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Showing 1–24 of 82 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Fracture of Ankle Clear all
Completed No phase listed Observational Accepts healthy volunteers

Evaluating Muscle Function After Ankle Surgery

NCT00060970
View directory record Official record
Conditions
Muscle Atrophy, Muscle Weakness, Fractures
Interventions
Physical Therapy
Procedure
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1995 – 2000
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jul 22, 2026, 4:14 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Comparison of Two Injection Locations in Obese Patients Having Lower Leg/Foot Surgery

NCT01550094
View directory record Official record
Conditions
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot, Complete Tear, Ankle and/or Foot Ligament, Pathological Fracture - Ankle and/or Foot, Loose Body in Joint of Ankle and/or Foot
Interventions
Not listed
Lead sponsor
Jose Soberon, MD
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2015 · Synced Jul 22, 2026, 4:14 PM EDT
Not listed Not applicable Interventional

Nerve Block for Pain Control After Fracture Surgery

NCT05391464
View directory record Official record
Conditions
Ankle Fractures, Distal Radius Fracture
Interventions
Peripheral Nerve Block
Procedure
Lead sponsor
MaineGeneral Health
Other
Eligibility
18 Years and older
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Augusta, Maine
Source: ClinicalTrials.gov public record
Updated May 25, 2022 · Synced Jul 22, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Assessment of Ability of 3D Fluorscopy in Aiding Accurate Syndesmotic Reduction Following Traumatic Ankle Injury

NCT03163017
View directory record Official record
Conditions
Displaced Ankle Fractures
Interventions
2D Fluoroscopy, 3D Fluoroscopy
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 75 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 11, 2019 · Synced Jul 22, 2026, 4:14 PM EDT
Completed No phase listed Observational

Pilon Fracture Reduction and Functional Outcome

NCT01316289
View directory record Official record
Conditions
Pilon Fracture of Tibia
Interventions
Not listed
Lead sponsor
AO Clinical Investigation and Publishing Documentation
Other
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
4
States / cities
Indianapolis, Indiana • Saint Paul, Minnesota • Jackson, Mississippi + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Jul 22, 2026, 4:14 PM EDT
Completed No phase listed Observational Results available

Computed Tomography for Evaluating Supination-external Rotation Type Ankle Fractures

NCT02599441
View directory record Official record
Conditions
Supination-external Rotation Ankle Fractures
Interventions
Not listed
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 24, 2019 · Synced Jul 22, 2026, 4:14 PM EDT
Terminated Not applicable Interventional Results available

Effect of Early Saline Lavage on Synovial Fluid Composition Following Intra Articular Ankle Fractures

NCT05465382
View directory record Official record
Conditions
Intra-Articular Fractures
Interventions
Saline Lavage, No intra-articular saline lavage, Lidocaine - intra-articular injection, Synovial Fluid Aspiration
Device · Other · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jul 22, 2026, 4:14 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers Results available

Wright Foot & Ankle Post-Market Observational Study

NCT04118894
View directory record Official record
Conditions
Arthritis, Rheumatoid Arthritis, Fracture, Trauma Injury, Fusion of Joint
Interventions
Foot and Ankle Devices
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
2
States / cities
Hamilton, New Jersey • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 13, 2025 · Synced Jul 22, 2026, 4:14 PM EDT
Completed Phase 4 Interventional Results available

Anesthesia for Pain After Ankle Fracture Surgery

NCT02950558
View directory record Official record
Conditions
Chronic Pain, Ankle Fracture Surgery, Regional Anesthesia
Interventions
Ropivacaine, Nerve block
Drug · Procedure
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years to 65 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Cincinnati, Ohio • West Chester, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Jul 22, 2026, 4:14 PM EDT
Not yet recruiting Phase 1 Interventional

Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging.

NCT07004764
View directory record Official record
Conditions
Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia, Tibial Plateau Fracture, Ankle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar), Calcaneus Fractures, Talus Fracture, Wound Infection Deep, Wound Infection Post-Traumatic, Wound Dehiscence, Surgical
Interventions
Nitroglycerin Ointment 2%
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Jul 22, 2026, 4:14 PM EDT
Enrolling by invitation Not applicable Interventional

Conjoint Analysis of Patient Preferences in Joint Interventions

NCT02664337
View directory record Official record
Conditions
Arthritis, Femoroacetabular Impingement, Osteochondritis Dissecans, Hip Fractures, Ankle Fractures, Tibial Fractures
Interventions
Decision tool, Standard treatment information
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
2,310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 22, 2026, 4:14 PM EDT
Completed Not applicable Interventional

Exparel and Ankle Surgery

NCT02072135
View directory record Official record
Conditions
Ankle Fracture
Interventions
Exparel
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 22, 2016 · Synced Jul 22, 2026, 4:14 PM EDT
Recruiting Phase 4 Interventional

