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ClinicalTrials.gov public records Last synced Oct 27, 2026, 10:41 AM EDT

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Showing 793–816 of 872 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Extremity Lower Wounds Clear all
Completed Not applicable Interventional Results available

Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation

NCT06071715
View directory record Official record
Conditions
Amputation, Surgical, Amputation, Traumatic, Phantom Limb Pain, Phantom Pain Following Amputation of Lower Limb
Interventions
ACTIVE cryoneurolysis, SHAM cryoneurolysis
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

A Pilot Study of the Provant Therapy System in Subjects With Diabetic Foot Ulcers

NCT00761176
View directory record Official record
Conditions
Diabetic Foot Ulcers
Interventions
The Provant Therapy System
Device
Lead sponsor
Regenesis Biomedical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 5, 2016 · Synced Oct 27, 2026, 10:41 AM EDT
Completed Not applicable Interventional

Ideal Anatomic Location for Saphenous Nerve Blocks: A Prospective Clinical Evaluation

NCT02645097
View directory record Official record
Conditions
Foot Injury, Ankle Injury
Interventions
Saphenous Nerve Block
Procedure
Lead sponsor
Paul J. Juliano, M.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Oct 27, 2026, 10:41 AM EDT
Recruiting Not applicable Interventional

Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS)

NCT05889559
View directory record Official record
Conditions
Acute Compartment Syndrome, Fracture, Bone, Tibial Fractures
Interventions
Tissue Ultrafiltration Catheters
Device
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Baltimore, Maryland • Minneapolis, Minnesota • Charlotte, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Oct 27, 2026, 10:41 AM EDT
Completed Not applicable Interventional

HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial

NCT02027896
View directory record Official record
Conditions
Hip Fractures
Interventions
Accelerated medical clearance and surgery
Other
Lead sponsor
McMaster University
Other
Eligibility
45 Years and older
Enrollment
3,001 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2022
U.S. locations
5
States / cities
San Jose, California • Baltimore, Maryland • Burlington, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2024 · Synced Oct 27, 2026, 10:41 AM EDT
Recruiting Not applicable Interventional

CAMPR-II RWE TRIAL: A Saline-hydrated Allogeneic Dual-layer Amniotic Membrane Product or a Synthetic, Resorbable Polymeric Wound Matrix to a Coarsened Exact Matched Retrospective Control Cohort of Hard to Heal DFUs and VLUs

NCT07701590
View directory record Official record
Conditions
Wound, Foot, Diabetic Foot Ulcer (DFU), Venus Leg Ulcer
Interventions
Microlyte®, IP 1: Membrane Wrap - Hydro
Device
Lead sponsor
Capsicure, LLC
Network
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
7
States / cities
San Diego, California • Coral Gables, Florida • Miami, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Recruiting Not applicable Interventional

Semiconductor Embedded Socks for Ankle Sprains

NCT07025733
View directory record Official record
Conditions
Ankle Sprain
Interventions
Semiconductor Embedded Sock, Control Compression Sock
Device
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Completed Not applicable Interventional

Pericapsular Nerve Group Block for Hip Fractures

NCT04882384
View directory record Official record
Conditions
Hip Fractures, Pain, Acute
Interventions
Pericapsular Nerve Group Block
Procedure
Lead sponsor
Jacobi Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Oct 27, 2026, 10:41 AM EDT
Recruiting Phase 4 Interventional

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

NCT06511232
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Interventions
Intraosseous Morphine
Drug
Lead sponsor
The Methodist Hospital Research Institute
Other
Eligibility
18 Years to 40 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Recruiting Not applicable Interventional

Transverse Tibial Bone Transport (TTT) in the Management of Chronic Diabetic Lower Extremity Wounds

NCT07444593
View directory record Official record
Conditions
Diabetic Foot Ulcer, Chronic Ulcers of the Lower Limb
Interventions
Biodynamik XT3
Device
Lead sponsor
Biodynamik, Inc
Industry
Eligibility
22 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Recruiting Not applicable Interventional

EDX110 Randomized Control Trial for Treatment of DFUs

NCT07209358
View directory record Official record
Conditions
Wound Heal, Diabetic Foot Ulcer
Interventions
EDX110
Device
Lead sponsor
ConvaTec Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
298 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
4
States / cities
Phoenix, Arizona • Santa Ana, California • Vista, California + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 27, 2026, 10:41 AM EDT
Recruiting Phase 4 Interventional

