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ClinicalTrials.gov public records Last synced Sep 10, 2026, 11:41 PM EDT

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Showing 1–24 of 60 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Fracture Fixation, Internal Clear all
Active, not recruiting Not applicable Interventional

Minimally Displaced Femoral Neck Fracture Pilot Study

NCT05947058
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
Arthroplasty, Internal Fixation
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
8
States / cities
Los Angeles, California • New Haven, Connecticut • Gainesville, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 10, 2026, 11:41 PM EDT
Withdrawn Phase 1Phase 2 Interventional

A Study of Postsurgical Pain Control for Lower Extremity Fractures

NCT02214810
View directory record Official record
Conditions
Lower Extremity Fractures.
Interventions
Bupivacaine/Exparel
Drug
Lead sponsor
Broward Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 18, 2016 · Synced Sep 10, 2026, 11:41 PM EDT
Withdrawn No phase listed Observational

Treatment Of Supracondylar Fractures Closed Reduction And Circular Ring External Fixation Versus Open Reduction and Internal Fixation

NCT02196311
View directory record Official record
Conditions
Supracondylar Humerus Fractures
Interventions
Not listed
Lead sponsor
Baylor College of Medicine
Other
Eligibility
12 Years to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 11, 2020 · Synced Sep 10, 2026, 11:41 PM EDT
Completed No phase listed Observational

MatrixRIB Implants for Surgical Stabilization of Flail Chest Injuries: A Registry

NCT00810251
View directory record Official record
Conditions
Flail Chest
Interventions
MatrixRIB (FDA Approval # K081623)
Device
Lead sponsor
Legacy Biomechanics Laboratory
Other
Eligibility
21 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 5, 2011 · Synced Sep 10, 2026, 11:41 PM EDT
Withdrawn Not applicable Interventional

Auricular Acupuncture As Part Of A Multimodal Regimen After Distal Radius Open Reduction and Internal Fixation

NCT05974254
View directory record Official record
Conditions
Radius Fracture Distal, Pain, Postoperative
Interventions
Acupuncture
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 10, 2026, 11:41 PM EDT
Withdrawn Not applicable Interventional

Arthroscopic Assisted Open Reduction Internal Fixation Versus Open Reduction Internal Fixation in Ankle Fractures

NCT03084263
View directory record Official record
Conditions
Ankle Fractures
Interventions
Arthroscopic Assisted Open Reduction Internal Fixation, Open Reduction Internal Fixation
Procedure
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated May 24, 2017 · Synced Sep 10, 2026, 11:41 PM EDT
Terminated Phase 4 Interventional Results available

Dynamic Locking Screws 5.0 vs. Standard Locking Screws in Fracture of Distal Femur Treated With Locked Plate Fixation

NCT01693367
View directory record Official record
Conditions
Distal Femur Fractures
Interventions
DLS 5.0 (Dynamic locking screws), SLS (Standard locking screw)
Device
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
21 Years to 120 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
5
States / cities
Sacramento, California • Columbia, Missouri • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Sep 10, 2026, 11:41 PM EDT
Terminated Not applicable Interventional

Diabetic Fibular Nail Study

NCT05204485
View directory record Official record
Conditions
Ankle Fractures
Interventions
Fibular intramedullary nail, Open reduction and internal fixation
Procedure
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 85 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 15, 2024 · Synced Sep 10, 2026, 11:41 PM EDT
Terminated Not applicable Interventional

Reverse Total Shoulder Arthroplasty Versus Open Reduction Internal Fixation of 3&4 Part Proximal Humerus Fractures

NCT02597972
View directory record Official record
Conditions
Closed Fracture Proximal Humerus, Four Part
Interventions
Fracture repair, Fracture repair with joint replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
70 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Sep 10, 2026, 11:41 PM EDT
Withdrawn Not applicable Interventional

Incisional Wound Vac in Obese Patients

NCT00789659
View directory record Official record
Conditions
Wound Infection, Postoperative Complication
Interventions
Negative pressure dressing
Other
Lead sponsor
University of Mississippi Medical Center
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Feb 9, 2017 · Synced Sep 10, 2026, 11:41 PM EDT
Not listed No phase listed Observational

Treatment of Complex Pilon Fractures

NCT06089525
View directory record Official record
Conditions
Pilon Fracture
Interventions
Not listed
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 17, 2023 · Synced Sep 10, 2026, 11:41 PM EDT
Recruiting Phase 3 Interventional

