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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:38 PM EST

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Showing 25–48 of 127 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Facial Rhytides Clear all

Conditions: Photoaging, Wrinkle, Skin Laxity
Interventions: Fractional Ablative CO2 Laser, Facial Cleanser, Facial Moisturizer, Sunscreen, Basic Ointment; Procedure · Other
Lead sponsor: Revision Skincare; Industry
Eligibility: 35 Years to 65 Years · Female only
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Blue Ash, Ohio

Conditions: Forehead Rhytides, Glabellar Rhytides
Interventions: OnabotulinumtoxinA, Normal Saline; Biological · Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years and older
Enrollment: 421 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 9
States / cities: Birmingham, Alabama • Glendale, Arizona • Santa Monica, California + 6 more

Conditions: Facial Rhytides
Interventions: MyoScience Tissue Remodeling Device; Device
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 30 Years to 70 Years · Female only
Enrollment: 380 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 1
States / cities: Redwood City, California

Conditions: Facial Wrinkles
Interventions: NADGL; Device
Lead sponsor: Genzyme, a Sanofi Company; Industry
Eligibility: 18 Years and older
Enrollment: 45 participants
Timeline: 2007
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
Interventions: Botulinum Toxin Type A, Placebo (Dose B); Drug
Lead sponsor: Revance Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010
U.S. locations: 1
States / cities: Coral Gables, Florida

Conditions: Skin Aging
Interventions: Poly-L-lactic acid, Placebo comparator; Device
Lead sponsor: Sadick Research Group; Other
Eligibility: 30 Years to 60 Years · Female only
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 2
States / cities: Carmel, Indiana • New York, New York

Conditions: Wrinkle, Elastic Skin, Collagen Degeneration
Interventions: Straberi Epistamp Microneedling Treatment; Device
Lead sponsor: Universal Skincare Institute; Other
Eligibility: 21 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: New York, New York

Conditions: Facial Wrinkles, Skin Aging
Interventions: Cryo-Touch II; Device
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 30 Years to 70 Years
Enrollment: 54 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 3
States / cities: Beverly Hills, California • Redwood City, California • Roseville, California

Conditions: Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
Interventions: Botulinum Toxin Type A, Placebo; Drug
Lead sponsor: Revance Therapeutics, Inc.; Industry
Eligibility: 30 Years to 60 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: Coral Gables, Florida

Conditions: Skin Texture Irregularities, Facial Skin Wrinkles
Interventions: Not listed
Lead sponsor: Candela Corporation; Industry
Eligibility: 35 Years to 60 Years
Enrollment: 61 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 3
States / cities: Boca Raton, Florida • Hunt Valley, Maryland • Great Neck, New York

Conditions: Facial Wrinkles
Interventions: Hylaform, Hylaform Plus (hylan B gel); Device
Lead sponsor: Genzyme, a Sanofi Company; Industry
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006
U.S. locations: 3
States / cities: Los Angeles, California • Warren, Michigan • Philadelphia, Pennsylvania

Conditions: Wrinkles
Interventions: Botulinum Toxin, Chemical Peel Only; Drug · Procedure
Lead sponsor: Loyola University; Other
Eligibility: 30 Years to 75 Years
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2013
U.S. locations: 1
States / cities: La Grange Park, Illinois

Conditions: Fine Lines, Wrinkles, Photoaging
Interventions: Facial cleanser, Facial moisturizer, Sunscreen; Combination Product
Lead sponsor: Revision Skincare; Industry
Eligibility: 35 Years to 60 Years · Female only
Enrollment: 56 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Manhattan Beach, California

Conditions: Lateral Canthal Lines
Interventions: Vehicle Control, RT001 (Botulinum Toxin Type A Topical Gel); Other · Drug
Lead sponsor: Revance Therapeutics, Inc.; Industry
Eligibility: 30 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Forehead/Glabellar Rhytid Complexes
Interventions: Combination Botulinum Toxin A and Hyaluronic Acid, Botulinum Toxin A; Procedure
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Facial Wrinkles
Interventions: TriPollar; Device
Lead sponsor: Pollogen; Industry
Eligibility: 35 Years to 65 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: Started 2013
U.S. locations: 2
States / cities: Beverly Hills, California • Plano, Texas

