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ClinicalTrials.gov public records Last synced Oct 22, 2026, 5:24 AM EDT

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Showing 73–96 of 102 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Fracture, Tibial Clear all
Completed Phase 2Phase 3 Interventional

Hyperbaric Oxygen in Lower Leg Trauma

NCT00264511
View directory record Official record
Conditions
Tibial Fracture, Soft Tissue Injury
Interventions
Hyperbaric Oxygen Treatment
Other
Lead sponsor
Bayside Health
Government
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Concord, California
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Oct 22, 2026, 5:24 AM EDT
Completed Not applicable Interventional

SPRINT - Randomized Trial of Tibial Fracture Fixation

NCT00038129
View directory record Official record
Conditions
Tibial Fracture
Interventions
Intramedullary nail implant
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
16 Years and older
Enrollment
1,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
16
States / cities
San Francisco, California • Jacksonville, Florida • Evansville, Indiana + 13 more
Source: ClinicalTrials.gov public record
Updated Nov 1, 2019 · Synced Oct 22, 2026, 5:24 AM EDT
Enrolling by invitation No phase listed Observational

Early Weight Bearing in Unicondylar Tibial Plateau Fractures

NCT06389240
View directory record Official record
Conditions
Early Mobilization
Interventions
6 weeks post-operatively early weight bearing, 10 weeks post-operatively weight bearing (standard of care)
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Timeline
2022 – 2028
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 22, 2026, 5:24 AM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation

NCT05317676
View directory record Official record
Conditions
Tibial Fractures, Fibula Fracture, Knee Fracture
Interventions
Palmitoylethanolamide, Placebo
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Oct 22, 2026, 5:24 AM EDT
Recruiting Phase 1 Interventional

Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau

NCT06639503
View directory record Official record
Conditions
Tibial Plateau Fractures
Interventions
Bupivacain
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 22, 2026, 5:24 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Blood Flow Restriction Training in Patients With Lower Extremity Fractures

NCT06496035
View directory record Official record
Conditions
Tibial Fractures, Lower Extremity Fracture
Interventions
Blood Flow Restriction with low load exercise, Therapeutic Exercise
Device · Other
Lead sponsor
Denver Health and Hospital Authority
Other
Eligibility
18 Years to 100 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 21, 2025 · Synced Oct 22, 2026, 5:24 AM EDT
Completed No phase listed Observational

Quantifying Quadriceps Atrophy Following Tibial Plateau Fracture

NCT02781623
View directory record Official record
Conditions
Atrophy
Interventions
MRI
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 16, 2022 · Synced Oct 22, 2026, 5:24 AM EDT
Terminated No phase listed Observational

Safety Study of Treatment of Leg Fractures

NCT03881241
View directory record Official record
Conditions
Tibial Fractures
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Athens, Georgia • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 10, 2020 · Synced Oct 22, 2026, 5:24 AM EDT
Completed No phase listed Observational

Depuy Synthes Lower Extremity Shaft Nail Registry

NCT05272631
View directory record Official record
Conditions
Femoral Fractures, Tibial Fractures
Interventions
Retrograde Femoral Nail Advanced, Tibial Nail Advanced
Device
Lead sponsor
DePuy Synthes Products, Inc.
Industry
Eligibility
12 Years and older
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
8
States / cities
Indianapolis, Indiana • Ann Arbor, Michigan • Columbia, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 16, 2026 · Synced Oct 22, 2026, 5:24 AM EDT
Completed Not applicable Interventional Results available

Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries

NCT00582998
View directory record Official record
Conditions
Fracture of Calcaneus, Pilon or Tibial Plateau
Interventions
Standard Wound Dressing, Vacuum Assisted Closure Device
Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 25, 2019 · Synced Oct 22, 2026, 5:24 AM EDT
Active, not recruiting Early Phase 1 Interventional

Role of Multimodal Analgesia in Decreasing Perioperative Pain in Tibial Plateau Fractures

NCT05037812
View directory record Official record
Conditions
Tibial Plateau Fractures
Interventions
Saline injection, Multimodal injections
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 79 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2028
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 22, 2026, 5:24 AM EDT
Completed Phase 3 Interventional