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

NCT05699174
View directory record Official record
Conditions
Infections, Infected Wound, Nonunion of Fracture, Injury Leg, Amputation, Internal Fixation; Complications, Infection or Inflammation, Fracture, Lower Extremity Fracture, Antibiotic Side Effect
Interventions
Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
Drug
Lead sponsor
Major Extremity Trauma Research Consortium
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
13
States / cities
Indianapolis, Indiana • Baltimore, Maryland • Minneapolis, Minnesota + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 10, 2026, 11:41 PM EDT
Withdrawn Not applicable Interventional

Artemis Proximal Femoral Nail for Internal Fixation of Intertrochanteric Femur Fractures

NCT05559736
View directory record Official record
Conditions
Intertrochanteric Fractures, Femoral Fracture, Femoral Neck Fractures
Interventions
Artemis Proximal Femoral Nail (PFN) implant
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 30, 2025 · Synced Sep 10, 2026, 11:41 PM EDT
Completed Phase 2 Interventional Results available

Study to Assess Safety and Clinical Activity of Local MBN-101 in Treatment of Infected Bone Sites

NCT02436876
View directory record Official record
Conditions
Bacterial Infection
Interventions
MBN-101, Placebo
Drug · Other
Lead sponsor
Microbion Corporation
Industry
Eligibility
18 Years to 75 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
6
States / cities
San Francisco, California • Baltimore, Maryland • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 29, 2021 · Synced Sep 10, 2026, 11:41 PM EDT
Terminated Not applicable Interventional Results available

Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia

NCT01430182
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Methadone, Morphine
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 50 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 3, 2016 · Synced Sep 10, 2026, 11:41 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Does Early Elbow Motion Improve Patient Outcomes After Surgically Treated Elbow Fractures?

NCT05980312
View directory record Official record
Conditions
Elbow Fracture, Range of Motion, Immobilization
Interventions
Splint Immobilization, Early Motion
Other
Lead sponsor
The Cooper Health System
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 6, 2023 · Synced Sep 10, 2026, 11:41 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Impact of Early ADL Education on Outcomes Post DRF ORIF

NCT06251206
View directory record Official record
Conditions
Distal Radius Fractures
Interventions
ADL/Postoperative Instruction, Postoperative Instruction
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 110 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Washington, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Sep 10, 2026, 11:41 PM EDT
Recruiting Phase 4 Interventional

Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures

NCT06113211
View directory record Official record
Conditions
Opioid Use, Fractures, Bone, Trauma
Interventions
Narcotic pain medication, Nonnarcotic pain medications
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 10, 2026, 11:41 PM EDT
Completed Not applicable Interventional

Open Reduction Internal Fixation of Calcaneus Fractures With and Without Bone Graft

NCT00582686
View directory record Official record
Conditions
Calcaneus Fractures
Interventions
ORIF of Calcaneus with bone grafting, ORIF of Calcaneus without bone grafting
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2008
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 30, 2013 · Synced Sep 10, 2026, 11:41 PM EDT
Active, not recruiting Not applicable Interventional

Early vs Delayed Weightbearing After Surgical Fixation of Unstable Ankle Fractures With Syndesmosis Disruption

NCT05587842
View directory record Official record
Conditions
Unstable Ankle Fractures With Syndesmotic Disruption
Interventions
Early Weightbearing management post operation, Delayed Weightbearing management post operation (Traditional)
Procedure
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 10, 2026, 11:41 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pediatric Femur Research Project

NCT00943332
View directory record Official record
Conditions
Femur Fracture
Interventions
femur fracture repair
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
2 Years to 6 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2018
U.S. locations
3
States / cities
Columbia, Missouri • Kansas City, Missouri • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Sep 10, 2026, 11:41 PM EDT
Terminated No phase listed Observational

Safety Study of Treatment of Leg Fractures

NCT03881241
View directory record Official record
Conditions
Tibial Fractures
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Athens, Georgia • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Sep 10, 2026, 11:41 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery

NCT01167907
View directory record Official record
Conditions
Orthopedic Surgery of Lower Extremity
Interventions
0.2% ropivacaine, saline
Device · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 10, 2026, 11:41 PM EDT
Recruiting Not applicable Interventional

MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

NCT07244211
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
Hip arthroplasty, Internal fixation
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
60 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
20
States / cities
Irvine, California • Los Angeles, California • Miami, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 10, 2026, 11:41 PM EDT