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Showing 1–24 of 317 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Fracture Lower Leg Clear all
Recruiting Not applicable Interventional

Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)

NCT05792189
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Timed Up and Go Test on subjects with ORIF of distal femur fractures, Koos Jr assesment on subjects with ORIF of distal femur fractures, Timed Up and Go Test on subjects with DFR of distal femur fracture, Koos Jr assesment on subjects with DFR of distal femur fracture
Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 100 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Recruiting Not applicable Interventional

Carbo-fix Lateral Plate Devices and Standard Plate-Nail Constructs in Distal Femur Fractures

NCT07280169
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Carbo-fix Lateral Plate Device, Standard Plate-Nail Construct
Device
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Withdrawn Phase 4 Interventional

Duloxetine Tibial Plateau

NCT04639011
View directory record Official record
Conditions
Tibial Plateau Fracture, Pain, Postoperative
Interventions
Duloxetine, Placebo, Standard of care (SOC) for tibial plateau surgery
Drug · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts • Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Sep 3, 2026, 2:12 PM EDT
Active, not recruiting Not applicable Interventional

Minimally Displaced Femoral Neck Fracture Pilot Study

NCT05947058
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
Arthroplasty, Internal Fixation
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
8
States / cities
Los Angeles, California • New Haven, Connecticut • Gainesville, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Completed Not applicable Interventional

Ultrasound Guided Femoral Nerve Block

NCT02381717
View directory record Official record
Conditions
Hip Fracture
Interventions
ultra-sound guide, bupivacaine, morphine
Other · Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 101 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
2
States / cities
Boston, Massachusetts • Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Completed Phase 4 Interventional

Exparel Use in Peripheral Nerve Blocks and Local Infiltration for Foot and Ankle Surgery

NCT05494645
View directory record Official record
Conditions
Pain, Postoperative, Pain, Acute Postoperative, Ankle Fractures, Ankle Injuries and Disorders
Interventions
Exparel, Peripheral Nerve Block
Drug
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
248 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Completed Not applicable Interventional

Early Weight Bearing for Unstable Ankle Fractures Undergoing Operative Stabilization

NCT02779244
View directory record Official record
Conditions
Ankle Fracture
Interventions
Early Weight bearing + Cam Boot, Non-Weight Bearing + Cam Boot
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 70 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Sep 3, 2026, 2:12 PM EDT
Completed No phase listed Observational

Depuy Synthes Lower Extremity Shaft Nail Registry

NCT05272631
View directory record Official record
Conditions
Femoral Fractures, Tibial Fractures
Interventions
Retrograde Femoral Nail Advanced, Tibial Nail Advanced
Device
Lead sponsor
DePuy Synthes Products, Inc.
Industry
Eligibility
12 Years and older
Enrollment
241 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
8
States / cities
Indianapolis, Indiana • Ann Arbor, Michigan • Columbia, Missouri + 5 more
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Completed Not applicable Interventional

Immobilization Versus Observation in Children With Toddler's Fractures: a Prospective Randomized Controlled Trial

NCT01926795
View directory record Official record
Conditions
Tibial Fractures
Interventions
Short leg cast, No Immobilization
Procedure
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
1 Year to 5 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Sep 3, 2026, 2:12 PM EDT
Terminated No phase listed Observational

Curvafix® Intramedullary System for Fixation of Pelvic and Acetabular Fractures, A Post Market Evaluation

NCT05606042
View directory record Official record
Conditions
Pelvic Ring Fracture, Acetabular Fracture, Pelvic Fracture, Pelvic Fracture Acetabulum
Interventions
IM Implant
Device
Lead sponsor
CurvaFix, Inc.
Industry
Eligibility
Not listed
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
6
States / cities
Springfield, Illinois • Columbia, Missouri • Columbus, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Recruiting Phase 4 Interventional

Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial

NCT05421741
View directory record Official record
Conditions
Osteomyelitis Tibia, Tibial Fractures, Open Tibia Fracture
Interventions
Antibiotic coated intramedullary Nail, Standard Intramedullary Nail
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
242 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
15
States / cities
Gainesville, Florida • Temple Terrace, Florida • Macon, Georgia + 12 more
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Not yet recruiting Not applicable Interventional

Effect of a Femoral Venting Hole on Embolic Load in Prophylactic Intramedullary Nailing

