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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:44 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 49–72 of 127 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Facial Rhytides Clear all

Conditions: Facial Skin Aging, Facial Volume Loss, Wrinkle Appearance
Interventions: GLP-1 Receptor Agonists; Drug
Lead sponsor: Ponsky Facial Aesthetics And Plastic Surgery, Llc; Industry
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Beachwood, Ohio

Conditions: Photoaging, Wrinkle, Sun Damaged Skin
Interventions: Same Day Intervention of VI Peel (Procedure) and Botulinum Toxin (Drug); Combination Product
Lead sponsor: Vitality Institute Medical Products; Industry
Eligibility: 30 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Rancho Mirage, California

Conditions: Cosmetic Techniques
Interventions: Onabotulinumtoxina for Injection, Abobotulinumtoxina for Injection, IncobotulinumtoxinA for Injection, PrabotulinumtoxinA for Injection; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 30 Years to 65 Years · Female only
Enrollment: 143 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Intrinsic Aging of Skin
Interventions: Juvéderm Ultra, Cosmoderm 1; Device
Lead sponsor: Steven Fagien; Other
Eligibility: 25 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Boca Raton, Florida

Conditions: Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin, Sebum Deficiency
Interventions: Topical Product: Almond Oil, Topical Product: Almond oil augmented with 0.5% Vitamin E, Topical Product: 0.025% Tretinoin oil augmented with castor oil; Other
Lead sponsor: Integrative Skin Science and Research; Industry
Eligibility: 18 Years and older · Female only
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Skin Laxity, Wrinkles
Interventions: Ulthera System Treatment, Thermage; Device
Lead sponsor: Ulthera, Inc; Industry
Eligibility: 30 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: San Diego, California

Conditions: Facial Wrinkles
Interventions: CosmoDerm1, Belotero Soft; Device
Lead sponsor: Merz North America, Inc.; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 5
States / cities: Los Angeles, California • San Francisco, California • New Haven, Connecticut + 2 more

Conditions: Lax Skin
Interventions: Sofwave; Device
Lead sponsor: Sofwave Medical LTD; Industry
Eligibility: 35 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 2
States / cities: La Mesa, California • Durham, North Carolina

Conditions: Skin Wrinkling
Interventions: Emervel Classic Lidocaine, Juvederm® Ultra; Device
Lead sponsor: Galderma R&D; Industry
Eligibility: 18 Years and older
Enrollment: 171 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 12
States / cities: Birmingham, Alabama • Los Angeles, California • San Diego, California + 8 more

Conditions: Skin Rejuvenation, Skin Quality, Wrinkle, Nasolabial Fold
Interventions: PRFM injection, Saline injection; Procedure
Lead sponsor: New York Medical College; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Valhalla, New York

Conditions: Skin Wrinkling
Interventions: Emervel Deep Lidocaine, Juvederm Ultra Plus; Device
Lead sponsor: Galderma R&D; Industry
Eligibility: 18 Years and older
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 11
States / cities: Los Angeles, California • San Francisco, California • New Haven, Connecticut + 8 more

Conditions: Rhytides, Wrinkle
Interventions: Venus Viva; Device
Lead sponsor: Venus Concept; Industry
Eligibility: 22 Years and older
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
Interventions: RT001 Botulinum toxin type A (Dose A), RT001 Botulinum Toxin Type A (Dose B), Vehicle, Placebo; Drug · Other
Lead sponsor: Revance Therapeutics, Inc.; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010
U.S. locations: 1
States / cities: Coral Gables, Florida

Conditions: Wrinkle, Pigmentation, Skin Laxity, Skin Scarring
Interventions: Treatment with BTL-785F; Device
Lead sponsor: BTL Industries Ltd.; Industry
Eligibility: 22 Years and older
Enrollment: 39 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 3
States / cities: Greenwood Village, Colorado • Chevy Chase, Maryland • Birmingham, Michigan

Conditions: Facial Wrinkles, Jawline Contour, Skin Laxity
Interventions: SofWave; Device
Lead sponsor: Sofwave Medical LTD; Industry
Eligibility: 40 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Facial Wrinkles
Interventions: Cryo-Touch II; Device
Lead sponsor: Pacira Pharmaceuticals, Inc; Industry
Eligibility: 30 Years to 70 Years
Enrollment: 42 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Redwood City, California

