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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Fracture of Lower Leg Clear all
Enrolling by invitation Not applicable Interventional

Conjoint Analysis of Patient Preferences in Joint Interventions

NCT02664337
View directory record Official record
Conditions
Arthritis, Femoroacetabular Impingement, Osteochondritis Dissecans, Hip Fractures, Ankle Fractures, Tibial Fractures
Interventions
Decision tool, Standard treatment information
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
2,310 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 3, 2026 · Synced Jul 23, 2026, 5:21 AM EDT
Not listed No phase listed Observational

Pelvic Fractures and Radiation Therapy for Cervical Cancer

NCT00800644
View directory record Official record
Conditions
Cervical Cancer, Endometrial Cancer, Vaginal Cancer
Interventions
CT or MRI + Blood Test
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
Female only
Enrollment
239 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Jul 23, 2026, 5:21 AM EDT
Completed No phase listed Observational Results available

DePuy Trochanteric (ATN) Nailing Clinical Outcomes Trial

NCT00546429
View directory record Official record
Conditions
Femoral Fracture (Proximal)
Interventions
Intramedullary nailing
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
4
States / cities
Colorado Springs, Colorado • Englewood, Colorado • Buffalo, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Jul 23, 2026, 5:21 AM EDT
Terminated Not applicable Interventional

Reamed Locked Plating - Metaphyseal Fractures of the Distal Femur and Tibia

NCT01553630
View directory record Official record
Conditions
Femoral Fractures, Tibial Fractures
Interventions
RIA bone graft, Surgery without bone graft
Procedure
Lead sponsor
Florida Orthopaedic Institute
Network
Eligibility
18 Years to 90 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
2
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 10, 2014 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Not applicable Interventional

Stress Radiography for Pelvic Ring Injuries

NCT05876871
View directory record Official record
Conditions
Pelvic Fracture
Interventions
Pelvic Binder Radiography
Diagnostic Test
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 7, 2025 · Synced Jul 23, 2026, 5:21 AM EDT
Recruiting Phase 4 Interventional

Single Shot Exparel vs Catheters in Lower Extremity Trauma

NCT07221019
View directory record Official record
Conditions
Fracture Dislocation of Ankle Joint, Fracture Leg, Fracture Femur, Fracture Lower Leg, Fracture
Interventions
Bupivacaine, Exparel + Bupivacaine
Drug
Lead sponsor
George Washington University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Jul 23, 2026, 5:21 AM EDT
Not listed Not applicable Interventional

Effects of Tranexamic Acid on Blood Loss and Transfusion Requirement Following Hip Fracture

NCT02738073
View directory record Official record
Conditions
Hip Fracture
Interventions
Control: Saline, Tranexamic Acid
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Bryn Mawr, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 13, 2016 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Not applicable Interventional Results available

Audio Distraction for Traction Pin Placement

NCT05927480
View directory record Official record
Conditions
Lower Extremity Fracture
Interventions
Audio distraction
Behavioral
Lead sponsor
HealthPartners Institute
Other
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
2
States / cities
Miami, Florida • Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 2, 2024 · Synced Jul 23, 2026, 5:21 AM EDT
Not listed Not applicable Interventional

Intertrochanteric Femoral Fracture Fixation Trial

NCT02627040
View directory record Official record
Conditions
Intertrochanteric Fracture, Hip Fracture
Interventions
InterTan Intertrochanteric Nail, Gamma 3 Intertrochanteric Nail
Device
Lead sponsor
Florida Orthopaedic Institute
Network
Eligibility
60 Years and older
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
2
States / cities
Brandon, Florida • Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Postoperative Aspirin and Ankle Fracture Healing

NCT03765619
View directory record Official record
Conditions
Ankle Fractures
Interventions
Aspirin
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 110 Years
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 12, 2025 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Not applicable Interventional Results available

Role of Vacuum Assisted Closure (VAC) Device in Postoperative Management of Pelvic and Acetabular Fractures

NCT00635479
View directory record Official record
Conditions
Pelvic Fractures, Acetabular Fractures, Hip Fractures
Interventions
VAC device, Gauze dressing
Device · Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 10, 2017 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Not applicable Interventional Results available

Regional Versus General Anesthesia for Promoting Independence After Hip Fracture

NCT02507505
View directory record Official record
Conditions
Hip Fractures
Interventions
Regional Anesthesia, General Anesthesia
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
50 Years and older
Enrollment
1,848 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
38
States / cities
Birmingham, Alabama • Sacramento, California • Hartford, Connecticut + 31 more
Source: ClinicalTrials.gov public record
Updated May 12, 2024 · Synced Jul 23, 2026, 5:21 AM EDT
Withdrawn Not applicable Interventional

Can Mobility Technicians Provide Value to Hospitalized Patients?

