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Showing 1–24 of 135 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Facial Pain Clear all
Withdrawn Not applicable Interventional Accepts healthy volunteers

Comparison Study on Topical Anesthetic Agents (LMX4 and BLT) Prior to Fractional Skin Resurfacing

NCT01842373
View directory record Official record
Conditions
Pain
Interventions
LMX4, BLT
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 24, 2017 · Synced Jun 25, 2026, 6:41 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

RHA® Redensity With New Anesthetic Agent Perioral Rhytids (PAS)

NCT06378086
View directory record Official record
Conditions
Pain, Aging
Interventions
RHA® Redensity with new anesthetic agent, RHA® Redensity with lidocaine
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Birmingham, Alabama • New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Self-Natural Posture Exercise Programs on Chronic Low Back Pain

NCT05136729
View directory record Official record
Conditions
Chronic Low-back Pain
Interventions
Self-Natural Posture Exercise training
Behavioral
Lead sponsor
Billings Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Billings, Montana
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 2 Interventional Results available

Phase 2 Study of Indomethacin Capsules to Treat Dental Pain

NCT00964431
View directory record Official record
Conditions
Dental Pain
Interventions
Celecoxib 400 mg, Placebo, Indomethacin Test (lower dose), Indomethacin Test (upper dose)
Drug
Lead sponsor
Iroko Pharmaceuticals, LLC
Industry
Eligibility
18 Years to 50 Years
Enrollment
203 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated May 21, 2012 · Synced Jun 25, 2026, 6:41 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Pediatric Pain Assessment in the Emergency Department

NCT03157882
View directory record Official record
Conditions
Pain, Acute Pain
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
3 Years to 7 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 1, 2022 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 4 Interventional Results available

(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist

NCT03381261
View directory record Official record
Conditions
Migraine
Interventions
Botulinum toxin type A
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
37 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Jun 25, 2026, 6:41 PM EDT
Not yet recruiting Not applicable Interventional

Marine Lipids Ease Painful TMD

NCT07437313
View directory record Official record
Conditions
Temporomandibular Disorder (TMD)
Interventions
SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

New Formulation and Food Effect Study of BIIB074

NCT02951221
View directory record Official record
Conditions
Trigeminal Neuralgia (TN), Other Neuropathic Pain
Interventions
BIIB074 Treatment A, BIIB074 Treatment B, BIIB074 Treatment C, BIIB074 Treatment D
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 55 Years
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Daytona Beach, Florida
Source: ClinicalTrials.gov public record
Updated Feb 26, 2017 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Vibrating, Cold Device for Pediatric Intravenous (IV) Cannulation Pain Relief

NCT01394250
View directory record Official record
Conditions
Pain, Anxiety
Interventions
Buzzy, Topical Lidocaine 4% Cream
Device · Drug
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
4 Years to 18 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 15, 2016 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 3 Interventional Results available

Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction

NCT02517905
View directory record Official record
Conditions
Dental Pain
Interventions
Bupivacaine liposome, Placebo
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Evaluate Onset of Action of a Fast Release Aspirin

NCT01420094
View directory record Official record
Conditions
Healthy Subjects
Interventions
Acetylsalicyclic acid (Fast release Aspirin, BAY1019036), Acetaminophen (Tylenol extra strength), Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
16 Years to 45 Years
Enrollment
510 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Jun 25, 2026, 6:41 PM EDT
Withdrawn Phase 4 Interventional

Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures

NCT02957097
View directory record Official record
Conditions
Pain, Postoperative, Acute Pain, Facial Pain
Interventions
Gabapentin, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Jun 25, 2026, 6:41 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques

NCT00992108
View directory record Official record
Conditions
Face Pain
Interventions
lidocaine, chemodenervation
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 28, 2016 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 2 Interventional

Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain

NCT00001725
View directory record Official record
Conditions
Facial Neuralgia, Pain, Trigeminal Neuralgia
Interventions
Dextromethorphan
Drug
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Controlled Study on Pain Management With Injection of Botulinum Toxin for Glabellar Line Correction

NCT06161246
View directory record Official record
Conditions
Injection Site Discomfort
Interventions
Vibrating Beauty Bar
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
18 Years to 64 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 21, 2024 · Synced Jun 25, 2026, 6:41 PM EDT
Completed No phase listed Observational

Diagnosis and Evaluation of Patients Needing Third Molar (Wisdom Tooth) Extraction and Patients With Chronic Facial Pain

NCT00001600
View directory record Official record
Conditions
Facial Pain, Temporomandibular Joint Disorder
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 4 Interventional Results available

Erenumab for Idiosyncratic Facial Pain

NCT04249427
View directory record Official record
Conditions
Facial Pain, Rhinosinusitis
Interventions
Erenumab Prefilled Syringe, Placebo
Drug · Other
Lead sponsor
David Jang, M.D.
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 23, 2024 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Not applicable Interventional

Focused Ultrasound (FUS) Mesencephalotomy for Head & Neck Cancer Pain

NCT03894553
View directory record Official record
Conditions
Cancer of Head and Neck, Pain, Face, Pain, Neck
Interventions
ExAblate Neuro
Device
Lead sponsor
Jeff Elias, MD
Other
Eligibility
18 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 22, 2025 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 2 Interventional Results available

Study of Long-Acting Acetaminophen in Postoperative Dental Pain

NCT01960114
View directory record Official record
Conditions
Dental Pain
Interventions
Acetaminophen ER, Placebo
Drug
Lead sponsor
McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Industry
Eligibility
17 Years to 45 Years
Enrollment
403 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 9, 2015 · Synced Jun 25, 2026, 6:41 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

NCT04439552
View directory record Official record
Conditions
Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury, Surgical Wound, Cornea Injury, Cornea, Keratoconus
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
8 Years to 35 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 2 Interventional Results available

Acetaminophen/Naproxen Sodium Dose Ranging Study

NCT04447040
View directory record Official record
Conditions
Pain
Interventions
Acetaminophen/naproxen sodium Dose A, Acetaminophen/naproxen sodium Dose B, Acetaminophen/naproxen sodium Dose C, Acetaminophen/naproxen sodium Dose D, Acetaminophen/naproxen sodium Dose E, Placebo
Drug
Lead sponsor
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
Industry
Eligibility
17 Years to 50 Years
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 2 Interventional

Study of Acetaminophen (ACE) in Post-operative Dental Pain

NCT02320708
View directory record Official record
Conditions
Dental Pain
Interventions
Acetaminophen (ACE) (1000 mg), Commercial ACE (1000 mg), Commercial Ibuprofen (IBU) (400 mg), Placebo
Drug
Lead sponsor
Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc.
Industry
Eligibility
17 Years to 50 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 2, 2021 · Synced Jun 25, 2026, 6:41 PM EDT
Completed No phase listed Observational

Machine Learning to Analyze Facial Imaging, Voice and Spoken Language for the Capture and Classification of Cancer/Tumor Pain

NCT04442425
View directory record Official record
Conditions
Cancer, Neoplasms, Solid Tumors
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
12 Years to 120 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 25, 2026, 6:41 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Buffered Local Anesthetic

NCT05757648
View directory record Official record
Conditions
Dental Pain
Interventions
Non-buffered Anesthetic, Buffered Anesthetic, Onset
Drug · Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
2 Years to 6 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Jun 25, 2026, 6:41 PM EDT