Randomized Controlled Trial for Ankle Fracture Pain Control

NCT03696199
View directory record Official record
Conditions
Ankle Fractures
Interventions
Long-Acting Local Anesthesia, Regional Anesthesia
Drug
Lead sponsor
Lahey Clinic
Other
Eligibility
18 Years to 89 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Burlington, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Completed Not applicable Interventional

A Dual-center Study Evaluating Clinical Acceptance of a NPWT Wound Care System

NCT04593693
View directory record Official record
Conditions
Diabetic Foot Ulcer, Pressure Injury, Pressure Ulcer, Surgical Wound, Acute Wound, Traumatic Wound, Dehiscence, Edema
Interventions
Invia Motion Endure NPWT system
Device
Lead sponsor
Medela AG
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Augusta, Georgia • Austell, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 24, 2021 · Synced Oct 27, 2026, 10:41 AM EDT
Not yet recruiting Not applicable Interventional

Reducing Disparities in Knee Arthroscopy for Adolescents

NCT07580625
View directory record Official record
Conditions
Knee Injury, ACL Injury, Meniscus Tear, Hispanic or Latino, Adolescent
Interventions
Educational program and patient navigator
Behavioral
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
14 Years to 18 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Completed Not applicable Interventional

Utilization of a 3D Printed Customized Knee Extender and At-Home Rehabilitation Program on Patient Outcomes Following ACL Surgery

NCT06524349
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture
Interventions
3D printed knee extender device
Device
Lead sponsor
Sanford Health
Other
Eligibility
14 Years to 60 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
Fargo, North Dakota • Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Active, not recruiting Phase 2 Interventional

Non-Narcotic Pain Control After ACL Reconstruction

NCT06973785
View directory record Official record
Conditions
ACL - Anterior Cruciate Ligament Rupture, ACL Injuries
Interventions
dispense of study drug, Ketorolac
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
15 Years to 55 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
3
States / cities
Coral Springs, Florida • Garfield, Ohio • Strongsville, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Terminated Not applicable Interventional Results available

Foot and Ankle Range of Motion (Stretching) Apparatus

NCT00527748
View directory record Official record
Conditions
Plantar Fasciitis, Flatfoot, Calcaneus Fractures
Interventions
Non-Measuring Ankle Exerciser
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 21, 2017 · Synced Oct 27, 2026, 10:41 AM EDT
Completed No phase listed Observational

Indications for Osteochondral Allograft Transplantation

NCT03711747
View directory record Official record
Conditions
Post-Traumatic Osteoarthritis of Ankle, Ankle Osteoarthritis, Ankle Injuries
Interventions
Osteochondral allograft ankle
Procedure
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 55 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 17, 2022 · Synced Oct 27, 2026, 10:41 AM EDT
Completed Phase 3 Interventional Results available

Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)

NCT02480621
View directory record Official record
Conditions
Ankle Fracture
Interventions
Liposomal Bupivacaine with Bupivacaine
Drug
Lead sponsor
Jamaica Hospital Medical Center
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Jamaica, New York
Source: ClinicalTrials.gov public record
Updated Oct 20, 2017 · Synced Oct 27, 2026, 10:41 AM EDT
Not listed Not applicable Interventional

Effect of Early Range of Motion Following First Time Patellar Dislocation

NCT04294199
View directory record Official record
Conditions
Patellar Dislocation
Interventions
Early Range of MOtion
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
11 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Oct 27, 2026, 10:41 AM EDT
Recruiting Not applicable Interventional

The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial

NCT05754632
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Knee Injuries, Quadriceps Muscle Atrophy
Interventions
Blood Flow Restriction using Delfi Personalized Tourniquet System
Device
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
12 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Active, not recruiting Not applicable Interventional

Dual Implant Versus Single Implant Distal End of Femur

NCT06032299
View directory record Official record
Conditions
Femur Fracture
Interventions
Single Distal Femur Implant, Dual Distal Femur Implant
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Not yet recruiting Phase 1 Interventional

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

NCT07004764
View directory record Official record
Conditions
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions
Nitroglycerin Ointment 2%
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 27, 2026, 10:41 AM EDT
Active, not recruiting Phase 3 Interventional

Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury

NCT03992404
View directory record Official record
Conditions
Lower Limb or Combined Lower Limb and Upper Limb Spasticity Due to Stroke or Traumatic Brain Injury
Interventions
NT 201, Placebo
Drug
Lead sponsor
Merz Pharmaceuticals GmbH
Industry
Eligibility
18 Years to 85 Years
Enrollment
603 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
15
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Downey, California + 11 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2026 · Synced Oct 27, 2026, 10:41 AM EDT