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ClinicalTrials.gov public records Last synced Oct 23, 2026, 5:10 AM EDT

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Showing 1–24 of 114 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Frail Elderly Clear all
Completed Phase 3 Interventional

Weight Loss and Exercise in Obese, Physically Limited, Older Women and Men

NCT00146107
View directory record Official record
Conditions
Obesity
Interventions
Diet, Exercise, Weight Loss and Exercise
Behavioral · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years to 85 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 23, 2013 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Phase 2 Interventional

Effects of Functional Incidental Training in VA NHCU Residents

NCT00013507
View directory record Official record
Conditions
Aging
Interventions
Falls
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2002
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Not applicable Interventional

AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program

NCT06079762
View directory record Official record
Conditions
Frailty, Aging, Frailty Syndrome, Frail Elderly Syndrome
Interventions
AGE SELF CARE group visit program
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
65 Years to 110 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Oct 23, 2026, 5:10 AM EDT
Terminated Not applicable Interventional Results available

Educational-Medical-Behavioral Treatment of Fecal Incontinence

NCT01717456
View directory record Official record
Conditions
Fecal Incontinence
Interventions
Education, Fiber supplements, Laxatives or anti-diarrheals, Pelvic floor muscle exercises, Tips on how to prevent fecal incontinence, Daily diary, Protective pads or garments
Other · Dietary Supplement · Drug + 1 more
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 17, 2017 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Phase 2 Interventional Results available

Bevacizumab Plus Capecitabine (Xeloda) in Patients With Untreated Metastatic Colorectal Cancer

NCT00203411
View directory record Official record
Conditions
Colorectal Cancer
Interventions
Capecitabine (Xeloda), Bevacizumab
Drug
Lead sponsor
Translational Oncology Research International
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
12
States / cities
Alhambra, California • Bakersfield, California • Fullerton, California + 9 more
Source: ClinicalTrials.gov public record
Updated Feb 6, 2017 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Not applicable Interventional

The Effect of Intradialytic Exercise on the Physical Function of People Undergoing Hemodialysis

NCT03944824
View directory record Official record
Conditions
End Stage Renal Failure on Dialysis, Frail Elderly Syndrome
Interventions
Exercise Plan using resistance bands, Modified Fried Frailty Scale
Other · Diagnostic Test
Lead sponsor
Satellite Healthcare
Other
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Milpitas, California
Source: ClinicalTrials.gov public record
Updated Sep 23, 2019 · Synced Oct 23, 2026, 5:10 AM EDT
Recruiting Phase 2 Interventional

Use of Isatuximab, Dexamethasone and Lenalidomide in a Go-Slow Fashion for Ultra-Frail Patients With Multiple Myeloma

NCT06517017
View directory record Official record
Conditions
Multiple Myeloma, Plasma Cell Leukemia
Interventions
Isatuximab
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 23, 2026, 5:10 AM EDT
Terminated Not applicable Interventional

A STEP for Patients Prior to Undergoing TAVR: A Pilot Study

NCT02766075
View directory record Official record
Conditions
Frail Elderly, Aortic Valve Stenosis
Interventions
Supervised TAVR Exercise Program
Behavioral
Lead sponsor
OSF Healthcare System
Other
Eligibility
50 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Peoria, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 12, 2018 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

MOWI Research Pilot

NCT03104192
View directory record Official record
Conditions
Obesity
Interventions
Develop & Refine MOWI w/o Amulet, MOWI Weight Loss Maintenance, Develop & Refine MOWI w Fitbit, Develop & Refine MOWI w Fitbit/Protein
Behavioral · Dietary Supplement
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
65 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Nov 29, 2022 · Synced Oct 23, 2026, 5:10 AM EDT
Completed No phase listed Observational

Simulation of Risk of Adverse Drug Events Associated With the Initiation of Drugs Repurposed for the Treatment of COVID-19 in Frail Elderly Adults With Polypharmacy

NCT04339634
View directory record Official record
Conditions
COVID, Drug Effect, Drug Interaction, Adverse Drug Event
Interventions
Simulation of Repurposed Drugs for COVID-19
Other
Lead sponsor
Tabula Rasa HealthCare
Industry
Eligibility
55 Years and older
Enrollment
12,873 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Translating 3-Step Workout for Life in a Local Senior Living Community

NCT03095534
View directory record Official record
Conditions
Frail Elderly, Muscle Weakness
Interventions
3-Step Workout for Life
Behavioral
Lead sponsor
Indiana University
Other
Eligibility
60 Years to 90 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 17, 2018 · Synced Oct 23, 2026, 5:10 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Anabolic Response to Beef vs Plant Protein in (Pre)Frail Older Adults Using a Novel Stable Isotope Pulse Method

NCT07254403
View directory record Official record
Conditions
Protein Metabolism
Interventions
Beef, Tofu, Placebo
Other
Lead sponsor
Texas A&M University
Other
Eligibility
65 Years to 95 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
College Station, Texas
Source: ClinicalTrials.gov public record
Updated Nov 28, 2025 · Synced Oct 23, 2026, 5:10 AM EDT
Terminated Phase 1 Interventional