Single Shot Exparel vs Catheters in Lower Extremity Trauma

NCT07221019
View directory record Official record
Conditions
Fracture Dislocation of Ankle Joint, Fracture Leg, Fracture Femur, Fracture Lower Leg, Fracture
Interventions
Bupivacaine, Exparel + Bupivacaine
Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Jul 22, 2026, 4:14 PM EDT
Recruiting Not applicable Interventional

Correlation Between Intraoperative Tourniquet Use and Limb pH, Functional Measures and Patient-reported Outcomes After Ankle Fracture Surgery

NCT05445960
View directory record Official record
Conditions
Ankle Fractures, Ankle Fracture - Lateral Malleolus, Ankle Fracture, Bimalleolar, Ankle Fracture, Trimalleolar, Ankle Fracture - Medial Malleolus, Maisonneuve's Fracture, Syndesmotic Injuries, Fibula Fracture
Interventions
Tourniquet
Procedure
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 89 Years
Enrollment
390 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 23, 2025 · Synced Jul 22, 2026, 4:14 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Postoperative Aspirin and Ankle Fracture Healing

NCT03765619
View directory record Official record
Conditions
Ankle Fractures
Interventions
Aspirin
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 110 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 12, 2025 · Synced Jul 22, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

Augment® Bone Graft (Formerly GEM OS™1 Bone Graft) Compared to Autologous Bone Graft in Foot and Ankle Fusions

NCT00583375
View directory record Official record
Conditions
Foot Fusion
Interventions
Augment® Bone Graft, Standard of Care
Device · Procedure
Lead sponsor
BioMimetic Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
414 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
31
States / cities
Tucson, Arizona • San Francisco, California • Santa Cruz, California + 27 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2018 · Synced Jul 22, 2026, 4:14 PM EDT
Completed Not applicable Interventional

Manual Therapy After Ankle/Hindfoot Fractures

NCT02609347
View directory record Official record
Conditions
Ankle Fracture, Calcaneus Fracture, Talus Fracture, Pilon Fracture
Interventions
Manual Therapy Group, Control Group
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years to 70 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Jul 22, 2026, 4:14 PM EDT
Not listed Not applicable Interventional

Surgical Versus Nonsurgical Treatment of Fibular Fractures: A Prospective Randomized Study

NCT02032966
View directory record Official record
Conditions
Ankle Fracture, Malleolus Fracture, Medial Malleolus Fracture, Bimalleolar Fracture, Trimalleolar Fracture
Interventions
Nonsurgical, Surgical
Procedure
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2019
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 27, 2018 · Synced Jul 22, 2026, 4:14 PM EDT
Completed Not applicable Interventional

Early Weight Bearing for Unstable Ankle Fractures Undergoing Operative Stabilization

NCT02779244
View directory record Official record
Conditions
Ankle Fracture
Interventions
Early Weight bearing + Cam Boot, Non-Weight Bearing + Cam Boot
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 70 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Jul 22, 2026, 4:14 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Prevalence of Neuropathic Pain Pathophysiology Associated With Ankle Fracture

NCT06420141
View directory record Official record
Conditions
Neuropathic Pain
Interventions
Not listed
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 85 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Jul 22, 2026, 4:14 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Is Deltoid Ligament Repair for Ankle Fracture Necessary?

NCT02863042
View directory record Official record
Conditions
Ankle Fracture
Interventions
Repair Deltoid Tendon, Ankle Fracture Without Deltoid Tendon Repair
Procedure · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Jul 22, 2026, 4:14 PM EDT
Completed Not applicable Interventional Results available

A Multicenter Randomized Trial Comparing Antiglide and Lateral Plate Fixation in Ankle Fractures

NCT00718302
View directory record Official record
Conditions
Ankle Injuries
Interventions
Antiglide Plate, Lateral Plate
Device
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 85 Years
Enrollment
249 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
9
States / cities
Indianapolis, Indiana • Boston, Massachusetts • Grand Rapids, Michigan + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2017 · Synced Jul 22, 2026, 4:14 PM EDT
Recruiting Phase 4 Interventional

Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery

NCT06949826
View directory record Official record
Conditions
Pain, Postoperative, Ankle Fracture Surgery, Opioid Use Disorder, Opioid Dependence, Opioid Analgesia
Interventions
Buprenorphine Transdermal System, Placebo Patch
Drug
Lead sponsor
Jenna-Leigh Wilson
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced Jul 22, 2026, 4:14 PM EDT
Completed Early Phase 1 Interventional

Bedside Ultrasound in the Diagnosis of Ankle Fractures in Children

NCT01341015
View directory record Official record
Conditions
Ankle Fracture
Interventions
Ultrasound
Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
2 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 4, 2012 · Synced Jul 22, 2026, 4:14 PM EDT