Independent directory Public ClinicalTrials.gov records United States
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ClinicalTrials.gov public records Last synced Oct 21, 2026, 3:23 AM EDT

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Showing 1–24 of 70 matching trials from the live ClinicalTrials.gov search.
Conditions
Ametropia, Myopia, Hyperopia, Astigmatism
Interventions
Serafilcon A toric contact lenses, Senofilcon A toric contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
7
States / cities
Oakland, California • San Francisco, California • Maitland, Florida + 4 more
Conditions
Myopia, Hyperopia, Astigmatism
Interventions
fanfilcon A, enfilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
17 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Berkeley, California
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Safety and Efficacy Study of Topography-Guided LASIK to Treat Myopia and Hyperopia

NCT01028378
Conditions
Myopia, Hyperopia
Interventions
T-CAT topography-guided LASIK treatment with the Allegretto Wave Eye-Q 400 Hz Excimer Laser
Device
Lead sponsor
Clinical Research Consultants, Inc.
Industry
Eligibility
18 Years and older
Enrollment
212 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2009
U.S. locations
10
States / cities
La Quinta, California • San Diego, California • Atlanta, Georgia + 5 more
Conditions
Laser in Situ Keratomileusis
Interventions
Not listed
Lead sponsor
Food and Drug Administration (FDA)
Federal
Eligibility
21 Years to 84 Years
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
San Diego, California
Conditions
Refractive Ametropia, Hyperopia, Myopia
Interventions
Lotrafilcon A spherical contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
108 participants
Timeline
2023
U.S. locations
4
States / cities
Tallahassee, Florida • Franklin Park, Illinois • Eden Prairie, Minnesota + 1 more
Conditions
Hyperopia, Myopia, Astigmatism
Interventions
LASIK and PRK
Procedure
Lead sponsor
Edward E. Manche
Other
Eligibility
21 Years to 60 Years
Enrollment
137 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2022
U.S. locations
1
States / cities
Stanford, California
Completed Not applicable Interventional Accepts healthy volunteers Results available

Correction of Farsightedness in Children Study

NCT00472212
Conditions
Hyperopia, Farsightedness
Interventions
Spectacles, Control
Device
Lead sponsor
Ohio State University
Other
Eligibility
6 Years to 11 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
4
States / cities
Chicago, Illinois • New York, New York • Columbus, Ohio + 1 more
Conditions
Hyperopia
Interventions
MEL 80 Hyperopic LASIK Treatment
Device
Lead sponsor
Carl Zeiss Meditec, Inc.
Industry
Eligibility
21 Years and older
Enrollment
189 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
6
States / cities
San Diego, California • Greenwood Village, Colorado • Kansas City, Missouri + 3 more
Completed Not applicable Interventional Results available

Clinical Investigation of the WaveLight® EX500 Excimer Laser

NCT04805593
Conditions
Hyperopia, Hyperopic Astigmatism
Interventions
WaveLight EX500 excimer laser system, LASIK
Device · Procedure
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Overland Park, Kansas • Kansas City, Missouri • Greensboro, North Carolina + 2 more
Conditions
Myopia, Amblyopia, Hyperopia, Refractive Errors
Interventions
Fitz Frames 3-D Printed Glasses
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
5 Years to 17 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Hyperopia Correction Using the NTK Optimal Keratoplasty (Opti-K) System

NCT01028937
Conditions
Hyperopia
Interventions
Optimal Keratoplasty
Device
Lead sponsor
NTK Enterprises, Inc.
Industry
Eligibility
40 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2018
U.S. locations
1
States / cities
Los Angeles, California
Conditions
Presbyopia, Astigmatism
Interventions
Lehfilcon A multifocal for astigmatism contact lenses, Samfilcon A multifocal for astigmatism contact lenses, CLEAR CARE® Cleaning & Disinfecting Solution
Device
Lead sponsor
Alcon Research
Industry
Eligibility
40 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
11
States / cities
Oakland, California • San Francisco, California • Maitland, Florida + 8 more
Completed Not applicable Interventional Results available

Hyperopia Treatment Study 1 (HTS1) - Glasses vs Observation

NCT01515475
Conditions
Hyperopia
Interventions
Glasses
Procedure
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
12 Months to 71 Months
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Columbus, Ohio • Salt Lake City, Utah
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

The VIS Opti-K Low Vision Aid Device Provides Vision Improvement.

