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ClinicalTrials.gov public records Last synced Oct 23, 2026, 5:30 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 322 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Functional Aging Clear all
Enrolling by invitation Phase 1Phase 2 Interventional Accepts healthy volunteers

Safety, Efficacy of FFP From Healthy Donors to Ameliorate Frailty and Enhance Immune Function in Older Individuals

NCT03458429
View directory record Official record
Conditions
Frailty
Interventions
GMFFP
Drug
Lead sponsor
Dipnarine Maharaj
Other
Eligibility
55 Years to 95 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2030
U.S. locations
1
States / cities
Boynton Beach, Florida
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 23, 2026, 5:30 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Glucose Variability and Cognition in Prediabetes

NCT04201600
View directory record Official record
Conditions
Glucose Metabolism Disorders (Including Diabetes Mellitus), Cognitive Decline, PreDiabetes, Aging, Alzheimer's Disease
Interventions
Continuous Glucose Monitoring System (CGMS)
Device
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Phase 2 Interventional

Effects of Functional Incidental Training in VA NHCU Residents

NCT00013507
View directory record Official record
Conditions
Aging
Interventions
Falls
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2002
U.S. locations
1
States / cities
Decatur, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of a Dietary Supplement on Parameters of Skin Aging in Men and Women

NCT06083402
View directory record Official record
Conditions
Skin Aging
Interventions
HyaCera™, Placebo
Dietary Supplement
Lead sponsor
Natals, Inc. dba Ritual
Industry
Eligibility
25 Years to 70 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Raritan, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 16, 2023 · Synced Oct 23, 2026, 5:30 PM EDT
Terminated Not applicable Interventional Results available

Functional Rehabilitation for Older Patients With Schizophrenia

NCT00712075
View directory record Official record
Conditions
Schizophrenia, Aging
Interventions
CBSST+PDA, Cognitive Behavioral Social Skills Training, PDA-only
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
45 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Blueberry Enhances Activity and Cognition Through Increased Vascular Efficiency

NCT04049162
View directory record Official record
Conditions
Sedentary Lifestyle, Blood Pressure, Arterial Stiffness, Overweight and Obesity
Interventions
Blueberry Plus Exercise (BB-EX), Blueberry Placebo Plus Exercise (P-EX)
Dietary Supplement
Lead sponsor
Duke University
Other
Eligibility
60 Years and older
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 20, 2023 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Energetics and Function in Older Humans

NCT02348762
View directory record Official record
Conditions
Aging, Erythrocyte Glutathione Deficiency, Muscle Weakness
Interventions
Cysteine (as n-acetylcysteine) and Glycine
Dietary Supplement
Lead sponsor
Baylor College of Medicine
Other
Eligibility
21 Years to 80 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2022 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Immune Function Intervention Trial

NCT00548990
View directory record Official record
Conditions
Immune Response
Interventions
cardiovascular exercise training, flexibility/balance control
Behavioral
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
62 Years to 82 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 27, 2009 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Intervention to Enhance Lateral Balance Function and Prevent Falls in Aging

NCT01370174
View directory record Official record
Conditions
Accidental Falls
Interventions
Physical Training Interventions
Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
65 Years and older
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Safety & Efficacy of Nicotinamide Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults

NCT02921659
View directory record Official record
Conditions
Aging
Interventions
Niagen™, Placebo
Dietary Supplement
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
55 Years to 79 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 1, 2016 · Synced Oct 23, 2026, 5:30 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Exploring Blood Flow Restriction as an Accessible Fitness Solution for Healthy Aging in Seniors

NCT07460609
View directory record Official record
Conditions
Healthy Ageing
Interventions
Blood Flow Restriction Training Exercise, Health Education
Behavioral
Lead sponsor
Baylor University
Other
Eligibility
60 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Waco, Texas
Source: ClinicalTrials.gov public record
Updated Mar 10, 2026 · Synced Oct 23, 2026, 5:30 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Oral Curcumin Supplementation in Middle-Aged and Older Adults Improves Vascular Function

