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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Foot Surgery Clear all
Terminated Not applicable Interventional Results available

Pericapsular Exparel for Pain Relief in Bunionectomy and Related Procedures

NCT02499575
View directory record Official record
Conditions
Bunion, Hallux Rigidus
Interventions
0.5% ropivacaine, Exparel
Drug
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
2
States / cities
Columbus, Ohio • Westerville, Ohio
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Jun 10, 2026, 7:21 PM EDT
Enrolling by invitation Phase 4 Interventional

Mepivacaine Versus Bupivacaine Onset Time in Ultrasound-guided Ankle Blocks

NCT05425979
View directory record Official record
Conditions
Ankle Block, Foot Surgery
Interventions
Mepivacaine, Bupivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 10, 2025 · Synced Jun 10, 2026, 7:21 PM EDT
Terminated Not applicable Interventional Results available

Surgical Treatment for Great Toe Arthritis

NCT03935880
View directory record Official record
Conditions
Hallux Rigidus
Interventions
Cartiva Implant, Cheilectomy
Device · Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 88 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 27, 2022 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Phase 3 Interventional Results available

Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries

NCT04518462
View directory record Official record
Conditions
Lower Extremity Surgery, Bunion, Metatarsophalangeal Fushion, Midfoot Fusion, Hindfoot Fushion, Total Ankle Arthroplasty
Interventions
Exparel, Bupivacaine Hydrochloride
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
5
States / cities
Phoenix, Arizona • Pasadena, California • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 17, 2022 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Phase 4 Interventional Results available

Using Santyl on Diabetic Foot Ulcers

NCT01408277
View directory record Official record
Conditions
Diabetic Foot Ulcers, Diabetic Foot Wounds
Interventions
Santyl, Control
Biological · Procedure
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
7
States / cities
Phoenix, Arizona • Tucson, Arizona • Southfield, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2014 · Synced Jun 10, 2026, 7:21 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Liposomal Bupivacaine Versus Bupivacaine Plain for Operative Pain Management of Forefoot Surgery

NCT04751344
View directory record Official record
Conditions
Liposomal Bupivacaine, Postoperative Pain, Forefoot Surgery, Opioid Use, Bunion
Interventions
Liposomal bupivacaine, Bupivacaine HCl
Drug
Lead sponsor
Alexandra Black
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Jun 10, 2026, 7:21 PM EDT
Terminated Not applicable Interventional Results available

Diabetic Foot Infection Antibiotic Study

NCT01539811
View directory record Official record
Conditions
Diabetic Foot Infections
Interventions
Surgical incision and drainage of diabetic foot infection, Short course antibiotics, Long course antibiotics
Procedure · Drug
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Jun 10, 2026, 7:21 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Measurement of Arch Motion After Bunion Surgery

NCT02074748
View directory record Official record
Conditions
Hallux Valgus, Instability of the Foot Arch
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 80 Years · Female only
Enrollment
2 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Phase 3 Interventional Results available

Bunionectomy Study for Postoperative Analgesia (EPOCH 1)

NCT03295721
View directory record Official record
Conditions
Postoperative Pain
Interventions
HTX-011, Saline Placebo, Bupivacaine HCl, Luer-lock applicator, Vial access device
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
412 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
15
States / cities
Mobile, Alabama • Mesa, Arizona • Phoenix, Arizona + 11 more
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Phase 2 Bunionectomy HTX-011 Administration Study

NCT03718039
View directory record Official record
Conditions
Postoperative Pain
Interventions
HTX-011, Luer Lock applicator, Vial access device, aprepitant
Drug · Device
Lead sponsor
Heron Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Mar 1, 2026 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Phase 3 Interventional

Analgesic Efficacy And Safety of Valdecoxib For Treatment Of Post-Surgical Pain From Bunionectomy Surgery

NCT00683137
View directory record Official record
Conditions
Pain, Hallux Valgus
Interventions
valdecoxib, valdecoxib/placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
89
States / cities
Chandler, Arizona • Glendale, Arizona • Mesa, Arizona + 50 more
Source: ClinicalTrials.gov public record
Updated May 22, 2008 · Synced Jun 10, 2026, 7:21 PM EDT
Withdrawn Not applicable Interventional

Auricular Acupuncture as Part of Multimodal Analgesia After Lower Leg Fracture

NCT05984433
View directory record Official record
Conditions
Pain, Postoperative, Fracture, Ankle, Pilon Fracture of Tibia, Foot Fracture
Interventions
Auricular acupuncture
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jun 10, 2026, 7:21 PM EDT
Withdrawn Not applicable Interventional