NCT06597292
Conditions
Hyperopia, Presbyopia
Interventions
Vision improvement
Device
Lead sponsor
VIS, Inc.
Industry
Eligibility
40 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Austin, Texas
Conditions
Refractive Errors, Myopia, Hyperopia
Interventions
Lotrafilcon A contact lenses, Balafilcon A contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Fort Worth, Texas
Completed Phase 4 Interventional Accepts healthy volunteers Results available

On-Eye Optical Quality of Lotrafilcon B Lenses Over 12 Hours

NCT03881670
Conditions
Hyperopia, Myopia
Interventions
Lotrafilcon B, lotrafilcon B with Hydraluxe
Device
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 35 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Bloomington, Indiana
Conditions
Myopia, Hyperopia
Interventions
Sapphire, senofilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
17 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Berkeley, California
Conditions
Anisometropia, Hyperopia, High Myopia, Amblyopia Isometropic, Amblyopia Bilateral, High Astigmatism
Interventions
Photorefractive keratectomy
Procedure
Lead sponsor
Baylor College of Medicine
Other
Eligibility
2 Years to 17 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2024
U.S. locations
1
States / cities
Houston, Texas
Completed Not applicable Interventional Accepts healthy volunteers

APIOC for Presbyopia and APIOC for Presbyopia With Astigmatism

NCT04883099
Conditions
Presbyopia, Myopia, Hyperopia, Astigmatism
Interventions
APIOC for Presbyopia and APIOC for Presbyopia for Astigmatism
Device
Lead sponsor
Lentechs, LLC
Industry
Eligibility
40 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
6
States / cities
San Diego, California • Orlando, Florida • Lexington, Kentucky + 3 more
Conditions
Hyperopia
Interventions
TENEO 317 Model 2 excimer laser
Device
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
22 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
9
States / cities
Newport Beach, California • Fort Myers, Florida • Bloomington, Minnesota + 6 more
Conditions
Myopia, Hyperopia
Interventions
narafilcon B daily disposable soft contact lenses, etafilcon A daily disposable soft contact lenses
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
8 Years and older
Enrollment
1,171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
37
States / cities
Campbell, California • Fullerton, California • Huntington Beach, California + 29 more
Completed Not applicable Interventional Results available

Clinical Evaluation of a Daily Wear Silicone Hydrogel Lens

NCT04207749
Conditions
Refractive Errors, Myopia, Hyperopia
Interventions
LID015385 contact lenses, Comfilcon A contact lenses, CLEAR CARE
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
18
States / cities
Glendale, Arizona • Brentwood, California • Irvine, California + 15 more
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Silicone Hydrogel Daily Wear Contact Lenses for Up to One (1) Month of Daily Wear

NCT03722784
Conditions
Myopia, Hyperopia, Astigmatism
Interventions
Invigor A (test), Invigor B (control)
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
6
States / cities
Torrance, California • East Lansing, Michigan • St Louis, Missouri + 3 more
Completed Not applicable Interventional Results available

Clinical Assessment of a HYDRAGLYDE® Regimen

NCT03026257
Conditions
Refractive Errors, Myopia, Hypermetropia
Interventions
Lotrafilcon B contact lenses with added wetting agent, Samfilcon A contact lenses, POLYQUAD/ALDOX-preserved contact lens solution with added wetting agent, Hydrogen peroxide-based contact lens solution with added wetting agent, Senofilcon C contact lenses, Senofilcon A contact lenses, Comfilcon A contact lenses, Habitual Multi-Purpose Solution (HMPS)
Device
Lead sponsor
Alcon, a Novartis Company
Industry
Eligibility
18 Years and older
Enrollment
323 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
5
States / cities
Birmingham, Alabama • Cleveland, Ohio • Columbus, Ohio + 2 more