NCT01968564
View directory record Official record
Conditions
Vascular Aging
Interventions
Placebo pill, High-dose curcumin pill, Low-dose curcumin pill
Drug
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
45 Years to 80 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 20, 2017 · Synced Oct 23, 2026, 5:30 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults

NCT05300971
View directory record Official record
Conditions
Aging
Interventions
Heat therapy, Thermoneutral water immersion
Other
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
40 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Oct 23, 2026, 5:30 PM EDT
Recruiting Not applicable Interventional

Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome

NCT06821568
View directory record Official record
Conditions
Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
Interventions
Personalized Transcranial Direct Current Stimulation (tDCS), Active-Sham
Other
Lead sponsor
Hebrew SeniorLife
Other
Eligibility
65 Years to 90 Years
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Roslindale, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 23, 2026, 5:30 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Functional Neuroimaging in Parkinson's Disease

NCT04904068
View directory record Official record
Conditions
Parkinson Disease, Healthy Aging
Interventions
Not listed
Lead sponsor
University of Delaware
Other
Eligibility
45 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 23, 2026, 5:30 PM EDT
Withdrawn Phase 1Phase 2 Interventional Accepts healthy volunteers

Mesenchymal Stem Cells for Age-Related Frailty

NCT05284604
View directory record Official record
Conditions
Frailty
Interventions
Mesenchymal Stem Cells (MSCs)
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
65 Years to 85 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 6, 2023 · Synced Oct 23, 2026, 5:30 PM EDT
Completed No phase listed Observational

Development of Web-Based Mind-Body Trainings for Adults With Subjective Concerns

NCT06410807
View directory record Official record
Conditions
Aging, Focus Groups
Interventions
Focus groups
Other
Lead sponsor
Ohio State University
Other
Eligibility
50 Years and older
Enrollment
23 participants
Timeline
2024 – 2025
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

L-Citrulline and Endothelial Function

NCT05722860
View directory record Official record
Conditions
Aging
Interventions
L-Citrulline, capsule
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 90 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Mar 12, 2026 · Synced Oct 23, 2026, 5:30 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effects of a Carotenoid Intervention on Cognitive Function

NCT02023645
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
active supplement, placebo
Dietary Supplement · Other
Lead sponsor
University of Georgia
Other
Eligibility
18 Years to 95 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Oct 23, 2026, 5:30 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

NCT05344001
View directory record Official record
Conditions
Aging, Athletic Injuries, Physical Inactivity, Knee Injuries and Disorders
Interventions
Not listed
Lead sponsor
Marquette University
Other
Eligibility
18 Years to 64 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 25, 2026 · Synced Oct 23, 2026, 5:30 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults

NCT07727577
View directory record Official record
Conditions
Healthy Aging, Cognitive Benefits, Cardio Respiratory Fitness, Brain Activity
Interventions
High-Intensity Interval Training
Behavioral
Lead sponsor
Colby-Sawyer College
Other
Eligibility
55 Years to 79 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New London, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 23, 2026, 5:30 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

LpD3.5 Intervention Study in Older Adults- LISA-I Trial

NCT07794956
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis, Leaky Gut Syndrome, Gut Inflammation, Inflammaging
Interventions
LpD3.5, Placebo
Dietary Supplement
Lead sponsor
University of South Florida
Other
Eligibility
60 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sleepiness and the Risk of Falling

NCT00383357
View directory record Official record
Conditions
Aging, Balance, Sleep
Interventions
zolpidem
Drug
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
18 Years to 85 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2004
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Sep 20, 2007 · Synced Oct 23, 2026, 5:30 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study

NCT03617302
View directory record Official record
Conditions
Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension, Cognitive Decline
Interventions
Experimental: Nitrate-containing, Placebo: Nitrate-depleted
Drug
Lead sponsor
Gary L. Pierce, PhD
Other
Eligibility
50 Years to 79 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Oct 23, 2026, 5:30 PM EDT