Conditions: Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin
Interventions: Food: whole almonds, Food: non-nut snack; Other
Lead sponsor: Integrative Skin Science and Research; Industry
Eligibility: 35 Years to 70 Years · Female only
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Rhytidosis Facialis
Interventions: Blended Belotero; Device
Lead sponsor: Skin Care and Laser Physicians of Beverly Hills; Other
Eligibility: 25 Years to 75 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Photodamage of the Face, Anti Aging
Interventions: MASK LED, LED MASK AND COSMETIC FORMULA; Device · Combination Product
Lead sponsor: L'Oreal; Industry
Eligibility: 35 Years to 60 Years · Female only
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Piscataway, New Jersey

Conditions: Periocular Fine Wrinkles
Interventions: Split-Face Tixel Treatment With and Without Topical Peptide-Based Cosmeceutical (P-TIOX); Combination Product
Lead sponsor: Main Line Center for Laser Surgery; Other
Eligibility: 30 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Ardmore, Pennsylvania

Conditions: Wrinkles, Rhytids, Skin Laxity
Interventions: Ulthera® Treatment; Device
Lead sponsor: Ulthera, Inc; Industry
Eligibility: 30 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Rockville, Maryland

Conditions: Skin Laxity, Wrinkles
Interventions: Not listed
Lead sponsor: Ulthera, Inc; Industry
Eligibility: 25 Years to 85 Years
Enrollment: 48 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: San Diego, California

Conditions: Facial Wrinkles
Interventions: Aquamid, Restylane; Device
Lead sponsor: Contura; Industry
Eligibility: 18 Years and older
Enrollment: 315 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: White Plains, New York

Conditions: Facial Wrinkles, Skin Aging
Interventions: Cryo-Touch III; Device
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 30 Years to 70 Years
Enrollment: 88 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2014
U.S. locations: 1
States / cities: Redwood City, California

Search by objective public record fields.

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation

A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides

Study of the MyoScience Tissue Remodeling Device for Facial Rejuvenation

A Study to Compare Subject Comfort During and After Injections With the Study Products and the Safety of the Non-FDA Approved Product for the Correction of Nasolabial Folds (NLFs)

Efficacy and Safety Study of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults

Poly-L-lactic Acid for Skin Quality

Straberi Epistamp Needling Treatment For Skin Rejuvenation

A Study to Evaluate the Safety and Effectiveness of the Cryo-Touch II Device for the Treatment of Forehead and/or Glabellar Lines

Efficacy and Safety Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines

Safety & Efficacy Evaluation of a Radiofrequency & Laser/Light System for Improvement of Skin Texture

A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique.

Lateral Canthal Rhytides With Medium Depth Chemical Peel With or Without Pretreatment With Botulinum Toxin A

A Clinical Study to Evaluate Efficacy and Safety of a Cosmetic Product in the Treatment of Facial Lines

Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines

Treatment of Forehead/Glabellar Rhytide Complex With Combination Botulinum Toxin A and Hyaluronic Acid Versus Botulinum Toxin A Injection Alone

Evaluation of Safety and Efficacy of TriPollar Device for Treatment of Wrinkles

The Effects of Almond on Facial Skin Collagen and Wrinkles

A Study Evaluating Blended Belotero for the Treatment of Etched-in Fine Facial Lines

Evaluation of the Efficacy and Tolerability of the LED Mask With or Without the Serum Formula on the Signs of Facial Photodamage .

Effects of P-TIOX and Tixel Combined on Reducing Eye Wrinkles

Evaluation of the Ulthera® System for Treatment of the Face and Neck

A Retrospective Study to Evaluate the Effectiveness of the Ulthera System

Safety and Effectiveness of Aquamid as Compared to Restylane for the Aesthetic Treatment of Nasolabial Folds

Cryo-Touch III Refinement Study Investigational Plan