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ClinicalTrials.gov public records Last synced Sep 30, 2026, 4:00 AM EDT

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Showing 25–48 of 61 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Foot Orthoses Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

The Effects of Footplate Stiffness on Foot Loading Within Carbon Fiber Custom Dynamic Orthoses

NCT07312032
View directory record Official record
Conditions
Trauma Injury
Interventions
Carbon Fiber Custom Dynamic Orthosis, Carbon Fiber Footplate
Device
Lead sponsor
Jason Wilken
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 31, 2025 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Not applicable Interventional Results available

Ankle-foot Orthoses for Peripheral Artery Disease

NCT02280200
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
AFO to improve outcomes
Device
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated Jul 31, 2019 · Synced Sep 30, 2026, 4:00 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Reliability of Force Measurement Within the Carbon Fiber Orthosis Proximal Cuff

NCT06127264
View directory record Official record
Conditions
Healthy, Ankle Foot Orthosis (AFO), Peripheral Neuropathy
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 31, 2025 · Synced Sep 30, 2026, 4:00 AM EDT
Active, not recruiting Not applicable Interventional

C-Brace II Spinal Cord Injury

NCT03930056
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
C-Brace II, Traditional Care KAFO intervention
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Not applicable Interventional

Evaluating a New Knee-Ankle-Foot Brace to Improve Gait in Children With Movement Disorders

NCT01961557
View directory record Official record
Conditions
Incomplete Spinal Cord Injury, Muscular Dystrophy, Spina Bifida, Cerebral Palsy
Interventions
EA-KAFO
Device
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
5 Years to 100 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Heel Wedges and Carbon Fiber Custom Dynamic Orthoses to Control Knee Biomechanics

NCT05209360
View directory record Official record
Conditions
Adult ALL, Healthy
Interventions
Medial or Lateral Wedge, Carbon Fiber Custom Dynamic Orthosis
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 45 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 30, 2024 · Synced Sep 30, 2026, 4:00 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Software Generated Customized Foot Orthoses

NCT05462912
View directory record Official record
Conditions
Arthropathy of Ankle or Foot
Interventions
custom foot orthotic
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Aug 1, 2025 · Synced Sep 30, 2026, 4:00 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

SCANLOAD: The Effect of Limb Loading on Lower Limb Geometry

NCT04600102
View directory record Official record
Conditions
Foot Injuries and Disorders
Interventions
Structure Sensor
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 11, 2022 · Synced Sep 30, 2026, 4:00 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers Results available

SCANREP: Reliability of 3D Lower Limb Scanning

NCT04032041
View directory record Official record
Conditions
Foot Injuries and Disorders
Interventions
Structure Sensor, Caliper
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 10, 2025 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Custom Molded Foot Orthoses Effect on Foot Kinematics and Lower Extremity Electromyography During Walking and Running.

NCT02143947
View directory record Official record
Conditions
Lower Extremity Pain of a Mechanical Origin
Interventions
Maximal Arch Subtalar Stabilization, Full Contact Orthosis
Device
Lead sponsor
Quinnipiac University
Other
Eligibility
18 Years to 60 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Hamden, Connecticut
Source: ClinicalTrials.gov public record
Updated May 18, 2015 · Synced Sep 30, 2026, 4:00 AM EDT
Not listed Not applicable Interventional

Efficacy of a Custom Temporary Foot Orthosis for Plantar Fasciitis Treatment

NCT01882894
View directory record Official record
Conditions
Plantar Fasciitis
Interventions
Custom PFO, Faux orthosis
Device · Other
Lead sponsor
University of Puget Sound
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Jun 21, 2013 · Synced Sep 30, 2026, 4:00 AM EDT
Terminated Not applicable Interventional Results available

Effectiveness of Ankle Foot Orthoses on Gait in Multiple Sclerosis

NCT01796860
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
AFO
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2015 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Not applicable Interventional Results available

Comparison of the Functional Walking Outcomes of Two Settings of a Commercially Available AFO in Adult Stroke Patients

