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ClinicalTrials.gov public records Last synced Oct 22, 2026, 5:10 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 871 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Extremity Lower Wounds Clear all
Not listed Not applicable Interventional Accepts healthy volunteers

Evaluating the Outcomes for Incisional Application of Negative Pressure for Nontraumatic Amputations

NCT03250442
View directory record Official record
Conditions
Surgical Wound, Wound Heal, Amputation
Interventions
PrevenaTM Device, Standard Dry Dressing
Device · Other
Lead sponsor
Georgetown University
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Sep 25, 2019 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation and Eccentric Exercise for Anterior Cruciate Ligament (ACL) Injury

NCT01555567
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Electrical Stimulation, Eccentric Exercise
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 35 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 8, 2015 · Synced Oct 22, 2026, 5:10 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

NCT05344001
View directory record Official record
Conditions
Aging, Athletic Injuries, Physical Inactivity, Knee Injuries and Disorders
Interventions
Not listed
Lead sponsor
Marquette University
Other
Eligibility
18 Years to 64 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Not applicable Interventional

Telehealth Delivered Physical Rehabilitation for an Ankle Sprain

NCT04520854
View directory record Official record
Conditions
Ankle Sprains, Telerehabilitation, Analgesic, Opioid, Analgesics, Non-narcotic, Anti-Inflammatory Agents, Non-Steroidal, Implementation Science, Acute Pain, Quality of Life
Interventions
Telehealth Protocol, Usual Care
Other
Lead sponsor
Kyle Kosik
Other
Eligibility
15 Years to 35 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Oct 22, 2026, 5:10 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Hip Fracture Exercise and Rehabilitation Post Hip Fracture Study

NCT03247205
View directory record Official record
Conditions
Hip Fractures, Cognitive Impairment
Interventions
HipERS
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
65 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics

NCT05456295
View directory record Official record
Conditions
Healthy, Lower Limb Injury, Post-Traumatic Osteoarthritis
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Phase 2 Interventional Results available

Does Early Administration of Tranexamic Acid Reduce Blood Loss and Perioperative Transfusion Requirement

NCT03182751
View directory record Official record
Conditions
Hip Fractures, Intertrochanteric Fractures
Interventions
Tranexamic Acid (TXA), Placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 30, 2023 · Synced Oct 22, 2026, 5:10 PM EDT
Not listed Early Phase 1 Interventional Accepts healthy volunteers

Blood Loss After Early TXA in Hip Fractures.

NCT04488367
View directory record Official record
Conditions
Hip Fractures
Interventions
Tranexamic acid, Normal Saline
Drug
Lead sponsor
Community Memorial Health System
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Ventura, California
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Phase 2 Interventional Results available

Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period

NCT00586196
View directory record Official record
Conditions
Delirium
Interventions
donepezil, Placebo
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
70 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 22, 2014 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Phase 2 Interventional

Efficacy Study of a Bioelectric Dressing Used With Negative Pressure Wound Therapy to Treat Diabetic and Pressure Ulcers

NCT01022216
View directory record Official record
Conditions
Wound Healing
Interventions
Procellera™ Wound Dressing with V.A.C.® Therapy, V.A.C.® Therapy
Device
Lead sponsor
Vomaris Innovations
Industry
Eligibility
18 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Feb 22, 2012 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Not applicable Interventional Results available

Skeletal Versus Cutaneous Traction For Treatment of Femur Fractures

NCT00916136
View directory record Official record
Conditions
Femur Fracture
Interventions
Femoral Traction
Procedure
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Not applicable Interventional Results available

Blood Flow Restriction Following ACL Reconstruction

NCT03758755
View directory record Official record
Conditions
Anterior Cruciate Ligament Rupture
Interventions
Blood Flow Restriction Therapy, ACL Reconstruction rehabilitation
Device · Other
Lead sponsor
Inova Health Care Services
Other
Eligibility
13 Years to 50 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Fairfax, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 22, 2022 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Phase 3 Interventional Results available