Assessment of Fixation Strategies for Severe Open Tibia Fractures

NCT01494519
View directory record Official record
Conditions
Severe Open Fractures of the Tibia (Shin) Bone
Interventions
Surgery with an external ring fixator, Definitive fixation with a locked IM nail or plate
Procedure
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years to 64 Years
Enrollment
442 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
33
States / cities
Birmingham, Alabama • San Diego, California • San Francisco, California + 27 more
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Oct 22, 2026, 5:24 AM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers Results available

Tibial Delayed Healing Pivotal Clinical Trial

NCT01016067
View directory record Official record
Conditions
Tibial Delayed Healing
Interventions
INFUSE/MASTERGRAFT, Autograft bone
Device · Procedure
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
21 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
16
States / cities
Denver, Colorado • Fort Lauderdale, Florida • Jacksonville, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2015 · Synced Oct 22, 2026, 5:24 AM EDT
Withdrawn Phase 3 Interventional

Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures

NCT03826784
View directory record Official record
Conditions
Tibial Fractures
Interventions
BHA
Combination Product
Lead sponsor
Carmell Therapeutics Corporation
Industry
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 23, 2020 · Synced Oct 22, 2026, 5:24 AM EDT
Terminated Not applicable Interventional Results available

Pilot Study Comparing Diagnostic Imaging Versus Tomosynthesis in Detection of Hip, Wrist or Tibia Injury

NCT01927575
View directory record Official record
Conditions
Wrist Injury, Tibial Fracture, Hip Injury
Interventions
Standard X-Ray + CT, Standard X-Ray + MRI, TOMO
Device
Lead sponsor
Fujifilm Medical Systems USA, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 4, 2020 · Synced Oct 22, 2026, 5:24 AM EDT
Not yet recruiting Phase 1 Interventional

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

NCT07004764
View directory record Official record
Conditions
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions
Nitroglycerin Ointment 2%
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 22, 2026, 5:24 AM EDT
Completed No phase listed Observational

Mobile Monitoring of Fracture Healing

NCT02534259
View directory record Official record
Conditions
Tibial Fractures
Interventions
Force monitoring of external fixator struts
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 18, 2019 · Synced Oct 22, 2026, 5:24 AM EDT
Completed No phase listed Observational Results available

Zimmer® MotionLoc® in Distal Tibia Fractures

NCT02717546
View directory record Official record
Conditions
Distal Tibia Fractures
Interventions
Zimmer MotionLoc Screw
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
3
States / cities
Springfield, Illinois • Indianapolis, Indiana • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 4, 2021 · Synced Oct 22, 2026, 5:24 AM EDT
Completed Not applicable Interventional

Distal Locking Using an Electromagnetic Field Guided Computer Based Real Time System for Orthopaedic Trauma Patients

NCT01183078
View directory record Official record
Conditions
Tibial Fractures, Femoral Fractures
Interventions
free-hand, Wand technique
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 16, 2023 · Synced Oct 22, 2026, 5:24 AM EDT
Completed Early Phase 1 Interventional

Continuous Femoral Nerve Block With a Tibial Plateau Fracture

NCT02168959
View directory record Official record
Conditions
Tibial Plateau Fracture
Interventions
bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 14, 2016 · Synced Oct 22, 2026, 5:24 AM EDT
Withdrawn Not applicable Interventional

Auricular Acupuncture as Part of Multimodal Analgesia After Lower Leg Fracture

NCT05984433
View directory record Official record
Conditions
Pain, Postoperative, Fracture, Ankle, Pilon Fracture of Tibia, Foot Fracture
Interventions
Auricular acupuncture
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Oct 22, 2026, 5:24 AM EDT
Recruiting Not applicable Interventional

Continuous Passive Motion Following Fixation of Pelvic and Knee Fractures

NCT04389749
View directory record Official record
Conditions
Fractures, Bone
Interventions
CPM
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 22, 2026, 5:24 AM EDT
Completed Phase 2 Interventional Results available

Optimal Vitamin D3 Supplementation Strategies for Acute Fracture Healing

NCT02786498
View directory record Official record
Conditions
Fracture
Interventions
Vitamin D3, Placebo
Drug · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years to 50 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 31, 2022 · Synced Oct 22, 2026, 5:24 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Intramedullary Nailing of Tibia Fractures

NCT01797640
View directory record Official record
Conditions
Tibial Fractures, Malleolar Fractures
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 95 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 9, 2015 · Synced Oct 22, 2026, 5:24 AM EDT