NCT02122783
View directory record Official record
Conditions
Walking Aided by a Leg Brace in Stroke Subjects
Interventions
ADR™ brace resistance, Conventional brace resistance (using hard stops)
Device
Lead sponsor
Albert Einstein Healthcare Network
Other
Eligibility
21 Years to 70 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
1
States / cities
Elkins Park, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 30, 2026, 4:00 AM EDT
Withdrawn Not applicable Interventional

Custom Dynamic Orthoses to Reduce Articular Contact Stress

NCT05209347
View directory record Official record
Conditions
Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions
Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 30, 2026, 4:00 AM EDT
Not listed Not applicable Interventional

Kinematic and Kinetic Effects of Orthotic Devices for Subjects With Stage II Posterior Tibial Tendon Dysfunction

NCT01749657
View directory record Official record
Conditions
Posterior Tibial Tendon Dysfunction
Interventions
Arizona
Device
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
40 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2014 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Orthotic Dose Response Study

NCT02629731
View directory record Official record
Conditions
Ankle Osteoarthritis, Flat Foot or Pes Planus
Interventions
custom orthoses with varying degrees of hindfoot posting
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2023
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 21, 2024 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Do Rocker Bottom Shoes and Ankle-Foot Orthoses Reduce Pain and Improve Mobility for Ankle Osteoarthritis Patients

NCT03524729
View directory record Official record
Conditions
Ankle Osteoarthritis, Healthy Ankles
Interventions
Rocker bottom shoe, Ankle foot orthosis, Standard walking shoe
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Sep 30, 2026, 4:00 AM EDT
Recruiting Phase 2 Interventional

Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy

NCT07434492
View directory record Official record
Conditions
Cerebral Palsy
Interventions
Smart Ankle-Foot Orthosis, 5-Azacitidine, Placebo
Device · Drug
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
8 Years to 17 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Not applicable Interventional

Understanding the Effects of Quantitatively-Prescribing Passive-Dynamic Ankle-Foot Orthosis Bending Stiffness for Individuals Post-Stroke

NCT04619043
View directory record Official record
Conditions
Gait, Hemiplegic
Interventions
Ankle Orthotic
Device
Lead sponsor
University of Delaware
Other
Eligibility
Not listed
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Sep 15, 2023 · Synced Sep 30, 2026, 4:00 AM EDT
Not listed Phase 2 Interventional

Smart Ankle-Foot Orthosis to Improve Stroke Outcomes: Smart AFO

NCT05619484
View directory record Official record
Conditions
Stroke
Interventions
Smart AFO
Device
Lead sponsor
Orthocare Innovations, LLC
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
3
States / cities
Troy, Michigan • Salt Lake City, Utah • Edmonds, Washington
Source: ClinicalTrials.gov public record
Updated Oct 10, 2023 · Synced Sep 30, 2026, 4:00 AM EDT
Recruiting Not applicable Interventional

From Opinion to Evidence: Multi-site Evaluation of Custom Dynamic Orthosis Best Practices

NCT06352788
View directory record Official record
Conditions
Foot Injury
Interventions
Modular Carbon Fiber Custom Dynamic Orthosis (CDO), Mono Carbon Fiber Custom Dynamic Orthosis (CDO)
Device
Lead sponsor
Jason Wilken
Other
Eligibility
18 Years to 65 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
5
States / cities
San Diego, California • Iowa City, Iowa • Minneapolis, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress

NCT04562896
View directory record Official record
Conditions
Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions
Custom Carbon Fiber Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Sep 30, 2026, 4:00 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluating the Effects of Foot Orthotics on Plantar Pressures in the Diabetic Population

NCT00240175
View directory record Official record
Conditions
Diabetes
Interventions
No Intervention
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 66 Years
Enrollment
65 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
2
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 1, 2012 · Synced Sep 30, 2026, 4:00 AM EDT
Active, not recruiting Not applicable Interventional

Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis

NCT02089880
View directory record Official record
Conditions
Spinal Cord Injuries, Poliomyelitis, Post-polio Syndrome, Arthritis, Lower Motor Neurone Lesion
Interventions
C-brace, Stance control orthosis
Device
Lead sponsor
Shirley Ryan AbilityLab
Other
Eligibility
18 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Sep 30, 2026, 4:00 AM EDT