Randomized Study Of Exercise And Vitamin D In Frail Elderly Subjects

NCT00249704
View directory record Official record
Conditions
Elderly, Frail
Interventions
Vitamin D + Sham Exercise, Vitamin D Placebo + Exercise, Vitamin D Placebo + Sham Exercise, Vitamin D + Exercise
Drug · Procedure
Lead sponsor
Pfizer
Industry
Eligibility
75 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
4
States / cities
Farmington, Connecticut • Hyattsville, Maryland • Roslindale, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 8, 2009 · Synced Oct 23, 2026, 5:10 AM EDT
Enrolling by invitation Phase 2 Interventional

Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women

NCT03430037
View directory record Official record
Conditions
Frail Elderly Syndrome
Interventions
Fisetin, Placebo oral capsule
Dietary Supplement · Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
70 Years and older · Female only
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Electronic Frailty Index (eFI)Cacious-Diabetes Care

NCT05047237
View directory record Official record
Conditions
Diabetes, Type2 Diabetes
Interventions
Pharmacist-Led Optimization Intervention
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
65 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Phase 3 Interventional

Evaluation of an Oral Nutritional Supplement Containing AN777

NCT01191125
View directory record Official record
Conditions
Malnutrition, Sarcopenia
Interventions
medical food with AN777, oral nutritional formula
Other
Lead sponsor
Abbott Nutrition
Industry
Eligibility
65 Years to 90 Years
Enrollment
331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
8
States / cities
Birmington, Alabama • Santa Rosa, California • Addison, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 7, 2013 · Synced Oct 23, 2026, 5:10 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Training the Brain with a Robotic Device for Balance Recovery

NCT02765425
View directory record Official record
Conditions
Fall Risk, Healthy Elderly
Interventions
AMES
Device
Lead sponsor
University of Arkansas
Other
Eligibility
65 Years to 90 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Fayetteville, Arkansas
Source: ClinicalTrials.gov public record
Updated Sep 3, 2024 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Phase 2 Interventional

Rehabilitation for Older Adults From Acute Medical Conditions

NCT00038155
View directory record Official record
Conditions
Aging, Frail Elderly
Interventions
Ambulation training
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
60 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 24, 2010 · Synced Oct 23, 2026, 5:10 AM EDT
Recruiting Phase 3 Interventional

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

NCT05561387
View directory record Official record
Conditions
Plasma Cell Myeloma
Interventions
Bortezomib, Daratumumab and Hyaluronidase-fihj, Dexamethasone, Lenalidomide, Quality-of-Life Assessment, Questionnaire Administration
Drug · Other
Lead sponsor
SWOG Cancer Research Network
Network
Eligibility
Not listed
Enrollment
510 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2031
U.S. locations
397
States / cities
Anchorage, Alaska • Phoenix, Arizona • Fort Smith, Arkansas + 287 more
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Phase 2 Interventional Results available

Reducing Frailty for Older Cancer Survivors Using Supplements

NCT04553666
View directory record Official record
Conditions
Frailty, Inflammation
Interventions
Epigallocatechin-3-Gallate (EGCG) plus Ascorbic Acid (Vitamin C)
Drug
Lead sponsor
University of Rochester
Other
Eligibility
65 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Not applicable Interventional

Nurse Physical Activity Counseling in Primary Care

NCT00105781
View directory record Official record
Conditions
Frail Elderly, Aged, Physical Fitness
Interventions
Exercise counseling
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
60 Years to 85 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Jacksonport, Arkansas
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Oct 23, 2026, 5:10 AM EDT
Not yet recruiting Phase 2 Interventional

Phase II Elderly/Frail Pts With Newly Diagnosed or Recurrent Malignant Glioma Treated With Cesium-131 GammaTile®

NCT07821112
View directory record Official record
Conditions
Glioma, Glioblastoma, GBM, Glioma, Malignant, Astrocytoma, Oligodendroglioma, Elderly Glioblastoma, Elderly GBM
Interventions
GammaTile®
Device
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 23, 2026, 5:10 AM EDT
Completed Phase 4 Interventional Results available

Preventing Osteoporosis Using Denosumab

NCT02753283
View directory record Official record
Conditions
Osteoporosis, Postmenopausal, Osteoporosis, Osteoporotic Fractures
Interventions
denosumab, Placebo, Calcium and Vitamin D
Drug · Dietary Supplement
Lead sponsor
Susan L. Greenspan
Other
Eligibility
65 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 23, 2026, 5:10 AM EDT
Terminated Phase 2 Interventional

Effects Of An Oral Growth Hormone Secretagogue In Older Functionally Limited Adults

NCT00527046
View directory record Official record
Conditions
Aging, Frail Older Adults
Interventions
CP-424,391
Drug
Lead sponsor
Pfizer
Industry
Eligibility
65 Years to 84 Years
Enrollment
396 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2001
U.S. locations
12
States / cities
Palo Alto, California • San Diego, California • Hamden, Connecticut + 9 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2012 · Synced Oct 23, 2026, 5:10 AM EDT