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ClinicalTrials.gov public records Last synced Oct 22, 2026, 4:38 PM EDT

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Showing 1–24 of 33 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Fontan Operation Clear all
Completed Not applicable Interventional Results available

Spironolactone in Patients With Single Ventricle Heart

NCT00211081
View directory record Official record
Conditions
Congenital Disorders
Interventions
Spironolactone (drug)
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 22, 2026, 4:38 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Early Use of Vasopressin in Post-Fontan Management

NCT03088345
View directory record Official record
Conditions
Circulatory Perfusion Disorder, Congenital Heart Disease, Single-ventricle
Interventions
Vasopressin, Arginine, Placebo
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
3 Weeks to 18 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 7, 2020 · Synced Oct 22, 2026, 4:38 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Use of Vasopressin Following the Fontan Operation

NCT02975999
View directory record Official record
Conditions
Pleural Effusion, Single-ventricle
Interventions
Vasopressin, Normal Saline
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Months to 7 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Oak Lawn, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 24, 2024 · Synced Oct 22, 2026, 4:38 PM EDT
Terminated Phase 4 Interventional Results available

The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart Disease

NCT01971593
View directory record Official record
Conditions
Tetralogy of Fallot, Transposition of the Great Vessels With an Arterial Switch, Single Ventricle With a Fontan Palliation
Interventions
Eplerenone
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 4, 2018 · Synced Oct 22, 2026, 4:38 PM EDT
Terminated Phase 4 Interventional Results available

Aspirin as a Novel Anti-Inflammatory Modality in the Fontan Patients

NCT02966002
View directory record Official record
Conditions
Fontan Procedure
Interventions
Aspirin
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 18, 2018 · Synced Oct 22, 2026, 4:38 PM EDT
Completed No phase listed Observational

Biomarker Study for Heart Failure in Children With Single Ventricle Physiology

NCT00571233
View directory record Official record
Conditions
Tricuspid Atresia, Hypoplastic Left Heart Syndrome, Unbalanced AV Canal
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
1 Month to 6 Years
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2015
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 14, 2015 · Synced Oct 22, 2026, 4:38 PM EDT
Terminated Phase 2Phase 3 Interventional Results available

Colchicine in Postoperative Fontan Patients

NCT03575572
View directory record Official record
Conditions
Single-ventricle, Heart Diseases
Interventions
Colchicine
Drug
Lead sponsor
University of Michigan
Other
Eligibility
20 Months to 5 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 9, 2022 · Synced Oct 22, 2026, 4:38 PM EDT
Terminated No phase listed Observational

Development of Novel MRI Methods for Detecting, Discriminating, and Measuring Liver Fibrosis and Congestion in Fontan Patients

NCT03539757
View directory record Official record
Conditions
Liver Fibrosis
Interventions
Non-Contrast Magnetic Resonance Imaging
Device
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
8 Years to 99 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Oct 22, 2026, 4:38 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques

NCT01107990
View directory record Official record
Conditions
Fontan Procedure, Hypoplastic Left Heart Syndrome, Tricuspid Atresia, Double Inlet Left Ventricle
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
10 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Oct 22, 2026, 4:38 PM EDT
Active, not recruiting Phase 1 Interventional

Intramyocardial Injection of Autologous UCB-MNC During Fontan Surgery for SRV Dependent CHD

NCT04907526
View directory record Official record
Conditions
Congenital Heart Disease, SRV Dependent
Interventions
Autologous mononuclear cells
Biological
Lead sponsor
Timothy J Nelson, MD, PhD
Other
Eligibility
2 Years to 5 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
6
States / cities
Birmingham, Alabama • Los Angeles, California • Aurora, Colorado + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2025 · Synced Oct 22, 2026, 4:38 PM EDT
Completed Phase 4 Interventional Results available

Study of Effects of Sildenafil on Patients With Fontan Heart Circulation

NCT01815502
View directory record Official record
Conditions
Single Ventricle Heart Disease After Fontan Surgery
Interventions
Cardiac catheterization
Diagnostic Test
Lead sponsor
Medical University of South Carolina
Other
Eligibility
3 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 7, 2018 · Synced Oct 22, 2026, 4:38 PM EDT
Completed No phase listed Observational

Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction

NCT02135081
View directory record Official record
Conditions
Single Ventricle Defect
Interventions
Not listed
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
4 Months to 10 Years
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 19, 2018 · Synced Oct 22, 2026, 4:38 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis

NCT04867954
View directory record Official record
Conditions
Cirrhosis, Liver, Gastroesophageal Varices, Fontan Procedure
Interventions
Ensure Plus®, Pre-clinical validation contrast enhanced MRI, Clinical validation MRI, Pre-clinical validation contrast enhanced MRI + fasting
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 22, 2026, 4:38 PM EDT
Completed No phase listed Observational

Ventricular and Pulmonary Vascular Reserve After the Fontan Operation

NCT03853837
View directory record Official record
Conditions
Heart Failure, Congenital Heart Disease
Interventions
rest-exercise echocardiography
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 6, 2022 · Synced Oct 22, 2026, 4:38 PM EDT
Completed Phase 2Phase 3 Interventional Results available

The Effects of Inhaled Nitric Oxide After Fontan Operation

NCT00945529
View directory record Official record
Conditions
Congenital Heart Defect
Interventions
inhaled nitric oxide (iNO)
Drug
Lead sponsor
Ellen Spurrier
Other
Eligibility
1 Year to 5 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated May 19, 2023 · Synced Oct 22, 2026, 4:38 PM EDT
Completed No phase listed Observational

Fontan Imaging Biomarkers (FIB) Study

NCT03119090
View directory record Official record
Conditions
Single-ventricle, Congenital Heart Disease
Interventions
Not listed
Lead sponsor
Boston Children's Hospital
Other
Eligibility
3 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 5, 2021 · Synced Oct 22, 2026, 4:38 PM EDT
Completed Not applicable Interventional Results available

Stage 3 Fontan Operation Liver Ultrasound Study

NCT02269709
View directory record Official record
Conditions
Fontan Operation
Interventions
ARFI Ultrasound
Device
Lead sponsor
University of Michigan
Other
Eligibility
Up to 17 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 12, 2018 · Synced Oct 22, 2026, 4:38 PM EDT
Terminated Not applicable Interventional Results available

Perioperative Treprostinil in Pediatric Patients Undergoing the Fontan Operation

NCT02498444
View directory record Official record
Conditions
Single Ventricle
Interventions
Treprostinil
Drug
Lead sponsor
Stanford University
Other
Eligibility
1 Year to 18 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Mar 31, 2022 · Synced Oct 22, 2026, 4:38 PM EDT
Completed Phase 2 Interventional Results available

Transfusion Strategies in Pediatric Cardiothoracic Surgery

NCT00350220
View directory record Official record
Conditions
Congenital Heart Disease
Interventions
transfusion strategy, Low Hb transfusion group
Other
Lead sponsor
University of Rochester
Other
Eligibility
4 Months to 7 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 26, 2015 · Synced Oct 22, 2026, 4:38 PM EDT
Terminated No phase listed Observational

Pulmonary Resistance in Fontan Who Have Undergone Heart Transplantation

NCT00268047
View directory record Official record
Conditions
Congenital Disorders
Interventions
Not listed
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
Up to 21 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 6, 2011 · Synced Oct 22, 2026, 4:38 PM EDT
Completed No phase listed Observational

Cholate Clearance in Fontans

NCT03726229
View directory record Official record
Conditions
Fontan Procedure
Interventions
Cholate assay
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 10, 2022 · Synced Oct 22, 2026, 4:38 PM EDT
Completed Phase 3 Interventional Results available

A Extension Study of Udenafil in Adolescents

NCT03013751
View directory record Official record
Conditions
Functional Single Ventricle Heart Disease
Interventions
Udenafil
Drug
Lead sponsor
Mezzion Pharma Co. Ltd
Industry
Eligibility
12 Years to 18 Years
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
21
States / cities
Phoenix, Arizona • Los Angeles, California • San Diego, California + 18 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2025 · Synced Oct 22, 2026, 4:38 PM EDT
Completed Phase 4 Interventional Results available

The Effects of Ambrisentan on Exercise Capacity in Fontan Patients

NCT01971580
View directory record Official record
Conditions
Single Ventricle Fontan Palliation
Interventions
Ambrisentan
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Oct 22, 2026, 4:38 PM EDT
Terminated No phase listed Observational

Intra-Atrial vs. Extra-Cardiac Technique During Fontan Operation

NCT00266942
View directory record Official record
Conditions
Congenital Disorders
Interventions
Not listed
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
Up to 18 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1990 – 2007
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated May 23, 2007 · Synced Oct 22, 2026, 4:38 PM EDT