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Showing 1–24 of 30 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Flavonoids Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Flavonoids, Exercise, Gut-Derived Phenolics

NCT03249571
View directory record Official record
Conditions
Exercise and Gut-derived Phenolics
Interventions
Flavonoid supplement, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 50 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 10, 2017 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans

NCT05773794
View directory record Official record
Conditions
Human Health, Reactive Carbonyl Species, Polyphenols
Interventions
Soymilk, green tea, or blueberry, Control group
Dietary Supplement
Lead sponsor
North Carolina Agriculture & Technical State University
Other
Eligibility
25 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 7, 2026, 4:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cognition, Flavonoids, Exercise, Gut Microbiome

NCT06495190
View directory record Official record
Conditions
Cognitive Decline, Mild
Interventions
Blueberry, Walking, Placebo, Stretching
Dietary Supplement · Behavioral
Lead sponsor
Appalachian State University
Other
Eligibility
65 Years to 85 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 11, 2025 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional

Effect of Grape Seed Extract Plus Ascorbic Acid on Endothelial Function

NCT00554242
View directory record Official record
Conditions
Coronary Artery Disease
Interventions
Grape seed extract and ascorbic acid
Dietary Supplement
Lead sponsor
Boston University
Other
Eligibility
21 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 17, 2009 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

ABSORB (Amount of Blueberries So Older Adults Reap Benefits)

NCT05937165
View directory record Official record
Conditions
Depressive Symptoms, Aging
Interventions
Freeze-dried Blueberry Powder
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
65 Years and older
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 7, 2026, 4:56 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Flavonoids in the Treatment of Endothelial Dysfunction in Children With Diabetes

NCT01307917
View directory record Official record
Conditions
Diabetic Nephropathy, Endothelial Dysfunction
Interventions
flavonoids
Dietary Supplement
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
12 Years to 21 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
Amarillo, Texas
Source: ClinicalTrials.gov public record
Updated Dec 16, 2012 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Phase 2 Interventional Results available

Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease

NCT04514510
View directory record Official record
Conditions
Sickle Cell Disease
Interventions
Isoquercetin, Placebo
Drug
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 70 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 1, 2024 · Synced Sep 7, 2026, 4:56 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers Results available

Carotenoid and Flavonoid Absorption From Red and Tangerine-Type Tomatoes

NCT01696773
View directory record Official record
Conditions
Carotenoid and Flavonoid Absorption
Interventions
Tangerine tomato juice, Red tomato juice
Other
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 70 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2027
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Blackberry Flavonoid Absorption and Effects on Intestinal Bacteria

NCT01944579
View directory record Official record
Conditions
Metabolic Syndrome
Interventions
Blackberries, Control
Other
Lead sponsor
Janet Novotny
Federal
Eligibility
25 Years to 75 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Beltsville, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 21, 2014 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Phase 1 Interventional Results available

Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD)

NCT01708278
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Quercetin, Placebo - sugar chew
Drug · Other
Lead sponsor
University of Michigan
Other
Eligibility
40 Years to 80 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 25, 2016 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of a Cocoa Shot on the Human Brain

NCT01924481
View directory record Official record
Conditions
Caffeine, Flavonoids
Interventions
High Caffeine, Low caffeine, High theobromine, low theobromine, No theobromine
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 38 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Black Tea Intake on Serum Lipids

NCT01882283
View directory record Official record
Conditions
Hypercholesterolemia
Interventions
Tea Treatment Group, Placebo
Dietary Supplement
Lead sponsor
University of Minnesota
Other
Eligibility
45 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2004
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2019 · Synced Sep 7, 2026, 4:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Flavonoid Foods on Carbonyl Stress

NCT07767149
View directory record Official record
Conditions
Human Health, Flavonoids, Carbonyl Stress
Interventions
High-Flavonoid Diet, Low-Flavonoid Diet
Dietary Supplement
Lead sponsor
North Carolina Agriculture & Technical State University
Other
Eligibility
25 Years to 70 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Flavonoid Effect on Activation and Stimulation of Thrombocytes, hsCRP and Lipid Profile

NCT00559663
View directory record Official record
Conditions
Healthy
Interventions
Green tea, 70% dark chocolate
Dietary Supplement
Lead sponsor
LifeBridge Health
Other
Eligibility
18 Years to 55 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 19, 2007 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Bioavailability of Flavonoids and Phenolic Acids From Cranberry Juice Cocktail in Healthy Older Adults

NCT00740077
View directory record Official record
Conditions
Healthy
Interventions
Low calorie, sugar-free cranberry juice cocktail (54% juice)
Other
Lead sponsor
Tufts University
Other
Eligibility
50 Years to 70 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2009 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional

Pomegranate and Hemodialysis Pilot Trial

NCT01562340
View directory record Official record
Conditions
End Stage Renal Disease, Cardiovascular Disease, Inflammation
Interventions
Pomegranate juice, Pomegranate fruit extract
Other
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Sep 7, 2026, 4:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Polyphenols and Cognitive Decline

NCT06507254
View directory record Official record
Conditions
Cognitive Decline, Cognitive Dysfunction
Interventions
Polyphenol Supplement, Placebo Supplement
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
50 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Phase 1 Interventional

A Pilot Study of the Grapefruit Flavonoid Naringenin for HCV Infection

NCT01091077
View directory record Official record
Conditions
Hepatitis C Virus, HCV Infection, Chronic HCV, Hepatitis C
Interventions
Naringenin
Dietary Supplement
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 22, 2015 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Flavonoid-rich Supplement Influence on the Human Metabolome

NCT03004742
View directory record Official record
Conditions
Inflammation
Interventions
Flavonoid, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 1, 2017 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Gut Microbial Metabolites of Apple Polyphenols

NCT06107192
View directory record Official record
Conditions
Healthy, Controlled Feeding Trial
Interventions
Dietary intervention - apple catechin diet, Dietary intervention - low catechin diet
Other
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 45 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 21, 2025 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Influence of Flavonoids and Caffeine Supplementation on Resting Metabolism

NCT03752125
View directory record Official record
Conditions
Diet Modification
Interventions
Flavonoid, caffeine, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
20 Years to 47 Years · Female only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 4, 2019 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Phase 4 Interventional

Inhibition of HBV Replication and Biological Reversal of Cirrhosis (F3-F4) and HCC by Flavonoids

NCT07084948
View directory record Official record
Conditions
Hepatitis B Virus Infection
Interventions
Flavonoid, Tenofovir
Drug
Lead sponsor
Trieu, Nguyen Thi, M.D.
Individual
Eligibility
18 Years to 80 Years
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2026
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Flavonoids on Gut Permeability in Cyclists

NCT03427879
View directory record Official record
Conditions
Gut Permeability, Gut Inflammation
Interventions
Low flavonoid beverage, High flavonoid beverage
Drug
Lead sponsor
Utah State University
Other
Eligibility
18 Years to 49 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Sep 7, 2026, 4:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tart Cherry Juice for Sleep in Older Adults With Insomnia: A Pilot Study of Feasibility and Comprehensive Mechanisms

NCT06786494
View directory record Official record
Conditions
Sleep Problems, Insomnia
Interventions
Tart Cherry Juice, Placebo juice
Other
Lead sponsor
Courtney Millar
Other
Eligibility
65 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 7, 2026, 4:56 PM EDT