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Showing 1–24 of 111 matching trials from the live ClinicalTrials.gov search.
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Completed Not applicable Interventional

Frailty Prevention Program to Prevent Frailty Among Older African Americans

NCT03585972
View directory record Official record
Conditions
Frail Elderly Syndrome
Interventions
Frailty Prevention Program
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
55 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 29, 2019 · Synced Jun 25, 2026, 4:54 PM EDT
Terminated Phase 2Phase 3 Interventional

Identifying Best Approach in Improving Quality of Life and Survival After a Donor Stem Cell Transplant in Older, Medically Infirm, or Frail Patients With Blood Diseases

NCT03870750
View directory record Official record
Conditions
Hematopoietic and Lymphoid Cell Neoplasm, Non-Neoplastic Hematologic and Lymphocytic Disorder
Interventions
Supportive Palliative Care, Clinical Management, Best Practice, Allogeneic Hematopoietic Stem Cell Transplantation, Questionnaire Administration, Quality-of-Life Assessment, Survey Administration
Other · Procedure
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
20 Years and older
Enrollment
458 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
11
States / cities
Palo Alto, California • San Francisco, California • Detroit, Michigan + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause

NCT02404792
View directory record Official record
Conditions
HIV, Inflammation, Obesity, Aging, Biological
Interventions
High-intensity cardiovascular and resistance exercise, Moderate-intensity cardiovascular and resistance exercise
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 75 Years
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jan 15, 2019 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Phase 2 Interventional

Effectiveness of a Health Education Program in a Primary Care Setting

NCT00012779
View directory record Official record
Conditions
Frail Elderly
Interventions
Health Education Program
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
55 Years and older
Enrollment
288 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Ends 2003
U.S. locations
3
States / cities
Brockton, Massachusetts • Albany, New York • Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2015 · Synced Jun 25, 2026, 4:54 PM EDT
Enrolling by invitation Phase 2 Interventional

Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults

NCT03675724
View directory record Official record
Conditions
Frail Elderly Syndrome
Interventions
Fisetin, Placebo oral capsule
Dietary Supplement · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
70 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 25, 2026, 4:54 PM EDT
Recruiting Not applicable Interventional

Pilot Study to Evaluate Targeted Physical Activity Among Pancreatic Cancer Patients Receiving Neoadjuvant Chemotherapy

NCT07647250
View directory record Official record
Conditions
Physiological Reactivity to Cues, Physical Exercise
Interventions
36-session targeted physical exercise program delivered twice weekly
Other
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Phase 2 Interventional Results available

Bevacizumab Plus Capecitabine (Xeloda) in Patients With Untreated Metastatic Colorectal Cancer

NCT00203411
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Capecitabine (Xeloda), Bevacizumab
Drug
Lead sponsor
Translational Oncology Research International
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
12
States / cities
Alhambra, California • Bakersfield, California • Fullerton, California + 9 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2017 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Relationships Between Exercise and Emotion Regulation on Physical Activity in Frail Older Adults

NCT03514160
View directory record Official record
Conditions
Mobility Limitation, Sedentary Lifestyle, Older Adults
Interventions
Group exercise
Behavioral
Lead sponsor
Northeastern University
Other
Eligibility
60 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 1, 2018 · Synced Jun 25, 2026, 4:54 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Anabolic Response to Beef vs Plant Protein in (Pre)Frail Older Adults Using a Novel Stable Isotope Pulse Method

NCT07254403
View directory record Official record
Conditions
Protein Metabolism
Interventions
Beef, Tofu, Placebo
Other
Lead sponsor
Texas A&M University
Other
Eligibility
65 Years to 95 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Nov 27, 2025 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Phase 2 Interventional

Comparison of Subacute and Hospital Based Rehabilitation Care

NCT00038363
View directory record Official record
Conditions
Aging
Interventions
Rehabilitation, Subacute care
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 20, 2009 · Synced Jun 25, 2026, 4:54 PM EDT
Active, not recruiting Not applicable Interventional

The Impact of Whey Protein on Frailty in Older Adults Classified as Pre-frail

NCT07167277
View directory record Official record
Conditions
Pre-frail, Pre-Frail Older Adults, Cognition, Physical Function, Dietary Intake Assessment, MRI
Interventions
Whey Protein, Placebo
Dietary Supplement
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
65 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Phase 2 Interventional Results available

Ghrelin Repeated Dose Study

NCT01833078
View directory record Official record
Conditions
Frailty in Aging
Interventions
ghrelin
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
70 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Jun 25, 2026, 4:54 PM EDT
Withdrawn Phase 2 Interventional

