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ClinicalTrials.gov public records Last synced Oct 25, 2026, 11:41 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 937–960 of 1,048 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Fatigue Symptom Clear all
Completed Not applicable Interventional

Yoga in Controlling Symptoms and Reducing Stress in Women With Ovarian Cancer or Breast Cancer

NCT00337233
View directory record Official record
Conditions
Breast Cancer, Fatigue, Ovarian Cancer, Psychosocial Effects of Cancer and Its Treatment
Interventions
yoga therapy
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 120 Years · Female only
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2016
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Not applicable Interventional

Refining a Biobehavioral Intervention to Enhance Recovery Following Hematopoietic Stem Cell Transplantation

NCT02719821
View directory record Official record
Conditions
Hodgkin's Lymphoma, Leukemia, Lymphoid Leukemia, Multiple Myeloma, Myeloid Leukemia, Non-hodgkin's Lymphoma, Myelodysplastic Syndrome
Interventions
Behavioral techniques
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 74 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 15, 2019 · Synced Oct 25, 2026, 11:41 PM EDT
Recruiting Phase 3 Interventional

Two Arm, Double-blind, Phase III Study Assessing Efficacy and Safety of Ianalumab Versus Placebo, in Participants With Sjögren's Disease With High Symptom Burden

NCT07621809
View directory record Official record
Conditions
Sjögren´s Disease
Interventions
VAY736, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
570 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2033
U.S. locations
20
States / cities
Peoria, Arizona • Clearwater, Florida • Tampa, Florida + 17 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Not applicable Interventional

A Pilot Study to Examine Sleep and Fatigue in Pediatric Brain Tumor Patients Hospitalized for High Dose Chemotherapy

NCT00666614
View directory record Official record
Conditions
Sleep, Fatigue
Interventions
Sleep Environment Intervention, Normal Hospital Environment
Other
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
4 Years to 21 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Aug 19, 2019 · Synced Oct 25, 2026, 11:41 PM EDT
Recruiting Not applicable Interventional

A Motion Exergaming Approach for Symptom Management: HNC

NCT04632654
View directory record Official record
Conditions
Head and Neck Cancer
Interventions
A personalized Physical Activity intervention with fitness graded Motion Exergames (PAfitME)
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Phase 4 Interventional Results available

Rasagiline for the Symptomatic Treatment of Fatigue in Parkinson's Disease

NCT01168596
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Rasagiline, Placebo
Drug
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 85 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
3
States / cities
Aurora, Colorado • Gainesville, Florida • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 10, 2014 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Phase 2 Interventional

Testing the Effects of Methylphenidate on Multiple Sclerosis

NCT02286557
View directory record Official record
Conditions
Fatigue in Multiple Sclerosis
Interventions
Methelphenidate, Placebo
Drug
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Disulfiram: A Test of Symptom Reduction Among Patients With Previously Treated Lyme Disease

NCT03891667
View directory record Official record
Conditions
Fatigue, Quality of Life
Interventions
Disulfiram
Drug
Lead sponsor
Research Foundation for Mental Hygiene, Inc.
Other
Eligibility
18 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Oct 25, 2026, 11:41 PM EDT
Completed No phase listed Observational

Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy

NCT01143467
View directory record Official record
Conditions
Cancer, Fatigue
Interventions
Not listed
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
18 Years to 100 Years · Male only
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 6, 2017 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Not applicable Interventional Results available

Mindfulness-Based Stress Reduction for Gulf War Syndrome

NCT01267045
View directory record Official record
Conditions
Persian Gulf Syndrome
Interventions
Mindfulness-based stress reduction
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 80 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 7, 2015 · Synced Oct 25, 2026, 11:41 PM EDT
Recruiting Phase 1 Interventional

Early Cognitive Behavioral Therapy for Insomnia (CBT-I) in People Planning to Under Hematopoietic Stem Cell Transplant (HSCT)

NCT07774039
View directory record Official record
Conditions
Hematopoietic Stem Cell Transplant
Interventions
Cognitive behavioral therapy for insomnia (CBT-I)
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Oct 25, 2026, 11:41 PM EDT
Terminated Early Phase 1 Interventional

