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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Foot Ulcer, Diabetic Clear all
Not listed Phase 4 Interventional Accepts healthy volunteers

A Comparison of TCC-EZ Using Human Amnion Allograft vs TCC-EZ and Standard Wound Care in Treating Diabetic Foot Ulcers.

NCT02344329
View directory record Official record
Conditions
Diabetic Foot Ulcers, Diabetes
Interventions
Topical wound dressing, Human Amnion Allograft, usual wound care
Device · Biological · Other
Lead sponsor
University of North Dakota
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated May 8, 2017 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Not applicable Interventional Results available

A Non-significant Risk Clinical Study of Therapeutic Ultrasound for Patients With Diabetic Foot Ulcers.

NCT05145439
View directory record Official record
Conditions
Diabetic Foot Ulcer, Peripheral Arterial Disease, Wound; Foot
Interventions
VibratoSleeve Therapeutic Ultrasound Device
Device
Lead sponsor
Vibrato Medical, Inc.
Industry
Eligibility
22 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Phase 1 Interventional

EZCast-DFU Study With Portal for Application of Topical Medications

NCT02131961
View directory record Official record
Conditions
Foot Ulcer, Diabetic Foot
Interventions
Collagenase ointment, Modified Contact Cast System
Drug · Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 80 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 9, 2015 · Synced Sep 28, 2026, 9:05 PM EDT
Recruiting Not applicable Interventional

Total Contact Soft Cast in Diabetic Foot Ulcers

NCT04210089
View directory record Official record
Conditions
Diabetic Foot Ulcer, Diabetes Mellitus, Foot Ulcer, Foot Ulcer, Diabetic, Ulcer, Ulcer Foot, Ulcer, Leg, Ankle Ulcer
Interventions
Total Contact Soft Cast, Cam Boot
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Sep 28, 2026, 9:05 PM EDT
Terminated Not applicable Interventional Results available

Diabetic Foot Ulcer Study Comparing Cytal Wound Matrix 1-Layer to Standard of Care

NCT03626623
View directory record Official record
Conditions
Diabetes, Diabetic Foot, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Interventions
Cytal Wound Matrix 1-Layer, Standard of Care (SOC)
Device · Other
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
Fresno, California • New Orleans, Louisiana • Hyattsville, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 24, 2021 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Phase 1 Interventional

PHASE 1, OPEN-LABEL SAFETY STUDY OF UMBILICAL CORD LINING MESENCHYMAL STEM CELLS (CORLICYTE®) TO HEAL CHRONIC DIABETIC FOOT ULCERS

NCT04104451
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Corlicyte
Drug
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 28, 2024 · Synced Sep 28, 2026, 9:05 PM EDT
Terminated No phase listed Observational

Adjunct Collection of Additional Biorepository Data From Patients Enrolled in Diabetic Foot Consortium (DFC) Trials

NCT05092620
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Not listed
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
142 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
5
States / cities
Palo Alto, California • San Francisco, California • Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2024 · Synced Sep 28, 2026, 9:05 PM EDT
Terminated Phase 2 Interventional Results available

Efficacy and Safety of Intramuscular PDA-002 in Subjects With Diabetic Foot Ulcer With and Without PAD.

NCT02264288
View directory record Official record
Conditions
Peripheral Arterial Disease, Diabetic Foot
Interventions
PDA-002, Placebo
Biological · Other
Lead sponsor
Celularity Incorporated
Industry
Eligibility
18 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
45
States / cities
Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 37 more
Source: ClinicalTrials.gov public record
Updated Jun 11, 2026 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Phase 2 Interventional

Topical PluroGel N for the Treatment of Mildly Infected Diabetic Foot Ulcers

NCT02091596
View directory record Official record
Conditions
Diabetic Foot Ulcer, Infection
Interventions
PluroGel N, PluroGel
Drug
Lead sponsor
PluroGen Therapeutics, Inc
Industry
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
15
States / cities
Phoenix, Arizona • Los Angeles, California • Oakland, California + 8 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2014 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Not applicable Interventional

Outcomes of Irrisept Irrigation as an Adjunctive Treatment in the Management of Diabetic Foot Ulcers

NCT06024590
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Irrisept, Saline
Device
Lead sponsor
Northern Illinois Foot and Ankle Specialists
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
5
States / cities
Cary, Illinois • Crystal Lake, Illinois • Elgin, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Sep 28, 2026, 9:05 PM EDT
Completed No phase listed Observational

The Effect of Implementing a Limb Loss Prevention Program on Amputation Rates

NCT03978715
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
No intervention-retrospective study
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2023 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Not applicable Interventional

Online Wound Electronic Medical Record (OWEMR) to Decrease Amputations in Diabetics

NCT01371318
View directory record Official record
Conditions
Wounds, Diabetes Complications, Diabetic Foot, Foot Ulcer
Interventions
Online Wound Electronic Medical Record
Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
1,609 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
13
States / cities
Phoenix, Arizona • Tuscon, Arizona • Pomona, California + 8 more
Source: ClinicalTrials.gov public record
Updated Dec 30, 2014 · Synced Sep 28, 2026, 9:05 PM EDT
Not listed Not applicable Interventional

A Feasibility Study of Advance Plasma Therapy001 Plasma/Nitric Oxide Therapy for the Treatment of Diabetic Foot Ulcers