Conditions: Rosacea, Wrinkles
Interventions: Luxe; Device
Lead sponsor: Syneron Medical; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 23 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012
U.S. locations: 2
States / cities: New York, New York

Conditions: Wrinkle, Photoaging, Fine Lines
Interventions: Gentle Cleansing Lotion, Revision Skincare, Aveeno Face Milk SPF 40+; Other
Lead sponsor: Revision Skincare; Industry
Eligibility: 35 Years to 65 Years · Female only
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Richardson, Texas

Conditions: Jowls
Interventions: JUVÉDERM VOLUMA™ XC; Device
Lead sponsor: Advanced Dermatology; Other
Eligibility: 35 Years to 75 Years · Female only
Enrollment: 16 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Lincolnshire, Illinois

Conditions: Wrinkle
Interventions: Defyne Treatment in Nasolabial Fold, RHA3 Treatment in Nasolabial Fold; Device
Lead sponsor: Galderma R&D; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Santa Rosa Beach, Florida

Conditions: Sebum Production, Stool Microbiome, Transepidermal Water Loss, Facial Brrightness, Erythema, Wrinkles, Facial Shine
Interventions: Placebo Oral Tablet, Rubia Cordifolia, Triphala; Dietary Supplement
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years to 60 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Laxity; Skin
Interventions: MCD; Device
Lead sponsor: Cytrellis Biosystems, Inc.; Industry
Eligibility: 40 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 5
States / cities: Sacramento, California • Miami, Florida • New York, New York + 2 more

Conditions: Skin Manifestations
Interventions: GP0116, Active Comparator: FDA approved dermal filler device (RHA 3); Device
Lead sponsor: Galderma R&D; Industry
Eligibility: 22 Years and older
Enrollment: 186 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 18
States / cities: Santa Monica, California • Vista, California • Westport, Connecticut + 14 more

Conditions: Facial Wrinkles
Interventions: Xeomin to right side of face in half of the subjects; Xeomin to left side of face in the other half of subjects, Botox to right side of face in half of the subjects (randomized); Botox to the left side of the face in the other half of subjects; Drug
Lead sponsor: YMD Eye and Face; Other
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Sarasota, Florida

Search by objective public record fields.

Comparing Facial Aging Between Identical Twins With 3D Imaging

Same-Day Combination of VI Peel and Botox for Correction of Sun Damage, Fine Lines and Wrinkles

Evaluation of Four Injectable Neuromodulators in the Glabella Area Glabella Area

Comparative Study of Reconstituted JUVÉDERM® Ultra vs COSMODERM® 1 for Lip and Cheek Lines, Folds or Wrinkles

The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles

Feasibility Study: Evaluation of Ulthera Versus Thermage for Treating the Face and Neck

Multicenter Study of the Safety and Efficacy of Dermal Filler, Belotero® Soft

Treatment to Lift Facial Lax Skin and Improve Facial Wrinkles Using Precise and Lift Applicators

Emervel Classic Lidocaine Versus Juvederm® Ultra in Treatment of Moderate to Severe Facial Wrinkles and Folds

The Effect of Platelet-rich Fibrin Matrix on Skin Rejuvenation

Emervel® Deep Lidocaine vs. Juvederm® Ultra Plus in Treatment of Moderate to Severe Facial Wrinkles and Folds

Clinical Evaluation of Fractional Radiofrequency for the Treatment and Reduction of Facial Wrinkles

A 4-Arm Efficacy and Safety Study of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults

Device for Improving Skin Quality and Texture on the Face and Neck

Evaluation of SofWave Sofware-Guided Energy Delivery for Lower Face and Neck Rejuvenation

Cryo-Touch II for the Treatment of Wrinkles

Safety and Efficacy of the Luxe Device to Treat Facial Wrinkles and Rosacea

An Open-Label Clinical Study to Evaluate the Efficacy of a Face Cream and Eye Cream

Jowl Improvement With Injectable Fillers

A Comparative Analysis of Two Hyaluronic Acid Fillers for Nasolabial Fold Correction

Pilot Study of Triphala and Rubia Cordifolia on Gut Microbiome and Skin

Pivotal Study to Evaluate the Safety and Efficacy of a Micro-coring Device Treating Moderate to Severe Facial Wrinkles

Study to Evaluate the Safety and Effectiveness of GP0116

Split-Face Prospective Study Comparing Botox to Xeomin for the Treatment of Facial Wrinkles