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Showing 1–22 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Eyelid Spasm Clear all
Completed No phase listed Observational Accepts healthy volunteers

Blepharospasm Tools

NCT02780336
View directory record Official record
Conditions
Blepharospasm, Dystonia, Other Eye and Face Disorders
Interventions
No intervention.
Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
405 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
7
States / cities
Aurora, Colorado • Atlanta, Georgia • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated May 30, 2019 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 2 Interventional

Brain Stimulation to Treat Blepharospasm or Meige Syndrome

NCT00411255
View directory record Official record
Conditions
Blepharospasm, Focal Dystonia
Interventions
repetitive transcranial magnetic stimulation (rTMS)
Procedure
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 2 Interventional

Study of a Single Administration of 3 Doses of Dysport® for the Treatment of Benign Essential Blepharospasm

NCT00234507
View directory record Official record
Conditions
Blepharospasm
Interventions
Botulinum toxin type A
Biological
Lead sponsor
Ipsen
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
14
States / cities
Phoenix, Arizona • Fountain Valley, California • Los Angeles, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2019 · Synced Jun 10, 2026, 1:36 PM EDT
Completed No phase listed Observational

Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin

NCT05103202
View directory record Official record
Conditions
Cervical Dystonia, Blepharospasm, Limb Dystonia, Hemifacial Spasm, Spasticity, Muscle, Fragments of Torsion Dystonia
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
Not listed
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional Results available

Deep Brain Stimulation in Patients With Dystonia

NCT00773604
View directory record Official record
Conditions
Dystonia
Interventions
Medtronic implantable deep brain stimulation (DBS) system
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
7 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 18, 2019 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated Phase 2 Interventional Results available

Acetyl Hexapeptide-8 for Blepharospasm

NCT01750346
View directory record Official record
Conditions
Focal Dystonia
Interventions
Topical acetyl hexapeptide-8, Placebo
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 9, 2016 · Synced Jun 10, 2026, 1:36 PM EDT
Not yet recruiting Phase 2 Interventional

DaxibotulinumtoxinA for Blepharospasm

NCT07489430
View directory record Official record
Conditions
Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid, Blepharospasm of Right Eyelid, Blepharospasm, Benign Essential, Blepharospasm
Interventions
Botulinum Neurotoxin Type A
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Recruiting Phase 4 Interventional

Effects of DaxibotulinumtoxinA for Blepharospasm and Hemifacial Spasm

NCT06195241
View directory record Official record
Conditions
Benign Essential Blepharospasm, Hemifacial Spasm
Interventions
DaxibotulinumtoxinA
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Brain Changes in Blepharospasm

NCT00487383
View directory record Official record
Conditions
Dystonia, Focal Dystonia, Cerebellar Disease
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 85 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 15, 2019 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 3 Interventional Results available

IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Blepharospasm

NCT00406367
View directory record Official record
Conditions
Blepharospasm
Interventions
incobotulinumtoxinA (Xeomin), Placebo
Drug
Lead sponsor
Merz Pharmaceuticals GmbH
Industry
Eligibility
18 Years to 80 Years
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 14, 2013 · Synced Jun 10, 2026, 1:36 PM EDT
Completed No phase listed Observational

Blepharospasm Patient Survey for Patients With Blepharospasm

NCT01686061
View directory record Official record
Conditions
Blepharospasm
Interventions
No intervention- only one time survey
Other
Lead sponsor
Merz Pharmaceuticals GmbH
Industry
Eligibility
18 Years to 81 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
5
States / cities
Fountain Valley, California • Sarasota, Florida • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2022 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 1Phase 2 Interventional Results available

A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm

NCT00942851
View directory record Official record
Conditions
Focal Dystonia
Interventions
Acetyl-Hexapeptide Topical Treatment, placebo
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 5, 2012 · Synced Jun 10, 2026, 1:36 PM EDT
Completed No phase listed Observational

Neurophysiological Markers in Patients With Craniofacial Dystonia and Their Relatives

NCT00082615
View directory record Official record
Conditions
Dystonia
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Not applicable Interventional Results available

rTMS and Botulinum Toxin in Benign Essential Blepharospasm

NCT02370875
View directory record Official record
Conditions
Benign Essential Blepharospasm
Interventions
Magstim RapidStim2, Sham Magstim RapidStim2
Device
Lead sponsor
University of Florida
Other
Eligibility
30 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 14, 2023 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Effect of Non-psychoactive Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm

NCT04423341
View directory record Official record
Conditions
Blepharospasm, Blepharospasm, Benign Essential, CBD
Interventions
Cannabidiol Oral Solution [Epidiolex]
Drug
Lead sponsor
Silkiss Eye Surgery
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Oakland, California
Source: ClinicalTrials.gov public record
Updated Nov 1, 2021 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 2 Interventional

Mexiletine for the Treatment of Focal Dystonia

NCT00001784
View directory record Official record
Conditions
Blepharospasm, Dystonia, Spasm
Interventions
Mexiletine
Drug
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
Not listed
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Photic Blink Reflex in People With Blepharospasm and Increased Blinking

NCT03263000
View directory record Official record
Conditions
Blepharospasm
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Jun 10, 2026, 1:36 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Changes in Blepharospasm

NCT00500799
View directory record Official record
Conditions
Blepharospasm
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jun 10, 2026, 1:36 PM EDT
Terminated Phase 4 Interventional Results available

Effect of Topical Botulinum Toxin Eyedrop on Palpebral Fissure

NCT06080438
View directory record Official record
Conditions
Tears; Excess, Eyelid Spasm
Interventions
Botulinum toxin
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 4, 2024 · Synced Jun 10, 2026, 1:36 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Brain Networks in Dystonia

NCT03042962
View directory record Official record
Conditions
Spasmodic Dysphonia, Singer's Dystonia, Writer's Cramp, Musician's Focal Hand Dystonia, Craniofacial Dystonia, Blepharospasm Oromandibular Dystonia
Interventions
MRI, Blood draw
Other · Procedure
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
21 Years to 80 Years
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 7, 2025 · Synced Jun 10, 2026, 1:36 PM EDT
Completed No phase listed Observational

Trial Evaluating Xeomin® (incobotulinumtoxinA) for Cervical Dystonia or Blepharospasm in the United States

NCT01287247
View directory record Official record
Conditions
Cervical Dystonia, Blepharospasm
Interventions
Xeomin®
Biological
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
688 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
70
States / cities
Cullman, Alabama • Scottsdale, Arizona • Tucson, Arizona + 60 more
Source: ClinicalTrials.gov public record
Updated Apr 9, 2015 · Synced Jun 10, 2026, 1:36 PM EDT
Completed Phase 2 Interventional

Exploratory Study of Dipraglurant (ADX48621) for the Treatment of Patients With Blepharospasm

NCT05027997
View directory record Official record
Conditions
Blepharospasm, Dystonia
Interventions
Dipraglurant, Placebo
Drug
Lead sponsor
Addex Pharma S.A.
Industry
Eligibility
18 Years to 85 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Jun 10, 2026, 1:36 PM EDT