Exercise and Testosterone Therapy in Elderly Men With Physical Frailty

NCT00345969
View directory record Official record
Conditions
Physical Frailty, Hip Fracture, Elective Hip Replacement, Hypogonadism
Interventions
Transdermal Testosterone gel (1%), Supervised exercise training
Drug · Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years and older · Male only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2009
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 22, 2026, 5:10 PM EDT
Terminated Not applicable Interventional Results available

Clinical Trial Evaluating Acutrak Headless Compression Screw Fixation of Medial Malleolus Fractures

NCT03061279
View directory record Official record
Conditions
Medial Malleolus Fractures
Interventions
Fixation by Acutrak headless screw, Fixation by headed screws, plates, and or wires
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
3
States / cities
Palo Alto, California • Sacramento, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2020 · Synced Oct 22, 2026, 5:10 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Mechanical Perturbation Training for ACL Injury Prevention

NCT03080402
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, ACL
Interventions
Mechanical Perturbation Training
Device
Lead sponsor
University of Delaware
Other
Eligibility
15 Years to 30 Years · Female only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Mar 15, 2017 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Phase 4 Interventional Results available

iPACK for Post-op Pain Following ACL Reconstruction

NCT05498870
View directory record Official record
Conditions
ACL Injury, Post Operative Pain
Interventions
Adductor Canal Block (ACB) Only, Adductor Canal Block (ACB) + iPACK Block
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 16, 2024 · Synced Oct 22, 2026, 5:10 PM EDT
Enrolling by invitation Not applicable Interventional

The Safety of Reusing Walking Boot Components for Patients Recovering From Acute Foot and Ankle Injuries

NCT07287969
View directory record Official record
Conditions
Foot Injuries, Ankle Injuries
Interventions
New durable medical equipment (DME) walking boot, Re-used durable medical equipment (DME) walking boot
Device
Lead sponsor
University of Utah
Other
Eligibility
1 Year to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Oct 22, 2026, 5:10 PM EDT
Not listed Not applicable Interventional

Comparison of TKAs Using Force Plate Analysis

NCT04163445
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty, Knee Injuries, Knee Arthritis
Interventions
MicroPort Orthopedics EVOLUTION Medial Pivot TKA, Depuy Synthes ATTUNE PCR TKA
Device
Lead sponsor
Russell Nevins, M.D.
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Aug 6, 2021 · Synced Oct 22, 2026, 5:10 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Retrograde Femoral Nail-Advanced Outcomes for Fixation of Distal Femur and Femoral Shaft Fractures

NCT05680987
View directory record Official record
Conditions
Femoral Fracture
Interventions
RFN-Advanced Retrograde Femoral Nailing System
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Oct 22, 2026, 5:10 PM EDT
Completed Not applicable Interventional

Factors Affecting the Speed of Recovery After ACL Reconstruction

NCT03770806
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury, ACL Injury, ACL - Anterior Cruciate Ligament Rupture
Interventions
Femoral Nerve Block, Adductor Nerve Block, No Block
Procedure · Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Oct 22, 2026, 5:10 PM EDT
Recruiting Not applicable Interventional

Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT

NCT05461326
View directory record Official record
Conditions
Orthopedic Disorder, Anterior Cruciate Ligament Injuries
Interventions
Quad tendon, BTB
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
14 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 22, 2026, 5:10 PM EDT
Terminated Phase 4 Interventional Results available

Intra-articular Local Anesthetic Injection and Hematoma Aspiration

NCT02951884
View directory record Official record
Conditions
Tibial Fractures
Interventions
Aspiration, Bupivacaine
Procedure · Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 17, 2018 · Synced Oct 22, 2026, 5:10 PM EDT
Completed No phase listed Observational Results available

In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)

NCT04113785
View directory record Official record
Conditions
Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
Interventions
Klassic Knee System
Device
Lead sponsor
The University of Tennessee, Knoxville
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Nov 15, 2019 · Synced Oct 22, 2026, 5:10 PM EDT
Completed No phase listed Observational

RFN-Advanced Retrograde Femoral Nailing System

NCT05668117
View directory record Official record
Conditions
Femur Fracture
Interventions
Depuy Synthes Advanced Retrograde femoral nail
Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated May 1, 2023 · Synced Oct 22, 2026, 5:10 PM EDT