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ClinicalTrials.gov public records Last synced Nov 15, 2026, 1:56 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 73–96 of 127 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Facial Rhytides Clear all

Conditions: Facial Rhytides, Glabellar Rhytides
Interventions: OnabotulinumtoxinA, Normal Saline; Biological · Drug
Lead sponsor: Allergan; Industry
Eligibility: 18 Years and older
Enrollment: 787 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 10
States / cities: Little Rock, Arkansas • Los Angeles, California • Newport Beach, California + 6 more

Conditions: Wrinkles
Interventions: Onabotulinum Toxin A, Incobotulinum Toxin A; Drug
Lead sponsor: Northwestern University; Other
Eligibility: 20 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Wrinkle, Facial and Neck Skin Laxity
Interventions: micro-excisional skin removal with coring needle; Device
Lead sponsor: Cytrellis Biosystems, Inc.; Industry
Eligibility: 40 Years to 75 Years
Enrollment: 45 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2017
U.S. locations: 6
States / cities: Sacramento, California • Miami, Florida • Chestnut Hill, Massachusetts + 3 more

Conditions: Facial Wrinkles and Creases
Interventions: Autologous Human Fibroblasts (azficel-T); Biological
Lead sponsor: Castle Creek Biosciences, LLC.; Industry
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 5
States / cities: Beverly Hills, California • Santa Monica, California • Orlando, Florida + 2 more

Conditions: Hyperpigmentation, Photodamaged Skin, Wrinkle, Fine Lines
Interventions: Gentle Cleansing Lotion, Revision Skincare; Other
Lead sponsor: Revision Skincare; Industry
Eligibility: 35 Years to 60 Years · Female only
Enrollment: 33 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 3
States / cities: Solana Beach, California • Greenwood Village, Colorado • Nashville, Tennessee

Conditions: Nasolabial Folds
Interventions: tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream), benzocaine 20% / lidocaine 6% / tetracaine 4% ointment; Drug
Lead sponsor: Galderma R&D; Industry
Eligibility: 30 Years to 65 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008
U.S. locations: 4
States / cities: Aventura, Florida • West Palm Beach, Florida • New York, New York + 1 more

Conditions: Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
Interventions: Botulinum Toxin Type A, Placebo; Drug
Lead sponsor: Revance Therapeutics, Inc.; Industry
Eligibility: 30 Years to 60 Years
Enrollment: 73 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Wrinkle
Interventions: Cleansing Balm, Facial Serum, Moisturizer; Other
Lead sponsor: Integrative Skin Science and Research; Industry
Eligibility: 35 Years to 65 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Facial Wrinkles, Rhytides
Interventions: J-Plasma; Device
Lead sponsor: Apyx Medical; Industry
Eligibility: 30 Years and older
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 3
States / cities: Miami, Florida • Sarasota, Florida • Alpharetta, Georgia

Conditions: Skin Ageing, Facial Wrinkles, Acne, Skin Elasticity, Infraorbital Dark Circle Severity, Skin Firmness, UV Spots, Skin Texture, Skin Pores, Brown Spots, Porphyrins, Red Spots
Interventions: NIRA Laser M2.1, Topical; Device · Other
Lead sponsor: NIRA Innovations Inc.; Industry
Eligibility: 35 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025
U.S. locations: 1
States / cities: Beverly, Massachusetts

Conditions: Subjects Displaying Facial Ageing
Interventions: Skinstylus microneedling device; Device
Lead sponsor: Beauty Health; Industry
Eligibility: 35 Years to 75 Years
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Manhattan Beach, California • San Diego, California

Conditions: Skin Wrinkling
Interventions: Thermage FLX; Device
Lead sponsor: Lorraine Hickson; Other
Eligibility: 40 Years to 80 Years
Enrollment: 12 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Correction of Nasolabial Folds and Lip Augmentation
Interventions: PREVELLE Shape, Restylane; Device
Lead sponsor: Mentor Worldwide, LLC; Industry
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2007
U.S. locations: 1
States / cities: Santa Barbara, California

Conditions: Wrinkle
Interventions: BTL-785-7 Treatment; Device
Lead sponsor: BTL Industries Ltd.; Industry
Eligibility: 21 Years and older
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Upper Facial Lines
Interventions: BOTOX; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 7
States / cities: Birmingham, Alabama • San Francisco, California • Vista, California + 4 more

Conditions: Photoaging, Wrinkle, Skin Laxity
Interventions: Hybrid Fractional Laser, Facial Cleanser, Facial Moisturizer, Sunscreen; Procedure · Other
Lead sponsor: Revision Skincare; Industry
Eligibility: 35 Years to 65 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 2
States / cities: Atlanta, Georgia • Dallas, Texas