NCT03874767
View directory record Official record
Conditions
Hip Fractures, Lower Extremity Fracture, Lung Transplant
Interventions
Patient Mobility
Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 3, 2022 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Not applicable Interventional Results available

Augment® Bone Graft (Formerly GEM OS™1 Bone Graft) Compared to Autologous Bone Graft in Foot and Ankle Fusions

NCT00583375
View directory record Official record
Conditions
Foot Fusion
Interventions
Augment® Bone Graft, Standard of Care
Device · Procedure
Lead sponsor
BioMimetic Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
414 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
31
States / cities
Tucson, Arizona • San Francisco, California • Santa Cruz, California + 27 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2018 · Synced Jul 23, 2026, 5:21 AM EDT
Completed No phase listed Observational

A Post-Market Clinical Evaluation of the Treatment of Femur Fractures With the Femoral Nail PF

NCT04015154
View directory record Official record
Conditions
Femoral Fracture
Interventions
Femoral Nail PF of the T2 Alpha Femur Antegrade GT/PF Nailing System
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years to 80 Years
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
4
States / cities
Sartell, Minnesota • New York, New York • Cincinnati, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jul 23, 2026, 5:21 AM EDT
Terminated Phase 4 Interventional Results available

Dynamic Locking Screws 5.0 vs. Standard Locking Screws in Fracture of Distal Femur Treated With Locked Plate Fixation

NCT01693367
View directory record Official record
Conditions
Distal Femur Fractures
Interventions
DLS 5.0 (Dynamic locking screws), SLS (Standard locking screw)
Device
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
21 Years to 120 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
5
States / cities
Sacramento, California • Columbia, Missouri • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 12, 2020 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Not applicable Interventional Results available

Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Secondary Procedures and Quality of Life in Adults With Displaced Hip Fractures

NCT00556842
View directory record Official record
Conditions
Hip Fractures, Femoral Neck Fractures
Interventions
Total hip arthroplasty, Hemi-arthroplasty
Device
Lead sponsor
McMaster University
Other
Eligibility
50 Years and older
Enrollment
1,495 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 6, 2020 · Synced Jul 23, 2026, 5:21 AM EDT
Terminated No phase listed Observational

Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System

NCT06400732
View directory record Official record
Conditions
Fractures, Bone, Fractures, Closed, Fractures, Open, Fracture of Femur, Fracture Nonunion, Fracture of Tibia, Limb Deformity, Limb Fracture, Limb Defect, Limb Asymmetry
Interventions
Fitbone Transport and Lengthening System
Device
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
9
States / cities
Los Angeles, California • Orange, California • Atlanta, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jul 23, 2026, 5:21 AM EDT
Recruiting Phase 4 Interventional

Pre-Incision Peripheral Nerve Blocks for Lower Extremity Fracture Surgery in Older Adults

NCT07217626
View directory record Official record
Conditions
Lower Extremity Fracture, Surgical Fracture Repair, Orthopaedic Trauma, Orthogeriatric Fractures
Interventions
Local anesthesia injections
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Not applicable Interventional

Manual Therapy After Ankle/Hindfoot Fractures

NCT02609347
View directory record Official record
Conditions
Ankle Fracture, Calcaneus Fracture, Talus Fracture, Pilon Fracture
Interventions
Manual Therapy Group, Control Group
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years to 70 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Phase 2 Interventional

Navigator vs Standard Needle Injection for Hip

NCT02066844
View directory record Official record
Conditions
Hip Pain Etiology Unknown
Interventions
Celestone, Lidocaine
Drug
Lead sponsor
Cartiva, Inc.
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2016 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Not applicable Interventional Results available

A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Distal Femur Fractures

NCT00429663
View directory record Official record
Conditions
Femoral Fractures
Interventions
reamed, interlocking intramedullary nail, locking periarticular plate
Device
Lead sponsor
Boston Medical Center
Other
Eligibility
Not listed
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
22
States / cities
Sacramento, California • Tampa, Florida • Indianapolis, Indiana + 18 more
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Jul 23, 2026, 5:21 AM EDT
Recruiting No phase listed Observational

MDR - PMCF Study for Taperloc Complete Stems

NCT04028687
View directory record Official record
Conditions
Hip Arthritis, Hip Disease, Hip Fractures, Hip Injuries, Hip Pain Chronic
Interventions
Taperloc Complete Stem
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
820 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2032
U.S. locations
3
States / cities
Henderson, Nevada • Plano, Texas • Bellevue, Washington
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Jul 23, 2026, 5:21 AM EDT
Completed Not applicable Interventional

Intramedullary Nail Versus Sliding Hip Screw Inter-Trochanteric Evaluation

NCT01380444
View directory record Official record
Conditions
Femoral Neck Fractures, Intertrochanteric Fracture
Interventions
Gamma3 Intramedullary Nails (Stryker), Sliding Hip Screws
Procedure
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
18 Years and older
Enrollment
880 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
7
States / cities
Fresno, California • San Francisco, California • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Jul 23, 2026, 5:21 AM EDT