interventions
NMES, Strength Walking, Standard Rehabilitation Protocol
Device · Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years to 50 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Andrews Air Force Base, Maryland • Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 21, 2026, 8:24 AM EDT
Completed No phase listed Observational

Clinical Outcome of Posterior Cruciate Ligament (PCL) Posterolateral Reconstruction

NCT00991588
View directory record Official record
Conditions
Knee Injuries
Interventions
PCL, posterolateral reconstruction
Procedure
Lead sponsor
Sue Barber-Westin
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Oct 21, 2026, 8:24 AM EDT
Enrolling by invitation Not applicable Interventional

G7 Freedom Constrained Vivacit-E Liners

NCT05587244
View directory record Official record
Conditions
Osteoarthritis, Hip, Rheumatoid Arthritis, Non-Union Fracture, Trochanteric Fractures, Femoral Neck Fractures, Avascular Necrosis, Dislocation, Hip
Interventions
Total Hip Arthroplasty with G7 Freedom Constrained Vivacit-E Liners
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years to 80 Years
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2038
U.S. locations
10
States / cities
Birmingham, Alabama • Los Angeles, California • Gainesville, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Oct 21, 2026, 8:24 AM EDT
Terminated Not applicable Interventional

Gait Retraining Enhances Athletes' Technique

NCT03918681
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Knee Osteoarthritis
Interventions
Therapeutic Intervention
Other
Lead sponsor
Keller Army Community Hospital
Federal
Eligibility
18 Years to 50 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
West Point, New York
Source: ClinicalTrials.gov public record
Updated Sep 23, 2025 · Synced Oct 21, 2026, 8:24 AM EDT
Completed Phase 4 Interventional Results available

Ultrasound Guided Pain Control Versus Standard Treatment in Emergency Department HIP Fracture Patients

NCT01904071
View directory record Official record
Conditions
Hip Fracture
Interventions
UFNB (Ultrasound guided femoral nerve block), UFIB (Ultrasound Guided Fascia Iliaca Compartment Block), IVMS (IV Morphine)
Procedure · Drug
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2018 · Synced Oct 21, 2026, 8:24 AM EDT
Recruiting Not applicable Interventional

Tibial IMN Vs. Tibial Micromotion IMN

NCT06976801
View directory record Official record
Conditions
Tibial Fracture
Interventions
Intramedullary tibial Nail, Intermedullary nail
Device
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
372 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 21, 2026, 8:24 AM EDT
Active, not recruiting Not applicable Interventional

The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration

NCT03348995
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
Interventions
Bridge-Enhanced ACL Restoration (BEAR)
Device
Lead sponsor
Miach Orthopaedics
Industry
Eligibility
12 Years to 80 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2034
U.S. locations
11
States / cities
San Diego, California • Tampa, Florida • Atlanta, Georgia + 8 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Oct 21, 2026, 8:24 AM EDT
Completed Phase 4 Interventional Results available

Using Santyl on Diabetic Foot Ulcers

NCT01408277
View directory record Official record
Conditions
Diabetic Foot Ulcers, Diabetic Foot Wounds
Interventions
Santyl, Control
Biological · Procedure
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
7
States / cities
Phoenix, Arizona • Tucson, Arizona • Southfield, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2014 · Synced Oct 21, 2026, 8:24 AM EDT
Withdrawn Not applicable Interventional

Managing Wounds With Allevyn Life in a Home Health Care Environment

NCT02776800
View directory record Official record
Conditions
Wounds and Injuries
Interventions
Allevyn Life, Foam dressing with an integrated adhesive border
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
3
States / cities
Tustin, California • Wichita, Kansas • McAllen, Texas
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Oct 21, 2026, 8:24 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Role of Tissue Oxygenation and the miR-210 Gene In Wound Healing

NCT02024243
View directory record Official record
Conditions
Non-Diabetic Patients, Wound Leg, Chronic Ulcer Leg/Foot
Interventions
Not listed
Lead sponsor
Chandan Sen
Other
Eligibility
30 Years and older
Enrollment
54 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2023
U.S. locations
3
States / cities
Indianapolis, Indiana • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Oct 21, 2026, 8:24 AM EDT
Recruiting Not applicable Interventional

CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs

NCT07701590
View directory record Official record
Conditions
Wound, Foot, Diabetic Foot Ulcer (DFU), Venus Leg Ulcer
Interventions
Microlyte®, IP 1: Membrane Wrap - Hydro
Device
Lead sponsor
Capsicure, LLC
Network
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
7
States / cities
San Diego, California • Coral Gables, Florida • Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 21, 2026, 8:24 AM EDT
Recruiting Phase 4 Interventional

Trial to Evaluate Cyclical Topical Wound Oxygen Therapy in the Treatment of Chronic Venous Leg Ulcers

NCT06754735
View directory record Official record
Conditions
Venous Leg Ulcer (VLU)
Interventions
Topical Wound Oxygen Therapy, Sham Control Topical Wound Oxygen
Device
Lead sponsor
AOTI Ltd.
Industry
Eligibility
18 Years and older
Enrollment
212 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 21, 2026, 8:24 AM EDT
Completed Not applicable Interventional

Suprapatellar Versus Infrapatellar Nailing in Tibial Fractures: A Pilot Study

NCT01341418
View directory record Official record
Conditions
Tibial Fractures
Interventions
Suprapatellar approach, Infrapatellar approach
Procedure
Lead sponsor
Florida Orthopaedic Institute
Network
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2017 · Synced Oct 21, 2026, 8:24 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Joint Mobilization in the Treatment of Chronic Ankle Instability

NCT01438905
View directory record Official record
Conditions
Ankle Sprain
Interventions
Small amplitude (Grade IV) mobilization, High velocity, low amplitude (Grade V) mobilization
Other
Lead sponsor
Creighton University
Other
Eligibility
19 Years to 45 Years · Male only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 23, 2018 · Synced Oct 21, 2026, 8:24 AM EDT