Conditions: Skin Aging, Skin Wrinkling
Interventions: PrabotulinumtoxinA-Xvfs, IncobotulinumtoxinA, saline solution (placebo); Drug
Lead sponsor: Kalpna Kay Durairaj, MD, FACS; Other
Eligibility: 18 Years to 65 Years · Female only
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Pasadena, California

Conditions: Skin Aging
Interventions: Active Mask, Sham Mask; Device
Lead sponsor: Johnson & Johnson Consumer Inc. (J&JCI); Industry
Eligibility: 35 Years to 70 Years · Female only
Enrollment: 124 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Broomall, Pennsylvania

Conditions: Benign Pigmented Lesions, Facial Wrinkles
Interventions: PicoWay™ 532nm fractional handpiece, PicoWay™ 730nm wavelength, PicoWay™ 1064nm fractional handpiece; Device
Lead sponsor: Candela Corporation; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Wayland, Massachusetts

Conditions: Fine Lines, Wrinkles, Laxity; Skin
Interventions: Gentle Cleanser, Facial Moisturizer, sunscreen SPF 30; Other
Lead sponsor: Revision Skincare; Industry
Eligibility: 35 Years to 60 Years · Female only
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Richardson, Texas

Conditions: Wrinkle
Interventions: BTL-785-7; Device
Lead sponsor: BTL Industries Ltd.; Industry
Eligibility: 21 Years and older
Enrollment: 21 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 5
States / cities: Gilbert, Arizona • San Marcos, California • Davie, Florida + 2 more

Conditions: Wrinkle
Interventions: Venus Aime; Device
Lead sponsor: Venus Concept; Industry
Eligibility: 22 Years to 75 Years
Enrollment: 70 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2025
U.S. locations: 2
States / cities: Chicago, Illinois • Charlotte, North Carolina

Conditions: Upper Facial Lines (Glabellar Lines, Forehead Lines, & Lateral Canthal Lines)
Interventions: DaxibotulinumtoxinA for injection; Drug
Lead sponsor: Revance Therapeutics, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 6
States / cities: Manhattan Beach, California • San Diego, California • Santa Monica, California + 3 more

Conditions: Lax Skin, Improve Facial Wrinkles
Interventions: Sofwave; Device
Lead sponsor: Sofwave Medical LTD; Industry
Eligibility: 35 Years to 60 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: San Diego, California

Search by objective public record fields.

A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides

A Pilot Study Testing Onabotulinum Toxin A Versus Incobotulinum Toxin A Injections for Facial Wrinkles

Evaluation of Safety and Efficacy of Micro-coring Device for Treatment of Facial Wrinkles and Skin Laxity

Safety and Efficacy Study of Isolagen TherapyTM in Treatment of Facial Wrinkles and Creases

A Multi-Center, Open-label Study Evaluate the Efficacy and Tolerability of a Dual Skincare Regimen Treatment for Facial Hyperpigmentation and Photodamaged Skin in Patients Exposed to Extrinsic Factors of Aging

Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections

Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines

The Effects of a 3-Part Skin Care Regimen on Facial Wrinkles and Biophysical Attributes

The Use of J-Plasma® for Dermal Resurfacing

Clinical Study Evaluating the Safety and Effectiveness of the NIRA Laser M2.1 for the Treatment of Full-Face Wrinkles

Evaluation of Efficacy and Safety of the Skinstylus Sterilock Microneedling System for the Treatment of Facial Wrinkles

Bausch Health Thermage FXL for Use on Lower Face and Submentum Area

PREVELLE Shape (CX002) Dermal Filler Protocol

BTL-785F Device for Non-invasive Facial Rejuvenation in Patients Injected With Botulinum Toxin

A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With a Hybrid-Fractional Laser for Facial Rejuvenation

Effects of Microtox on Facial Skin Quality, Fine Wrinkles, and Texture

Evaluation of the Efficacy and Tolerance of a Light Therapy Mask on Mild to Moderate Brown Spots and Moderate to Severe Facial Wrinkles

PicoWay™ 730 Resolve Fusion for Benign Pigmented Lesions and Wrinkles

A Clinical Study Evaluating the Efficacy and Tolerability of a Topical Facial Treatment For Facial Rejuvenation

BTL-785F Device for Non-invasive Reduction of Wrinkles and Overall Facial Improvement

Robotic Mechanical Coring for the Treatment of Moderate to Severe Facial Wrinkles

Efficacy and Safety of DaxibotulinumtoxinA (DAXI) for Injection for Treatment of Upper Facial Lines

In Vivo Study to Evaluate Tissue Remodeling Via Fibroblast Stimulation Following a Single SofWave Treatment