NCT07778238
View directory record Official record
Conditions
Femur Fracture
Interventions
Femoral venting+ intramedullary nailing, Standard intramedullary nailing
Procedure
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Not yet recruiting Not applicable Interventional

DePuy Synthes Variable Angle LCP Patella Plating System Study

NCT05824676
View directory record Official record
Conditions
Trauma, Patella Fracture, Knee Cap, Knee Cap Injury, Knee Discomfort, Knee Deformity
Interventions
Variable Angle LCP Patella Plating System, Traditional Fixation
Device
Lead sponsor
Hartford Hospital
Other
Eligibility
18 Years to 74 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 20, 2023 · Synced Sep 3, 2026, 2:12 PM EDT
Completed No phase listed Observational

Plating of Distal Femur Fractures by Far Cortical Locking Using MotionLoc Screws

NCT01667887
View directory record Official record
Conditions
Fracture of Distal Femur
Interventions
Not listed
Lead sponsor
Legacy Biomechanics Laboratory
Other
Eligibility
17 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 28, 2013 · Synced Sep 3, 2026, 2:12 PM EDT
Terminated Phase 4 Interventional Results available

Dynamic Locking Screws 5.0 vs. Standard Locking Screws in Fracture of Distal Femur Treated With Locked Plate Fixation

NCT01693367
View directory record Official record
Conditions
Distal Femur Fractures
Interventions
DLS 5.0 (Dynamic locking screws), SLS (Standard locking screw)
Device
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
21 Years to 120 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
5
States / cities
Sacramento, California • Columbia, Missouri • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Sep 3, 2026, 2:12 PM EDT
Completed Not applicable Interventional

Pericapsular Nerve Group Block for Hip Fractures

NCT04882384
View directory record Official record
Conditions
Hip Fractures, Pain, Acute
Interventions
Pericapsular Nerve Group Block
Procedure
Lead sponsor
Jacobi Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 20, 2022 · Synced Sep 3, 2026, 2:12 PM EDT
Completed Not applicable Interventional Results available

Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries

NCT00582998
View directory record Official record
Conditions
Fracture of Calcaneus, Pilon or Tibial Plateau
Interventions
Standard Wound Dressing, Vacuum Assisted Closure Device
Procedure · Device
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 24, 2019 · Synced Sep 3, 2026, 2:12 PM EDT
Completed Phase 3 Interventional

Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Hip Fracture Surgery

NCT00721760
View directory record Official record
Conditions
Venous Thromboembolism
Interventions
Enoxaparin sodium, Semuloparin sodium, Placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
1,003 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Jan 22, 2013 · Synced Sep 3, 2026, 2:12 PM EDT
Enrolling by invitation Not applicable Interventional

Ankle Fracture Tourniquet Utilization

NCT06863688
View directory record Official record
Conditions
Ankle Fracture
Interventions
Tourniquet, No Tourniquet
Device · Other
Lead sponsor
Alex Demers
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Hip Strength and Nerve Palsy After the Modified Stoppa Approach to Acetabular Fracture Reduction and Fixation

NCT01763359
View directory record Official record
Conditions
Acetabular Fracture, Pelvic Fracture
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 99 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Sep 3, 2026, 2:12 PM EDT
Completed Early Phase 1 Interventional

Continuous Femoral Nerve Block With a Tibial Plateau Fracture

NCT02168959
View directory record Official record
Conditions
Tibial Plateau Fracture
Interventions
bupivacaine
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 13, 2016 · Synced Sep 3, 2026, 2:12 PM EDT
Active, not recruiting Not applicable Interventional

The Role of Blood Flow Restriction Therapy in Postoperative Elderly Patients With Hip Fracture

NCT04809714
View directory record Official record
Conditions
Hip Fractures, Muscle Atrophy
Interventions
Blood Flow Restriction with Delfi Tourniquet System Cuff, Routine Post-operative Physical Therapy
Device · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
65 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Sep 3, 2026, 2:12 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Insole Sensor to Determine Optimal Limb Loading

NCT02170493
View directory record Official record
Conditions
Lower Extremity Fractures
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 90 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Sep 3, 2026, 2:12 PM EDT
Recruiting Not applicable Interventional

MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

NCT07244211
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
Hip arthroplasty, Internal fixation
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
60 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
20
States / cities
Irvine, California • Los Angeles, California • Miami, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 3, 2026, 2:12 PM EDT