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Showing 1–24 of 316 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Functional Aging Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Mechanisms and Functional Outcomes of Exercise Progression Models in the Elderly

NCT01899586
View directory record Official record
Conditions
Elderly, Sedentary
Interventions
Regional Specific Training Stimulus (RSTS), Aerobic Exercise Regimen (AE)
Other
Lead sponsor
Duke University
Other
Eligibility
70 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
2
States / cities
Baton Rouge, Louisiana • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 3, 2014 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Phase 3 Interventional

Weight Loss and Exercise in Physically Limited Obese Elderly Subjects

NCT00146133
View directory record Official record
Conditions
Obesity, Frailty, Elderly
Interventions
diet, exercise
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years to 85 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 2, 2006 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Multidimensional Behavioral Intervention for Those at Risk for Alzheimer's Dementia

NCT03549078
View directory record Official record
Conditions
Functional Aging, Subjective Cognitive Concerns, Compensation Strategies, Brain Health Activities
Interventions
Intervention
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
65 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2020 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Life 2: Improving Fitness and Function in Elders

NCT00435188
View directory record Official record
Conditions
Aging, Mobility Limitations
Interventions
Multi-component physical activity counseling program
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
70 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 8, 2015 · Synced Sep 5, 2026, 9:18 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?

NCT07546409
View directory record Official record
Conditions
Prediabetes, Healthy (Controls)
Interventions
Ketone Monoester (KE), Placebo
Dietary Supplement
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
60 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
2
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fit & Active Seniors Trial

NCT01472744
View directory record Official record
Conditions
Aging
Interventions
Dance Group, Strength, Stretching, Stability, Walking, Walking + Nutrition
Behavioral
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
60 Years to 79 Years
Enrollment
247 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 22, 2017 · Synced Sep 5, 2026, 9:18 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Oral Curcumin Supplementation in Middle-Aged and Older Adults Improves Vascular Function

NCT01968564
View directory record Official record
Conditions
Vascular Aging
Interventions
Placebo pill, High-dose curcumin pill, Low-dose curcumin pill
Drug
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
45 Years to 80 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 19, 2017 · Synced Sep 5, 2026, 9:18 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

LpD3.5 Intervention Study in Older Adults- LISA-I Trial

NCT07794956
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis, Leaky Gut Syndrome, Gut Inflammation, Inflammaging
Interventions
LpD3.5, Placebo
Dietary Supplement
Lead sponsor
University of South Florida
Other
Eligibility
60 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline

NCT06466655
View directory record Official record
Conditions
Middle-aged Adults, Major Depressive Disorder
Interventions
MitoTempol, Lactated Ringer's (control)
Drug
Lead sponsor
University of Delaware
Other
Eligibility
40 Years to 55 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Oct 1, 2025 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cerebromicrovascular Effects of Time-Restricted Eating in Older Adults

NCT05488652
View directory record Official record
Conditions
Time Restricted Eating
Interventions
Time restricted eating
Behavioral
Lead sponsor
University of Oklahoma
Other
Eligibility
21 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults

NCT03824041
View directory record Official record
Conditions
Endothelial Dysfunction, Aging
Interventions
Aronia full spectrum - half dose, Aronia full spectrum - full dose, Placebo
Dietary Supplement
Lead sponsor
Colorado State University
Other
Eligibility
45 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 2, 2023 · Synced Sep 5, 2026, 9:18 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

NCT01720472
View directory record Official record
Conditions
Aging, Physical Functioning, Cognitive Functioning, Fitness
Interventions
Biomarker studies
Genetic
Lead sponsor
Duke University
Other
Eligibility
30 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
6
States / cities
Charlotte, North Carolina • Concord, North Carolina • Davidson, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Miricell Supplementation on Biomarkers of Healthy Aging and Autophagy

NCT07675200
View directory record Official record
Conditions
Autophagy, Healthy Aging
Interventions
Spermidine, Placebo
Dietary Supplement
Lead sponsor
Nutraland USA, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Canfield, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Fisetin to Improve Vascular Function in Older Adults

NCT06133634
View directory record Official record
Conditions
Aging, Endothelial Dysfunction, Arterial Stiffness
Interventions
Fisetin, Placebo
Dietary Supplement · Other
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
65 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 11, 2025 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Training Improves Balance Control

NCT01547988
View directory record Official record
Conditions
Accidental Falls
Interventions
Balance Training Intervention
Other
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
65 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2003
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Biological Effects of Weight Loss In Older, Obese Women

NCT01032733
View directory record Official record
Conditions
Obesity, Sarcopenia
Interventions
Lifestyle Counseling, Educational Control
Behavioral · Other
Lead sponsor
University of Florida
Other
Eligibility
55 Years to 79 Years · Female only
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 13, 2012 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy

NCT00427193
View directory record Official record
Conditions
Aging
Interventions
Caloric Restriction (CR), Control
Behavioral
Lead sponsor
Duke University
Other
Eligibility
21 Years to 50 Years
Enrollment
238 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2012
U.S. locations
3
States / cities
Baton Rouge, Louisiana • Boston, Massachusetts • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 15, 2022 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

COMP-4 Supplementation and Brachial Artery FMD

NCT05595915
View directory record Official record
Conditions
Aging, Endothelial Dysfunction, Senescence
Interventions
COMP-4
Dietary Supplement
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 39 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans

NCT05625204
View directory record Official record
Conditions
Frailty
Interventions
Center based attention (stretching only) control, Center based HIIT, Home based HIIT
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
2
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Heat Therapy, Functional Capacity, and Vascular Health in Older Adults

NCT05706181
View directory record Official record
Conditions
Aging Well, Walking, Difficulty, Hyperemia
Interventions
Home-based leg heat therapy, Home-based sham therapy
Other
Lead sponsor
University of North Texas Health Science Center
Other
Eligibility
55 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Phase 4 Interventional Results available

Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults

NCT05786521
View directory record Official record
Conditions
Aging, Diabetes Mellitus, Type 2, PreDiabetes, Overweight and Obesity
Interventions
Semaglutide Injectable Product, Lifestyle Counseling
Drug · Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
65 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 3, 2025 · Synced Sep 5, 2026, 9:18 AM EDT
Not yet recruiting Phase 3 Interventional

Vibegron for ENergy Thinking and Resilience in Aging

NCT06987383
View directory record Official record
Conditions
Obesity
Interventions
Vibegron, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
45 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Recruiting Not applicable Interventional

Training Community Members to be Coaches to Deliver the HealthyLifetime Program

NCT06616246
View directory record Official record
Conditions
Health Behaviors, Functional Decline, Chronic Disease, Risk Factors
Interventions
HealthyLifetime
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
30 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 21, 2026 · Synced Sep 5, 2026, 9:18 AM EDT
Completed Phase 2 Interventional

STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH

NCT00277875
View directory record Official record
Conditions
Cardiovascular Disease
Interventions
ALT-711 (alagebrium chloride)
Drug
Lead sponsor
Synvista Therapeutics, Inc
Industry
Eligibility
50 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 26, 2009 · Synced Sep 5, 2026, 9:18 AM EDT