NCT03078933
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Standard of Care, Nitric Oxide Therapy 2x week 6 min. plus standard of care, Nitric Oxide Therapy 2x week 12 min. plus standard of care, Nitric Oxide Therapy 4x week 6 min. plus standard of care, Nitric Oxide Therapy 4x week 12 min. plus standard of care
Device
Lead sponsor
Origin Inc.
Industry
Eligibility
22 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
15
States / cities
Montgomery, Alabama • Phoenix, Arizona • Tucson, Arizona + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 6, 2017 · Synced Sep 28, 2026, 9:05 PM EDT
Terminated Phase 3 Interventional

Study to Evaluate the Safety and Efficacy of CHAM* for the Treatment of Diabetic Foot Ulcers

NCT02571738
View directory record Official record
Conditions
Chronic Diabetic Foot Ulcers
Interventions
CHAM, Control
Biological · Other
Lead sponsor
Osiris Therapeutics
Industry
Eligibility
18 Years to 80 Years
Enrollment
108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
18
States / cities
Tucson, Arizona • Carlsbad, California • Castro Valley, California + 15 more
Source: ClinicalTrials.gov public record
Updated Oct 5, 2017 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Phase 3 Interventional

Cryopreserved Human Umbilical Cord (TTAX01) for Late Stage, Complex Non-healing Diabetic Foot Ulcers (AMBULATE DFU)

NCT04176120
View directory record Official record
Conditions
Diabetic Foot Infection, Non-healing Wound, Non-healing Diabetic Foot Ulcer
Interventions
TTAX01, Standard Care
Biological · Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
16
States / cities
San Francisco, California • Sylmar, California • Miami, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Sep 28, 2026, 9:05 PM EDT
Completed No phase listed Observational

UT Southwestern Diabetic Foot Ulcers (DFU) and Osteomyelitis (DFO) Recruitment Database, Data and Tissue Repository

NCT02463500
View directory record Official record
Conditions
Diabetic Foot Ulcers, Osteomyelitis
Interventions
DFU
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
2
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jul 23, 2023 · Synced Sep 28, 2026, 9:05 PM EDT
Not listed Phase 2 Interventional

Safety & Efficacy Study for the Use of Extracorporeal Shockwaves in the Treatment of Diabetic Foot Ulcers

NCT00366132
View directory record Official record
Conditions
Chronic Diabetic Foot Ulcers
Interventions
Extracorporeal Shockwaves
Device
Lead sponsor
Tissue Regeneration Technologies
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
5
States / cities
Washington D.C., District of Columbia • The Bronx, New York • Akron, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2006 · Synced Sep 28, 2026, 9:05 PM EDT
Recruiting No phase listed Observational

A Real-World Registry of Chronic Wounds and Ulcers

NCT02280733
View directory record Official record
Conditions
Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis, Skin Ulcer, Leg Ulcer, Pyoderma, Peripheral Arterial Disease, Lymphedema, Surgical Complication, Venous Leg Ulcers (VLUs), Calciphylaxis, Sickle Cell Ulcer, Pressure Ulcer (PU), Diabetic Foot Ulcers (DFUs), Pressure Injury, Arterial Ulcers, Soft Tissue Radionecrosis (STRN), Traumatic Wounds, Chronic Ulcer
Interventions
Usual care
Other
Lead sponsor
U.S. Wound Registry
Other
Eligibility
Not listed
Enrollment
300,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2030
U.S. locations
1
States / cities
The Woodlands, Texas
Source: ClinicalTrials.gov public record
Updated Jul 15, 2025 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Clinical Investigation of Galnobax® for the Treatment of Diabetic Foot Ulcers

NCT01113515
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Esmolol hydrochloride, Placebo gel
Drug
Lead sponsor
Novalead Pharma Private Limited
Industry
Eligibility
18 Years to 95 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated May 19, 2024 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Not applicable Interventional

Diabetic Foot Ulcers-Comparing Transforming Powder to Standard of Care

NCT05046158
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Transforming Powder Dressing, Standard of care topical wound agents and dressings
Device · Other
Lead sponsor
ULURU Inc.
Industry
Eligibility
18 Years to 89 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
12
States / cities
Washington D.C., District of Columbia • Winter Park, Florida • Baltimore, Maryland + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Sep 28, 2026, 9:05 PM EDT
Not listed Early Phase 1 Interventional

Evaluating the Healing of Diabetic Foot Ulcers With Compounded Anti-Infective Irrigation Therapy

NCT05076955
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
vancomycin-tobramycin-itraconazole
Drug
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Oct 12, 2021 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Phase 4 Interventional Results available

Santyl vs. Sharp Debridement of Diabetic Foot Wounds

NCT01056198
View directory record Official record
Conditions
Diabetic Foot Ulcers, Foot Wounds
Interventions
Santyl, Control
Drug · Procedure
Lead sponsor
Healthpoint
Industry
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
9
States / cities
Phoenix, Arizona • Lincoln, Nebraska • Altoona, Pennsylvania + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2012 · Synced Sep 28, 2026, 9:05 PM EDT
Completed Not applicable Interventional

Impact of Remote Foot Temperature Monitoring

NCT04345016
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
Once-daily remote foot temperature monitoring
Device
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
3
States / cities
Kensington, Maryland • Upper Marlboro, Maryland • Springfield, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Sep 28, 2026, 9:05 PM EDT
Terminated Not applicable Interventional

Derm-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone

NCT06455475
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
Derm-Maxx
Other
Lead sponsor
Capsicure, LLC
Network
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
11
States / cities
Athens, Alabama • Encino, California • Hollywood, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 28, 2026, 9:05 PM EDT