Continuous Tibial Nerve Block Versus Single Shot Tibial Nerve Block

NCT01555216
View directory record Official record
Conditions
Hallux Valgus
Interventions
Single injection posterior tibial nerve block, Posterior tibial nerve catheter
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 26, 2016 · Synced Jun 10, 2026, 7:21 PM EDT
Not listed No phase listed Observational

Cellular and Tissue Based Therapy Registry

NCT02322554
View directory record Official record
Conditions
Diabetic Foot Ulcers, Venous Stasis Ulcer, Pressure Ulcer, Chronic Non Healing Wound, Surgical Wound Dehiscence
Interventions
Cellular and tissue based products
Biological
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
50,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2005
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Apr 30, 2018 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Not applicable Interventional

Popliteal Sciatic Nerve Block Catheter Placement for Foot Surgery

NCT01049906
View directory record Official record
Conditions
Foot Surgery, Ankle Surgery
Interventions
Placement of nerve block catheter
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 20, 2012 · Synced Jun 10, 2026, 7:21 PM EDT
Completed No phase listed Observational

Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study

NCT04771741
View directory record Official record
Conditions
Bunion of Unspecified Foot, Bunionette of Unspecified Foot, Hammertoe, Ankle Fractures, Achilles Tendon Surgery
Interventions
Acetominophen, Toradol, Meloxicam, Cyclobenzaprine, Lyrica
Drug
Lead sponsor
Prisma Health-Midlands
Other
Eligibility
18 Years to 99 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 26, 2023 · Synced Jun 10, 2026, 7:21 PM EDT
Terminated Not applicable Interventional

Immediate Weight-bearing Verses Non-Weight-bearing After Foot & Ankle Surgery

NCT03996707
View directory record Official record
Conditions
Foot and Ankle Surgery
Interventions
Weight Bearing, Strict non-weight bearing
Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 89 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Clairton, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 26, 2021 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Efficacy of Tranexamic Acid in Foot and Ankle Surgeries

NCT03653429
View directory record Official record
Conditions
Foot and Ankle Surgeries, Bunion
Interventions
Tranexamic Acid, Normal saline
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2020 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Not applicable Interventional

Ideal Anatomic Location for Saphenous Nerve Blocks: A Prospective Clinical Evaluation

NCT02645097
View directory record Official record
Conditions
Foot Injury, Ankle Injury
Interventions
Saphenous Nerve Block
Procedure
Lead sponsor
Paul J. Juliano, M.D.
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Jun 10, 2026, 7:21 PM EDT
Withdrawn No phase listed Observational

Investigation of the Use of Hyperspectral Imaging in Foot Surgery Patients

NCT03787862
View directory record Official record
Conditions
Foot Ulcers, Osteomyelitis, Amputation
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 25, 2018 · Synced Jun 10, 2026, 7:21 PM EDT
Active, not recruiting Early Phase 1 Interventional

Temporal Profile of Serum Vitamin D Levels in Foot and Ankle Fusion Surgery

NCT04772196
View directory record Official record
Conditions
Ankle Arthrodesis, MTP Arthrodesis
Interventions
Vitamin D3
Drug
Lead sponsor
Prisma Health-Midlands
Other
Eligibility
18 Years to 99 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
2
States / cities
Charleston, South Carolina • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Not applicable Interventional

NeoPatch Used as Adjunct in Foot and Ankle Tendon Surgery

NCT03307499
View directory record Official record
Conditions
Tendinopathy, Tendon Tear, Tendon Injuries, Foot Ankle Injuries
Interventions
NeoPatch
Other
Lead sponsor
CryoLife, Inc.
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sycamore, Illinois
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Jun 10, 2026, 7:21 PM EDT
Not yet recruiting Not applicable Interventional

Transverse Tibial Bone Transport (TTT) in the Management of Chronic Diabetic Lower Extremity Wounds

NCT07444593
View directory record Official record
Conditions
Diabetic Foot Ulcer, Chronic Ulcers of the Lower Limb
Interventions
Biodynamik XT3
Device
Lead sponsor
Biodynamik, Inc
Industry
Eligibility
22 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Jun 10, 2026, 7:21 PM EDT
Completed Phase 4 Interventional Results available

Efficacy of Popliteal Nerve Blocks With and Without Dexamethasone on the Duration of Analgesia for Foot & Ankle Surgery

NCT01975285
View directory record Official record
Conditions
Foot and Ankle Procedures
Interventions
Dexamethasone, Saline
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 5, 2016 · Synced Jun 10, 2026, 7:21 PM EDT