Frailty Score-guided Dosing of Lenalidomide, Dexamethasone and Daratumumab Induction Therapy

NCT04223661
View directory record Official record
Conditions
Multiple Myeloma
Interventions
Lenalidomide Pill, Dexamethasone, Daratumumab
Drug
Lead sponsor
Attaya Suvannasankha
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Dec 7, 2022 · Synced Jun 25, 2026, 4:54 PM EDT
Recruiting Not applicable Interventional

Comparison of Smartphone and Community-Based Delivery of the Otago Exercise Program for Fall Risk in Older Adults

NCT07433153
View directory record Official record
Conditions
Frail Elderly, Fall
Interventions
Smartphone-Based Intervention, Group-Based Intervention
Behavioral
Lead sponsor
Binghamton University
Other
Eligibility
55 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Binghamton, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Jun 25, 2026, 4:54 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Peanut Sip Feeding Protocol

NCT06693544
View directory record Official record
Conditions
Protein Metabolism
Interventions
Peanut protein
Dietary Supplement
Lead sponsor
Texas A&M University
Other
Eligibility
65 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Jun 25, 2026, 4:54 PM EDT
Recruiting Phase 2 Interventional

Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL

NCT05952024
View directory record Official record
Conditions
Diffuse Large B-Cell Lymphoma
Interventions
Acalabrutinib, Rituximab
Drug · Biological
Lead sponsor
AstraZeneca
Industry
Eligibility
65 Years to 99 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
14
States / cities
Berkeley, California • La Jolla, California • Orange, California + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jun 25, 2026, 4:54 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

NCT02339012
View directory record Official record
Conditions
Healthy Volunteers, Non-Healthy/Non-Frail, Frail
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
20 Years to 120 Years
Enrollment
900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2099
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 23, 2026 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Measuring Eating, Activity and Strength: Understanding the Response -Using Protein

NCT01715753
View directory record Official record
Conditions
Weight Loss
Interventions
Protein supplementation, Diet counseling and group education lessons
Dietary Supplement · Behavioral
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
71 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Improving Function, Participation and Function After Acute Hospitalization in Older Adults

NCT01872637
View directory record Official record
Conditions
Frail Older Adults
Interventions
Progressive Multi-Component Intervention, Usual Care
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
2
States / cities
Aurora, Colorado • Glenside, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 16, 2017 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Not applicable Interventional

Donor Stem Cell Transplant in Treating Older or Frail Patients With Hematologic Cancer

NCT00296023
View directory record Official record
Conditions
Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
Interventions
anti-thymocyte globulin, filgrastim, therapeutic allogeneic lymphocytes, busulfan, fludarabine phosphate, methotrexate, tacrolimus, nonmyeloablative allogeneic hematopoietic stem cell transplantation, peripheral blood stem cell transplantation
Biological · Drug · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2008
U.S. locations
2
States / cities
Berkeley, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 3, 2012 · Synced Jun 25, 2026, 4:54 PM EDT
Completed Not applicable Interventional

AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program

NCT06079762
View directory record Official record
Conditions
Frailty, Aging, Frailty Syndrome, Frail Elderly Syndrome
Interventions
AGE SELF CARE group visit program
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years to 110 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2024 · Synced Jun 25, 2026, 4:54 PM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals

NCT05808686
View directory record Official record
Conditions
Aging, Fragility, Endothelial Dysfunction
Interventions
Ischemic Conditioning
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
65 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2029
U.S. locations
1
States / cities
Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 22, 2025 · Synced Jun 25, 2026, 4:54 PM EDT
Terminated Phase 2 Interventional Results available

A Study of Loncastuximab Tesirine and Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Participants With Diffuse Large B-cell Lymphoma (DLBCL)

NCT05144009
View directory record Official record
Conditions
Diffuse Large B-cell Lymphoma
Interventions
Loncastuximab Tesirine, Rituximab
Drug
Lead sponsor
ADC Therapeutics S.A.
Industry
Eligibility
65 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
29
States / cities
Tucson, Arizona • Little Rock, Arkansas • Aurora, Colorado + 24 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Jun 25, 2026, 4:54 PM EDT
Recruiting Not applicable Interventional

Preoperative Comprehensive Geriatric Assessment (CGA) and Postoperative Delirium

NCT07059585
View directory record Official record
Conditions
CGA
Interventions
CGA, control
Behavioral · Other
Lead sponsor
University of Miami
Other
Eligibility
60 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 20, 2025 · Synced Jun 25, 2026, 4:54 PM EDT