Effect of Ketamine on Fatigue Following Cancer Therapy

NCT02317341
View directory record Official record
Conditions
Cancer, Fatigue, Ketamine
Interventions
Ketamine, Placebo (saline), Midazolam, Midazolam(placebo)
Drug
Lead sponsor
National Institute of Nursing Research (NINR)
NIH
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 20, 2019 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fire Fighter Fatigue Management Program: Operation Fight Fatigue

NCT01672502
View directory record Official record
Conditions
Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea, Impaired Driving
Interventions
Sleep health education provided via a web-based program, Sleep disorder detection and treatment, Optimization of Sleep in Fire Station
Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
620 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2016 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Not applicable Interventional

Maximizing Energy and Reducing Fatigue in Breast Cancer Survivors

NCT06879522
View directory record Official record
Conditions
Breast Cancer Survivor, Cancer Related Fatigue
Interventions
Maximizing Energy Intervention, Health Education
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 25, 2026, 11:41 PM EDT
Active, not recruiting Phase 2 Interventional

Ketamine for Multiple Sclerosis Fatigue

NCT05378100
View directory record Official record
Conditions
Multiple Sclerosis Fatigue
Interventions
Ketamine, Midazolam
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 25, 2026, 11:41 PM EDT
Completed No phase listed Observational

Examining the Relationships Between Sleep, Fatigue, and Pain in Aromatase Inhibitor-treated Patients

NCT01983995
View directory record Official record
Conditions
Breast Cancer
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older · Female only
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 25, 2016 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Phase 2 Interventional Results available

Vitamin D3 for Aromatase Inhibitor Induced Arthralgias

NCT00867217
View directory record Official record
Conditions
Breast Cancer
Interventions
High Dose Vitamin D, Placebo, Standard Dose Vitamin D3, Letrozole 2.5mg
Dietary Supplement · Drug
Lead sponsor
Qamar Khan
Other
Eligibility
18 Years and older · Female only
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
2
States / cities
Westwood, Kansas • Wichita, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 9, 2018 · Synced Oct 25, 2026, 11:41 PM EDT
Not yet recruiting Early Phase 1 Interventional Accepts healthy volunteers

The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold

NCT07224282
View directory record Official record
Conditions
Exogenous Ketosis
Interventions
Ketone supplementation, Carbohydrate
Dietary Supplement
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Norman, Oklahoma
Source: ClinicalTrials.gov public record
Updated Nov 4, 2025 · Synced Oct 25, 2026, 11:41 PM EDT
Terminated Phase 1 Interventional

A Study to Assess the Anti-fatigability Effect of CK-2127107 in Elderly Male and Female Subjects With Limitations in Mobility

NCT03065959
View directory record Official record
Conditions
Mobility Limitation
Interventions
reldesemtiv, Placebo
Drug
Lead sponsor
Astellas Pharma Global Development, Inc.
Industry
Eligibility
65 Years to 89 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
5
States / cities
Gainesville, Florida • Boston, Massachusetts • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 31, 2024 · Synced Oct 25, 2026, 11:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Muscle Fatigability and Trip-specific Fall Risk in Adults With Knee Osteoarthritis

NCT06229691
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
30 minute treadmill walk
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
55 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 25, 2026, 11:41 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Ashwagandha Extract on Stress Levels

NCT06793891
View directory record Official record
Conditions
Stress
Interventions
ashwagandha root, ashwagandha root and leaf, placebo
Dietary Supplement · Other
Lead sponsor
Nutraceuticals Research Institute
Other
Eligibility
30 Years to 59 Years · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Huntsville, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Oct 25, 2026, 11:41 PM EDT
Terminated Phase 2 Interventional Results available

Nuvigil or Placebo in Newly Diagnosed Malignant Glioma

NCT01400958
View directory record Official record
Conditions
Malignant Glioma
Interventions
Nuvigil®, Placebo
Drug
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 16, 2013 · Synced Oct 25, 2026, 11:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression

NCT00001479
View directory record Official record
Conditions
Fatigue Syndrome, Chronic, Healthy, Mood Disorders
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
Not listed
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 2000
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 25, 2026, 11:41 PM EDT
Terminated Phase 2 Interventional

Insulin-sensitizing NE3107 in Improving Sleep and Fatigue in Subjects With Traumatic Brain Injury

NCT05970575
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
NE3107
Drug
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
18 Years to 74 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Jul 25, 2025 · Synced Oct 25, 2026, 11:41 PM EDT